SUPERFAMILY 1.75 HMM library and genome assignments server

ADC synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ADC synthase [ 56321]
Superfamily:   ADC synthase [ 56322]
Families:   ADC synthase [ 56323] (5)


Superfamily statistics
Genomes (2,559) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,757 44,803 8
Proteins 6,736 44,781 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.000066650.000001586Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.000035710.0000007221Least InformativeDirect
Biological Process (BP)biosynthetic process00.000000000000001913Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000020680.00000000001563Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000053080.000001403Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0048770.005397Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0018450.0136Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.000000016580Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.0000052430.000002287Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.0000000075350.0000000000002699Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.000000025940.00000003448Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0000000098460.000000000000001913Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.0000000018170.0000000000007906Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000000029060.0000000000008636Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.000000011420.00000000000004707Moderately InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process0.00000031460.000000000003228InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.1570.2687InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.000039980.002789InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.14530.004716InformativeInherited
Biological Process (BP)folic acid-containing compound metabolic process0.00000072580.0000001035Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process0.0000016670Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process0.00000000002540Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process0.00012560.0000001475Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.00000015450.0000000002613Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.00081750.003416Highly InformativeInherited
Biological Process (BP)tryptophan metabolic process0.047410.002964Highly InformativeInherited
Molecular Function (MF)transferase activity0.42090.6786Least InformativeInherited
Molecular Function (MF)binding0.013150.7834Least InformativeInherited
Molecular Function (MF)lyase activity0.000010470.00000000457Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.000017990.0000008316Moderately InformativeDirect
Molecular Function (MF)cation binding0.0000000046520.0000001013Moderately InformativeDirect
Molecular Function (MF)magnesium ion binding0.000000000000011470.00000000000002882InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity0.00000000000019350InformativeDirect
Molecular Function (MF)transaminase activity0.0000000000043960Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity00Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity0.00000000000056550Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000001586 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000007221 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000000000001913 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000001563 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000001403 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.005397 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.0136 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000002287 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000000000002699 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000003448 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000000000001913 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000000007906 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000000000008636 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00000000000004707 Moderately Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.000000000003228 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.2687 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.002789 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.004716 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 0.0000001035 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.0000001475 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.000003233 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.0000000002613 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.003416 Highly Informative Inherited
Biological Process (BP) tryptophan metabolic process 0.002964 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.6786 Least Informative Inherited
Molecular Function (MF) binding 0.7834 Least Informative Inherited
Molecular Function (MF) lyase activity 0.00000000457 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0000008316 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0000001013 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 0.00000000000002882 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) transaminase activity 0 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0005844Least InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0.0000001323InformativeDirect
Enzyme Commission (EC)Anthranilate synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.001148Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.0000000004345InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Transferring hydroxy groups0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0.0000000003982Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Biological processFolate biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0.000000623Highly InformativeDirect
Cellular componentPlastid0.00004402Moderately InformativeDirect
Cellular componentChloroplast0.0000276InformativeDirect
DomainTransit peptide0.0000009121Moderately InformativeDirect
DomainGlutamine amidotransferase0.0000000005482Highly InformativeDirect
Molecular functionMetal-binding0.000000000006659Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationIsomerase0.000007445Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.6959Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.004382Moderately InformativeInherited
UniPathway (UP)tryptophan metabolism0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0.00000006218InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.00000008688InformativeDirect
UniPathway (UP)polyketide biosynthesis0.002923InformativeInherited
UniPathway (UP)quinone cofactor biosynthesis0.008522InformativeInherited
UniPathway (UP)pteridine biosynthesis0.9336InformativeInherited
UniPathway (UP)L-tryptophan biosynthesis0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate biosynthesis0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0.0001239Highly InformativeDirect
UniPathway (UP)siderophore biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005801 SSF56322 Protein matches
Abstract This entry represents the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase. Anthranilate synthase catalyses the reaction: chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate. The enzyme is a tetramer comprising 2 I and 2 II components: this entry is restricted to component I that catalyses the formation of anthranilate using ammonia rather than glutamine, while component II provides glutamine amidotransferase activity .

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADC synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the ADC synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]