SUPERFAMILY 1.75 HMM library and genome assignments server

ADC synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ADC synthase [ 56321]
Superfamily:   ADC synthase [ 56322]
Families:   ADC synthase [ 56323] (5)


Superfamily statistics
Genomes (2,560) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,759 44,803 8
Proteins 6,738 44,781 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.000056810.000001531Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.000033150.0000007272Least InformativeDirect
Biological Process (BP)biosynthetic process00.000000000000003755Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00005030.000000001827Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000050520.000001331Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.001630.01334Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.000000021080Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00000530.000002444Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.0000000073660.0000000000003033Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00000002680.00000003919Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.000000000016480Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00000022120.0000000001292Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000000030180.000000000000964Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.000000012650.00000000000006562Moderately InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process0.00000031660.000000000003311InformativeDirect
Biological Process (BP)alpha-amino acid biosynthetic process0.00004890.003271InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.24130.01098InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.17330.2872InformativeInherited
Biological Process (BP)folic acid-containing compound metabolic process0.00000018730.00000004339Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process0.0000016730Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process0.00000000002560Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process0.00012640.0000001491Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.00000015590.0000000002659Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.0016070.00536Highly InformativeInherited
Biological Process (BP)tryptophan metabolic process0.045550.002797Highly InformativeInherited
Molecular Function (MF)binding0.012670.7729Least InformativeInherited
Molecular Function (MF)transferase activity0.35030.4881Least InformativeInherited
Molecular Function (MF)lyase activity0.0000085240.000000003976Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.000018330.000000846Moderately InformativeDirect
Molecular Function (MF)cation binding0.0000000046520.00000009942Moderately InformativeDirect
Molecular Function (MF)magnesium ion binding0.000000000000011360.00000000000002888InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity0.0000000000001630InformativeDirect
Molecular Function (MF)transaminase activity0.0000000000043820Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity00Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity0.00000000000056210Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000001531 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000007272 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000000000003755 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000000001827 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000001331 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.01334 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000002444 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000000000003033 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000003919 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000001292 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000000000964 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00000000000006562 Moderately Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.000000000003311 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.003271 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01098 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.2872 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 0.00000004339 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.0000001491 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.000003539 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.0000000002659 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.00536 Highly Informative Inherited
Biological Process (BP) tryptophan metabolic process 0.002797 Highly Informative Inherited
Molecular Function (MF) binding 0.7729 Least Informative Inherited
Molecular Function (MF) transferase activity 0.4881 Least Informative Inherited
Molecular Function (MF) lyase activity 0.000000003976 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.000000846 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00000009942 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 0.00000000000002888 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) transaminase activity 0 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0005844Least InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0.0000001323InformativeDirect
Enzyme Commission (EC)Anthranilate synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.001148Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.0000000004345InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Transferring hydroxy groups0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0.0000000003982Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Biological processFolate biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0.000000623Highly InformativeDirect
Cellular componentPlastid0.00004402Moderately InformativeDirect
Cellular componentChloroplast0.0000276InformativeDirect
DomainTransit peptide0.0000009121Moderately InformativeDirect
DomainGlutamine amidotransferase0.0000000005482Highly InformativeDirect
Molecular functionMetal-binding0.000000000006659Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationIsomerase0.000007445Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.6959Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.004382Moderately InformativeInherited
UniPathway (UP)tryptophan metabolism0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0.00000006218InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.00000008688InformativeDirect
UniPathway (UP)polyketide biosynthesis0.002923InformativeInherited
UniPathway (UP)quinone cofactor biosynthesis0.008522InformativeInherited
UniPathway (UP)pteridine biosynthesis0.9336InformativeInherited
UniPathway (UP)L-tryptophan biosynthesis0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate biosynthesis0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0.0001239Highly InformativeDirect
UniPathway (UP)siderophore biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005801 SSF56322 Protein matches
Abstract This entry represents the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase. Anthranilate synthase catalyses the reaction: chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate. The enzyme is a tetramer comprising 2 I and 2 II components: this entry is restricted to component I that catalyses the formation of anthranilate using ammonia rather than glutamine, while component II provides glutamine amidotransferase activity .

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADC synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the ADC synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]