SUPERFAMILY 1.75 HMM library and genome assignments server


ADC synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ADC synthase [ 56321]
Superfamily:   ADC synthase [ 56322]
Families:   ADC synthase [ 56323] (5)


Superfamily statistics
Genomes (2,558) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,754 44,803 8
Proteins 6,733 44,781 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process5.498e-051.522e-06Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process3.227e-057.239e-07Least InformativeDirect
Biological Process (BP)biosynthetic process03.741e-15Least InformativeDirect
Biological Process (BP)single-organism metabolic process5.092e-051.968e-09Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process4.908e-051.321e-06Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0015860.01332Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process2.328e-080Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process4.488e-061.616e-06Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process5.753e-091.592e-13Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process2.107e-082.385e-08Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process1.69e-110Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process2.285e-071.298e-10Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process2.502e-085.573e-13Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process1.259e-086.059e-14Moderately InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process3.177e-073.352e-12InformativeDirect
Biological Process (BP)alpha-amino acid biosynthetic process4.821e-050.003313InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.2410.01091InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.16930.2814InformativeInherited
Biological Process (BP)folic acid-containing compound metabolic process1.864e-074.681e-08Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process1.793e-060Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process2.569e-110Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process0.00013451.744e-07Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process1.684e-072.854e-10Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.0015920.005316Highly InformativeInherited
Biological Process (BP)tryptophan metabolic process0.04550.002777Highly InformativeInherited
Molecular Function (MF)binding0.012490.7668Least InformativeInherited
Molecular Function (MF)transferase activity0.35040.489Least InformativeInherited
Molecular Function (MF)lyase activity8.654e-063.979e-09Moderately InformativeDirect
Molecular Function (MF)isomerase activity1.822e-058.266e-07Moderately InformativeDirect
Molecular Function (MF)cation binding4.597e-099.73e-08Moderately InformativeDirect
Molecular Function (MF)magnesium ion binding1.14e-142.744e-14InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity1.648e-130InformativeDirect
Molecular Function (MF)transaminase activity4.425e-120Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity00Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity5.237e-130Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 1.522e-06 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 7.239e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 3.741e-15 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1.968e-09 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1.321e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.01332 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.616e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 1.592e-13 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.385e-08 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 1.298e-10 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 5.573e-13 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 6.059e-14 Moderately Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 3.352e-12 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.003313 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01091 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.2814 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 4.681e-08 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 1.744e-07 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 3.605e-06 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 2.854e-10 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.005316 Highly Informative Inherited
Biological Process (BP) tryptophan metabolic process 0.002777 Highly Informative Inherited
Molecular Function (MF) binding 0.7668 Least Informative Inherited
Molecular Function (MF) transferase activity 0.489 Least Informative Inherited
Molecular Function (MF) lyase activity 3.979e-09 Moderately Informative Direct
Molecular Function (MF) isomerase activity 8.266e-07 Moderately Informative Direct
Molecular Function (MF) cation binding 9.73e-08 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 2.744e-14 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) transaminase activity 0 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0005844Least InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups1.323e-07InformativeDirect
Enzyme Commission (EC)Anthranilate synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.001156Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)4.282e-10InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups4.05e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Biological processFolate biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis4.841e-07Highly InformativeDirect
DomainTransit peptide0.0001729Moderately InformativeDirect
DomainGlutamine amidotransferase1.295e-06Highly InformativeDirect
Molecular functionMetal-binding7.901e-13Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationIsomerase5.007e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.1606Least InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1.391e-11Moderately InformativeDirect
UniPathway (UP)cofactor biosynthesis0.04297Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0.08696Moderately InformativeInherited
UniPathway (UP)aromatic amino-acid biosynthesis1.932e-09InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism9.938e-08InformativeDirect
UniPathway (UP)pteridine biosynthesis0.04791InformativeInherited
UniPathway (UP)L-tryptophan biosynthesis8.892e-13Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005801 SSF56322 Protein matches
Abstract This entry represents the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase. Anthranilate synthase catalyses the reaction: chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate. The enzyme is a tetramer comprising 2 I and 2 II components: this entry is restricted to component I that catalyses the formation of anthranilate using ammonia rather than glutamine, while component II provides glutamine amidotransferase activity .

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADC synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the ADC synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]