SUPERFAMILY 1.75 HMM library and genome assignments server


Metallo-dependent phosphatases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metallo-dependent phosphatases [ 56299]
Superfamily:   Metallo-dependent phosphatases [ 56300] (12)
Families:   Purple acid phosphatase-like [ 56301] (2)
  DNA double-strand break repair nuclease [ 64427]
  5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain [ 56307]
  Protein serine/threonine phosphatase [ 56310] (5)
  Phosphoesterase-related [ 82803]
  TT1561-like [ 103320] (2)
  YfcE-like [ 111233] (4)
  Hypothetical protein aq 1666 [ 118152]
  DR1281-like [ 118155] (2)
  TTHA0625-like [ 143938]
  GpdQ-like [ 160875] (2)
  ADPRibase-Mn-like [ 160880]


Superfamily statistics
Genomes (3,161) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 44,740 0 54
Proteins 44,317 0 54


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.0085681.274e-05Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.021040.2515Least InformativeInherited
Biological Process (BP)single-organism cellular process0.53011Least InformativeInherited
Biological Process (BP)localization0.066111Least InformativeInherited
Biological Process (BP)biosynthetic process0.9611Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)lipid biosynthetic process0.00015941.44e-05Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.8381Moderately InformativeInherited
Biological Process (BP)cellular localization3.251e-070.0693Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process2.007e-070.01449Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.0018820.2743Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.012390.6381Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.015060.9581Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.05361Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.076141.176e-10Moderately InformativeInherited
Biological Process (BP)membrane lipid metabolic process5.826e-120InformativeDirect
Biological Process (BP)dephosphorylation0.00021630InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.013249.23e-11InformativeInherited
Biological Process (BP)vesicle-mediated transport7.384e-060.001586InformativeInherited
Biological Process (BP)cytoplasmic transport0.0081170.001112InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.00062580.05454InformativeInherited
Biological Process (BP)phospholipid metabolic process8.12e-060.3567InformativeInherited
Biological Process (BP)glycolipid biosynthetic process4.253e-126.692e-12Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process7.004e-082.338e-07Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process1.627e-098.892e-06Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport2.188e-119.01e-08Highly InformativeDirect
Biological Process (BP)RNA phosphodiester bond hydrolysis, endonucleolytic0.000120Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process0.014180.0003543Highly InformativeInherited
Molecular Function (MF)hydrolase activity1.003e-090Least InformativeDirect
Molecular Function (MF)binding0.70731Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds3.199e-110Moderately InformativeDirect
Molecular Function (MF)cation binding2.869e-070Moderately InformativeDirect
Molecular Function (MF)anion binding0.63081Moderately InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity2.788e-060InformativeDirect
Molecular Function (MF)lipid binding2.289e-050.0496InformativeInherited
Molecular Function (MF)transition metal ion binding6.81e-111InformativeInherited
Molecular Function (MF)nuclease activity0.85491InformativeInherited
Molecular Function (MF)endoribonuclease activity6.01e-054.615e-07Highly InformativeDirect
Molecular Function (MF)endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo4.851e-068.818e-07Highly InformativeDirect
Molecular Function (MF)manganese ion binding4.456e-068.152e-10Highly InformativeDirect
Molecular Function (MF)phosphatidylinositol binding3.76e-112.612e-05Highly InformativeDirect
Molecular Function (MF)glycolipid binding3.112e-132.11e-13Highly InformativeDirect
Molecular Function (MF)iron ion binding0.044370.01397Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.42251Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.89181Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.9571Least InformativeInherited
Cellular Component (CC)protein complex0.47394.713e-07Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0023520.1377Moderately InformativeInherited
Cellular Component (CC)cis-Golgi network1.126e-147.325e-14Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex4.234e-050Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.274e-05 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2515 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 1.176e-10 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 1.44e-05 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0693 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3505 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01444 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.6503 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.9198 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.7061 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.2743 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.6381 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01449 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9581 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.00538 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.003847 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 9.285e-05 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.0005397 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) cell cycle process 2.768e-06 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 9.23e-11 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.1028 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001586 Informative Inherited
Biological Process (BP) response to light stimulus 0.1169 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2272 Informative Inherited
Biological Process (BP) response to nutrient levels 0.1786 Informative Inherited
Biological Process (BP) lipid catabolic process 0.0108 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.1081 Informative Inherited
Biological Process (BP) RNA processing 0.04412 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001112 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.06347 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.005623 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.3567 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.05454 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.8919 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.3335 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4474 Informative Inherited
Biological Process (BP) regulation of immune response 0.8214 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2794 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.6169 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.06805 Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.0008372 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0007635 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) meiosis 0.0001367 Highly Informative Direct
Biological Process (BP) RNA splicing 1.225e-05 Highly Informative Direct
Biological Process (BP) glycolipid biosynthetic process 6.692e-12 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 6.622e-07 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 2.338e-07 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 2.341e-08 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 1.705e-05 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0003543 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 8.892e-06 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 9.01e-08 Highly Informative Direct
Biological Process (BP) RNA phosphodiester bond hydrolysis, endonucleolytic 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.001054 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.00459 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.103 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3036 Highly Informative Inherited
Biological Process (BP) external encapsulating structure organization 0.003108 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.1197 Highly Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.002979 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.001704 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1645 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.00804 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.01135 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.04752 Highly Informative Inherited
Biological Process (BP) interphase 0.4844 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 4.689e-09 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.123 Informative Inherited
Molecular Function (MF) lipid binding 0.0496 Informative Inherited
Molecular Function (MF) transition metal ion binding 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) endoribonuclease activity 4.615e-07 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 7.042e-06 Highly Informative Direct
Molecular Function (MF) calcium ion binding 8.038e-09 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo 8.818e-07 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0 Highly Informative Direct
Molecular Function (MF) manganese ion binding 8.152e-10 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 2.612e-05 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0001658 Highly Informative Direct
Molecular Function (MF) glycolipid binding 2.11e-13 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.01397 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 1 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) protein complex 4.713e-07 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1377 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cis-Golgi network 7.325e-14 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases5.707e-05Moderately InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase2.986e-12Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase1.228e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.4837Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.09125Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.3017Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.3847Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant9.147e-08InformativeDirect
Worm Phenotype (WP)cell stress response variant0.2254InformativeInherited
Worm Phenotype (WP)protein expression variant0.3253InformativeInherited
Worm Phenotype (WP)genotoxic induced apoptosis variant7.183e-06Highly InformativeDirect
Worm Phenotype (WP)germ cell ionizing radiation response variant0.0004906Highly InformativeDirect
Worm Phenotype (WP)cell ionizing radiation response variant0.0006182Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.0006806Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sleep defective0.0002059Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit1.005e-11InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0002841InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCell cycle0.04552Moderately InformativeInherited
Biological processMeiosis1.856e-15InformativeDirect
Biological processLipid biosynthesis8.189e-14InformativeDirect
Biological processMitosis8.581e-07InformativeDirect
Biological processBiological rhythms0.000546InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Biological processER-Golgi transport5.302e-07Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentVacuole2.028e-07InformativeDirect
Cellular componentGPI-anchor6.293e-05InformativeDirect
Cellular componentLysosome0.0009182InformativeDirect
Cellular componentCentromere1.177e-11Highly InformativeDirect
Cellular componentKinetochore2.364e-05Highly InformativeDirect
DomainSignal3.532e-09Least InformativeDirect
DomainKelch repeat0.0002816Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Molecular functionCalmodulin-binding3.664e-15InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0.0006683InformativeDirect
Post-translational modificationGlycoprotein2.759e-06Least InformativeDirect
Post-translational modificationMethylation3.243e-10Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism1.988e-10Least InformativeDirect
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis5.31e-13Moderately InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0InformativeDirect
UniPathway (UP)gluconeogenesis0InformativeDirect
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)lipid IV(A) biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metallo-dependent phosphatases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the Metallo-dependent phosphatases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]