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Metallo-dependent phosphatases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metallo-dependent phosphatases [ 56299]
Superfamily:   Metallo-dependent phosphatases [ 56300] (12)
Families:   Purple acid phosphatase-like [ 56301] (2)
  DNA double-strand break repair nuclease [ 64427]
  5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain [ 56307]
  Protein serine/threonine phosphatase [ 56310] (5)
  Phosphoesterase-related [ 82803]
  TT1561-like [ 103320] (2)
  YfcE-like [ 111233] (4)
  Hypothetical protein aq 1666 [ 118152]
  DR1281-like [ 118155] (2)
  TTHA0625-like [ 143938]
  GpdQ-like [ 160875] (2)
  ADPRibase-Mn-like [ 160880]


Superfamily statistics
Genomes (3,167) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 45,254 190,174 54
Proteins 44,819 185,060 54


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.99121Least InformativeInherited
Biological Process (BP)protein metabolic process0.01010.000005092Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.027360.2244Least InformativeInherited
Biological Process (BP)single-organism cellular process0.49191Least InformativeInherited
Biological Process (BP)localization0.066041Least InformativeInherited
Biological Process (BP)biosynthetic process0.98831Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)RNA metabolic process0.84351Moderately InformativeInherited
Biological Process (BP)cellular localization0.000000470.05953Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00000010760.01338Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.0023490.1334Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.006570.5809Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0081550.9122Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.050351Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.072780.00000000005457Moderately InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.000000000010InformativeDirect
Biological Process (BP)dephosphorylation0.00007780InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.013870.000000001004InformativeInherited
Biological Process (BP)vesicle-mediated transport0.0000071590.001238InformativeInherited
Biological Process (BP)cytoplasmic transport0.0077990.001121InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.00056180.05309InformativeInherited
Biological Process (BP)phospholipid metabolic process0.000010920.3782InformativeInherited
Biological Process (BP)glycolipid biosynthetic process0.000000000008390.00000000001006Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process0.000000068150.0000003092Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.0000000017950.00000774Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport0.000000000027650.00000008414Highly InformativeDirect
Biological Process (BP)RNA phosphodiester bond hydrolysis, endonucleolytic0.00013310Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process0.012390.0003074Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00000000052680Least InformativeDirect
Molecular Function (MF)binding0.69321Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.000000000018040Moderately InformativeDirect
Molecular Function (MF)cation binding0.0000001250Moderately InformativeDirect
Molecular Function (MF)anion binding0.50211Moderately InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.0000014770InformativeDirect
Molecular Function (MF)lipid binding0.000026240.04612InformativeInherited
Molecular Function (MF)nuclease activity0.88111InformativeInherited
Molecular Function (MF)endoribonuclease activity0.000067250.0000004372Highly InformativeDirect
Molecular Function (MF)endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo0.0000051230.0000007023Highly InformativeDirect
Molecular Function (MF)manganese ion binding0.000006380.000000001224Highly InformativeDirect
Molecular Function (MF)phosphatidylinositol binding0.000000000047610.00002568Highly InformativeDirect
Molecular Function (MF)glycolipid binding0.00000000000035090.0000000000001802Highly InformativeDirect
Molecular Function (MF)iron ion binding0.023950.006496Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.3171Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.76521Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.7511Least InformativeInherited
Cellular Component (CC)protein complex0.35440.00000002507Least InformativeInherited
Cellular Component (CC)membrane0.57611Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0029740.1239Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.01721Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.000044330Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000005092 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2244 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8665 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00000000005457 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.05953 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3481 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.002578 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4003 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.9214 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9794 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.7291 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.1334 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.5809 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01338 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9122 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9765 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.00371 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.00007392 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.00008322 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) cell cycle process 0.0000002096 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.000000001004 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.002067 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.06983 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001238 Informative Inherited
Biological Process (BP) response to light stimulus 0.1091 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2347 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.6984 Informative Inherited
Biological Process (BP) response to nutrient levels 0.06942 Informative Inherited
Biological Process (BP) lipid catabolic process 0.01029 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.05733 Informative Inherited
Biological Process (BP) RNA processing 0.03916 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001121 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.05995 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.3782 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.05309 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.901 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.319 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1677 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4632 Informative Inherited
Biological Process (BP) regulation of immune response 0.8172 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2724 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.621 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.08503 Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.00003228 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0007496 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) meiosis 0.00007526 Highly Informative Direct
Biological Process (BP) RNA splicing 0.0000109 Highly Informative Direct
Biological Process (BP) glycolipid biosynthetic process 0.00000000001006 Highly Informative Direct
Biological Process (BP) pathogenesis 0.0002518 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.0000005198 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.0000003092 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.00000001803 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0.00004592 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.0000225 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0003074 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000774 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00000008414 Highly Informative Direct
Biological Process (BP) RNA phosphodiester bond hydrolysis, endonucleolytic 0 Highly Informative Direct
Biological Process (BP) response to salt stress 0.7965 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.001105 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.005415 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.1065 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3123 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.0914 Highly Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.002807 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.003321 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.006723 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.008051 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.002043 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.0639 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.000000002071 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.1088 Informative Inherited
Molecular Function (MF) lipid binding 0.04612 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) endoribonuclease activity 0.0000004372 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.000003754 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00000001028 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo 0.0000007023 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0 Highly Informative Direct
Molecular Function (MF) manganese ion binding 0.000000001224 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.00002568 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0001306 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.0000000000001802 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.006496 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 1 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) protein complex 0.00000002507 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1239 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9611 Moderately Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00005707Moderately InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.000000000002986Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase0.00000001228Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.4837Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.09125Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.3017Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.3847Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.00000009147InformativeDirect
Worm Phenotype (WP)cell stress response variant0.2254InformativeInherited
Worm Phenotype (WP)protein expression variant0.3253InformativeInherited
Worm Phenotype (WP)genotoxic induced apoptosis variant0.000007183Highly InformativeDirect
Worm Phenotype (WP)germ cell ionizing radiation response variant0.0004906Highly InformativeDirect
Worm Phenotype (WP)cell ionizing radiation response variant0.0006182Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.0006806Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sleep defective0.000331Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00000000001005InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0001453InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCell cycle0.04116Moderately InformativeInherited
Biological processMeiosis0.000000000000001859InformativeDirect
Biological processLipid biosynthesis0.0000000000000689InformativeDirect
Biological processMitosis0.00000073InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Biological processER-Golgi transport0.0000005295Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0.0006792Moderately InformativeDirect
Cellular componentVacuole0.0000002054InformativeDirect
Cellular componentGPI-anchor0.00006371InformativeDirect
Cellular componentLysosome0.0009344InformativeDirect
Cellular componentCentromere0.0000000000122Highly InformativeDirect
Cellular componentKinetochore0.00002371Highly InformativeDirect
DomainSignal0.000000002043Least InformativeDirect
DomainKelch repeat0.0002812Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Molecular functionCalmodulin-binding0.00000000000000365InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0.0006831InformativeDirect
Post-translational modificationGlycoprotein0.000002657Least InformativeDirect
Post-translational modificationMethylation0.0000000002881Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.0000000001916Least InformativeDirect
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.0000000000005217Moderately InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0InformativeDirect
UniPathway (UP)gluconeogenesis0InformativeDirect
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)lipid IV(A) biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metallo-dependent phosphatases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the Metallo-dependent phosphatases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]