SUPERFAMILY 1.75 HMM library and genome assignments server


DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,865) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,468 67,010 17
Proteins 25,133 66,677 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.00022430.2418Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.0004444Least InformativeInherited
Biological Process (BP)single-organism cellular process0.17230.7704Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.59110.8917Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.00075691Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00066850.3397Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.00024770.3126Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00044450.09413Least InformativeInherited
Biological Process (BP)organic substance catabolic process0.000020810.00000000000002434Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process0.11610Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.41030Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.34680Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00019370.001669Moderately InformativeInherited
Biological Process (BP)DNA metabolic process0.0000000000000017070.00000000000001077InformativeDirect
Biological Process (BP)cellular component disassembly0.0000029240.000002743InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.000014460.00000000000004724InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00000000067750InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.000064750.000000000000003722InformativeDirect
Biological Process (BP)phospholipid metabolic process0.0011320InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0036690InformativeInherited
Biological Process (BP)dephosphorylation0.0073940InformativeInherited
Biological Process (BP)DNA catabolic process0.0000000000075250Highly InformativeDirect
Biological Process (BP)lipid modification0.00028890Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.00001530Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000065410Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.93840.000000002301InformativeInherited
Molecular Function (MF)nuclease activity0.0000024170.09932InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0004444 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.8917 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7704 Least Informative Inherited
Biological Process (BP) localization 0.998 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7081 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8112 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3397 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3126 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.09413 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2418 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1732 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1786 Least Informative Inherited
Biological Process (BP) developmental process 0.8264 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0001778 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0006945 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000000000002434 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000000000000001922 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.5316 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5167 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01999 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3497 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1629 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01047 Moderately Informative Inherited
Biological Process (BP) reproduction 0.47 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5302 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6456 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7488 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7087 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.006956 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08486 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001533 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1745 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04119 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.265 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.03384 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.02584 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8087 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2051 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.002044 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1692 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.03973 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8696 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3139 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001176 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001669 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) DNA metabolic process 0.00000000000001077 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.00001802 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0005031 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0003786 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00001536 Informative Direct
Biological Process (BP) cellular membrane organization 0.0001838 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) cellular component disassembly 0.000002743 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.00009144 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001192 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.0007108 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000000000004724 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0007443 Informative Direct
Biological Process (BP) regulation of ion transport 0.0003126 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000006064 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00000000003189 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00006762 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002874 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000001164 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0000000001638 Informative Direct
Biological Process (BP) organelle localization 0.0004465 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.000337 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.000000000000003722 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0006391 Informative Direct
Biological Process (BP) regulation of system process 0.001973 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.001505 Informative Inherited
Biological Process (BP) protein transport 0.065 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1415 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.03414 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01329 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.003231 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.09925 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.3845 Informative Inherited
Biological Process (BP) regulation of response to stress 0.9126 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.1925 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.02379 Informative Inherited
Biological Process (BP) growth 0.3923 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.4058 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.006234 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005853 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4806 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.04014 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.0116 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1581 Informative Inherited
Biological Process (BP) sexual reproduction 0.3187 Informative Inherited
Biological Process (BP) single organism reproductive process 0.476 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5354 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9438 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.5021 Informative Inherited
Biological Process (BP) cell projection organization 0.05901 Informative Inherited
Biological Process (BP) RNA processing 0.06455 Informative Inherited
Biological Process (BP) secretion by cell 0.03604 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.06577 Informative Inherited
Biological Process (BP) cell-cell signaling 0.2046 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1694 Informative Inherited
Biological Process (BP) regulation of cell development 0.2886 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01814 Informative Inherited
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.0000000002125 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.00001011 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.00002053 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0007329 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000006198 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000000667 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.000000007274 Highly Informative Direct
Biological Process (BP) signal release 0.0002012 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00000001011 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000000896 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0000000003342 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0000007893 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0000006646 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.000000005394 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0000000002548 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.000001557 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00004948 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 0.000005249 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.00004054 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.000002871 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.00000002059 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.000001917 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 0.00000007476 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.00000001378 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00000002269 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00006139 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0000000000003666 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00005066 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.01584 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.002933 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1003 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2226 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.005933 Highly Informative Inherited
Biological Process (BP) DNA modification 0.001765 Highly Informative Inherited
Biological Process (BP) cell division 0.0271 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.2866 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.3174 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.00756 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.01081 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01136 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.03285 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.1582 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.000000002301 Informative Direct
Molecular Function (MF) DNA binding 0.01919 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.4657 Informative Inherited
Molecular Function (MF) receptor activity 0.5409 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.6097 Informative Inherited
Molecular Function (MF) nuclease activity 0.09932 Informative Inherited
Molecular Function (MF) manganese ion binding 0.00000000195 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.0000004508 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0.001292 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.4782 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.008205 Least Informative Inherited
Cellular Component (CC) membrane 0.6346 Least Informative Inherited
Cellular Component (CC) protein complex 0.8999 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5396 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.00005502 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.9555 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0.00000002834 Informative Direct
Cellular Component (CC) nucleoplasm part 0.01575 Informative Inherited
Cellular Component (CC) ruffle 0.000000002863 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.00000004227 Highly Informative Direct
Cellular Component (CC) nuclear body 0.00000001441 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.00000005231 Highly Informative Direct
Cellular Component (CC) leading edge membrane 0.000000000005927 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000001523 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000005811Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000038InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III0.000000000000008279Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest0.00007384Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.111Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05199Moderately InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.00008817InformativeDirect
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.000188Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0535Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.005707InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007654Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3544Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.001501Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.03173Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6682Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0002021InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000002295Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.0002401Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.2981Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation2.365e-16Moderately InformativeDirect
Biological processApoptosis0.00000000000001404Moderately InformativeDirect
Biological processDNA damage0.00000000001536Moderately InformativeDirect
Biological processLipid metabolism0.000003164Moderately InformativeDirect
Biological processEndocytosis0.00000001275InformativeDirect
Biological processCytolysis0.000001292InformativeDirect
Biological processTranslation regulation0.000002254InformativeDirect
Biological processDNA recombination0.00004691InformativeDirect
Biological processCell adhesion0.0008972InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000009297Highly InformativeDirect
Biological processHemolysis0.0000001934Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000001971Moderately InformativeDirect
Cellular componentCell projection0.000000006934Moderately InformativeDirect
Cellular componentGolgi apparatus0.000004789Moderately InformativeDirect
DomainRepeat0.00003502Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding9.214e-16InformativeDirect
DomainSH2 domain0.0000000002064InformativeDirect
Molecular functionMetal-binding0.0000000000002686Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0.000000001523Moderately InformativeDirect
Molecular functionCalcium0.000002364Moderately InformativeDirect
Molecular functionActin-binding0.000000000000006839InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator0.000000000004659Moderately InformativeDirect
Post-translational modificationRepressor0.000000006344Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.2394Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationRNA-directed DNA polymerase0.000000000001206Highly InformativeDirect
Post-translational modificationS-nitrosylation0.00000003732InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)sphingolipid metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]