SUPERFAMILY 1.75 HMM library and genome assignments server

DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,874) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 26,346 67,010 17
Proteins 25,990 66,677 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organic cyclic compound metabolic process0.00075090.3801Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.00027480.2666Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.81230.000000000001438Least InformativeInherited
Biological Process (BP)single-organism cellular process0.23760.00115Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.63830.7694Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.00029660.3406Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00050920.1074Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.00057121Least InformativeInherited
Biological Process (BP)organic substance catabolic process0.00001960.000000000000003707Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.47970Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.38140Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.16290Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00018490.001766Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.000013040.00000000000002089InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.0000000005920InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.000060.00000000000001071InformativeDirect
Biological Process (BP)dephosphorylation0.0083680InformativeInherited
Biological Process (BP)phospholipid metabolic process0.0012170InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.003420InformativeInherited
Biological Process (BP)DNA catabolic process0.0000000000031260Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.000001880.0000001804Highly InformativeDirect
Biological Process (BP)lipid modification0.00026430Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.000015950Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000055640Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphatase activity10.5904InformativeInherited
Molecular Function (MF)nuclease activity0.000000026830.03811InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000001438 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.7305 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3801 Least Informative Inherited
Biological Process (BP) localization 0.9299 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8038 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7694 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6488 Least Informative Inherited
Biological Process (BP) developmental process 0.7072 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1144 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1171 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.00115 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2666 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3406 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.1074 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00003404 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.2106 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8302 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001546 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.07699 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9198 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4762 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.323 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01142 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05302 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1876 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001753 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9938 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.00905 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7136 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.2651 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5065 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.197 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.00807 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.936 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06196 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001766 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.3878 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2111 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.01546 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9844 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001401 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.003957 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.09214 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.177 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.000678 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) DNA repair 0.000000008417 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0003545 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00001418 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00000000635 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0003512 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0004707 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000317 Informative Direct
Biological Process (BP) response to cytokine 0.000682 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000000000002089 Informative Direct
Biological Process (BP) regulation of system process 0.00002637 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00001074 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000000000001184 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0000758 Informative Direct
Biological Process (BP) positive regulation of transport 0.0000415 Informative Direct
Biological Process (BP) negative regulation of transport 0.0001071 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000002745 Informative Direct
Biological Process (BP) organelle localization 0.0001968 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.00000000000001071 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0006298 Informative Direct
Biological Process (BP) single-organism cellular localization 0.000247 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.03337 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01099 Informative Inherited
Biological Process (BP) sexual reproduction 0.3786 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6751 Informative Inherited
Biological Process (BP) cell projection organization 0.1643 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.03069 Informative Inherited
Biological Process (BP) protein transport 0.06036 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.001491 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.004145 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.003328 Informative Inherited
Biological Process (BP) regulation of ion transport 0.002255 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01237 Informative Inherited
Biological Process (BP) cell division 0.6712 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1303 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.009746 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0344 Informative Inherited
Biological Process (BP) growth 0.5387 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01356 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.01158 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.0116 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.01187 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4181 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7312 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01012 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.2877 Informative Inherited
Biological Process (BP) secretion by cell 0.01083 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.08346 Informative Inherited
Biological Process (BP) synaptic transmission 0.01876 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.05487 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.04648 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1183 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1673 Informative Inherited
Biological Process (BP) regulation of cell development 0.2094 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.3992 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.121 Informative Inherited
Biological Process (BP) RNA processing 0.04784 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.0003479 Highly Informative Direct
Biological Process (BP) negative regulation of protein phosphorylation 0.00000000001282 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.0000000002052 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.000009035 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.0000004327 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0007772 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0000001018 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000008052 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000001804 Highly Informative Direct
Biological Process (BP) signal release 0.000004573 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00000001334 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0000000007774 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0000000003519 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0000008828 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.00000002864 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.0002243 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00003504 Highly Informative Direct
Biological Process (BP) inositol phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.000232 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.000007663 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000000000743 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.00000002198 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.0000002048 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.000001292 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00000004157 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0000848 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.00003815 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.0001677 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0000000000005153 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00004722 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000551 Highly Informative Direct
Biological Process (BP) regulation of protein targeting 0.0000000425 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.01487 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.3422 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2604 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.104 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2507 Highly Informative Inherited
Biological Process (BP) DNA modification 0.001496 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.003384 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.01046 Highly Informative Inherited
Biological Process (BP) exocytosis 0.005703 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.007803 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.02642 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.007608 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01241 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.03805 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.2419 Moderately Informative Inherited
Molecular Function (MF) phosphatase activity 0.5904 Informative Inherited
Molecular Function (MF) DNA binding 0.01986 Informative Inherited
Molecular Function (MF) nuclease activity 0.03811 Informative Inherited
Molecular Function (MF) receptor activity 0.4384 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.505 Informative Inherited
Molecular Function (MF) manganese ion binding 0.000000008433 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.0000004851 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0933 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.4645 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.5079 Least Informative Inherited
Cellular Component (CC) protein complex 0.754 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9322 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.441 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01461 Least Informative Inherited
Cellular Component (CC) cell projection 0.00009408 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.7899 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.0000007641 Informative Direct
Cellular Component (CC) cell leading edge 0.00000002589 Informative Direct
Cellular Component (CC) nucleoplasm part 0.0004355 Informative Direct
Cellular Component (CC) trans-Golgi network 0.00000003829 Highly Informative Direct
Cellular Component (CC) nuclear body 0.000001315 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.00000007159 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000001639 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000005811Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000038InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III0.000000000000008279Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest0.00007384Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.111Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05199Moderately InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.00008817InformativeDirect
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.000188Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0535Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.005707InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007654Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3583Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.001471Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.03137Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6642Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0002028InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000002227Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.0002332Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.3051Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation4.711e-16Moderately InformativeDirect
Biological processApoptosis0.00000000000001384Moderately InformativeDirect
Biological processDNA damage0.00000000001505Moderately InformativeDirect
Biological processLipid metabolism0.000003289Moderately InformativeDirect
Biological processEndocytosis0.0000000133InformativeDirect
Biological processCytolysis0.000001289InformativeDirect
Biological processTranslation regulation0.000002242InformativeDirect
Biological processDNA recombination0.00004628InformativeDirect
Biological processCell adhesion0.0008951InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000009095Highly InformativeDirect
Biological processHemolysis0.0000001937Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000002209Moderately InformativeDirect
Cellular componentCell projection0.000000007343Moderately InformativeDirect
Cellular componentGolgi apparatus0.000004923Moderately InformativeDirect
DomainRepeat0.0000355Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding9.217e-16InformativeDirect
DomainSH2 domain0.0000000001998InformativeDirect
Molecular functionMetal-binding0.0000000000005142Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0.000000001496Moderately InformativeDirect
Molecular functionCalcium0.000002702Moderately InformativeDirect
Molecular functionActin-binding0.00000000000000682InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator0.000000000004654Moderately InformativeDirect
Post-translational modificationRepressor0.000000007548Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.2378Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationRNA-directed DNA polymerase0.000000000001181Highly InformativeDirect
Post-translational modificationS-nitrosylation0.00000003702InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)sphingolipid metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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