SUPERFAMILY 1.75 HMM library and genome assignments server


DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,829) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 24,104 36,058 17
Proteins 23,836 35,855 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.00099720.357Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.0001221Least InformativeInherited
Biological Process (BP)single-organism cellular process0.35021Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.56190.7043Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0025671Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0025590.4788Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0010970.4429Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0016690.1568Least InformativeInherited
Biological Process (BP)macromolecule catabolic process3.275e-062.447e-14Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process0.00026162.251e-09Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process0.078020Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.39170Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.26510Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0015160.002154Moderately InformativeInherited
Biological Process (BP)DNA metabolic process8.046e-137.006e-14InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.00014622.951e-14InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process3.36e-080InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis7.781e-062.951e-14InformativeDirect
Biological Process (BP)phospholipid metabolic process0.0010280InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0036130InformativeInherited
Biological Process (BP)dephosphorylation0.0072550InformativeInherited
Biological Process (BP)DNA catabolic process8.28e-100Highly InformativeDirect
Biological Process (BP)cellular component disassembly1.574e-061.073e-06Highly InformativeDirect
Biological Process (BP)lipid modification0.00028770Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process1.388e-050Highly InformativeDirect
Molecular Function (MF)hydrolase activity7.007e-080Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds6.318e-150Moderately InformativeDirect
Molecular Function (MF)phosphatase activity10.6004InformativeInherited
Molecular Function (MF)nuclease activity3.08e-050.222InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0001221 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.7043 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.8652 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.5918 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7716 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4788 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.4429 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.1568 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.357 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.169 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2505 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0001257 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 2.447e-14 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0003671 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 2.251e-09 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.4799 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4477 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01138 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2933 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1125 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.005997 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.4872 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7101 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7945 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9796 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.5146 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.007791 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1937 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.008217 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3516 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02645 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.1666 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.02541 Moderately Informative Inherited
Biological Process (BP) system process 0.009642 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8432 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3078 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.007615 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1213 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.0278 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8032 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5012 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9593 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001922 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002154 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) DNA metabolic process 7.006e-14 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 3.819e-05 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0003919 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002507 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0001455 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of intracellular transport 7.094e-05 Informative Direct
Biological Process (BP) regulation of organelle organization 6.767e-05 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.000365 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 2.951e-14 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0005382 Informative Direct
Biological Process (BP) regulation of ion transport 0.0002301 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.845e-06 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 1.903e-11 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 4.822e-05 Informative Direct
Biological Process (BP) positive regulation of transport 0.0001464 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 6.004e-07 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 4.889e-11 Informative Direct
Biological Process (BP) organelle localization 0.0004504 Informative Direct
Biological Process (BP) membrane organization 0.0001688 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0002187 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 2.951e-14 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0004563 Informative Direct
Biological Process (BP) regulation of system process 0.001373 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.001032 Informative Inherited
Biological Process (BP) protein transport 0.05284 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1127 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.02849 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.005563 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.002348 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.09695 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.3681 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.09538 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01552 Informative Inherited
Biological Process (BP) growth 0.32 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.3388 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00393 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00367 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.502 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03104 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.01159 Informative Inherited
Biological Process (BP) response to nutrient levels 0.07389 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4917 Informative Inherited
Biological Process (BP) cell projection organization 0.03029 Informative Inherited
Biological Process (BP) RNA processing 0.07038 Informative Inherited
Biological Process (BP) secretion by cell 0.02617 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.05861 Informative Inherited
Biological Process (BP) cell-cell signaling 0.1839 Informative Inherited
Biological Process (BP) generation of neurons 0.9837 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.135 Informative Inherited
Biological Process (BP) regulation of cell development 0.2376 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.012 Informative Inherited
Biological Process (BP) DNA modification 0.0002282 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) RNA catabolic process 3.13e-11 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 7.485e-06 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.4e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 3.418e-08 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 6.167e-09 Highly Informative Direct
Biological Process (BP) polyol metabolic process 7.608e-09 Highly Informative Direct
Biological Process (BP) cellular component disassembly 1.073e-06 Highly Informative Direct
Biological Process (BP) signal release 0.0001474 Highly Informative Direct
Biological Process (BP) cell projection assembly 6.351e-09 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 4.759e-07 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 2.669e-10 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 5.685e-07 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 6.312e-07 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 1.158e-10 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 1.15e-06 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 4.47e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 3.014e-05 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.632e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 1.79e-06 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 7.951e-08 Highly Informative Direct
Biological Process (BP) interaction with symbiont 4.142e-09 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 6.54e-05 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 1.477e-08 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 4.611e-05 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 0.0001226 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 2.066e-13 Highly Informative Direct
Biological Process (BP) cellular response to peptide 6.163e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.09203 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.004112 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.002604 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.001278 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.3051 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.006032 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.01069 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.003122 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.01969 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.2196 Moderately Informative Inherited
Molecular Function (MF) phosphatase activity 0.6004 Informative Inherited
Molecular Function (MF) DNA binding 0.005928 Informative Inherited
Molecular Function (MF) chromatin binding 0.07613 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.6508 Informative Inherited
Molecular Function (MF) nuclease activity 0.222 Informative Inherited
Molecular Function (MF) receptor activity 0.4455 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.5179 Informative Inherited
Molecular Function (MF) phospholipase activity 2.105e-11 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0.0008962 Highly Informative Direct
Molecular Function (MF) manganese ion binding 2.021e-09 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1.06e-07 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.4444 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.005007 Least Informative Inherited
Cellular Component (CC) membrane 0.3368 Least Informative Inherited
Cellular Component (CC) protein complex 0.8008 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3023 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 3.172e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.7166 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9463 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.627 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 2.857e-08 Informative Direct
Cellular Component (CC) nucleoplasm part 0.005517 Informative Inherited
Cellular Component (CC) ruffle 3.941e-09 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 3.132e-08 Highly Informative Direct
Cellular Component (CC) nuclear body 2.098e-09 Highly Informative Direct
Cellular Component (CC) cell projection membrane 5.54e-08 Highly Informative Direct
Cellular Component (CC) leading edge membrane 3.707e-12 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 3.386e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases5.811e-06Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase3.8e-10InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III8.279e-15Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest7.384e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.3954Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.1735Moderately InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to diet-induced obesity0.0009824Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.111Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05199Moderately InformativeInherited
Worm Phenotype (WP)locomotor coordination variant8.817e-05InformativeDirect
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.000188Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0535Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.005707InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007654Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3583Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.001541Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.02946Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6837Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0001907InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase2.538e-11Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.0002338Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.303Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis1.358e-14Moderately InformativeDirect
Biological processDNA damage1.666e-11Moderately InformativeDirect
Biological processLipid metabolism3.211e-06Moderately InformativeDirect
Biological processEndocytosis1.229e-08InformativeDirect
Biological processCytolysis1.171e-06InformativeDirect
Biological processTranslation regulation2.299e-06InformativeDirect
Biological processDNA recombination4.7e-05InformativeDirect
Biological processCell adhesion0.0008708InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processRNA-mediated gene silencing8.173e-12Highly InformativeDirect
Biological processHemolysis1.879e-07Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum1.096e-10Moderately InformativeDirect
Cellular componentCell projection4.497e-09Moderately InformativeDirect
Cellular componentGolgi apparatus3.952e-06Moderately InformativeDirect
DomainRepeat3.623e-05Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding9.245e-16InformativeDirect
DomainSH2 domain2.154e-10InformativeDirect
Molecular functionMetal-binding1.243e-13Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding3.541e-08Moderately InformativeDirect
Molecular functionCalcium2.03e-06Moderately InformativeDirect
Molecular functionActin-binding5.925e-15InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator4.502e-12Moderately InformativeDirect
Post-translational modificationRepressor5.523e-09Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.2415Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationRNA-directed DNA polymerase1.135e-12Highly InformativeDirect
Post-translational modificationS-nitrosylation2.735e-08InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]