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DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,873) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 26,015 67,010 17
Proteins 25,661 66,677 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.00023260.2378Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.0005747Least InformativeInherited
Biological Process (BP)single-organism cellular process0.19380.759Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.62480.819Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.00066811Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00070430.3388Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0002510.3066Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00046910.0942Least InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.000024690.000000001687Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process0.11680Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.43830Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.35730Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00018480.001744Moderately InformativeInherited
Biological Process (BP)DNA metabolic process0.0000000000000016840.00000000000001083InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.000013790.00000000000003782InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00000000056780InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.000061140.0000000000000126InformativeDirect
Biological Process (BP)phospholipid metabolic process0.0012190InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0034650InformativeInherited
Biological Process (BP)dephosphorylation0.0086750InformativeInherited
Biological Process (BP)DNA catabolic process0.0000000000037390Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.0000021150.000002162Highly InformativeDirect
Biological Process (BP)lipid modification0.00026790Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.000016120Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000059350Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.93620.000000003841InformativeInherited
Molecular Function (MF)nuclease activity0.0000025350.08992InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0005747 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.819 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.759 Least Informative Inherited
Biological Process (BP) localization 0.9265 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.571 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7528 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3388 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3066 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.0942 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2378 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1128 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1054 Least Informative Inherited
Biological Process (BP) developmental process 0.7076 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0001662 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0005457 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0.000000001687 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.5025 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4873 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02062 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3138 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.153 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.004616 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.005295 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4061 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5243 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.627 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7191 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6839 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.01125 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08034 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.00124 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1723 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05124 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.03014 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.02628 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8029 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1815 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.001759 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1715 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.03659 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8442 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2841 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9745 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001132 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001744 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) DNA metabolic process 0.00000000000001083 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.00001707 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0005609 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0003305 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00001342 Informative Direct
Biological Process (BP) cellular membrane organization 0.0002003 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.00009864 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001209 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.0006739 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000000000003782 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0006144 Informative Direct
Biological Process (BP) regulation of ion transport 0.0003123 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000006481 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00000000003305 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00006779 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002599 Informative Direct
Biological Process (BP) negative regulation of transport 0.00005324 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000008733 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0000000001249 Informative Direct
Biological Process (BP) organelle localization 0.0004492 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0003611 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.0000000000000126 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0005508 Informative Direct
Biological Process (BP) regulation of system process 0.001821 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.001255 Informative Inherited
Biological Process (BP) protein transport 0.0582 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1265 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.03263 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01243 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.002789 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.08228 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.1737 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.02031 Informative Inherited
Biological Process (BP) growth 0.5395 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.4081 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.005898 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005541 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4513 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03991 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.01187 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1447 Informative Inherited
Biological Process (BP) sexual reproduction 0.3139 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4762 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5323 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9355 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4603 Informative Inherited
Biological Process (BP) cell projection organization 0.05859 Informative Inherited
Biological Process (BP) RNA processing 0.06641 Informative Inherited
Biological Process (BP) secretion by cell 0.03656 Informative Inherited
Biological Process (BP) synaptic transmission 0.01696 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1575 Informative Inherited
Biological Process (BP) regulation of cell development 0.2701 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01723 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.3769 Informative Inherited
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.000000000225 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.00000864 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0007325 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000009472 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000008793 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.000000006199 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000002162 Highly Informative Direct
Biological Process (BP) signal release 0.0001754 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00000001089 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0000007931 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0000000002965 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0000006843 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.000001001 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.000000006674 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0000000002151 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.000001203 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00003291 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.00003294 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.000006034 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.000000000187 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.00000001786 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.000001702 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.00000001086 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00000003507 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00007392 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0000000000002698 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00004665 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.01737 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.003893 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1027 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2244 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.005969 Highly Informative Inherited
Biological Process (BP) DNA modification 0.001833 Highly Informative Inherited
Biological Process (BP) cell division 0.02704 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.2694 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.7093 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.007305 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.009795 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01176 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.0351 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.1444 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.000000003841 Informative Direct
Molecular Function (MF) DNA binding 0.01783 Informative Inherited
Molecular Function (MF) receptor activity 0.4733 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.5395 Informative Inherited
Molecular Function (MF) nuclease activity 0.08992 Informative Inherited
Molecular Function (MF) manganese ion binding 0.000000008061 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.0000004219 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0.001079 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.4175 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.006561 Least Informative Inherited
Cellular Component (CC) membrane 0.624 Least Informative Inherited
Cellular Component (CC) protein complex 0.8527 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3951 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000483 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0.00000002477 Informative Direct
Cellular Component (CC) nucleoplasm part 0.01285 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.00000003783 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0000000109 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0000001027 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000001767 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000005811Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000038InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III0.000000000000008279Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest0.00007384Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.111Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05199Moderately InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.00008817InformativeDirect
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.000188Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0535Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.005707InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007654Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3605Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.001489Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.03173Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6668Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0002069InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.0000000000226Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.0002366Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.3064Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation4.713e-16Moderately InformativeDirect
Biological processApoptosis0.00000000000001382Moderately InformativeDirect
Biological processDNA damage0.00000000001532Moderately InformativeDirect
Biological processLipid metabolism0.000003334Moderately InformativeDirect
Biological processEndocytosis0.00000001261InformativeDirect
Biological processCytolysis0.000001297InformativeDirect
Biological processTranslation regulation0.000002227InformativeDirect
Biological processDNA recombination0.00004663InformativeDirect
Biological processCell adhesion0.0008912InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000009172Highly InformativeDirect
Biological processHemolysis0.000000195Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000001935Moderately InformativeDirect
Cellular componentCell projection0.000000006844Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000474Moderately InformativeDirect
DomainRepeat0.00003429Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding9.229e-16InformativeDirect
DomainSH2 domain0.0000000002038InformativeDirect
Molecular functionMetal-binding0.0000000000002704Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0.00000000145Moderately InformativeDirect
Molecular functionCalcium0.00000234Moderately InformativeDirect
Molecular functionActin-binding0.000000000000006603InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator0.00000000000466Moderately InformativeDirect
Post-translational modificationRepressor0.000000006406Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.2387Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationRNA-directed DNA polymerase0.00000000000119Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0009896Least InformativeDirect
Post-translational modificationS-nitrosylation0.00000003734InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]