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4'-phosphopantetheinyl transferase superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Metabolism |
| Detailed category | Transferases |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR008278 SSF56214 Protein matches |
| Abstract | These proteins transfer the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A
(CoA) to the invariant serine of pp-binding. This post-translational modification renders
holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP
[ 7559576]. This superfamily consists of two subtypes: The ACPS type such as ACPS_ECOLI and the
Sfp type such as SFP_BACSU. The structure of the Sfp type is known [10581256], which shows the
active site accommodates a magnesium ion. The most highly conserved regions of the
alignment are involved in binding the magnesium ion. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 4 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a 4'-phosphopantetheinyl transferase domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 4 hidden Markov models representing the 4'-phosphopantetheinyl transferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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