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Hect, E3 ligase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Families:   Hect, E3 ligase catalytic domain [ 56205] (2)


Superfamily statistics
Genomes (495) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,328 7,923 2
Proteins 7,166 7,798 2


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.000000014940Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0000390.0001111Least InformativeDirect
Biological Process (BP)developmental process0.000010410.000209Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.00000019870Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.10030.2777Least InformativeInherited
Biological Process (BP)regulation of cellular process0.99590.9771Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000000000030860.00001398Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.27950.5205Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.072521Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.09621Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.073051Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.17510Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.26040Moderately InformativeInherited
Biological Process (BP)nervous system development0.15480.3308Moderately InformativeInherited
Biological Process (BP)tissue development0.082370.823Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal00InformativeDirect
Biological Process (BP)tube development0.004590.1639InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0049180.6349InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.016210InformativeInherited
Biological Process (BP)tissue morphogenesis0.010150.5898InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0066780.3581InformativeInherited
Biological Process (BP)protein catabolic process0.024890InformativeInherited
Biological Process (BP)proteolysis0.14260InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.00000021150.2678InformativeInherited
Biological Process (BP)epithelium development0.14050.333InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process0.0000062760Highly InformativeDirect
Biological Process (BP)morphogenesis of embryonic epithelium0.000000045990.0003088Highly InformativeDirect
Biological Process (BP)protein ubiquitination00Highly InformativeDirect
Biological Process (BP)epithelial tube formation0.000000004230.00001086Highly InformativeDirect
Biological Process (BP)neural tube development0.0000073210.001117Highly InformativeInherited
Molecular Function (MF)ligase activity0.00000000000041190InformativeDirect
Molecular Function (MF)transcription factor binding transcription factor activity0.000000032910.0000005038Highly InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity0.0000000000000019840Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0001111 Least Informative Direct
Biological Process (BP) developmental process 0.000209 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.2777 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9771 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4077 Least Informative Inherited
Biological Process (BP) localization 0.06718 Least Informative Inherited
Biological Process (BP) response to stimulus 0.03753 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00001398 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0007514 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002735 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00001812 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system process 0.4307 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3046 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5205 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.03781 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3307 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.017 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.005558 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.05087 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0945 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8779 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2456 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3308 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7917 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8464 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1111 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.823 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.00002046 Informative Direct
Biological Process (BP) blood circulation 0.0007729 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00002365 Informative Direct
Biological Process (BP) sexual reproduction 0.0005214 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00049 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 0.00001418 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000004095 Informative Direct
Biological Process (BP) positive regulation of transport 0.0003754 Informative Direct
Biological Process (BP) negative regulation of transport 0.000008923 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.05396 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1059 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.01598 Informative Inherited
Biological Process (BP) protein localization to organelle 0.002696 Informative Inherited
Biological Process (BP) growth 0.09625 Informative Inherited
Biological Process (BP) tube development 0.1639 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6349 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.5543 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.003365 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.5813 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.241 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.12 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.0524 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001922 Informative Inherited
Biological Process (BP) reproductive system development 0.01611 Informative Inherited
Biological Process (BP) gland development 0.02032 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.4461 Informative Inherited
Biological Process (BP) regulation of locomotion 0.07001 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.00483 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9577 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5898 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3581 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02212 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03869 Informative Inherited
Biological Process (BP) protein transport 0.005167 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2678 Informative Inherited
Biological Process (BP) epithelium development 0.333 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.00008577 Highly Informative Direct
Biological Process (BP) gonad development 0.0001711 Highly Informative Direct
Biological Process (BP) fertilization 0.0002093 Highly Informative Direct
Biological Process (BP) response to salt stress 0.0006672 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000001629 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0003088 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000002006 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0000002629 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.00000001352 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00000004303 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00000002978 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.000006309 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.00000004329 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000778 Highly Informative Direct
Biological Process (BP) membrane fusion 0.00000008504 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.00001086 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.00001861 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00003195 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0003387 Highly Informative Direct
Biological Process (BP) developmental growth 0.01247 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.002646 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.05465 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.008345 Highly Informative Inherited
Biological Process (BP) neural tube development 0.001117 Highly Informative Inherited
Molecular Function (MF) binding 0.0002586 Least Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0188 Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.0000005038 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.0000000000006498 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.000000004327 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.005621 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8608 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7186 Least Informative Inherited
Cellular Component (CC) protein complex 0.924 Least Informative Inherited
Cellular Component (CC) membrane 0.3748 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.005276 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.04801 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.000005872 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00005471 Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00006128Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000000012Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001058Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.000005251InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.0000005682Moderately InformativeDirect
Biological processDifferentiation0.0003586Moderately InformativeDirect
Biological processDNA damage0.0005506Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Cellular componentNucleus0.00000000000000128Least InformativeDirect
Cellular componentCytoplasm0.00002916Least InformativeDirect
Cellular componentGolgi apparatus0.000001005Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0002052Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat0.0000000001942InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00000002607Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000569 SSF56204 Protein matches
Abstract The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [PubMed7708685]. Proteins containing this domain at the C-terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediated proteolysis.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hect, E3 ligase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]