SUPERFAMILY 1.75 HMM library and genome assignments server


Hect, E3 ligase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Families:   Hect, E3 ligase catalytic domain [ 56205] (2)


Superfamily statistics
Genomes (444) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 6,591 5,515 2
Proteins 6,443 5,443 2


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process5.219e-090Least InformativeDirect
Biological Process (BP)multicellular organismal process1.602e-054.626e-05Least InformativeDirect
Biological Process (BP)developmental process4.149e-060.000115Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process6.929e-080Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.17360.4369Least InformativeInherited
Biological Process (BP)regulation of cellular process10.9463Least InformativeInherited
Biological Process (BP)cellular protein modification process1.115e-119.701e-06Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.41260.4362Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.1331Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.15721Moderately InformativeInherited
Biological Process (BP)single-organism developmental process2.457e-050.2153Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.07041Moderately InformativeInherited
Biological Process (BP)macromolecule catabolic process0.036680Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.17640Moderately InformativeInherited
Biological Process (BP)nervous system development0.15310.1955Moderately InformativeInherited
Biological Process (BP)tissue development0.07820.8544Moderately InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0046680.5609InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.016550InformativeInherited
Biological Process (BP)tissue morphogenesis0.0094730.5176InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0063750.3088InformativeInherited
Biological Process (BP)protein catabolic process0.024050InformativeInherited
Biological Process (BP)proteolysis0.14280InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching1.469e-070.2253InformativeInherited
Biological Process (BP)epithelium development0.14020.4315InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process4.527e-060Highly InformativeDirect
Biological Process (BP)morphogenesis of embryonic epithelium3.202e-080.0002351Highly InformativeDirect
Biological Process (BP)protein ubiquitination00Highly InformativeDirect
Biological Process (BP)neural tube development5.067e-060.0009515Highly InformativeDirect
Biological Process (BP)tube formation1.267e-050.000481Highly InformativeDirect
Biological Process (BP)epithelial tube morphogenesis4.795e-070.004437Highly InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds1.06e-143.233e-13InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity1.321e-150Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 4.626e-05 Least Informative Direct
Biological Process (BP) developmental process 0.000115 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.4369 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9463 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2276 Least Informative Inherited
Biological Process (BP) localization 0.04569 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02273 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 9.701e-06 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001414 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0005589 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 4.42e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.2153 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1045 Moderately Informative Inherited
Biological Process (BP) system process 0.346 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8125 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4362 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04116 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.146 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.006146 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.001644 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06925 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.781 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8629 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1955 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9139 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8978 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1504 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8791 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7918 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.08801 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8544 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 2.512e-05 Informative Direct
Biological Process (BP) blood circulation 0.0004075 Informative Direct
Biological Process (BP) negative regulation of cell communication 4.305e-05 Informative Direct
Biological Process (BP) sexual reproduction 7.889e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0007907 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 1.188e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 3.056e-07 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.000521 Informative Direct
Biological Process (BP) positive regulation of transport 4.023e-05 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.04791 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.0631 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.00431 Informative Inherited
Biological Process (BP) protein localization to organelle 0.006205 Informative Inherited
Biological Process (BP) membrane organization 0.001228 Informative Inherited
Biological Process (BP) growth 0.03413 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5609 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.7665 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.5888 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.3574 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.07106 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02899 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.00224 Informative Inherited
Biological Process (BP) reproductive structure development 0.07992 Informative Inherited
Biological Process (BP) gland development 0.01728 Informative Inherited
Biological Process (BP) regulation of locomotion 0.04912 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002945 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9128 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5176 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3088 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01696 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03611 Informative Inherited
Biological Process (BP) protein transport 0.005147 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2253 Informative Inherited
Biological Process (BP) epithelium development 0.4315 Informative Inherited
Biological Process (BP) regulation of sodium ion transport 3.188e-05 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 9.857e-05 Highly Informative Direct
Biological Process (BP) gonad development 0.0001119 Highly Informative Direct
Biological Process (BP) fertilization 0.0001982 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0002351 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) neural tube development 0.0009515 Highly Informative Direct
Biological Process (BP) ovulation cycle process 2.746e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.465e-06 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0008544 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 5.116e-09 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 7.005e-09 Highly Informative Direct
Biological Process (BP) tube formation 0.000481 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.753e-06 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 6.456e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 2.261e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0003404 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 8.88e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0002111 Highly Informative Direct
Biological Process (BP) developmental growth 0.009667 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.05281 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.007205 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.01814 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.004437 Highly Informative Inherited
Molecular Function (MF) binding 0.002999 Least Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 3.233e-13 Informative Direct
Molecular Function (MF) enzyme binding 0.01465 Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.0005478 Highly Informative Direct
Molecular Function (MF) channel regulator activity 2.002e-13 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 1.023e-09 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.01171 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8865 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5097 Least Informative Inherited
Cellular Component (CC) protein complex 0.747 Least Informative Inherited
Cellular Component (CC) membrane 0.3672 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.00153 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.02367 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 3.087e-06 Informative Direct
Cellular Component (CC) Golgi apparatus 4.801e-05 Informative Direct
Cellular Component (CC) cell cortex 0.000814 Informative Direct
Cellular Component (CC) Golgi membrane 3.755e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant6.128e-05Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.2e-09Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant1.058e-07Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis5.251e-06InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis5.637e-07Moderately InformativeDirect
Biological processDifferentiation0.0003299Moderately InformativeDirect
Biological processDNA damage0.0005752Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Cellular componentNucleus1.268e-15Least InformativeDirect
Cellular componentCytoplasm2.745e-05Least InformativeDirect
Cellular componentGolgi apparatus9.658e-07Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0001747Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat2.912e-10InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein2.58e-08Least InformativeDirect
Post-translational modificationUbl conjugation2.256e-14Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000569 SSF56204 Protein matches
Abstract The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [PubMed7708685]. Proteins containing this domain at the C-terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediated proteolysis.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hect, E3 ligase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]