SUPERFAMILY 1.75 HMM library and genome assignments server


Hect, E3 ligase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Families:   Hect, E3 ligase catalytic domain [ 56205] (2)


Superfamily statistics
Genomes (495) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,328 7,923 2
Proteins 7,166 7,798 2


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process4.8e-090Least InformativeDirect
Biological Process (BP)multicellular organismal process1.666e-055.711e-05Least InformativeDirect
Biological Process (BP)developmental process4.343e-060.0001172Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process6.672e-080Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.16310.4206Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular protein modification process9.576e-122.991e-06Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.12871Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.40950.5414Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.1581Moderately InformativeInherited
Biological Process (BP)single-organism developmental process2.47e-050.1544Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.07211Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.17220Moderately InformativeInherited
Biological Process (BP)nervous system development0.15160.3272Moderately InformativeInherited
Biological Process (BP)tissue development0.082320.8203Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal00InformativeDirect
Biological Process (BP)tube development0.0046340.1645InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0048050.6263InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.016340InformativeInherited
Biological Process (BP)tissue morphogenesis0.010260.5933InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0067040.3604InformativeInherited
Biological Process (BP)protein catabolic process0.024410InformativeInherited
Biological Process (BP)proteolysis0.14160InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching1.417e-070.2712InformativeInherited
Biological Process (BP)epithelium development0.140.3301InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process4.566e-060Highly InformativeDirect
Biological Process (BP)morphogenesis of embryonic epithelium3.374e-080.000292Highly InformativeDirect
Biological Process (BP)protein ubiquitination00Highly InformativeDirect
Biological Process (BP)epithelial tube formation3.09e-099.913e-06Highly InformativeDirect
Biological Process (BP)neural tube development7.394e-060.001128Highly InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds1.015e-143.372e-13InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity1.334e-150Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 5.711e-05 Least Informative Direct
Biological Process (BP) developmental process 0.0001172 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.4206 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3476 Least Informative Inherited
Biological Process (BP) localization 0.05059 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02499 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 2.991e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0003223 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002896 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 6.937e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1544 Moderately Informative Inherited
Biological Process (BP) system process 0.4244 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7448 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5414 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04006 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2113 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004961 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002698 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.05013 Moderately Informative Inherited
Biological Process (BP) reproduction 0.08156 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7712 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.921 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9786 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9778 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2549 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3272 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7897 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.846 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1069 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8203 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 2.196e-05 Informative Direct
Biological Process (BP) blood circulation 0.0007104 Informative Direct
Biological Process (BP) negative regulation of cell communication 2.084e-05 Informative Direct
Biological Process (BP) sexual reproduction 0.0004897 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0004317 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 1.459e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 3.626e-07 Informative Direct
Biological Process (BP) positive regulation of transport 7.247e-05 Informative Direct
Biological Process (BP) negative regulation of transport 8.467e-06 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.05266 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.08571 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.005142 Informative Inherited
Biological Process (BP) protein localization to organelle 0.002611 Informative Inherited
Biological Process (BP) growth 0.08671 Informative Inherited
Biological Process (BP) tube development 0.1645 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6263 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.003361 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.5907 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.2402 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1083 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.03752 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001939 Informative Inherited
Biological Process (BP) reproductive system development 0.01613 Informative Inherited
Biological Process (BP) gland development 0.01964 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.4402 Informative Inherited
Biological Process (BP) regulation of locomotion 0.05579 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.00334 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9591 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5933 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3604 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02146 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03792 Informative Inherited
Biological Process (BP) protein transport 0.005217 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2712 Informative Inherited
Biological Process (BP) epithelium development 0.3301 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 9e-05 Highly Informative Direct
Biological Process (BP) gonad development 0.0001721 Highly Informative Direct
Biological Process (BP) fertilization 0.0001945 Highly Informative Direct
Biological Process (BP) response to salt stress 0.0006065 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 1.901e-07 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.000292 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 2.713e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.473e-06 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 1.424e-08 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 2.278e-08 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.524e-07 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 6.403e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 3.831e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000416 Highly Informative Direct
Biological Process (BP) membrane fusion 6.837e-08 Highly Informative Direct
Biological Process (BP) epithelial tube formation 9.913e-06 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 1.957e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.625e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0002568 Highly Informative Direct
Biological Process (BP) developmental growth 0.01344 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.001134 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.05463 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.004726 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.008313 Highly Informative Inherited
Biological Process (BP) neural tube development 0.001128 Highly Informative Inherited
Molecular Function (MF) binding 0.0006345 Least Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 3.372e-13 Informative Direct
Molecular Function (MF) enzyme binding 0.01319 Informative Inherited
Molecular Function (MF) channel regulator activity 5.445e-13 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 3.282e-09 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0.00224 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01439 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7417 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5277 Least Informative Inherited
Cellular Component (CC) protein complex 0.8999 Least Informative Inherited
Cellular Component (CC) membrane 0.3249 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.002592 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.03499 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 4.215e-06 Informative Direct
Cellular Component (CC) Golgi apparatus 3.221e-05 Informative Direct
Cellular Component (CC) cell cortex 0.0009652 Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant6.128e-05Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.2e-09Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant1.058e-07Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis5.251e-06InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis5.654e-07Moderately InformativeDirect
Biological processDifferentiation0.0003433Moderately InformativeDirect
Biological processDNA damage0.0005513Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Cellular componentNucleus1.278e-15Least InformativeDirect
Cellular componentCytoplasm2.941e-05Least InformativeDirect
Cellular componentGolgi apparatus9.74e-07Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0001945Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat1.985e-10InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein2.518e-08Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000569 SSF56204 Protein matches
Abstract The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [PubMed7708685]. Proteins containing this domain at the C-terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediated proteolysis.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hect, E3 ligase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]