SUPERFAMILY 1.75 HMM library and genome assignments server

Hect, E3 ligase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Families:   Hect, E3 ligase catalytic domain [ 56205] (2)


Superfamily statistics
Genomes (496) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,371 7,923 2
Proteins 7,208 7,798 2


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.00000001710Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000030980.0000354Least InformativeDirect
Biological Process (BP)developmental process0.00001050.0002063Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.00000020050Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.11920.38Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000000000031690.00001315Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.1880.3025Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.052230.8765Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.045781Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.25450Moderately InformativeInherited
Biological Process (BP)tissue development0.071961Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.072641Moderately InformativeInherited
Biological Process (BP)nervous system development0.16450.3538Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.17250Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal00InformativeDirect
Biological Process (BP)tube development0.0080660.1819InformativeInherited
Biological Process (BP)proteolysis0.13850InformativeInherited
Biological Process (BP)protein catabolic process0.024460InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.01650InformativeInherited
Biological Process (BP)epithelium development0.14440.5395InformativeInherited
Biological Process (BP)tissue morphogenesis0.0055480.5611InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0033260.3634InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.00000022250.2683InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0048590.6409InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process0.0000065740Highly InformativeDirect
Biological Process (BP)morphogenesis of embryonic epithelium0.000000045750.0003069Highly InformativeDirect
Biological Process (BP)protein ubiquitination00Highly InformativeDirect
Biological Process (BP)epithelial tube formation0.0000000042140.00001078Highly InformativeDirect
Biological Process (BP)neural tube development0.0000059850.001087Highly InformativeInherited
Molecular Function (MF)transferase activity0.0000053590Least InformativeDirect
Molecular Function (MF)transcription factor binding transcription factor activity0.000000033040.0000005006Highly InformativeDirect
Molecular Function (MF)ubiquitin-protein transferase activity6.814e-160Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000354 Least Informative Direct
Biological Process (BP) developmental process 0.0002063 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4622 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) localization 0.08333 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.38 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.03747 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00001315 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000951 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00003837 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000135 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.8765 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.00946 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01443 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.5791 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.05739 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01181 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.03729 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2171 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.877 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9069 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2706 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3538 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7957 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.07003 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.117 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.3025 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) blood circulation 0.0007813 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0001557 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00006343 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0003131 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0008247 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 0.00001676 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000001174 Informative Direct
Biological Process (BP) positive regulation of transport 0.0005671 Informative Direct
Biological Process (BP) negative regulation of transport 0.000008792 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.1202 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.04984 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.07636 Informative Inherited
Biological Process (BP) gland development 0.07996 Informative Inherited
Biological Process (BP) reproductive structure development 0.09618 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03829 Informative Inherited
Biological Process (BP) growth 0.09469 Informative Inherited
Biological Process (BP) tube development 0.1819 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.01585 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.07697 Informative Inherited
Biological Process (BP) protein transport 0.001261 Informative Inherited
Biological Process (BP) sexual reproduction 0.00443 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.5377 Informative Inherited
Biological Process (BP) regulation of locomotion 0.07069 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.004763 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8234 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001793 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.499 Informative Inherited
Biological Process (BP) epithelium development 0.5395 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.06614 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03849 Informative Inherited
Biological Process (BP) protein localization to organelle 0.002596 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.0179 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5611 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3634 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2683 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6409 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0001322 Highly Informative Direct
Biological Process (BP) gonad development 0.0003734 Highly Informative Direct
Biological Process (BP) fertilization 0.00004053 Highly Informative Direct
Biological Process (BP) response to salt stress 0.000663 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0003069 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0000004781 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.00000202 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.000003279 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0002029 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.00000001331 Highly Informative Direct
Biological Process (BP) membrane fusion 0.00000008385 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.00001078 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00003754 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0003318 Highly Informative Direct
Biological Process (BP) negative regulation of chromosome organization 0.000000000004215 Highly Informative Direct
Biological Process (BP) regulation of ion transmembrane transport 0.009598 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.1098 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.01412 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.001005 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.02847 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.005628 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.01153 Highly Informative Inherited
Biological Process (BP) neural tube development 0.001087 Highly Informative Inherited
Molecular Function (MF) binding 0.0005874 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) enzyme binding 0.01946 Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.0000005006 Highly Informative Direct
Molecular Function (MF) ubiquitin-protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.0000000000008976 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.000000004346 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.7548 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8256 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.002921 Least Informative Inherited
Cellular Component (CC) membrane 0.3758 Least Informative Inherited
Cellular Component (CC) transferase complex 0.001959 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.04628 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00001083 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0001796 Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00006128Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000000012Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001058Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.000005251InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.0000005682Moderately InformativeDirect
Biological processDifferentiation0.0003586Moderately InformativeDirect
Biological processDNA damage0.0005506Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Cellular componentNucleus0.00000000000000128Least InformativeDirect
Cellular componentCytoplasm0.00002916Least InformativeDirect
Cellular componentGolgi apparatus0.000001005Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0002052Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat0.0000000001942InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00000002607Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000569 SSF56204 Protein matches
Abstract The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [PubMed7708685]. Proteins containing this domain at the C-terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediated proteolysis.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hect, E3 ligase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]