SUPERFAMILY 1.75 HMM library and genome assignments server


FAD-binding/transporter-associated domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FAD-binding/transporter-associated domain-like [ 56175]
Superfamily:   FAD-binding/transporter-associated domain-like [ 56176] (4)
Families:   FAD-linked oxidases, N-terminal domain [ 56177] (5)
  Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain [ 56184]
  CO dehydrogenase flavoprotein N-terminal domain-like [ 56187] (5)
  CorC/HlyC domain-like [ 160820] (12)


Superfamily statistics
Genomes (3,047) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 27,492 59,022 42
Proteins 27,392 58,926 42


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 8.632e-08 Least Informative Direct
Biological Process (BP) biosynthetic process 0.03857 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 2.376e-05 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0004623 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0.07506 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.001055 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.03132 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.01471 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.02721 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.258 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.155 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 1.199e-06 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 4.338e-05 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001676 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.001004 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.09871 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 7.805e-09 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.0004771 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0008744 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001398 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 1.555e-15 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 2.413e-07 Informative Direct
Molecular Function (MF) electron carrier activity 1.912e-05 Informative Direct
Molecular Function (MF) transition metal ion binding 0.3911 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.02136 Informative Inherited
Molecular Function (MF) metal cluster binding 3.544e-13 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 7.964e-06 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) microbody 0.0004004 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.9538Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.03512Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.02818InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor1.6e-09Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor8.129e-07Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.2146Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.05226Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0003673Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.5547Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)embryo sac cell5.383e-06Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.4981InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.8513InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor9.742e-11Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor1.039e-09Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor3.873e-06Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0.004431Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCell cycle0Moderately InformativeDirect
Biological processIon transport3.915e-10Moderately InformativeDirect
Biological processCell shape0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processPurine metabolism1.332e-05Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCell membrane0.01191Moderately InformativeInherited
Cellular componentPeroxisome2.52e-15InformativeDirect
Cellular componentCell inner membrane4.585e-08InformativeDirect
DomainTransit peptide0.0005199Moderately InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionIron-sulfur1.436e-07InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism9.617e-08Least InformativeDirect
UniPathway (UP)cofactor metabolism1.282e-06Least InformativeDirect
UniPathway (UP)lipid metabolism9.537e-05Least InformativeDirect
UniPathway (UP)lipid biosynthesis2.577e-06Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0InformativeDirect
UniPathway (UP)terpene metabolism1.908e-06InformativeDirect
UniPathway (UP)alcohol biosynthesis0.01716InformativeInherited
UniPathway (UP)glycerol metabolism1InformativeInherited
UniPathway (UP)L-ascorbate biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerolipid biosynthesis0Highly InformativeDirect
UniPathway (UP)cholesterol metabolism1.275e-12Highly InformativeDirect
UniPathway (UP)sterol biosynthesis3.261e-09Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-binding/transporter-associated domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the FAD-binding/transporter-associated domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]