SUPERFAMILY 1.75 HMM library and genome assignments server


FAD-binding/transporter-associated domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FAD-binding/transporter-associated domain-like [ 56175]
Superfamily:   FAD-binding/transporter-associated domain-like [ 56176] (4)
Families:   FAD-linked oxidases, N-terminal domain [ 56177] (5)
  Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain [ 56184]
  CO dehydrogenase flavoprotein N-terminal domain-like [ 56187] (5)
  CorC/HlyC domain-like [ 160820] (12)


Superfamily statistics
Genomes (3,081) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 28,189 117,270 42
Proteins 28,044 117,134 42


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000003247 Least Informative Direct
Biological Process (BP) biosynthetic process 0.02973 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9895 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.00001589 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0003362 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0009721 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0.06176 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.03483 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.22 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6602 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.1358 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 0.000001066 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00003827 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001309 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0009904 Informative Direct
Biological Process (BP) alcohol metabolic process 0.09204 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000000008553 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.0003989 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0007904 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001285 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.000000000000001558 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.0000001886 Informative Direct
Molecular Function (MF) electron carrier activity 0.00001698 Informative Direct
Molecular Function (MF) transition metal ion binding 0.3675 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.02145 Informative Inherited
Molecular Function (MF) metal cluster binding 0.0000000000002181 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00000828 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) microbody 0.0003481 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.9538Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.03512Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.02818InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0000000016Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0000008129Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.2146Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.05354Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0003738Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.5547Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)embryo sac cell0.000005383Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.4929InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.8583InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.00000000009814Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.0000000009423Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000003956Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0.004542Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCell cycle0Moderately InformativeDirect
Biological processIon transport0.0000000003195Moderately InformativeDirect
Biological processCell shape0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processPurine metabolism0.00001271Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCell membrane0.01498Moderately InformativeInherited
Cellular componentPeroxisome0.000000000000001908InformativeDirect
Cellular componentCell inner membrane0.00000002InformativeDirect
DomainTransit peptide0.0005298Moderately InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionIron-sulfur0.0000001135InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.00006493Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.0003395Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.8396Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect
UniPathway (UP)alkaloid metabolism0.00003655InformativeDirect
UniPathway (UP)purine degradation0.0007758InformativeDirect
UniPathway (UP)terpene metabolism0.03903InformativeInherited
UniPathway (UP)alcohol biosynthesis0.07958InformativeInherited
UniPathway (UP)glycerol metabolism0.3116InformativeInherited
UniPathway (UP)purine base metabolism0.3638InformativeInherited
UniPathway (UP)purine biosynthesis via salvage pathway1InformativeInherited
UniPathway (UP)L-ascorbate biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerolipid biosynthesis0.000000000000002455Highly InformativeDirect
UniPathway (UP)hypoxanthine degradation0.0000003755Highly InformativeDirect
UniPathway (UP)cholesterol metabolism0.000001103Highly InformativeDirect
UniPathway (UP)sterol biosynthesis0.00007831Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-binding/transporter-associated domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the FAD-binding/transporter-associated domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]