SUPERFAMILY 1.75 HMM library and genome assignments server


Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,104) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 280,067 384,172 233
Proteins 273,143 378,621 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process1.205e-100Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis1.432e-060Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)reproduction2.746e-110Moderately InformativeDirect
Biological Process (BP)immune system process9.261e-060Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.00096290Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process3.089e-053.86e-13Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00029924.662e-13Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process6.615e-050Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00030670Moderately InformativeDirect
Biological Process (BP)regulation of localization12.834e-06Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.11790.00141Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization10Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.55060Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.71820.04878Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)organelle organization10.7944Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.93681Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.64530Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0055031.339e-11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.058770Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.37925.937e-05Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00015130.02152Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.1353Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0048510Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.021640Moderately InformativeInherited
Biological Process (BP)tissue development0.021476.155e-10Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.85581Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.81831Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.6721Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.92221Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)system process10.4612Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.57530Moderately InformativeInherited
Biological Process (BP)organ development0.82280.1146Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.02553.77e-15Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0068350.0272Moderately InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway2.6e-060InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.00012530InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process2.333e-120InformativeDirect
Biological Process (BP)intracellular signal transduction00InformativeDirect
Biological Process (BP)growth0.00013940InformativeDirect
Biological Process (BP)regulation of kinase activity8.148e-071.332e-07InformativeDirect
Biological Process (BP)single organism reproductive process0.00058396.742e-08InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process1.745e-060InformativeDirect
Biological Process (BP)glycerolipid metabolic process1.359e-050InformativeDirect
Biological Process (BP)cellular process involved in reproduction2.352e-100InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.0006152.551e-06InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00018540.0001886InformativeDirect
Biological Process (BP)regulation of intracellular transport0.016690.0171InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process10.5881InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.70226.733e-14InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.25281.201e-10InformativeInherited
Biological Process (BP)positive regulation of developmental process0.026732.796e-05InformativeInherited
Biological Process (BP)regulation of cell development0.091869.473e-06InformativeInherited
Biological Process (BP)response to cytokine stimulus0.62320.8719InformativeInherited
Biological Process (BP)positive regulation of transport0.80781InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.90811InformativeInherited
Biological Process (BP)regulation of organelle organization10InformativeInherited
Biological Process (BP)blood circulation0.00035030.453InformativeInherited
Biological Process (BP)cytoskeleton organization0.020360InformativeInherited
Biological Process (BP)microtubule-based process0.027699.69e-12InformativeInherited
Biological Process (BP)protein complex assembly0.46471InformativeInherited
Biological Process (BP)organelle assembly0.020082.451e-05InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly11InformativeInherited
Biological Process (BP)sexual reproduction8.266e-050.2049InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.3240.8611InformativeInherited
Biological Process (BP)response to inorganic substance0.50691InformativeInherited
Biological Process (BP)alcohol metabolic process0.2411InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.22670InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.0090480InformativeInherited
Biological Process (BP)regulation of defense response0.86651InformativeInherited
Biological Process (BP)defense response10.8475InformativeInherited
Biological Process (BP)immune response0.90675.521e-05InformativeInherited
Biological Process (BP)mitotic cell cycle0.0035555.114e-09InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.024640InformativeInherited
Biological Process (BP)response to organic cyclic compound0.12211InformativeInherited
Biological Process (BP)response to lipid0.021371InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0034392.298e-14InformativeInherited
Biological Process (BP)reproductive system development0.4492.055e-06InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.2715.909e-13InformativeInherited
Biological Process (BP)regulation of cell cycle process10.2172InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle10.8204InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.2340.343InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.018133.586e-07InformativeInherited
Biological Process (BP)muscle system process0.0033951InformativeInherited
Biological Process (BP)response to other organism0.001341.06e-11InformativeInherited
Biological Process (BP)positive regulation of immune system process10.1965InformativeInherited
Biological Process (BP)regulation of immune response0.83690.9024InformativeInherited
Biological Process (BP)sensory organ development0.27720.1182InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.5150.6619InformativeInherited
Biological Process (BP)embryonic organ development0.24590.02618InformativeInherited
Biological Process (BP)cellular component morphogenesis0.001690InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.12141InformativeInherited
Biological Process (BP)DNA damage checkpoint1.041e-060Highly InformativeDirect
Biological Process (BP)protein phosphorylation00Highly InformativeDirect
Biological Process (BP)striated muscle contraction3.994e-061.205e-07Highly InformativeDirect
Biological Process (BP)regulation of cell size7.49e-093.679e-08Highly InformativeDirect
Biological Process (BP)peptidyl-serine modification00Highly InformativeDirect
Biological Process (BP)cell cycle phase3.484e-079.328e-05Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade6.509e-150Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process2.415e-056.887e-11Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition5.982e-051.054e-11Highly InformativeDirect
Biological Process (BP)innate immune response6.584e-050Highly InformativeDirect
Biological Process (BP)regulation of innate immune response3.803e-108.655e-14Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity2.868e-078.018e-14Highly InformativeDirect
Biological Process (BP)response to cadmium ion7.731e-052.559e-05Highly InformativeDirect
Biological Process (BP)cell division0.00068640Highly InformativeDirect
Biological Process (BP)heart contraction0.00023351.065e-07Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00016130.0001838Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00027070Highly InformativeDirect
Biological Process (BP)regulation of reproductive process9.864e-050Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.0071420.01065Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.001150.05885Highly InformativeInherited
Biological Process (BP)spindle organization0.003452.102e-13Highly InformativeInherited
Biological Process (BP)immune response-regulating cell surface receptor signaling pathway10.000133Highly InformativeInherited
Biological Process (BP)female gamete generation0.78260.06901Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0061890.06114Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.012587.579e-13Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0079030Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide2.08e-050.01384Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development10Highly InformativeInherited
Biological Process (BP)post-embryonic development0.066675.421e-13Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.34150.003641Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.0031140.0005127Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0044150Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction2.22e-070.002488Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.0013250.8572Highly InformativeInherited
Biological Process (BP)placenta development0.0042234.125e-09Highly InformativeInherited
Molecular Function (MF)binding2.368e-120Least InformativeDirect
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding0.00036990Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.6251Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)nucleotide binding1.76e-082.177e-13InformativeDirect
Molecular Function (MF)magnesium ion binding0.0001250InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine ribonucleoside binding1.216e-110InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding6.373e-130InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)enzyme binding0.01097.832e-12InformativeInherited
Molecular Function (MF)enzyme activator activity0.10220.3996InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity1.548e-051.461e-07Highly InformativeDirect
Molecular Function (MF)kinase binding0.00033526.47e-11Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.36641Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle2.355e-051Least InformativeInherited
Cellular Component (CC)protein complex0.11280.001183Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.040731.775e-05Least InformativeInherited
Cellular Component (CC)cytoskeleton1.544e-070Moderately InformativeDirect
Cellular Component (CC)nuclear part0.00091931Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton8.695e-063.114e-11InformativeDirect
Cellular Component (CC)spindle2.708e-140Highly InformativeDirect
Cellular Component (CC)midbody0.00032592.059e-12Highly InformativeDirect
Cellular Component (CC)adherens junction11.432e-06Highly InformativeInherited
Cellular Component (CC)cell-substrate junction0.090490.06859Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)