SUPERFAMILY 1.75 HMM library and genome assignments server


Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,104) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 280,071 384,172 233
Proteins 273,147 378,621 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process4.687e-100Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis2.332e-060Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)reproduction2.837e-110Moderately InformativeDirect
Biological Process (BP)immune system process4.47e-060Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process5.755e-057.747e-12Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00052468.954e-14Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process6.248e-050Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00058660Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.94390Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.4830Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.66090.008328Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)organelle organization10.8969Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.93811Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.001040Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.51130Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0095761.652e-11Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.064780Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00023640.04956Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.2226Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0027020Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.011340Moderately InformativeInherited
Biological Process (BP)tissue development0.030494.7e-08Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.90981Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.84911Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.61781Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)system process10.6593Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.60780Moderately InformativeInherited
Biological Process (BP)organ development0.83670.1023Moderately InformativeInherited
Biological Process (BP)regulation of localization15.902e-07Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.027063.733e-13Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0071130.04093Moderately InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway2.277e-060InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade5.057e-050InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process1.575e-120InformativeDirect
Biological Process (BP)intracellular signal transduction00InformativeDirect
Biological Process (BP)growth0.00045640InformativeDirect
Biological Process (BP)regulation of kinase activity1.015e-061.061e-08InformativeDirect
Biological Process (BP)single organism reproductive process0.00051571.961e-07InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process1.251e-050InformativeDirect
Biological Process (BP)glycerolipid metabolic process1.301e-050InformativeDirect
Biological Process (BP)cellular process involved in reproduction5.822e-110InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process3.039e-050InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00074273.317e-06InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00029180.0005014InformativeDirect
Biological Process (BP)regulation of intracellular transport0.017970.01433InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport10.183InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process10.5879InformativeInherited
Biological Process (BP)positive regulation of developmental process0.015697.09e-05InformativeInherited
Biological Process (BP)regulation of cell development0.12390.0001585InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.78045.907e-13InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.1592.939e-09InformativeInherited
Biological Process (BP)response to cytokine stimulus0.66820.9753InformativeInherited
Biological Process (BP)regulation of protein localization0.15530.8155InformativeInherited
Biological Process (BP)positive regulation of transport0.86920.9567InformativeInherited
Biological Process (BP)regulation of organelle organization10InformativeInherited
Biological Process (BP)blood circulation0.00034090.4814InformativeInherited
Biological Process (BP)cytoskeleton organization0.018890InformativeInherited
Biological Process (BP)microtubule-based process0.024782.343e-11InformativeInherited
Biological Process (BP)organelle assembly0.022742.34e-05InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly11InformativeInherited
Biological Process (BP)sexual reproduction8.156e-050.3692InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.32141InformativeInherited
Biological Process (BP)response to inorganic substance0.5391InformativeInherited
Biological Process (BP)alcohol metabolic process0.27991InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.009490InformativeInherited
Biological Process (BP)regulation of defense response0.86241InformativeInherited
Biological Process (BP)defense response10.9163InformativeInherited
Biological Process (BP)immune response0.88410.0002011InformativeInherited
Biological Process (BP)mitotic cell cycle0.0043792.034e-07InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.018550InformativeInherited
Biological Process (BP)response to organic cyclic compound0.10821InformativeInherited
Biological Process (BP)response to bacterium1.059e-050.04283InformativeInherited
Biological Process (BP)response to lipid0.01531InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0032453.211e-13InformativeInherited
Biological Process (BP)reproductive system development0.44421.162e-06InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.1891.938e-15InformativeInherited
Biological Process (BP)regulation of cell cycle process10.2221InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle10.6044InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.26750.3971InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.023111.048e-06InformativeInherited
Biological Process (BP)muscle system process0.0042521InformativeInherited
Biological Process (BP)positive regulation of immune system process10.1589InformativeInherited
Biological Process (BP)regulation of immune response0.85520.96InformativeInherited
Biological Process (BP)sensory organ development0.30130.2276InformativeInherited
Biological Process (BP)regulation of ion transport0.29630.1681InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.52990.7434InformativeInherited
Biological Process (BP)embryonic organ development0.24970.007088InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0017610InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.11141InformativeInherited
Biological Process (BP)DNA damage checkpoint9.544e-070Highly InformativeDirect
Biological Process (BP)protein phosphorylation00Highly InformativeDirect
Biological Process (BP)striated muscle contraction3.878e-062.076e-07Highly InformativeDirect
Biological Process (BP)regulation of cell size1.545e-081.019e-07Highly InformativeDirect
Biological Process (BP)peptidyl-serine modification00Highly InformativeDirect
Biological Process (BP)cell cycle phase2.599e-076.089e-05Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade6.398e-150Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process2.358e-055.927e-11Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition4.267e-053.348e-12Highly InformativeDirect
Biological Process (BP)innate immune response6.057e-050Highly InformativeDirect
Biological Process (BP)regulation of innate immune response2.347e-101.751e-13Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity1.465e-061.588e-12Highly InformativeDirect
Biological Process (BP)response to cadmium ion7.209e-052.904e-05Highly InformativeDirect
Biological Process (BP)cell division0.00066280Highly InformativeDirect
Biological Process (BP)heart contraction0.00023341.584e-07Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00027460.0002946Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00039520Highly InformativeDirect
Biological Process (BP)regulation of reproductive process9.03e-050Highly InformativeDirect
Biological Process (BP)regulation of striated muscle cell differentiation11Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.007140.004323Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0011870.03619Highly InformativeInherited
Biological Process (BP)spindle organization0.0032193.033e-13Highly InformativeInherited
Biological Process (BP)immune response-regulating cell surface receptor signaling pathway10.0001385Highly InformativeInherited
Biological Process (BP)female gamete generation0.77380.1551Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0026370.03923Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.021191.045e-12Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0042760Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide2.778e-050.01495Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development10Highly InformativeInherited
Biological Process (BP)post-embryonic development0.067078.977e-13Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.34250.003466Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0040580Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction2.101e-070.00261Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.0011680.8619Highly InformativeInherited
Biological Process (BP)placenta development0.0041392.788e-09Highly InformativeInherited
Molecular Function (MF)binding6.112e-120Least InformativeDirect
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding0.00049170Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.74031Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)nucleotide binding2.494e-081.326e-13InformativeDirect
Molecular Function (MF)magnesium ion binding0.00041180InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine ribonucleoside binding1.385e-110InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding7.494e-130InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)enzyme binding0.010625.741e-12InformativeInherited
Molecular Function (MF)enzyme activator activity0.20050.3079InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity9.052e-055.896e-08Highly InformativeDirect
Molecular Function (MF)kinase binding0.00030894.724e-11Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.28121Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle6.98e-051Least InformativeInherited
Cellular Component (CC)protein complex0.180.04429Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.038527.026e-06Least InformativeInherited
Cellular Component (CC)cytoskeleton4.018e-080Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0013021Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton1.747e-051.662e-10InformativeDirect
Cellular Component (CC)cell junction1.645e-090InformativeDirect
Cellular Component (CC)spindle4.186e-150Highly InformativeDirect
Cellular Component (CC)midbody0.00028431.728e-12Highly InformativeDirect
Cellular Component (CC)adherens junction11.443e-05Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)