SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,104) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 280,071 384,172 233
Proteins 273,147 378,621 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000000010580Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0000018210Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)reproduction0.000000000027310Moderately InformativeDirect
Biological Process (BP)immune system process0.0000090610Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.00098750Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000022070.000000000001016Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00023490.0000000000002637Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.000000019840Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.000064660Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00049080Moderately InformativeDirect
Biological Process (BP)regulation of localization10.000001488Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.95440Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.47380Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.66180.01411Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)organelle organization10.8783Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.9431Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.5910Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0045350.000000000007544Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.05860Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.43310.0001522Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.000180.05699Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.1662Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0026260Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.017470Moderately InformativeInherited
Biological Process (BP)tissue development0.020910.000000004974Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.88741Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.85931Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.6921Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.96381Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)system process10.6381Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.5060Moderately InformativeInherited
Biological Process (BP)organ development0.82740.1239Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.025170.0000000000000702Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0080620.03078Moderately InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0000020620InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.000076310InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process0.0000000000021160InformativeDirect
Biological Process (BP)intracellular signal transduction00InformativeDirect
Biological Process (BP)growth0.00019850InformativeDirect
Biological Process (BP)regulation of kinase activity0.00000052110.00000001002InformativeDirect
Biological Process (BP)single organism reproductive process0.00053780.0000003366InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.0000022910InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.000013760InformativeDirect
Biological Process (BP)cellular process involved in reproduction0.000000000061860InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00067020.000003147InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00024760.0006861InformativeDirect
Biological Process (BP)regulation of intracellular transport0.016310.01734InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport10.1786InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process10.5957InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.72030.0000000000001268InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.20510.000000002188InformativeInherited
Biological Process (BP)positive regulation of developmental process0.02460.00005681InformativeInherited
Biological Process (BP)regulation of cell development0.091980.00001912InformativeInherited
Biological Process (BP)response to cytokine stimulus0.68470.9435InformativeInherited
Biological Process (BP)positive regulation of transport0.81081InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.90741InformativeInherited
Biological Process (BP)regulation of organelle organization10.000000000000001931InformativeInherited
Biological Process (BP)blood circulation0.00035370.4811InformativeInherited
Biological Process (BP)cytoskeleton organization0.020130InformativeInherited
Biological Process (BP)microtubule-based process0.025050.00000000005408InformativeInherited
Biological Process (BP)organelle assembly0.020550.00002068InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly11InformativeInherited
Biological Process (BP)sexual reproduction0.000071650.2458InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.32960.9303InformativeInherited
Biological Process (BP)response to inorganic substance0.5431InformativeInherited
Biological Process (BP)alcohol metabolic process0.27581InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.24550InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.0099520InformativeInherited
Biological Process (BP)regulation of defense response0.89581InformativeInherited
Biological Process (BP)defense response10.9339InformativeInherited
Biological Process (BP)immune response0.8950.0002251InformativeInherited
Biological Process (BP)mitotic cell cycle0.004010.0000001833InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.017270InformativeInherited
Biological Process (BP)response to organic cyclic compound0.12941InformativeInherited
Biological Process (BP)response to lipid0.024071InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0032380.0000000000001911InformativeInherited
Biological Process (BP)reproductive system development0.45060.000002077InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.22060.00000000000001429InformativeInherited
Biological Process (BP)regulation of cell cycle process10.2306InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle10.617InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.26970.4036InformativeInherited
Biological Process (BP)muscle system process0.0033921InformativeInherited
Biological Process (BP)response to other organism0.0014960.000000000006667InformativeInherited
Biological Process (BP)positive regulation of immune system process10.1593InformativeInherited
Biological Process (BP)regulation of immune response0.87270.9418InformativeInherited
Biological Process (BP)sensory organ development0.27890.2275InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.52970.6856InformativeInherited
Biological Process (BP)embryonic organ development0.24720.00788InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0015540InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.1161InformativeInherited
Biological Process (BP)DNA damage checkpoint0.00000095140Highly InformativeDirect
Biological Process (BP)protein phosphorylation00Highly InformativeDirect
Biological Process (BP)striated muscle contraction0.0000040180.0000002075Highly InformativeDirect
Biological Process (BP)regulation of cell size0.0000000075190.00000003544Highly InformativeDirect
Biological Process (BP)peptidyl-serine modification00Highly InformativeDirect
Biological Process (BP)cell cycle phase0.00000025130.0001097Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade0.0000000000000048450Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process0.000024330.000000000064Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.000042560.000000000003948Highly InformativeDirect
Biological Process (BP)innate immune response0.000064850Highly InformativeDirect
Biological Process (BP)regulation of innate immune response0.00000000027660.00000000000007183Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity0.00000018720.00000000000003449Highly InformativeDirect
Biological Process (BP)response to cadmium ion0.0000720.00003109Highly InformativeDirect
Biological Process (BP)cell division0.00069960Highly InformativeDirect
Biological Process (BP)heart contraction0.00023290.0000001583Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00015610.0002068Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00023160Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.000096820Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.0065180.00775Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0010430.06753Highly InformativeInherited
Biological Process (BP)spindle organization0.0032750.0000000000002303Highly InformativeInherited
Biological Process (BP)female gamete generation0.78240.1415Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0061810.09359Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.019430.000000000000425Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0056860Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide0.000020020.0129Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development10Highly InformativeInherited
Biological Process (BP)post-embryonic development0.067190.0000000000008278Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.34690.003619Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.0032850.0005976Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0040530Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.00000022540.002432Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.0013280.8452Highly InformativeInherited
Biological Process (BP)placenta development0.004250.000000004665Highly InformativeInherited
Molecular Function (MF)binding0.000000000012890Least InformativeDirect
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding0.00052590Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.62711Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)nucleotide binding0.000000027030.000000000000154InformativeDirect
Molecular Function (MF)magnesium ion binding0.00041680InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine ribonucleoside binding0.000000000015870InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding0.00000000000085960InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)enzyme binding0.01020.000000000003887InformativeInherited
Molecular Function (MF)enzyme activator activity0.10250.3007InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity0.000015650.00000005951Highly InformativeDirect
Molecular Function (MF)kinase binding0.00032160.00000000005553Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.33581Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000066041Least InformativeInherited
Cellular Component (CC)protein complex0.12060.0007753Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.040380.000008283Least InformativeInherited
Cellular Component (CC)cytoskeleton0.000000040410Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0013761Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.000018690.000000000963InformativeDirect
Cellular Component (CC)cell junction0.0000000016530InformativeDirect
Cellular Component (CC)spindle0.000000000000017720Highly InformativeDirect
Cellular Component (CC)midbody0.00032070.000000000002245Highly InformativeDirect
Cellular Component (CC)adherens junction10.000002624Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)