SUPERFAMILY 1.75 HMM library and genome assignments server

Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,105) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 281,107 384,172 233
Proteins 274,154 378,621 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0000095830Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000010330Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00000024150Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.39560.00000000642Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)immune system process0.0000040110Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.00034120Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00075560.00000000000007887Moderately InformativeDirect
Biological Process (BP)reproductive process0.0000000000000048440Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process0.0000012020Moderately InformativeDirect
Biological Process (BP)multi-organism process0.000000000011950Moderately InformativeDirect
Biological Process (BP)regulation of localization10.0000006175Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.91661Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.46651Moderately InformativeInherited
Biological Process (BP)organ development0.8090.1821Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.57430Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.57480Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.037090.00000000347Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.9481Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0025240Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.38190Moderately InformativeInherited
Biological Process (BP)nervous system development0.48840.0004667Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.010320.0000000002081Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.14750.000000001668Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.57750Moderately InformativeInherited
Biological Process (BP)defense response10.5446Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.010360Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0011320Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00026710.05772Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.68690.01012Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.6098Moderately InformativeInherited
Biological Process (BP)tissue development0.20980.0003133Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.93121Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.94491Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.92491Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0068340.09125Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.62091Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)response to external stimulus10.02027Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.021490.00000000000002422Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization0.024850.000000006186Moderately InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0000022260InformativeDirect
Biological Process (BP)cell proliferation0.00083370InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process00InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.00000019530.00000000003474InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00000032790InformativeDirect
Biological Process (BP)intracellular signal transduction00InformativeDirect
Biological Process (BP)growth0.00019840InformativeDirect
Biological Process (BP)regulation of MAPK cascade0.0000016750InformativeDirect
Biological Process (BP)single organism reproductive process0.000000000120InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.000012990InformativeDirect
Biological Process (BP)organelle fission0.0000080030.00000001082InformativeDirect
Biological Process (BP)cell division0.00000057210InformativeDirect
Biological Process (BP)regulation of transferase activity00InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00027950.0003673InformativeDirect
Biological Process (BP)regulation of intracellular transport0.046610.01575InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport10.1705InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process10.00002211InformativeInherited
Biological Process (BP)regulation of organelle organization0.75930InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.95270.04459InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.74980.000000000001342InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.033440.00000000000365InformativeInherited
Biological Process (BP)response to cytokine0.65870.974InformativeInherited
Biological Process (BP)regulation of protein localization0.068580.6848InformativeInherited
Biological Process (BP)positive regulation of transport0.8530.7083InformativeInherited
Biological Process (BP)reproductive structure development0.15170.000000121InformativeInherited
Biological Process (BP)embryonic organ development0.18450.001525InformativeInherited
Biological Process (BP)blood circulation0.00039820.4588InformativeInherited
Biological Process (BP)cytoskeleton organization0.027180InformativeInherited
Biological Process (BP)organelle assembly0.029850.00000137InformativeInherited
Biological Process (BP)regulation of response to external stimulus11InformativeInherited
Biological Process (BP)generation of neurons0.26640.0000002076InformativeInherited
Biological Process (BP)regulation of nervous system development0.20410.05631InformativeInherited
Biological Process (BP)regulation of cell development0.13140.01233InformativeInherited
Biological Process (BP)regulation of response to wounding11InformativeInherited
Biological Process (BP)response to inorganic substance0.55091InformativeInherited
Biological Process (BP)alcohol metabolic process0.33531InformativeInherited
Biological Process (BP)immune response0.88490.0002952InformativeInherited
Biological Process (BP)mitotic cell cycle0.17560.000006084InformativeInherited
Biological Process (BP)response to organic cyclic compound0.10631InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.3560.0000001297InformativeInherited
Biological Process (BP)response to lipid0.014781InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.15860InformativeInherited
Biological Process (BP)regulation of cell cycle process10.3297InformativeInherited
Biological Process (BP)positive regulation of developmental process0.028390.00000066InformativeInherited
Biological Process (BP)positive regulation of catabolic process11InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle10.09394InformativeInherited
Biological Process (BP)epithelium development0.0095570.001336InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.0021370.00002756InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.26760.3977InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.022720.000001203InformativeInherited
Biological Process (BP)muscle system process0.00049480.1973InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)regulation of defense response0.80641InformativeInherited
Biological Process (BP)response to bacterium0.000010450.03705InformativeInherited
Biological Process (BP)regulation of immune response0.85180.9436InformativeInherited
Biological Process (BP)positive regulation of immune system process0.94280.07593InformativeInherited
Biological Process (BP)sensory organ development0.19620.07136InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.024870.000000001149InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.33540.6782InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0010340InformativeInherited
Biological Process (BP)microtubule-based process0.0011340InformativeInherited
Biological Process (BP)MAPK cascade00Highly InformativeDirect
Biological Process (BP)protein phosphorylation00Highly InformativeDirect
Biological Process (BP)striated muscle contraction0.0000038640.0000002263Highly InformativeDirect
Biological Process (BP)regulation of cell size0.000000015490.0000001066Highly InformativeDirect
Biological Process (BP)peptidyl-serine modification00Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade0.0000000000000032510Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process0.00078380.000004332Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.000014210.00000000004149Highly InformativeDirect
Biological Process (BP)innate immune response0.000060350.00000000000009454Highly InformativeDirect
Biological Process (BP)regulation of innate immune response0.00000000050750.0000000005231Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity0.0000017840.000000000007673Highly InformativeDirect
Biological Process (BP)response to cadmium ion0.00007160.00002926Highly InformativeDirect
Biological Process (BP)regulation of nuclear division0.000074930Highly InformativeDirect
Biological Process (BP)heart contraction0.0001910.0000007372Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.0002690.00006991Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00042570Highly InformativeDirect
Biological Process (BP)regulation of proteolysis involved in cellular protein catabolic process0.0000046710.0000000000006293Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.018590.0003886Highly InformativeInherited
Biological Process (BP)placenta development0.0021830.00000000002645Highly InformativeInherited
Biological Process (BP)spindle organization0.0082110.00000000001092Highly InformativeInherited
Biological Process (BP)immune response-regulating cell surface receptor signaling pathway10.0001349Highly InformativeInherited
Biological Process (BP)regulation of neuron projection development0.12910.000000004744Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0058110Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide0.000027310.01295Highly InformativeInherited
Biological Process (BP)regulation of autophagy0.057080.000003252Highly InformativeInherited
Biological Process (BP)epidermis development0.024680.00000001859Highly InformativeInherited
Biological Process (BP)post-embryonic development0.079030.000000000001945Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.34230.0034Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.0084940.00009006Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0038630Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.001531Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.000000210.00262Highly InformativeInherited
Biological Process (BP)in utero embryonic development0.75050.000006754Highly InformativeInherited
Biological Process (BP)DNA integrity checkpoint0.0043461Highly InformativeInherited
Molecular Function (MF)binding0.000000000011940Least InformativeDirect
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding0.00050710Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00045080Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.56121Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.031430Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)nucleotide binding0.000000025270InformativeDirect
Molecular Function (MF)magnesium ion binding0.00041620InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine ribonucleoside binding0.000000000014080InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding0.00000000000081750InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)enzyme binding0.011760.000000000001404InformativeInherited
Molecular Function (MF)enzyme activator activity0.21080.3533InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity0.00010220.00000007046Highly InformativeDirect
Molecular Function (MF)kinase binding0.00026650.000000000009726Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00010521Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.011030.000000001728Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.72451Least InformativeInherited
Cellular Component (CC)protein complex0.45921Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000000042990Moderately InformativeDirect
Cellular Component (CC)cell projection0.000074250Moderately InformativeDirect
Cellular Component (CC)transferase complex0.00000000000068220.00000000000001464Moderately InformativeDirect
Cellular Component (CC)nuclear part0.12441Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.000050571Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.00057580.00006768InformativeDirect
Cellular Component (CC)cell junction0.0000000017910InformativeDirect
Cellular Component (CC)synapse0.000044280InformativeDirect
Cellular Component (CC)spindle0.0000000000000094780Highly InformativeDirect
Cellular Component (CC)midbody0.00032970.000000000007038Highly InformativeDirect
Cellular Component (CC)ciliary part0.019440.2198Highly InformativeInherited
Cellular Component (CC)adherens junction10.00001371Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)