SUPERFAMILY 1.75 HMM library and genome assignments server


Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (2,386) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 228,826 242,451 233
Proteins 224,200 238,795 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process8.454e-090Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis4.423e-070Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)reproduction1.236e-110Moderately InformativeDirect
Biological Process (BP)immune system process6.866e-080Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process7.614e-050Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.0005171.79e-10Moderately InformativeDirect
Biological Process (BP)response to organic substance8.1e-060Moderately InformativeDirect
Biological Process (BP)single-organism developmental process9.303e-060Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00010060Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.77060.0135Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)organelle organization10.9482Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.022140Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.82441Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.43980Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0093860Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.19851.014e-11Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.34540.008427Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.14740Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.017470Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0010030.01058Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization10Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.2291Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.97351Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.80861Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.83951Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.4560Moderately InformativeInherited
Biological Process (BP)cell differentiation10.6436Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.79061Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)system process10.7115Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.37290Moderately InformativeInherited
Biological Process (BP)regulation of localization0.81092.258e-07Moderately InformativeInherited
Biological Process (BP)organ development10.3622Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.082180.1783Moderately InformativeInherited
Biological Process (BP)protein phosphorylation00InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00022670InformativeDirect
Biological Process (BP)positive regulation of phosphorus metabolic process0.00031480InformativeDirect
Biological Process (BP)cell cycle process1.066e-100InformativeDirect
Biological Process (BP)intracellular signal transduction00InformativeDirect
Biological Process (BP)regulation of kinase activity5.831e-082.476e-06InformativeDirect
Biological Process (BP)single organism reproductive process0.00014594.199e-10InformativeDirect
Biological Process (BP)glycerolipid metabolic process6.043e-060InformativeDirect
Biological Process (BP)cellular process involved in reproduction2.265e-080InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process0.00057990InformativeDirect
Biological Process (BP)regulation of response to stress0.00019434.699e-07InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process2.922e-052.144e-07InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00022021.37e-05InformativeDirect
Biological Process (BP)regulation of intracellular transport0.027440.09871InformativeInherited
Biological Process (BP)positive regulation of developmental process0.07824.3e-10InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process10.532InformativeInherited
Biological Process (BP)regulation of protein localization0.25990.9026InformativeInherited
Biological Process (BP)positive regulation of transport0.50521InformativeInherited
Biological Process (BP)regulation of organelle organization0.93281InformativeInherited
Biological Process (BP)blood circulation10.5741InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.41048.186e-12InformativeInherited
Biological Process (BP)cytoskeleton organization0.011970InformativeInherited
Biological Process (BP)microtubule-based process0.014445.745e-11InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly11InformativeInherited
Biological Process (BP)regulation of growth0.76070InformativeInherited
Biological Process (BP)response to inorganic substance0.51811InformativeInherited
Biological Process (BP)alcohol metabolic process0.16510.9003InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.26110.07383InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.026530.000186InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.039840InformativeInherited
Biological Process (BP)defense response10.625InformativeInherited
Biological Process (BP)immune response0.71846.036e-07InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.0010740InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0099410InformativeInherited
Biological Process (BP)response to organic cyclic compound0.23321InformativeInherited
Biological Process (BP)response to lipid0.042140.9914InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.98314.008e-15InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of cell cycle process10.0004065InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.38390.6129InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.014271.428e-07InformativeInherited
Biological Process (BP)regulation of body fluid levels0.081090.006779InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0068230InformativeInherited
Biological Process (BP)sexual reproduction0.00019120.007381InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.10290.2662InformativeInherited
Biological Process (BP)muscle system process0.0030281InformativeInherited
Biological Process (BP)response to other organism0.0031724.276e-10InformativeInherited
Biological Process (BP)regulation of immune response0.75580.9682InformativeInherited
Biological Process (BP)positive regulation of immune system process10.04267InformativeInherited
Biological Process (BP)regulation of ion transport0.67010.3383InformativeInherited
Biological Process (BP)chordate embryonic development0.70631InformativeInherited
Biological Process (BP)embryonic organ development0.052750.0005719InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.022861InformativeInherited
Biological Process (BP)DNA damage checkpoint5.141e-060Highly InformativeDirect
Biological Process (BP)microtubule cytoskeleton organization5.97e-051.187e-05Highly InformativeDirect
Biological Process (BP)mitotic cell cycle6.171e-061.417e-13Highly InformativeDirect
Biological Process (BP)embryonic placenta development6.459e-054.008e-15Highly InformativeDirect
Biological Process (BP)regulation of sodium ion transport7.991e-053.714e-07Highly InformativeDirect
Biological Process (BP)striated muscle contraction2.135e-061.008e-07Highly InformativeDirect
Biological Process (BP)response to osmotic stress0.00065650.0003551Highly InformativeDirect
Biological Process (BP)germ cell development9.093e-060.0003616Highly InformativeDirect
Biological Process (BP)hemostasis4.425e-050.0003275Highly InformativeDirect
Biological Process (BP)peptidyl-serine modification00Highly InformativeDirect
Biological Process (BP)cell cycle phase3.89e-070.0008758Highly InformativeDirect
Biological Process (BP)regulation of cell morphogenesis0.00017655.966e-15Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade1.345e-070Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process1.22e-051.477e-09Highly InformativeDirect
Biological Process (BP)cell cycle phase transition4.815e-070Highly InformativeDirect
Biological Process (BP)innate immune response8.081e-064.008e-15Highly InformativeDirect
Biological Process (BP)regulation of innate immune response2.058e-120Highly InformativeDirect
Biological Process (BP)negative regulation of cell cycle0.00070910Highly InformativeDirect
Biological Process (BP)response to cadmium ion0.00036047.999e-05Highly InformativeDirect
Biological Process (BP)cell division0.00072910Highly InformativeDirect
Biological Process (BP)heart contraction0.00058411.25e-08Highly InformativeDirect
Biological Process (BP)organelle assembly0.00024462.72e-08Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00049660Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport10.03012Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0019690.03016Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.00057510.02719Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.0099810.2215Highly InformativeInherited
Biological Process (BP)nuclear division2.64e-100.05417Highly InformativeInherited
Biological Process (BP)positive regulation of growth0.047754.941e-11Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.0010080Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0025140.1135Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.0026828.075e-11Highly InformativeInherited
Biological Process (BP)positive regulation of protein serine/threonine kinase activity0.061320.003798Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0079020Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide6.263e-050.05518Highly InformativeInherited
Biological Process (BP)cellular response to biotic stimulus0.0082210.01174Highly InformativeInherited
Biological Process (BP)regulation of cell projection organization0.00010580.001028Highly InformativeInherited
Biological Process (BP)post-embryonic development0.089714.008e-15Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.26710.001001Highly InformativeInherited
Biological Process (BP)regulation of cellular component size0.037630Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.0012510.00107Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0042450Highly InformativeInherited
Biological Process (BP)immune response-regulating signaling pathway0.99780.002751Highly InformativeInherited
Biological Process (BP)activation of immune response0.01691.186e-09Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)protein binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding1.221e-050Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding0.93571Moderately InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.81191Moderately InformativeInherited
Molecular Function (MF)enzyme regulator activity0.79991Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)nucleotide binding9.659e-111.562e-15InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)enzyme activator activity0.070940.5627InformativeInherited
Molecular Function (MF)magnesium ion binding6.5e-050Highly InformativeDirect
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity7.681e-061.106e-07Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.55361Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.15130.002462Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.013291Least InformativeInherited
Cellular Component (CC)protein complex0.099760.1558Least InformativeInherited
Cellular Component (CC)cytoskeleton4.497e-070Moderately InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.00011328.15e-11InformativeDirect
Cellular Component (CC)cell junction1.799e-110InformativeDirect
Cellular Component (CC)synapse9.516e-058.477e-08InformativeDirect
Cellular Component (CC)spindle1.676e-100Highly InformativeDirect
Cellular Component (CC)protein kinase CK2 complex00Highly InformativeDirect
Cellular Component (CC)midbody0.00087581.143e-10Highly InformativeDirect
Cellular Component (CC)neuromuscular junction4.78e-061.116e-10Highly InformativeDirect
Cellular Component (CC)adherens junction11.488e-06Highly InformativeInherited
Cellular Component (CC)cell-substrate junction0.0053460.0005282Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)