SUPERFAMILY 1.75 HMM library and genome assignments server


Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,063) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 237,708 242,451 233
Proteins 233,017 238,795 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process6.795e-070Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis1.835e-060Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)localization0.72520Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)reproduction2.052e-110Moderately InformativeDirect
Biological Process (BP)immune system process7.531e-070Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process3.054e-061.086e-14Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00028037.567e-13Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00028130Moderately InformativeDirect
Biological Process (BP)single-organism developmental process6.653e-080Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00010530Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00019720Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death0.2520.004228Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.42970Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.740.07271Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.77860Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.26832.877e-05Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.90011Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0011050Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.58060Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0034820Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00015350.06464Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.92960.1811Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0032580Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.028840Moderately InformativeInherited
Biological Process (BP)tissue development0.035513.623e-09Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.81651Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.79091Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.6271Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.89951Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)system process10.4576Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.63680Moderately InformativeInherited
Biological Process (BP)organ development0.7220.1285Moderately InformativeInherited
Biological Process (BP)regulation of localization17.923e-08Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.061693.746e-15Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0068920.02749Moderately InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway7.347e-070InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.00022210InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process8.269e-120InformativeDirect
Biological Process (BP)cellular component morphogenesis0.00073460InformativeDirect
Biological Process (BP)intracellular signal transduction00InformativeDirect
Biological Process (BP)growth9.885e-060InformativeDirect
Biological Process (BP)regulation of kinase activity3.136e-063.047e-07InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process8.222e-070InformativeDirect
Biological Process (BP)glycerolipid metabolic process1.076e-050InformativeDirect
Biological Process (BP)cellular process involved in reproduction2.988e-100InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process1.088e-060InformativeDirect
Biological Process (BP)regulation of cell cycle00InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00039721.024e-06InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00010580.0001929InformativeDirect
Biological Process (BP)regulation of intracellular transport0.015490.05306InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process10.655InformativeInherited
Biological Process (BP)positive regulation of developmental process0.013561.864e-09InformativeInherited
Biological Process (BP)regulation of cell development0.13170.0001129InformativeInherited
Biological Process (BP)response to cytokine stimulus0.76580.8806InformativeInherited
Biological Process (BP)positive regulation of transport0.88651InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.8851InformativeInherited
Biological Process (BP)organelle assembly0.019671.075e-06InformativeInherited
Biological Process (BP)regulation of organelle organization10InformativeInherited
Biological Process (BP)vesicle-mediated transport0.68882.438e-05InformativeInherited
Biological Process (BP)blood circulation0.00017230.4271InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.37610InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.091972.447e-14InformativeInherited
Biological Process (BP)cytoskeleton organization0.0056740InformativeInherited
Biological Process (BP)microtubule-based process0.020371.884e-13InformativeInherited
Biological Process (BP)protein complex assembly0.50781InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly11InformativeInherited
Biological Process (BP)regulation of growth0.59120InformativeInherited
Biological Process (BP)sexual reproduction7.577e-050.1585InformativeInherited
Biological Process (BP)single organism reproductive process0.0011931.798e-07InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.34710.7574InformativeInherited
Biological Process (BP)response to inorganic substance0.61541InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)alcohol metabolic process0.22451InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.006090InformativeInherited
Biological Process (BP)regulation of defense response0.74741InformativeInherited
Biological Process (BP)defense response10.8655InformativeInherited
Biological Process (BP)immune response0.80675.176e-05InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.037880InformativeInherited
Biological Process (BP)response to organic cyclic compound0.12461InformativeInherited
Biological Process (BP)response to bacterium3.731e-050.06134InformativeInherited
Biological Process (BP)response to lipid0.018081InformativeInherited
Biological Process (BP)reproductive structure development0.64824.865e-06InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.75748.456e-09InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.20780.2547InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.026546.751e-07InformativeInherited
Biological Process (BP)regulation of body fluid levels0.055920.007577InformativeInherited
Biological Process (BP)positive regulation of immune system process10.2424InformativeInherited
Biological Process (BP)regulation of immune response0.75330.8733InformativeInherited
Biological Process (BP)sensory organ development0.32660.05966InformativeInherited
Biological Process (BP)regulation of ion transport0.67760.3699InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.78680.6396InformativeInherited
Biological Process (BP)embryonic organ development0.1960.02374InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.20851InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization6.529e-051.634e-07Highly InformativeDirect
Biological Process (BP)regulation of sodium ion transport0.00012061.299e-06Highly InformativeDirect
Biological Process (BP)protein phosphorylation00Highly InformativeDirect
Biological Process (BP)striated muscle contraction2.974e-066.298e-08Highly InformativeDirect
Biological Process (BP)response to osmotic stress4.905e-051.438e-06Highly InformativeDirect
Biological Process (BP)hemostasis1.359e-050.0001537Highly InformativeDirect
Biological Process (BP)regulation of cell size2.329e-081.624e-06Highly InformativeDirect
Biological Process (BP)peptidyl-serine modification00Highly InformativeDirect
Biological Process (BP)cell cycle phase7.469e-070.0008771Highly InformativeDirect
Biological Process (BP)fruiting body development0.00034421.051e-07Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade9.134e-150Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process1.858e-054.716e-11Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition8.433e-053.211e-12Highly InformativeDirect
Biological Process (BP)innate immune response1.09e-050Highly InformativeDirect
Biological Process (BP)regulation of innate immune response2.57e-101.111e-13Highly InformativeDirect
Biological Process (BP)negative regulation of cell cycle0.00099060Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity4.384e-078.593e-14Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process0.00045740Highly InformativeDirect
Biological Process (BP)response to cadmium ion0.00016791.974e-05Highly InformativeDirect
Biological Process (BP)cell division0.00081040Highly InformativeDirect
Biological Process (BP)heart contraction0.00035451.667e-08Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00038660.0005951Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00025720Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.00015650Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport10.1126Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0046350.01743Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.002730.01841Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.0061210.105Highly InformativeInherited
Biological Process (BP)mitosis0.27440.01607Highly InformativeInherited
Biological Process (BP)regulation of cell growth0.38340Highly InformativeInherited
Biological Process (BP)positive regulation of growth0.044812.664e-10Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.0073750Highly InformativeInherited
Biological Process (BP)female gamete generation0.85090.1109Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0020670.02644Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.020541.912e-11Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0022080Highly InformativeInherited
Biological Process (BP)phosphatidylinositol metabolic process10.2992Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide4.561e-050.04936Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.0092860.7027Highly InformativeInherited
Biological Process (BP)post-embryonic development0.078687.169e-14Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.33290.002893Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.0024530.0004227Highly InformativeInherited
Biological Process (BP)immune response-regulating signaling pathway0.98340.0004922Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.00076660.7731Highly InformativeInherited
Biological Process (BP)activation of immune response0.0031871.478e-10Highly InformativeInherited
Biological Process (BP)placenta development0.0043541.643e-09Highly InformativeInherited
Biological Process (BP)cell cycle checkpoint0.15170.05368Highly InformativeInherited
Molecular Function (MF)binding1.107e-120Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding0.0006890Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.57811Moderately InformativeInherited
Molecular Function (MF)cation binding0.98661Moderately InformativeInherited
Molecular Function (MF)nucleotide binding5.603e-087.465e-15InformativeDirect
Molecular Function (MF)magnesium ion binding0.0001090InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine ribonucleoside binding5.782e-110InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding3.191e-120InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)enzyme activator activity0.097890.4142InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity1.048e-059.738e-08Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.31591Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00086581Least InformativeInherited
Cellular Component (CC)protein complex0.10960.0002327Least InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.038332.501e-05Least InformativeInherited
Cellular Component (CC)cytosol0.00076480Moderately InformativeDirect
Cellular Component (CC)cytoskeleton3.869e-080Moderately InformativeDirect
Cellular Component (CC)nuclear part0.00013261Moderately InformativeInherited
Cellular Component (CC)plasma membrane part11.276e-05Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton6.906e-052.442e-11InformativeDirect
Cellular Component (CC)spindle2.676e-150Highly InformativeDirect
Cellular Component (CC)protein kinase CK2 complex00Highly InformativeDirect
Cellular Component (CC)cell-substrate junction0.00055090.0003819Highly InformativeDirect
Cellular Component (CC)midbody0.00033375.051e-13Highly InformativeDirect
Cellular Component (CC)neuromuscular junction8.543e-074.337e-11Highly InformativeDirect
Cellular Component (CC)adherens junction12.906e-07Highly InformativeInherited
Cellular Component (CC)membrane raft0.026668.981e-06Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)