SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


Glutathione synthetase ATP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]


Superfamily statistics
Genomes (3,176) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,044 233,197 50
Proteins 44,440 215,931 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.45491Least InformativeInherited
Biological Process (BP)single-organism cellular process0.6021Least InformativeInherited
Biological Process (BP)microtubule-based process0.000031830.0000000006564InformativeDirect
Biological Process (BP)response to inorganic substance0.00056490.01215InformativeInherited
Biological Process (BP)response to cadmium ion0.0000028630.00002319Highly InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.0000000036591InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000000002284 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000002237 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000000001879 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00000000003733 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000001439 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000004843 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.000002554 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000231 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0009346 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.02171 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4911 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.7698 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.7407 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01376 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2344 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.8711 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.002184 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.04324 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.6209 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.00456 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.244 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.0000000006564 Informative Direct
Biological Process (BP) amide biosynthetic process 0.0000000000104 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000000000591 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0.0000000006335 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000001249 Informative Direct
Biological Process (BP) hexose metabolic process 0.0000002631 Informative Direct
Biological Process (BP) organelle assembly 0.0000007422 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.000001703 Informative Direct
Biological Process (BP) peptide metabolic process 0.00002077 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0001136 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0001704 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0002506 Informative Direct
Biological Process (BP) protein oligomerization 0.06615 Informative Inherited
Biological Process (BP) response to inorganic substance 0.01215 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.009711 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.05886 Informative Inherited
Biological Process (BP) cell projection organization 0.01133 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1569 Informative Inherited
Biological Process (BP) localization of cell 0.9493 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.2345 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.8348 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.0493 Informative Inherited
Biological Process (BP) secretion by cell 0.0892 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.2943 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.02451 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.126 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.01779 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.4681 Informative Inherited
Biological Process (BP) response to cadmium ion 0.00002319 Highly Informative Direct
Biological Process (BP) cilium organization 0 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00000000000002447 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000000002369 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.0000000003865 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.000000003438 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0.000000004249 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0.000000008261 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000002441 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.000004053 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.000006587 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0002993 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.0004266 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0005676 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0006088 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.01085 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.005024 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.007734 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.2146 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.0249 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.1079 Highly Informative Inherited
Biological Process (BP) signal release 0.001116 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.05614 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.000005936 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.9874 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.8477 Moderately Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.000000000000007513 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000002854 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0000008104 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00001555 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00002131 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.00009617 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0002038 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.5431 Informative Inherited
Molecular Function (MF) kinase activity 0.07973 Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.0000009665 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00003101 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 0.00019 Highly Informative Direct
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.4428 Highly Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0.3327 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0000000002913 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.2781 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00001509 Moderately Informative Direct
Cellular Component (CC) vesicle 0.2347 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.04583 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01939 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2037 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.05221 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) synapse part 0.00002542 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.00007756 Informative Direct
Cellular Component (CC) coated vesicle 0.0001775 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0007765 Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.000006177 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.0554 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.0001175InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004511InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0.000000000000002328Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0.000000000000002558Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001025Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase0.0000001639Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase0.000004259Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.00001238Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.0007799Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.05607Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09944Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.000002482Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.0455Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3054Moderately InformativeInherited
Phenotypic Abnormality (PA)Hyperammonemia0.00005772InformativeDirect
Phenotypic Abnormality (PA)Seizures0.0003527InformativeDirect
Phenotypic Abnormality (PA)Coma0.0003904InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.0007496InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carboxylic acid metabolism0.001732InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.01372InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.6219Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.5519Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1476InformativeInherited
Mammalian Phenotype (MP)abnormal social investigation0.0002205Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aggression-related behavior0.000382Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.001045Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pigmentation variant0.0009543InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.004499InformativeInherited
Worm Phenotype (WP)clear0.00003943Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001922Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.2676Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.339Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0008145InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.005228Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.009546Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01642Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.1352Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.3992InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with paired acceptors0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001296Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (ammonia)0.00001422Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase0.0000875Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004085Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)1Highly InformativeInherited
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.000003173Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processLipid biosynthesis0.03076InformativeInherited
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentCell projection0.0000000008629Moderately InformativeDirect
Cellular componentMicrotubule0.0001178InformativeDirect
Cellular componentCilium0Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0003605Moderately InformativeDirect
DomainRepeat0.0000003576Least InformativeDirect
DomainTransit peptide0.000001072Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.07387Least InformativeInherited
UniPathway (UP)L-arginine metabolism0Moderately InformativeDirect
UniPathway (UP)heterocycle metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.000001531Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.3872Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)cell wall biogenesis0InformativeDirect
UniPathway (UP)pyrimidine biosynthesis1InformativeInherited
UniPathway (UP)peptidoglycan biosynthesis0Highly InformativeDirect
UniPathway (UP)bacilysin biosynthesis0.0008954Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Glutathione synthetase ATP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]