SUPERFAMILY 1.75 HMM library and genome assignments server


Glutathione synthetase ATP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]


Superfamily statistics
Genomes (3,176) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,040 233,197 50
Proteins 44,436 215,931 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.44411Least InformativeInherited
Biological Process (BP)single-organism cellular process0.59051Least InformativeInherited
Biological Process (BP)microtubule-based process3.197e-058.121e-10InformativeDirect
Biological Process (BP)response to inorganic substance0.00052830.01144InformativeInherited
Biological Process (BP)response to cadmium ion2.618e-062.539e-05Highly InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds4.065e-091InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 1.784e-14 Least Informative Direct
Biological Process (BP) biosynthetic process 2.552e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 3.881e-11 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 1.731e-10 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 3.357e-10 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 3.295e-07 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 1.573e-06 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.571e-05 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.03355 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4959 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.7398 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.8047 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01943 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2806 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.9339 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.001737 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.03518 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.6145 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.003782 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.002675 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.238 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 8.121e-10 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 3.64e-10 Informative Direct
Biological Process (BP) fatty acid metabolic process 6.047e-10 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 1.049e-07 Informative Direct
Biological Process (BP) hexose metabolic process 2.66e-07 Informative Direct
Biological Process (BP) organelle assembly 7.438e-07 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 1.783e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 3.594e-05 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0001821 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0005906 Informative Direct
Biological Process (BP) protein complex assembly 0.6854 Informative Inherited
Biological Process (BP) response to inorganic substance 0.01144 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.008933 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.06166 Informative Inherited
Biological Process (BP) cell projection organization 0.01193 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.16 Informative Inherited
Biological Process (BP) localization of cell 0.9494 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.3316 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.8412 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.04948 Informative Inherited
Biological Process (BP) secretion by cell 0.08802 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.2841 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.02105 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.128 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.01906 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.4543 Informative Inherited
Biological Process (BP) response to cadmium ion 2.539e-05 Highly Informative Direct
Biological Process (BP) cilium organization 0 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 2.125e-14 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 1.578e-10 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 2.448e-10 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 2.11e-09 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 3.647e-09 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 8.65e-09 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 2.454e-08 Highly Informative Direct
Biological Process (BP) polyol metabolic process 3.81e-06 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 6.714e-06 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0002376 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.0004288 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0005707 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0005923 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.01085 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.01047 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.006124 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.2191 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.02489 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.107 Highly Informative Inherited
Biological Process (BP) signal release 0.001123 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.05254 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 2.626e-05 Moderately Informative Direct
Molecular Function (MF) cation binding 0.6267 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.9742 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.563e-15 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 3.758e-07 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8.392e-07 Informative Direct
Molecular Function (MF) magnesium ion binding 1.072e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1.347e-05 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 8.953e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0001981 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.6303 Informative Inherited
Molecular Function (MF) kinase activity 0.0806 Informative Inherited
Molecular Function (MF) carboxy-lyase activity 9.113e-07 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0001022 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 0.00024 Highly Informative Direct
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.4527 Highly Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0.3349 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 2.027e-10 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.2731 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 1.638e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.2378 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.04845 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.02062 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2061 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.04786 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) synapse part 1.992e-05 Informative Direct
Cellular Component (CC) mitochondrial matrix 7.704e-05 Informative Direct
Cellular Component (CC) coated vesicle 0.0001651 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0008165 Informative Direct
Cellular Component (CC) clathrin-coated vesicle 5.535e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.05628 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.0001175InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004511InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase2.328e-15Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase2.558e-15Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase1.025e-10Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase1.639e-07Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase4.259e-06Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase1.238e-05Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.0007799Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.03647Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.06989Least InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis3.201e-07Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.02135Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3068Moderately InformativeInherited
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Hyperammonemia2.914e-05InformativeDirect
Phenotypic Abnormality (PA)Aciduria8.044e-05InformativeDirect
Phenotypic Abnormality (PA)Coma0.0002135InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.000438InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carboxylic acid metabolism0.001699InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.6223Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.5521Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1465InformativeInherited
Mammalian Phenotype (MP)abnormal social investigation0.0002222Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aggression-related behavior0.0003846Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.00105Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pigmentation variant0.0009543InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.004499InformativeInherited
Worm Phenotype (WP)clear3.943e-05Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001922Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.2635Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.3386Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0008138InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.005228Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.009546Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01642Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.1352Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.3858InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with paired acceptors0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase1.303e-10Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (ammonia)1.422e-05Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase8.746e-05Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004105Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)1Highly InformativeInherited
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis3.173e-06Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processLipid biosynthesis0.03076InformativeInherited
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentCell projection8.629e-10Moderately InformativeDirect
Cellular componentMicrotubule0.0001178InformativeDirect
Cellular componentCilium0Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0003605Moderately InformativeDirect
DomainRepeat3.576e-07Least InformativeDirect
DomainTransit peptide1.072e-06Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)gluconeogenesis4.681e-06InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.0001196InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.7214InformativeInherited
UniPathway (UP)metabolic intermediate degradation0.7757InformativeInherited
UniPathway (UP)antibiotic biosynthesis0.8158InformativeInherited
UniPathway (UP)oligopeptide biosynthesis0Highly InformativeDirect
UniPathway (UP)L-leucine degradation3.837e-07Highly InformativeDirect
UniPathway (UP)propanoyl-CoA degradation2.271e-05Highly InformativeDirect
UniPathway (UP)malonyl-CoA biosynthesis8.87e-05Highly InformativeDirect
UniPathway (UP)carbon fixation0.0001268Highly InformativeDirect
UniPathway (UP)bacilysin biosynthesis0.0001766Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Glutathione synthetase ATP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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