SUPERFAMILY 1.75 HMM library and genome assignments server


The spindle assembly checkpoint protein mad2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   The spindle assembly checkpoint protein mad2 [ 56018]
Superfamily:   The spindle assembly checkpoint protein mad2 [ 56019]
Families:   The spindle assembly checkpoint protein mad2 [ 56020]


Superfamily statistics
Genomes (508) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,649 1,796 5
Proteins 1,634 1,783 5


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process1.354e-111.245e-10Least InformativeDirect
Biological Process (BP)regulation of cellular process6.88e-147.445e-08Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00053242.462e-10Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0048244.43e-06Least InformativeInherited
Biological Process (BP)response to stimulus1.187e-050.1902Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.50021Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0050725.802e-06Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.015747.33e-05Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0088311.743e-05Least InformativeInherited
Biological Process (BP)cellular response to stress8.312e-062.279e-06Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process1.774e-098.829e-12Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00013920.0001136Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization6.509e-154.326e-09Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.243e-098.55e-05Moderately InformativeDirect
Biological Process (BP)regulation of phosphate metabolic process10.001219Moderately InformativeInherited
Biological Process (BP)signal transduction0.57251Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.29611Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.016260.4471Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0012530.03169Moderately InformativeInherited
Biological Process (BP)organelle organization0.016727.459e-10Moderately InformativeInherited
Biological Process (BP)regulation of cell cycle process8.31e-061.332e-06InformativeDirect
Biological Process (BP)cell cycle process00InformativeDirect
Biological Process (BP)regulation of cellular catabolic process6.372e-079.08e-07InformativeDirect
Biological Process (BP)regulation of organelle organization01.944e-15InformativeDirect
Biological Process (BP)intracellular signal transduction9.197e-080.0002611InformativeDirect
Biological Process (BP)negative regulation of catalytic activity0.00024712.138e-05InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process4.158e-105.378e-06InformativeDirect
Biological Process (BP)negative regulation of cellular component organization05.114e-13InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process2.074e-135.86e-09InformativeDirect
Biological Process (BP)chromosome organization3.389e-059.774e-12InformativeDirect
Biological Process (BP)mitotic cell cycle0.031531InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.00092980.001366InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.039170.02127InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle3.617e-070.03318InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.16920.1457InformativeInherited
Biological Process (BP)regulation of growth0.0076790.04467InformativeInherited
Biological Process (BP)chromosome segregation2.889e-060Highly InformativeDirect
Biological Process (BP)regulation of mitosis8.085e-136.216e-07Highly InformativeDirect
Biological Process (BP)regulation of proteolysis1.206e-073.613e-09Highly InformativeDirect
Biological Process (BP)negative regulation of cellular catabolic process1.987e-091.066e-12Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination05.494e-13Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process3.098e-141.185e-09Highly InformativeDirect
Biological Process (BP)spindle checkpoint1.436e-059.452e-05Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process01.599e-13Highly InformativeDirect
Biological Process (BP)negative regulation of cell cycle00Highly InformativeDirect
Biological Process (BP)regulation of ligase activity1.162e-112.891e-13Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition00.1388Highly InformativeInherited
Biological Process (BP)mitosis0.079450.937Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex02.88e-09Least InformativeDirect
Cellular Component (CC)intracellular organelle part05.232e-06Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle10.6385Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0093870.8837Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.22890.1019Moderately InformativeInherited
Cellular Component (CC)nuclear part7.639e-060.001185Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex2.933e-091.168e-05InformativeDirect
Cellular Component (CC)chromosome8.209e-100InformativeDirect
Cellular Component (CC)microtubule cytoskeleton06.169e-15InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex2.327e-087.481e-08Highly InformativeDirect
Cellular Component (CC)kinetochore00Highly InformativeDirect
Cellular Component (CC)spindle01.589e-10Highly InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex3.036e-132.014e-08Highly InformativeDirect
Cellular Component (CC)DNA polymerase complex00Highly InformativeDirect
Cellular Component (CC)nuclear chromosome part0.00052960.0002502Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 5.802e-06 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 7.33e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.245e-10 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 4.43e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 7.445e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.462e-10 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1.743e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.1902 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.66 Least Informative Inherited
Biological Process (BP) developmental process 0.6297 Least Informative Inherited
Biological Process (BP) reproduction 1.222e-10 Moderately Informative Direct
Biological Process (BP) organelle organization 7.459e-10 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.279e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 8.829e-12 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0001136 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 4.326e-09 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 8.55e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.001219 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4471 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.07056 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.03169 Moderately Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 4.613e-07 Informative Direct
Biological Process (BP) regulation of cell cycle process 1.332e-06 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 9.08e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 1.944e-15 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002611 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 2.138e-05 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 5.378e-06 Informative Direct
Biological Process (BP) cellular process involved in reproduction 3.135e-14 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 5.114e-13 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 5.86e-09 Informative Direct
Biological Process (BP) chromosome organization 9.774e-12 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 3.722e-07 Informative Direct
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.001366 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.02127 Informative Inherited
Biological Process (BP) sexual reproduction 0.4176 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001168 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01686 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.03318 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1457 Informative Inherited
Biological Process (BP) regulation of growth 0.04467 Informative Inherited
Biological Process (BP) chromosome segregation 0 Highly Informative Direct
Biological Process (BP) regulation of mitosis 6.216e-07 Highly Informative Direct
Biological Process (BP) meiosis 2.695e-07 Highly Informative Direct
Biological Process (BP) spermatogenesis 9.002e-10 Highly Informative Direct
Biological Process (BP) female gamete generation 4.539e-10 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 3.613e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 1.066e-12 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 5.494e-13 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 1.185e-09 Highly Informative Direct
Biological Process (BP) spindle checkpoint 9.452e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.599e-13 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 2.891e-13 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 3.185e-09 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.002275 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.1388 Highly Informative Inherited
Biological Process (BP) mitosis 0.937 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 2.88e-09 Least Informative Direct
Cellular Component (CC) intracellular organelle part 5.232e-06 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.6385 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.8837 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1019 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.001185 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 1.168e-05 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 6.169e-15 Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 7.481e-08 Highly Informative Direct
Cellular Component (CC) kinetochore 0 Highly Informative Direct
Cellular Component (CC) spindle 1.589e-10 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 2.014e-08 Highly Informative Direct
Cellular Component (CC) DNA polymerase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.0002502 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0.004218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.01078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.0182Moderately InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.0002449InformativeDirect
Mammalian Phenotype (MP)abnormal gametes0.0002473InformativeDirect
Mammalian Phenotype (MP)abnormal male germ cell morphology0.0003937InformativeDirect
Mammalian Phenotype (MP)abnormal sex determination0.0004469InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0005906InformativeDirect
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.0009366InformativeDirect
Mammalian Phenotype (MP)abnormal sex gland morphology0.00147InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.007328InformativeInherited
Mammalian Phenotype (MP)abnormal oogenesis3.641e-06Highly InformativeDirect
Mammalian Phenotype (MP)azoospermia7.541e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal testis weight4.057e-05Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.0002473Highly InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.001823Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant2.604e-05Moderately InformativeDirect
Worm Phenotype (WP)chromosome segregation variant0InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant9.872e-08InformativeDirect
Worm Phenotype (WP)meiotic chromosome segregation variant0Highly InformativeDirect
Worm Phenotype (WP)aneuploidy0.02146Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle9.138e-15Moderately InformativeDirect
Biological processDifferentiation2.535e-12Moderately InformativeDirect
Biological processDNA damage3.419e-07Moderately InformativeDirect
Biological processTranscription regulation0.0001831Moderately InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processSpermatogenesis0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton3.42e-13Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Post-translational modificationPhosphoprotein6.093e-08Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003511 SSF56019 Protein matches
Abstract The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognise chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a The spindle assembly checkpoint protein mad2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the The spindle assembly checkpoint protein mad2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]