SUPERFAMILY 1.75 HMM library and genome assignments server


Glutamine synthetase/guanido kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Glutamine synthetase/guanido kinase [ 55930]
Superfamily:   Glutamine synthetase/guanido kinase [ 55931] (5)
Families:   Glutamine synthetase catalytic domain [ 55932]
  Guanido kinase catalytic domain [ 55935] (2)
  Glutamate-cysteine ligase family 2 (GCS2) [ 111160]
  Glutamate-cysteine ligase [ 118090]
  GatB/GatE catalytic domain-like [ 143812] (2)


Superfamily statistics
Genomes (3,215) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,172 70,751 24
Proteins 14,073 70,608 24


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1.48e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 7.485e-11 Least Informative Direct
Biological Process (BP) response to stimulus 0.3157 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 2.907e-11 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 1.706e-12 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.4354 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.06566 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1952 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.009667 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1074 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1299 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.5534 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 8.303e-09 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 1.209e-05 Informative Direct
Biological Process (BP) amide biosynthetic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 5.892e-12 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 1 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.5968 Informative Inherited
Biological Process (BP) glutathione metabolic process 9.677e-10 Highly Informative Direct
Biological Process (BP) response to heat 0.0001011 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 2.165e-05 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 6.043e-09 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 3.741e-15 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.2957 Highly Informative Inherited
Molecular Function (MF) binding 0.9448 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 2.762e-05 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0008232 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5932 Moderately Informative Inherited
Molecular Function (MF) kinase activity 3.909e-06 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.46e-05 Informative Direct
Molecular Function (MF) nucleotide binding 0.02087 Informative Inherited
Molecular Function (MF) amino acid binding 6.71e-07 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 3.637e-06 Least Informative Direct
Cellular Component (CC) protein complex 0.9252 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2543 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.0952Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a nitrogenous group as ac0InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.03504InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)Glutamate decarboxylase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione synthase3.637e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.497InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a nitrogenous group as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processNitrogen fixation0InformativeDirect
Biological processProtein biosynthesis0InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationKinase3.471e-12Moderately InformativeDirect
Post-translational modificationNitration7.589e-06InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutamine synthetase/guanido kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Glutamine synthetase/guanido kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]