SUPERFAMILY 1.75 HMM library and genome assignments server

ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,243) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 98,307 513,894 56
Proteins 97,224 511,116 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.0000019180.0000001188Least InformativeDirect
Biological Process (BP)response to stimulus0.0000041040Least InformativeDirect
Biological Process (BP)single-organism cellular process0.17290.00005845Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.000075021Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00020261Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0035880Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00016260.2223Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.000070321Least InformativeInherited
Biological Process (BP)cellular response to stress0.000075340.000009226Moderately InformativeDirect
Biological Process (BP)DNA repair00InformativeDirect
Molecular Function (MF)binding0.0000018570.00000002125Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.00000047141Moderately InformativeInherited
Molecular Function (MF)DNA binding0.0000000024770.01974InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000007055 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000001188 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00005845 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.01573 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2223 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000009226 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000000007869 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00008867 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0001484 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.1378 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7745 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9997 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.3309 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.05833 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02521 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.628 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9428 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.01075 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.03667 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4095 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.0198 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00000000001766 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000079 Informative Direct
Biological Process (BP) response to nutrient levels 0.00003085 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000000000005349 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) organelle fission 0.000000001461 Informative Direct
Biological Process (BP) reproductive structure development 0.0006192 Informative Direct
Biological Process (BP) chromosome organization 0.0003108 Informative Direct
Biological Process (BP) cell division 0.0001448 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0008284 Informative Direct
Biological Process (BP) response to light stimulus 0.006916 Informative Inherited
Biological Process (BP) response to acid chemical 0.01712 Informative Inherited
Biological Process (BP) response to lipid 0.03235 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8323 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.8239 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) organelle localization 0.1651 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.9661 Informative Inherited
Biological Process (BP) organelle assembly 0.2345 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3877 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8818 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.003135 Informative Inherited
Biological Process (BP) regulation of ion transport 0.07854 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.01844 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1085 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.3569 Informative Inherited
Biological Process (BP) cell cycle process 0.05532 Informative Inherited
Biological Process (BP) cation homeostasis 0.1665 Informative Inherited
Biological Process (BP) nuclear division 0.0002612 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.000000000001032 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.0000006798 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.0000007232 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) response to cytokinin 0.0005719 Highly Informative Direct
Biological Process (BP) regulation of proton transport 0.000005574 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00000003476 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000003712 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00003924 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.0000000000008105 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0005603 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.00000000002292 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.2392 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.03718 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.006359 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.04859 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.02274 Highly Informative Inherited
Biological Process (BP) spindle organization 0.001998 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.2614 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.07114 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.00979 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.4353 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.5269 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.2754 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.06247 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.06058 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.003191 Highly Informative Inherited
Molecular Function (MF) binding 0.00000002125 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.00000000004335 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000003553 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000001878 Moderately Informative Direct
Molecular Function (MF) anion binding 0.006782 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.08537 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.000000000001616 Informative Direct
Molecular Function (MF) magnesium ion binding 0.000008131 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000008949 Informative Direct
Molecular Function (MF) phosphatase activity 0.0009159 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.793 Informative Inherited
Molecular Function (MF) DNA binding 0.01974 Informative Inherited
Molecular Function (MF) protein kinase activity 0.00000000000544 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0004099 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.01384 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.008984 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Cellular Component (CC) protein complex 0.9473 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7673 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.4306 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3036 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.02723 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000003563 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.005867 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.00145 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.000009802 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.00001001 Informative Direct
Cellular Component (CC) lipid particle 0.000109 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.000002668 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.02775 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3834Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.045Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.08052Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.0824Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0007621InformativeDirect
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.009391InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.02InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.03629InformativeInherited
Phenotypic Abnormality (PA)Uterine neoplasm0.000004576Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the large intestine0.00001056Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.00009088Highly InformativeDirect
Phenotypic Abnormality (PA)Sarcoma0.0001048Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.003754InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.003754InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.006266InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.009543InformativeInherited
Mammalian Phenotype (MP)azoospermia0.00007504Highly InformativeDirect
Mammalian Phenotype (MP)abnormal meiosis0.00009752Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)gametogenesis variant0.001002Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0002562Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001876Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.00002301Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.01306Least InformativeInherited
Drugbank ATC_code (DB)antiinfectives0.01178Moderately InformativeInherited
Drugbank ATC_code (DB)antibacterials for systemic use0.305Moderately InformativeInherited
Drugbank ATC_code (DB)quinolone antibacterials0.00000000762InformativeDirect
Drugbank ATC_code (DB)fluoroquinolones0.0000002443InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processBiological rhythms9.345e-16InformativeDirect
Biological processNitrogen fixation0.0000000003363InformativeDirect
Biological processAntibiotic resistance0.0000622InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGlucose metabolism0.000000000000001398Highly InformativeDirect
Biological processEthylene signaling pathway0.00000000000002322Highly InformativeDirect
Cellular componentMembrane0.0000000336Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionDNA-binding0.0000000005645Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionCopper0.0001287InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0.0000000002691Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationProtein phosphatase0.000000000000006994InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationS-nitrosylation0.00002015InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]