SUPERFAMILY 1.75 HMM library and genome assignments server


ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,241) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 98,145 513,894 56
Proteins 97,064 511,116 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process1.873e-064.572e-07Least InformativeDirect
Biological Process (BP)response to stimulus4.041e-060Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0002762.419e-08Least InformativeDirect
Biological Process (BP)heterocycle metabolic process6.142e-051Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process6.543e-051Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00015420.2391Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00018991Least InformativeInherited
Biological Process (BP)cellular response to stress7.413e-055.458e-06Moderately InformativeDirect
Biological Process (BP)DNA metabolic process3.11e-091.12e-10InformativeDirect
Biological Process (BP)response to DNA damage stimulus2.449e-140.08319InformativeInherited
Molecular Function (MF)binding1.686e-061.401e-08Least InformativeDirect
Molecular Function (MF)nucleic acid binding2.699e-071Moderately InformativeInherited
Molecular Function (MF)DNA binding2.357e-090.001059InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 4.572e-07 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.419e-08 Least Informative Direct
Biological Process (BP) protein metabolic process 3.788e-07 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2391 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.007602 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular response to stress 5.458e-06 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 1.378e-13 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.005e-10 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 3.72e-05 Moderately Informative Direct
Biological Process (BP) reproduction 0.0003605 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3769 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7238 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9747 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8189 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4886 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.007041 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02627 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1248 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02038 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2961 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9399 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 1.12e-10 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 5.088e-14 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 2.678e-12 Informative Direct
Biological Process (BP) response to nutrient levels 1.803e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 7.761e-05 Informative Direct
Biological Process (BP) chromosome organization 8.304e-05 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0007449 Informative Direct
Biological Process (BP) apoptotic process 0.572 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) reproductive system development 0.003588 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1244 Informative Inherited
Biological Process (BP) response to light stimulus 0.006434 Informative Inherited
Biological Process (BP) response to lipid 0.0299 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7133 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7232 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9851 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.001769 Informative Inherited
Biological Process (BP) cell cycle process 0.01589 Informative Inherited
Biological Process (BP) organelle localization 0.1459 Informative Inherited
Biological Process (BP) organelle assembly 0.1848 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.9926 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.3017 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3805 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1055 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8595 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.002776 Informative Inherited
Biological Process (BP) regulation of ion transport 0.06427 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.09785 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.03372 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.3501 Informative Inherited
Biological Process (BP) cation homeostasis 0.1697 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.08319 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) meiosis 2.447e-14 Highly Informative Direct
Biological Process (BP) ATP metabolic process 2.033e-13 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 7.4e-13 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.354e-11 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 3.054e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 3.364e-08 Highly Informative Direct
Biological Process (BP) chromosome segregation 2.28e-06 Highly Informative Direct
Biological Process (BP) regulation of proton transport 7.115e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 2.053e-05 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 4.067e-05 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 6.155e-05 Highly Informative Direct
Biological Process (BP) response to cytokinin stimulus 0.0006064 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.196 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.02731 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.04835 Highly Informative Inherited
Biological Process (BP) spindle organization 0.005959 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.5115 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.007744 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.06348 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.5188 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.2563 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.2746 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.06114 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.05924 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.002909 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.001064 Highly Informative Inherited
Molecular Function (MF) binding 1.401e-08 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.557e-15 Moderately Informative Direct
Molecular Function (MF) isomerase activity 4.362e-11 Moderately Informative Direct
Molecular Function (MF) anion binding 0.006548 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.2436 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 1.336e-12 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 8.881e-07 Informative Direct
Molecular Function (MF) magnesium ion binding 7.445e-06 Informative Direct
Molecular Function (MF) enzyme binding 0.7723 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.008375 Informative Inherited
Molecular Function (MF) DNA binding 0.001059 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 6.733e-12 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0003531 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.01278 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.008183 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3565 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6341 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.05204 Least Informative Inherited
Cellular Component (CC) protein complex 0.9611 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.8173 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 4.175e-05 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.005714 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.005476 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 3.513e-06 Informative Direct
Cellular Component (CC) chromosome 9.22e-06 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.01636 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.265e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3833Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.04514Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.08114Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.08251Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0007693InformativeDirect
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.009435InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.02007InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.03636InformativeInherited
Phenotypic Abnormality (PA)Uterine neoplasm4.655e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the large intestine1.071e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm9.221e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Sarcoma0.0001062Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1737Moderately InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.003893InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.003973InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.006446InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.009991InformativeInherited
Mammalian Phenotype (MP)azoospermia7.995e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal meiosis0.0001003Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)gametogenesis variant0.001002Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0002571Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.852e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processStress response0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processNitrogen fixation3.384e-10InformativeDirect
Biological processAntibiotic resistance6.257e-05InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGlucose metabolism1.399e-15Highly InformativeDirect
Biological processEthylene signaling pathway2.343e-14Highly InformativeDirect
Cellular componentMembrane2.968e-08Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionDNA-binding6.642e-10Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionCopper0.0001316InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor2.743e-10Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationProtein phosphatase7.207e-15InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationS-nitrosylation2.046e-05InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]