SUPERFAMILY 1.75 HMM library and genome assignments server


ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,242) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 98,162 513,894 56
Proteins 97,081 511,116 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus4.446e-070Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process1.698e-061.515e-06Least InformativeDirect
Biological Process (BP)single-organism cellular process4.539e-051.778e-09Least InformativeDirect
Biological Process (BP)heterocycle metabolic process6.111e-051Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process6.59e-051Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00015090.1435Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00018671Least InformativeInherited
Biological Process (BP)cellular response to stress0.00023177.446e-06Moderately InformativeDirect
Biological Process (BP)DNA metabolic process3.226e-092.226e-11InformativeDirect
Biological Process (BP)response to DNA damage stimulus2.193e-140.07159InformativeInherited
Molecular Function (MF)binding1.272e-062.26e-08Least InformativeDirect
Molecular Function (MF)nucleic acid binding2.305e-071Moderately InformativeInherited
Molecular Function (MF)DNA binding2.059e-090.001083InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.515e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.778e-09 Least Informative Direct
Biological Process (BP) protein metabolic process 3.122e-06 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1435 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.0092 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular response to stress 7.446e-06 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 1.196e-13 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.802e-10 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 1.505e-05 Moderately Informative Direct
Biological Process (BP) reproduction 0.0002738 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4762 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6994 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9525 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7707 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.4318 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.003952 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01558 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1097 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6489 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02234 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2597 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9199 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 2.226e-11 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 4.463e-14 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 2.736e-12 Informative Direct
Biological Process (BP) response to nutrient levels 9.904e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 6.512e-05 Informative Direct
Biological Process (BP) chromosome organization 6.801e-05 Informative Direct
Biological Process (BP) reproductive system development 0.003151 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1166 Informative Inherited
Biological Process (BP) response to light stimulus 0.005762 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.001872 Informative Inherited
Biological Process (BP) response to lipid 0.0299 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9705 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9764 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.001381 Informative Inherited
Biological Process (BP) cell cycle process 0.0159 Informative Inherited
Biological Process (BP) organelle localization 0.1395 Informative Inherited
Biological Process (BP) organelle assembly 0.1758 Informative Inherited
Biological Process (BP) protein complex assembly 0.2539 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.9955 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2742 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3269 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1093 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8437 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.007989 Informative Inherited
Biological Process (BP) regulation of ion transport 0.05859 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1015 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.03246 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.3367 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.07159 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) meiosis 2.462e-14 Highly Informative Direct
Biological Process (BP) ATP metabolic process 2.256e-13 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 6.039e-13 Highly Informative Direct
Biological Process (BP) protein phosphorylation 6.005e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1.337e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 2.264e-08 Highly Informative Direct
Biological Process (BP) chromosome segregation 2.245e-06 Highly Informative Direct
Biological Process (BP) regulation of proton transport 7.491e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 2.049e-05 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 2.301e-05 Highly Informative Direct
Biological Process (BP) response to cytokinin stimulus 0.0006139 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0008961 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.182 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.02831 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.04487 Highly Informative Inherited
Biological Process (BP) spindle organization 0.006005 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.508 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.006968 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.05846 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.5287 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.2412 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.2574 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.05765 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.05927 Highly Informative Inherited
Molecular Function (MF) binding 2.26e-08 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.563e-15 Moderately Informative Direct
Molecular Function (MF) isomerase activity 2.047e-11 Moderately Informative Direct
Molecular Function (MF) anion binding 0.007156 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.2169 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.563e-15 Informative Direct
Molecular Function (MF) nucleotide binding 1.906e-11 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 5.156e-07 Informative Direct
Molecular Function (MF) magnesium ion binding 1.669e-05 Informative Direct
Molecular Function (MF) DNA binding 0.001083 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.06471 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 2.633e-12 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 6.704e-05 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0.0005376 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.01261 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.00688 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4052 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6527 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.04247 Least Informative Inherited
Cellular Component (CC) protein complex 0.9287 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.8216 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 7.79e-05 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.01146 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.005377 Moderately Informative Inherited
Cellular Component (CC) chromosome 7.651e-06 Informative Direct
Cellular Component (CC) mitochondrial matrix 1.073e-05 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.01551 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.265e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1176Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3843Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.04645Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.2515Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0007924InformativeDirect
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.008544InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.02048InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.03727InformativeInherited
Phenotypic Abnormality (PA)Uterine neoplasm3.632e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the large intestine1.015e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm8.076e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Sarcoma0.0001093Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.173Moderately InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.00389InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.003929InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.00644InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.009943InformativeInherited
Mammalian Phenotype (MP)azoospermia8.107e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal meiosis9.849e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)gametogenesis variant0.001002Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.000253Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.839e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processStress response0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processNitrogen fixation3.384e-10InformativeDirect
Biological processAntibiotic resistance6.257e-05InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGlucose metabolism1.399e-15Highly InformativeDirect
Biological processEthylene signaling pathway2.343e-14Highly InformativeDirect
Cellular componentMembrane2.968e-08Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionDNA-binding6.642e-10Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionCopper0.0001316InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor2.743e-10Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationProtein phosphatase7.207e-15InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationS-nitrosylation2.046e-05InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]