SUPERFAMILY 1.75 HMM library and genome assignments server


ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,236) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 97,817 513,894 56
Proteins 96,767 511,116 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus3.487e-070Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process1.513e-062.638e-05Least InformativeDirect
Biological Process (BP)single-organism cellular process3.84e-055.213e-10Least InformativeDirect
Biological Process (BP)heterocycle metabolic process5.96e-051Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process6.475e-051Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0001480.1163Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00018261Least InformativeInherited
Biological Process (BP)cellular response to stress0.0002424.885e-06Moderately InformativeDirect
Biological Process (BP)DNA metabolic process3.658e-092.942e-12InformativeDirect
Biological Process (BP)response to DNA damage stimulus1.874e-140.087InformativeInherited
Molecular Function (MF)binding1.032e-066.271e-08Least InformativeDirect
Molecular Function (MF)nucleic acid binding2.14e-071Moderately InformativeInherited
Molecular Function (MF)DNA binding1.879e-090.0009335InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.638e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.213e-10 Least Informative Direct
Biological Process (BP) protein metabolic process 6.36e-05 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1163 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.009893 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular response to stress 4.885e-06 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 4.491e-10 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 1.923e-05 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 4.793e-05 Moderately Informative Direct
Biological Process (BP) reproduction 0.0003895 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9883 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4072 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6685 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9121 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7311 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0156 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.4378 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.004989 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01567 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1361 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.614 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.05603 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2429 Moderately Informative Inherited
Biological Process (BP) immune system process 0.8998 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 2.942e-12 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 1.809e-13 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 5.894e-12 Informative Direct
Biological Process (BP) response to nutrient levels 7.581e-06 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 5.146e-05 Informative Direct
Biological Process (BP) chromosome organization 5.227e-05 Informative Direct
Biological Process (BP) reproductive system development 0.005345 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1487 Informative Inherited
Biological Process (BP) response to light stimulus 0.00494 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.001903 Informative Inherited
Biological Process (BP) response to lipid 0.03129 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9454 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9519 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.001252 Informative Inherited
Biological Process (BP) cell cycle process 0.01709 Informative Inherited
Biological Process (BP) organelle localization 0.1285 Informative Inherited
Biological Process (BP) organelle assembly 0.1373 Informative Inherited
Biological Process (BP) protein complex assembly 0.2181 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.9885 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2488 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3236 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1095 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9187 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001805 Informative Inherited
Biological Process (BP) regulation of ion transport 0.05115 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.08839 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.04112 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2993 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.087 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) meiosis 2.434e-14 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 5.795e-13 Highly Informative Direct
Biological Process (BP) ATP metabolic process 8.343e-13 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1.275e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.537e-08 Highly Informative Direct
Biological Process (BP) protein phosphorylation 9.38e-08 Highly Informative Direct
Biological Process (BP) chromosome segregation 2.216e-06 Highly Informative Direct
Biological Process (BP) regulation of proton transport 8.223e-06 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 1.989e-05 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 2.77e-05 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0008229 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.2789 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.02865 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.047 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1404 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.5057 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.006285 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.05361 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.5679 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.245 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.2924 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.05342 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.06197 Highly Informative Inherited
Molecular Function (MF) binding 6.271e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 6.955e-11 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01708 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.1917 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0.0009335 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 5.867e-14 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 2.278e-13 Informative Direct
Molecular Function (MF) nucleotide binding 1.037e-09 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 7.596e-07 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.06025 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 4.531e-12 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 5.881e-05 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0.0004925 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.01332 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.005859 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4653 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6516 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.02823 Least Informative Inherited
Cellular Component (CC) protein complex 0.8848 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.8897 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0001088 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.01042 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.00695 Moderately Informative Inherited
Cellular Component (CC) chromosome 5.142e-06 Informative Direct
Cellular Component (CC) mitochondrial matrix 7.943e-06 Informative Direct
Cellular Component (CC) condensed chromosome 0.0004301 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.01316 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.265e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3846Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.04632Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.08061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2473Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0007773InformativeDirect
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.009156InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.02106InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.03702InformativeInherited
Phenotypic Abnormality (PA)Uterine neoplasm3.795e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the large intestine1.063e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm8.431e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Sarcoma0.0001052Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1726Moderately InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.003869InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.006376InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.00977InformativeInherited
Mammalian Phenotype (MP)azoospermia8.264e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal meiosis9.712e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)gametogenesis variant0.001002Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0002436Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.154e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processStress response0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processNitrogen fixation3.182e-10InformativeDirect
Biological processAntibiotic resistance4.983e-05InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGlucose metabolism9.334e-16Highly InformativeDirect
Biological processEthylene signaling pathway2.208e-14Highly InformativeDirect
Cellular componentMembrane5.568e-08Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionDNA-binding3.993e-10Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionCopper0.0001231InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor2.488e-10Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationProtein phosphatase6.544e-15InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationS-nitrosylation1.811e-05InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]