SUPERFAMILY 1.75 HMM library and genome assignments server


Profilin (actin-binding protein) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   Profilin (actin-binding protein) [ 55770]
Families:   Profilin (actin-binding protein) [ 55771]


Superfamily statistics
Genomes (480) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,325 1,735 12
Proteins 1,308 1,729 12


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process3.717e-080.000274Least InformativeDirect
Biological Process (BP)localization4.754e-063.79e-06Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)single-organism cellular process6.73e-050.002632Least InformativeInherited
Biological Process (BP)developmental process5.671e-060.008346Least InformativeInherited
Biological Process (BP)multicellular organismal process0.00074080.09999Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.16330.4252Least InformativeInherited
Biological Process (BP)organelle organization7.821e-053.491e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00024150.0005322Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization8.48e-123.663e-11Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.055920.02034Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.00028920.002128Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0016990.01637Moderately InformativeInherited
Biological Process (BP)nervous system development0.0085380.02307Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.088470.1737Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.15430.6175Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.31570.6766Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0086190.07939Moderately InformativeInherited
Biological Process (BP)tissue development0.0066510.01567Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter2.237e-070.0006068InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)actin filament-based process2.727e-133.77e-15InformativeDirect
Biological Process (BP)regulation of organelle organization2.496e-142.462e-14InformativeDirect
Biological Process (BP)tube development6.801e-050.0001196InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis00InformativeDirect
Biological Process (BP)embryonic morphogenesis8.41e-081.862e-06InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis3.059e-050.0001459InformativeDirect
Biological Process (BP)tissue morphogenesis2.361e-071.417e-06InformativeDirect
Biological Process (BP)negative regulation of cellular component organization5.472e-134.251e-13InformativeDirect
Biological Process (BP)positive regulation of cellular component organization1.531e-065.693e-06InformativeDirect
Biological Process (BP)epithelium development8.905e-108.658e-07InformativeDirect
Biological Process (BP)regulation of anatomical structure size1.252e-131.844e-13InformativeDirect
Biological Process (BP)embryo development ending in birth or egg hatching0.017130.01583InformativeInherited
Biological Process (BP)actin filament organization6.489e-091.128e-06Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization3.555e-072.985e-07Highly InformativeDirect
Biological Process (BP)morphogenesis of embryonic epithelium7.179e-061.228e-05Highly InformativeDirect
Biological Process (BP)neural tube development7.211e-101.719e-08Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization00Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly2.919e-113.04e-13Highly InformativeDirect
Biological Process (BP)maintenance of location6.022e-141.389e-11Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization2.441e-081.543e-08Highly InformativeDirect
Biological Process (BP)epithelial tube formation2.193e-142.004e-11Highly InformativeDirect
Molecular Function (MF)binding1.366e-101.69e-08Least InformativeDirect
Molecular Function (MF)anion binding0.00022465.58e-06Moderately InformativeDirect
Molecular Function (MF)cytoskeletal protein binding6.811e-144.58e-15InformativeDirect
Molecular Function (MF)lipid binding0.00080783.788e-06InformativeDirect
Molecular Function (MF)actin binding00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.000274 Least Informative Direct
Biological Process (BP) localization 3.79e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.002632 Least Informative Inherited
Biological Process (BP) developmental process 0.008346 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.09999 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4252 Least Informative Inherited
Biological Process (BP) organelle organization 3.491e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0005322 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 3.663e-11 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.02034 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002128 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01637 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02307 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1737 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.6175 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6766 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.07939 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01567 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0006068 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 3.77e-15 Informative Direct
Biological Process (BP) regulation of organelle organization 2.462e-14 Informative Direct
Biological Process (BP) tube development 0.0001196 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.862e-06 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001459 Informative Direct
Biological Process (BP) tissue morphogenesis 1.417e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 4.251e-13 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 5.693e-06 Informative Direct
Biological Process (BP) epithelium development 8.658e-07 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.844e-13 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.01583 Informative Inherited
Biological Process (BP) actin filament organization 1.128e-06 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 2.985e-07 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 1.228e-05 Highly Informative Direct
Biological Process (BP) neural tube development 1.719e-08 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 3.04e-13 Highly Informative Direct
Biological Process (BP) maintenance of location 1.389e-11 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 1.543e-08 Highly Informative Direct
Biological Process (BP) epithelial tube formation 2.004e-11 Highly Informative Direct
Molecular Function (MF) binding 1.69e-08 Least Informative Direct
Molecular Function (MF) anion binding 5.58e-06 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 4.58e-15 Informative Direct
Molecular Function (MF) lipid binding 3.788e-06 Informative Direct
Molecular Function (MF) actin binding 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.03241 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0004003 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 9.293e-05 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)root system0.2381Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.5764Least InformativeInherited
Plant ANatomical entity (PAN)root tip1.91e-05InformativeDirect
Plant ANatomical entity (PAN)anther1.739e-06Highly InformativeDirect
Plant ANatomical entity (PAN)plant ovule6.465e-06Highly InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionLipid-binding3.822e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002097 SSF55770 Protein matches
Abstract Profilin is a small eukaryotic protein that binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerization of actin into filaments (F-actin). It can also in certain circumstance promote actin polymerization. Profilin also binds to polyphosphoinositides such as PIP2. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. That region is thought to be involved in the binding to actin.

A protein structurally similar to profilin is present in the genome of Variola virus and Vaccinia virus (gene A42R).

Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P., Hoffmann D., Loewenstein H., Marsh D.G., Platts-Mills T.A.E., Thomas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed of the first three letters of the genus; a space; the first letter of the species name; a space and an arabic number. In the event that two species names have identical designations, they are discriminated from one another by adding one or more letters (as necessary) to each species designation.

The allergens in this family include allergens with the following designations: Ara t 8, Bet v 2, Cyn d 12, Hel a 2, Mer a 1 and Phl p 11.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Profilin (actin-binding protein) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Profilin (actin-binding protein) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]