SUPERFAMILY 1.75 HMM library and genome assignments server

Profilin (actin-binding protein) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   Profilin (actin-binding protein) [ 55770]
Families:   Profilin (actin-binding protein) [ 55771]


Superfamily statistics
Genomes (481) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,326 1,735 12
Proteins 1,309 1,729 12


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.000000069090.0003816Least InformativeDirect
Biological Process (BP)localization0.0000076250.000006095Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00059090.08245Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.12910.1836Least InformativeInherited
Biological Process (BP)single-organism cellular process0.004390.009064Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.20040.4831Least InformativeInherited
Biological Process (BP)developmental process0.0000061410.008965Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00045490.0007838Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.000000000018850.0000000000738Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000000062280.00000003698Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization0.000000042480.000000154Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.13880.1891Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.00029110.002121Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.001270.01257Moderately InformativeInherited
Biological Process (BP)tissue development0.0050750.01584Moderately InformativeInherited
Biological Process (BP)nervous system development0.009820.02534Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.053980.1188Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.47240.7326Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.048580.2759Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0031640.05097Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.23890.7451Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00000027040.0007108InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)actin filament-based process0.0000000000000094410.000000000000001913InformativeDirect
Biological Process (BP)regulation of organelle organization0.000000000000033220.00000000000007734InformativeDirect
Biological Process (BP)tube development0.00018470.0004041InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis00InformativeDirect
Biological Process (BP)embryonic morphogenesis0.00000014140.00000369InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.000032850.0001571InformativeDirect
Biological Process (BP)tissue morphogenesis0.000000480.000003643InformativeDirect
Biological Process (BP)negative regulation of cellular component organization0.00000000000074110.0000000000007329InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0000050170.00001371InformativeDirect
Biological Process (BP)epithelium development0.00000000076670.000001999InformativeDirect
Biological Process (BP)regulation of anatomical structure size0.00000000000018760.000000000000264InformativeDirect
Biological Process (BP)embryo development ending in birth or egg hatching0.019390.01544InformativeInherited
Biological Process (BP)actin filament organization0.0000000035030.0000003762Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.0000011350.00000104Highly InformativeDirect
Biological Process (BP)morphogenesis of embryonic epithelium0.0000069710.00001115Highly InformativeDirect
Biological Process (BP)neural tube development0.00000000049260.00000001182Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization00Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.0000000000140.0000000000002136Highly InformativeDirect
Biological Process (BP)positive regulation of cellular component biogenesis0.000000003450.000000004839Highly InformativeDirect
Biological Process (BP)maintenance of location0.00000000000072880.0000000001618Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization0.000000020890.00000000952Highly InformativeDirect
Biological Process (BP)epithelial tube formation0.000000000000021460.00000000002059Highly InformativeDirect
Molecular Function (MF)binding0.00000000024530.0000000304Least InformativeDirect
Molecular Function (MF)anion binding0.00025440.000006654Moderately InformativeDirect
Molecular Function (MF)cytoskeletal protein binding0.000000000000076530.000000000000003138InformativeDirect
Molecular Function (MF)lipid binding0.00075170.000003826InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0003816 Least Informative Direct
Biological Process (BP) localization 0.000006095 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.08245 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.1836 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.009064 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4831 Least Informative Inherited
Biological Process (BP) developmental process 0.008965 Least Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0007838 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000000738 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000003698 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000000154 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.1891 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002121 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01257 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01584 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02534 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1188 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7326 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2759 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.05097 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.7451 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0007108 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0.000000000000001913 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00000000000007734 Informative Direct
Biological Process (BP) tube development 0.0004041 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00000369 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001571 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000003643 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000000007329 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00001371 Informative Direct
Biological Process (BP) epithelium development 0.000001999 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000000000264 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.01544 Informative Inherited
Biological Process (BP) actin filament organization 0.0000003762 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00000104 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.00001115 Highly Informative Direct
Biological Process (BP) neural tube development 0.00000001182 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0000000000002136 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000000004839 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000000001618 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.00000000952 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.00000000002059 Highly Informative Direct
Molecular Function (MF) binding 0.0000000304 Least Informative Direct
Molecular Function (MF) anion binding 0.000006654 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000000000003138 Informative Direct
Molecular Function (MF) lipid binding 0.000003826 Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.06928 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0004127 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00007314 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)root system0.2381Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.5764Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0000191InformativeDirect
Plant ANatomical entity (PAN)anther0.000001739Highly InformativeDirect
Plant ANatomical entity (PAN)plant ovule0.000006465Highly InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionLipid-binding0.00000003749InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002097 SSF55770 Protein matches
Abstract Profilin is a small eukaryotic protein that binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerization of actin into filaments (F-actin). It can also in certain circumstance promote actin polymerization. Profilin also binds to polyphosphoinositides such as PIP2. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. That region is thought to be involved in the binding to actin.

A protein structurally similar to profilin is present in the genome of Variola virus and Vaccinia virus (gene A42R).

Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P., Hoffmann D., Loewenstein H., Marsh D.G., Platts-Mills T.A.E., Thomas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed of the first three letters of the genus; a space; the first letter of the species name; a space and an arabic number. In the event that two species names have identical designations, they are discriminated from one another by adding one or more letters (as necessary) to each species designation.

The allergens in this family include allergens with the following designations: Ara t 8, Bet v 2, Cyn d 12, Hel a 2, Mer a 1 and Phl p 11.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Profilin (actin-binding protein) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Profilin (actin-binding protein) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]