SUPERFAMILY 1.75 HMM library and genome assignments server


Class II aaRS and biotin synthetases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Class II aaRS and biotin synthetases [ 55680]
Superfamily:   Class II aaRS and biotin synthetases [ 55681] (4)
Families:   Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain [ 55682] (15)
  Biotin holoenzyme synthetase [ 55707] (2)
  LplA-like [ 143642] (5)
  PH0223-like [ 160611]


Superfamily statistics
Genomes (3,251) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 52,541 268,710 47
Proteins 52,352 268,507 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.00074140Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.15060Least InformativeInherited
Biological Process (BP)protein metabolic process0.0040990Least InformativeInherited
Biological Process (BP)biosynthetic process0.012640Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.019870Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.022530Least InformativeInherited
Biological Process (BP)cellular protein modification process0.095141Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.00019980.1168Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.00051560.345Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.03861Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.05311Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.013511Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.025411Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.059961Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.080341Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.018270.0257InformativeInherited
Biological Process (BP)coenzyme biosynthetic process3.303e-060.002071InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.00088230.8503InformativeInherited
Biological Process (BP)fatty acid metabolic process0.003480.08956InformativeInherited
Molecular Function (MF)transferase activity0.0041731Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.57110.4513Moderately InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.32091InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity7.884e-050.003335InformativeInherited
Molecular Function (MF)DNA polymerase activity3.999e-087.285e-07Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.077410Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.080920.06502Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.5639 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.04027 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.5793 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1466 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1168 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.345 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ncRNA metabolic process 0 Informative Direct
Biological Process (BP) translation 0 Informative Direct
Biological Process (BP) mitochondrion organization 9.286e-14 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 5.267e-09 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 7.727e-08 Informative Direct
Biological Process (BP) reproductive system development 0.01992 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.2661 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1084 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.9874 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0257 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.002071 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.8503 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.08956 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.7835 Informative Inherited
Biological Process (BP) cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) regulation of translation 9.286e-14 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 1.854e-05 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.0003951 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0005666 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.03461 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01443 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.02765 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.01354 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.4513 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 1.541e-06 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 3.324e-06 Informative Direct
Molecular Function (MF) nucleotide binding 0.5025 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.003335 Informative Inherited
Molecular Function (MF) RNA binding 0.005422 Informative Inherited
Molecular Function (MF) DNA polymerase activity 7.285e-07 Highly Informative Direct
Molecular Function (MF) ATP binding 4.222e-09 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0.0006439 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.384 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.06502 Least Informative Inherited
Cellular Component (CC) plastid 9.237e-06 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases1InformativeInherited
Enzyme Commission (EC)Aspartate--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)Proline--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Threonine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Alanine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Histidine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.07992Least InformativeInherited
Disease Ontology (DO)neuropathy0.01833InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.605Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.0007976Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001569Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002224Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal8.31e-08Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0001255Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0002205Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0003423Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0009283Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.1877Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.4728Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb4.98e-11InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant4.291e-07InformativeDirect
Worm Phenotype (WP)rachis morphology variant4.989e-07InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant5.472e-07InformativeDirect
Worm Phenotype (WP)receptor mediated endocytosis defective9.107e-06InformativeDirect
Worm Phenotype (WP)transgene expression increased9.949e-06InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0001403InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.0001414Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.3917Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.009363Moderately InformativeInherited
Yeast Phenotype (YP)heat sensitivity0.0001612InformativeDirect
Yeast Phenotype (YP)utilization of carbon source0.002667InformativeInherited
Yeast Phenotype (YP)respiratory growth5.454e-05Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)decreased cell size0.0005292Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage4.856e-05InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processProtein biosynthesis0InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding3.833e-07Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0.8638Moderately InformativeInherited
Molecular functiontRNA-binding0InformativeDirect
Molecular functionBiotin0.0006155Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0.07896Moderately InformativeInherited
UniPathway (UP)L-histidine biosynthesis0InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)protein maturation0InformativeDirect
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)protein lipoylation0Highly InformativeDirect
UniPathway (UP)aminoacyl-tRNA biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Class II aaRS and biotin synthetases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the Class II aaRS and biotin synthetases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]