SUPERFAMILY 1.75 HMM library and genome assignments server


Cell cycle regulatory proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cell cycle regulatory proteins [ 55636]
Superfamily:   Cell cycle regulatory proteins [ 55637]
Families:   Cell cycle regulatory proteins [ 55638] (4)


Superfamily statistics
Genomes (421) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 690 604 6
Proteins 690 602 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00023170.003626Least InformativeInherited
Biological Process (BP)single-organism cellular process0.000530.005292Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.079760.1151Least InformativeInherited
Biological Process (BP)regulation of catalytic activity3.226e-061.6e-06Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process8.848e-071.138e-06Moderately InformativeDirect
Biological Process (BP)regulation of phosphate metabolic process17.197e-07Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.828e-081.464e-08InformativeDirect
Biological Process (BP)cell cycle process9.308e-091.788e-07InformativeDirect
Biological Process (BP)regulation of kinase activity2.142e-092.271e-09InformativeDirect
Biological Process (BP)regulation of cell cycle1.843e-112.875e-11InformativeDirect
Molecular Function (MF)binding0.00056750.002719Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.003626 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.005292 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1151 Least Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 7.197e-07 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 1.6e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.138e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.464e-08 Informative Direct
Biological Process (BP) cell cycle process 1.788e-07 Informative Direct
Biological Process (BP) regulation of kinase activity 2.271e-09 Informative Direct
Biological Process (BP) regulation of cell cycle 2.875e-11 Informative Direct
Molecular Function (MF) binding 0.002719 Least Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000789 SSF55637 Protein matches
Abstract

In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division [PubMed3322810]. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded beta-barrel structure [PubMed8211159]. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs [PubMed8491379]. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation [PubMed8491379, PubMed8211159].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cell cycle regulatory proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Cell cycle regulatory proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]