SUPERFAMILY 1.75 HMM library and genome assignments server


SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (439) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,230 0 94
Proteins 11,874 0 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus2.963e-080Least InformativeDirect
Biological Process (BP)protein metabolic process0.00012160Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.00088699.313e-11Least InformativeDirect
Biological Process (BP)regulation of cellular process11.113e-07Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.71620.6199Least InformativeInherited
Biological Process (BP)multicellular organismal process0.045640Least InformativeInherited
Biological Process (BP)developmental process0.020460Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0038240Least InformativeInherited
Biological Process (BP)immune system process5.012e-080Moderately InformativeDirect
Biological Process (BP)cellular protein modification process8.004e-070Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process2.16e-050Moderately InformativeDirect
Biological Process (BP)organ development0.0001568.347e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00019290Moderately InformativeDirect
Biological Process (BP)signal transduction0.00073050Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00080870Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.01769.195e-05Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0028920Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.10440.3349Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.011536.389e-09Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.087062.439e-13Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.043220.1532Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction13.799e-08Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.080851Moderately InformativeInherited
Biological Process (BP)regulation of immune effector process8.892e-070.0002704InformativeDirect
Biological Process (BP)positive regulation of immune system process1.62e-050InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00011610InformativeDirect
Biological Process (BP)phosphorylation0.00014560InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development0.00017810InformativeDirect
Biological Process (BP)gland development0.00024910.0006629InformativeDirect
Biological Process (BP)regulation of protein phosphorylation3.032e-080.1887InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.016015.386e-06InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.011981InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.093090.9518InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.0045920InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0011790.003137InformativeInherited
Biological Process (BP)negative regulation of cell communication0.065470.0003174InformativeInherited
Biological Process (BP)negative regulation of signaling0.079079.556e-05InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.091110.3236InformativeInherited
Biological Process (BP)regulation of immune response0.0014431.122e-08InformativeInherited
Biological Process (BP)regulation of response to stress0.0020961InformativeInherited
Biological Process (BP)regulation of cell killing02.218e-05Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification2.222e-130Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process2.635e-054.983e-06Highly InformativeDirect
Biological Process (BP)protein phosphorylation4.309e-050Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process7.237e-051.948e-06Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00068450Highly InformativeDirect
Biological Process (BP)positive regulation of peptidyl-tyrosine phosphorylation0.00069484.52e-05Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.011460.04014Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.014750.004721Highly InformativeInherited
Biological Process (BP)positive regulation of defense response4.338e-080.2964Highly InformativeInherited
Biological Process (BP)regulation of innate immune response1.193e-061Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte mediated immunity0.00042541Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte mediated immunity01Highly InformativeInherited
Molecular Function (MF)binding7.039e-080Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 9.313e-11 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.113e-07 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6199 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.005465 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 8.347e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 6.389e-09 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 9.195e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.439e-13 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 5.979e-07 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.832e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 2.074e-11 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.612e-10 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 3.436e-09 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 3.799e-08 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 3.55e-07 Moderately Informative Direct
Biological Process (BP) reproduction 8.48e-07 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.268e-05 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 1.514e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0001864 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0002076 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0002126 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1532 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7965 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.04145 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.8031 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.003635 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3349 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.065 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.497 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.003257 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0002704 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) gland development 0.0006629 Informative Direct
Biological Process (BP) regulation of immune response 1.122e-08 Informative Direct
Biological Process (BP) regulation of cytokine production 2.137e-05 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 5.386e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0003174 Informative Direct
Biological Process (BP) negative regulation of signaling 9.556e-05 Informative Direct
Biological Process (BP) leukocyte activation 8.553e-13 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) programmed cell death 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) response to organonitrogen compound 3.722e-15 Informative Direct
Biological Process (BP) glycerolipid metabolic process 2.766e-14 Informative Direct
Biological Process (BP) transcription, DNA-dependent 1.229e-13 Informative Direct
Biological Process (BP) response to hormone stimulus 6.776e-13 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 5.423e-11 Informative Direct
Biological Process (BP) defense response 1.017e-10 Informative Direct
Biological Process (BP) cellular component movement 1.174e-10 Informative Direct
Biological Process (BP) blood circulation 1.521e-10 Informative Direct
Biological Process (BP) regulation of cell proliferation 7.005e-10 Informative Direct
Biological Process (BP) response to wounding 1.709e-09 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 6.276e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 8.682e-09 Informative Direct
Biological Process (BP) negative regulation of developmental process 2.918e-08 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 3.431e-08 Informative Direct
Biological Process (BP) metal ion homeostasis 5.474e-08 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 6.162e-08 Informative Direct
Biological Process (BP) cellular cation homeostasis 8.674e-08 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 5.932e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 5.971e-07 Informative Direct
Biological Process (BP) cytoplasmic transport 2.185e-06 Informative Direct
Biological Process (BP) biological adhesion 1.45e-05 Informative Direct
Biological Process (BP) regulation of cellular component movement 4.398e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 5.699e-05 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 6.86e-05 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 6.942e-05 Informative Direct
Biological Process (BP) generation of neurons 0.0001154 Informative Direct
Biological Process (BP) regulation of locomotion 0.0003995 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004691 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0008802 Informative Direct
Biological Process (BP) regulation of growth 0.0009095 Informative Direct
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01676 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.3825 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.6569 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.708 Informative Inherited
Biological Process (BP) protein transport 0.04685 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.925 Informative Inherited
Biological Process (BP) regulation of ion transport 0.2987 Informative Inherited
Biological Process (BP) actin filament-based process 0.06418 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003137 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.49 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.03859 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.009113 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.264 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8365 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.4711 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.09609 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1887 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.9518 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.04141 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.2367 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.3236 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.1382 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) immune effector process 0.9075 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.003186 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.01965 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) chromosome organization 0.9358 Informative Inherited
Biological Process (BP) dephosphorylation 0.9637 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5066 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01685 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9817 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.002299 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6743 Informative Inherited
Biological Process (BP) cell projection organization 0.07479 Informative Inherited
Biological Process (BP) lipid localization 0.007532 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.9151 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to other organism 0.009767 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.06017 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3515 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3636 Informative Inherited
Biological Process (BP) sexual reproduction 0.01187 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.006644 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.005927 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) secretion by cell 0.09648 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.8113 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of cell killing 2.218e-05 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 4.983e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.948e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 4.52e-05 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 7.419e-09 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 1.075e-13 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) phagocytosis 1.922e-15 Highly Informative Direct
Biological Process (BP) coagulation 1.121e-13 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 2.946e-11 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 6.641e-11 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 1.238e-10 Highly Informative Direct
Biological Process (BP) lactation 1.784e-10 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 2.124e-10 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 1.784e-09 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.741e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 2.318e-08 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 2.496e-08 Highly Informative Direct
Biological Process (BP) leukocyte migration 1.362e-07 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 1.404e-07 Highly Informative Direct
Biological Process (BP) activation of immune response 1.834e-07 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 2.383e-07 Highly Informative Direct
Biological Process (BP) female gamete generation 2.767e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 4.711e-07 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 7.374e-07 Highly Informative Direct
Biological Process (BP) monoamine transport 7.439e-07 Highly Informative Direct
Biological Process (BP) eye morphogenesis 9.487e-07 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.557e-06 Highly Informative Direct
Biological Process (BP) nuclear import 1.6e-06 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 4.927e-06 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 5.987e-06 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 8.783e-06 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 1.405e-05 Highly Informative Direct
Biological Process (BP) myeloid cell development 2.109e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 2.967e-05 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 7.121e-05 Highly Informative Direct
Biological Process (BP) protein import 7.255e-05 Highly Informative Direct
Biological Process (BP) innate immune response 7.678e-05 Highly Informative Direct
Biological Process (BP) wound healing 8.066e-05 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0001005 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.0001068 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0001601 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0002374 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0.0002549 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0002825 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0003853 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0004453 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0004673 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0008762 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.189 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2532 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.3886 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.01003 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.01427 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.08965 Highly Informative Inherited
Biological Process (BP) renal system development 0.2823 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.05851 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.4645 Highly Informative Inherited
Biological Process (BP) placenta development 0.6793 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.04225 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.004907 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.09289 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.01012 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.04014 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.004721 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.2964 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.9485 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.2859 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.702 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6791 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.123 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.07404 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.07326 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.3023 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.5066 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.06462 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.1624 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.5278 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.9084 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.298 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.004522 Highly Informative Inherited
Biological Process (BP) response to UV 0.07758 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.001692 Highly Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 0.003935 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.81 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.7383 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01207 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01165 Highly Informative Inherited
Biological Process (BP) muscle organ development 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.02908 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.4089 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 1 Highly Informative Inherited
Biological Process (BP) hemostasis 0.1506 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.9318 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.5599 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4339 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.002114 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) cellular transition metal ion homeostasis 0.6221 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.6828 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) exocytosis 0.3143 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.914 Highly Informative Inherited
Biological Process (BP) response to fungus 0.2632 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.005405 Highly Informative Inherited
Biological Process (BP) gonad development 0.3734 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 3.819e-13 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1.001e-06 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.8346 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 1.404e-14 Informative Direct
Molecular Function (MF) DNA binding 7.194e-06 Informative Direct
Molecular Function (MF) tetrapyrrole binding 2.795e-05 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 4.27e-05 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) protein domain specific binding 7.982e-16 Highly Informative Direct
Molecular Function (MF) protein kinase activity 2.846e-10 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 2.039e-07 Highly Informative Direct
Molecular Function (MF) heme binding 1.253e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 2.594e-05 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 3.271e-05 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0005197 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0005383 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.1803 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3553 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.08639 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.002283 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.2589 Highly Informative Inherited
Cellular Component (CC) membrane 2.453e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4755 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01095 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 4.137e-09 Moderately Informative Direct
Cellular Component (CC) vesicle 2.815e-05 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.4069 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.5607 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1177 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.1861 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 1.947e-09 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) membrane raft 0 Highly Informative Direct
Cellular Component (CC) ruffle 3.563e-12 Highly Informative Direct
Cellular Component (CC) adherens junction 2.117e-11 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.894e-06 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 9.333e-06 Highly Informative Direct
Cellular Component (CC) receptor complex 5.438e-05 Highly Informative Direct
Cellular Component (CC) microtubule organizing center part 0.0001608 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.0479 Highly Informative Inherited
Cellular Component (CC) centrosome 0.2406 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds6.817e-06Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases2.804e-06Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases7.356e-05Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C1.01e-14InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001114Least InformativeDirect
Disease Ontology (DO)immune system disease0.01015Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05709Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8522Moderately InformativeInherited
Disease Ontology (DO)in situ carcinoma0.0002552InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3195InformativeInherited
Disease Ontology (DO)polycythemia1.773e-08Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues9.109e-07Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system2.735e-05Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of humoral immunity9.912e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of leukocytes0.009563InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype3.535e-11Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype9.441e-11Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.09092Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1102Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis2.691e-10Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology4.06e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology9.884e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.000128Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.0002112Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0003476Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.005246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.00762Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01574Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.02294Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1748Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.233Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.6193Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response1.799e-06InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology6.522e-06InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation5.159e-05InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.002747InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.009015InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.02743InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.03282InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05838InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.06822InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.1134InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.1215InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1629InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1805InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.2147InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2347InformativeInherited
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity1.264e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number2.892e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0004468Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005707Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0009402Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.0232Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03499Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01539Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.3188InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0003212Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible5.604e-05InformativeDirect
Fly Phenotype (FP)size defective0.0002543InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0005882Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.02111Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.02165Least InformativeInherited
Fly Anatomy (FA)anatomical group0.033Least InformativeInherited
Fly Anatomy (FA)organ system0.04981Least InformativeInherited
Fly Anatomy (FA)cell0.7073Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment4.007e-05Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0007622Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.002415Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.002787Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.003078Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.02937Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.03093Moderately InformativeInherited
Fly Anatomy (FA)appendage0.03308Moderately InformativeInherited
Fly Anatomy (FA)neuron0.04447Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.06596Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.08408Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08564Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.126Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.235Moderately InformativeInherited
Fly Anatomy (FA)head0.3364Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.398Moderately InformativeInherited
Fly Anatomy (FA)ovariole0.0006762InformativeDirect
Fly Anatomy (FA)germline stem cell0.01342InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.01971InformativeInherited
Fly Anatomy (FA)germline cyst0.02122InformativeInherited
Fly Anatomy (FA)male germline cell0.1126InformativeInherited
Fly Anatomy (FA)testis0.6869InformativeInherited
Fly Anatomy (FA)somatic stem cell0.7193InformativeInherited
Fly Anatomy (FA)male germline stem cell0.0005766Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0009122Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.3799Least InformativeInherited
Zebrafish Anatomy (ZA)lymphoid progenitor cell1.063e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0001343Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases3.906e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases8.039e-05InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001609InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C9.862e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation1.896e-14Moderately InformativeDirect
Biological processApoptosis9.721e-11Moderately InformativeDirect
Biological processHost-virus interaction8.853e-05Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processCell adhesion1.215e-10InformativeDirect
Biological processEndocytosis1.578e-08InformativeDirect
Biological processInflammatory response1.039e-06InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity3.813e-13Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane6.421e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome4.404e-13Moderately InformativeDirect
Cellular componentCytoplasmic vesicle1.994e-10Moderately InformativeDirect
Cellular componentGolgi apparatus5.776e-09Moderately InformativeDirect
Cellular componentCell membrane0.0009175Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene1.059e-05Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding1.917e-13InformativeDirect
Molecular functionNucleotide-binding8.083e-06Least InformativeDirect
Molecular functionATP-binding1.448e-10Moderately InformativeDirect
Molecular functionCalcium4.597e-05Moderately InformativeDirect
Molecular functionLipid-binding5.157e-11InformativeDirect
Molecular functionActin-binding1.329e-07InformativeDirect
Post-translational modificationTransferase3.525e-09Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator4.432e-16Moderately InformativeDirect
Post-translational modificationDevelopmental protein6.115e-15Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationProtein phosphatase2.276e-08InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation2.138e-11Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]