SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (448) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,022 15,320 94
Proteins 12,605 13,787 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00000013550Least InformativeDirect
Biological Process (BP)protein metabolic process0.00013820Least InformativeDirect
Biological Process (BP)regulation of cellular process0.97690.00000003065Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.78380.8063Least InformativeInherited
Biological Process (BP)multicellular organismal process0.060470Least InformativeInherited
Biological Process (BP)developmental process0.028120Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0010350.00000000001894Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0037350Least InformativeInherited
Biological Process (BP)immune system process0.000000089140Moderately InformativeDirect
Biological Process (BP)cellular protein modification process0.00000088880Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.000029620Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00018640Moderately InformativeDirect
Biological Process (BP)organ development0.00018740.00003268Moderately InformativeDirect
Biological Process (BP)cell differentiation0.0009420Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.025530.00002151Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.81520.002257Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.012080.000000001563Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.07130.1583Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.00000007202Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.082191Moderately InformativeInherited
Biological Process (BP)regulation of immune effector process0.00000075590.0003276InformativeDirect
Biological Process (BP)positive regulation of immune system process0.000011930InformativeDirect
Biological Process (BP)negative regulation of immune system process0.000035320.000009783InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00011470InformativeDirect
Biological Process (BP)phosphorylation0.00012620InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development0.00018020InformativeDirect
Biological Process (BP)gland development0.00023310.0008837InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.000000039680.1467InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.014710.000006137InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.0037260InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0013160.0004757InformativeInherited
Biological Process (BP)negative regulation of cell communication0.069530.00003577InformativeInherited
Biological Process (BP)negative regulation of signaling0.082840.000008688InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.09670.1596InformativeInherited
Biological Process (BP)regulation of defense response0.0000000000000032610.05865InformativeInherited
Biological Process (BP)regulation of immune response0.0014310.000000007795InformativeInherited
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation0.0000000000022190Highly InformativeDirect
Biological Process (BP)protein phosphorylation0.000040450Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.000068450.000003421Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.01090.05486Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.013670.008985Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.000000030730.3312Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte mediated immunity0.0026480.7056Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.00000093131Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte mediated cytotoxicity0.042670.005017Highly InformativeInherited
Molecular Function (MF)binding0.00000014890Least InformativeDirect
Cellular Component (CC)cell junction0.0000070480InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000001894 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000003065 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.8063 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.004141 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) organ development 0.00003268 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000001563 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00002151 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000007296 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00001886 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000000000001457 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000000009846 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000000005202 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000007202 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000007668 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000299 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00003345 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0005645 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1583 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8581 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002257 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7374 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.7237 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.006241 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.006496 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.006533 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.04937 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2865 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.5049 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.003014 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0003276 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000009783 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) gland development 0.0008837 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0004757 Informative Direct
Biological Process (BP) regulation of immune response 0.000000007795 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0000003913 Informative Direct
Biological Process (BP) regulation of cell activation 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.000006137 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00003577 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000008688 Informative Direct
Biological Process (BP) leukocyte activation 0.000000000000003755 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000000000000003755 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.000000000000007347 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00000000000002119 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000000000002458 Informative Direct
Biological Process (BP) cellular component movement 0.000000000005247 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00000000003539 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.00000000005926 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0.00000000008229 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000000001705 Informative Direct
Biological Process (BP) response to hormone stimulus 0.000000000185 Informative Direct
Biological Process (BP) blood circulation 0.0000000002521 Informative Direct
Biological Process (BP) defense response 0.0000000003825 Informative Direct
Biological Process (BP) response to wounding 0.000000003097 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000000009766 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000001866 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00000006953 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0000001439 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0000005123 Informative Direct
Biological Process (BP) biological adhesion 0.0000006322 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.000001121 Informative Direct
Biological Process (BP) cytoplasmic transport 0.000002205 Informative Direct
Biological Process (BP) generation of neurons 0.00003821 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00004097 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00004147 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.00007894 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00008028 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000852 Informative Direct
Biological Process (BP) response to bacterium 0.000164 Informative Direct
Biological Process (BP) regulation of locomotion 0.000383 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000414 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0004159 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0004764 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0006843 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000875 Informative Direct
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.8753 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7856 Informative Inherited
Biological Process (BP) regulation of secretion 0.2029 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.3661 Informative Inherited
Biological Process (BP) cation homeostasis 0.2386 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.2392 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8946 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.05865 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.6367 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.7759 Informative Inherited
Biological Process (BP) protein localization to organelle 0.006685 Informative Inherited
Biological Process (BP) protein transport 0.04911 Informative Inherited
Biological Process (BP) regulation of ion transport 0.3379 Informative Inherited
Biological Process (BP) actin filament-based process 0.01344 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.00177 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.1581 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6969 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1467 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03321 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.3155 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1596 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.1367 Informative Inherited
Biological Process (BP) immune effector process 0.8615 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001132 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.01495 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.001553 Informative Inherited
Biological Process (BP) regulation of growth 0.001854 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6023 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) dephosphorylation 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.7915 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5471 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.009778 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8522 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.005347 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6878 Informative Inherited
Biological Process (BP) cell projection organization 0.01032 Informative Inherited
Biological Process (BP) lipid localization 0.01588 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9394 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.06891 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3707 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1518 Informative Inherited
Biological Process (BP) sexual reproduction 0.03887 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.008391 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) secretion by cell 0.1092 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.8558 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000003421 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00000001253 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) coagulation 0.0000000000003019 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00000000001224 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.00000000013 Highly Informative Direct
Biological Process (BP) lactation 0.0000000001504 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000000001864 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000002533 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.0000000004713 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.000000004087 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.00000004878 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.00000006002 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0000001582 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0000003273 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0000003346 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.0000004071 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000000499 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0000006744 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0000008547 Highly Informative Direct
Biological Process (BP) monoamine transport 0.000001002 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00000117 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000001943 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000002144 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000002683 Highly Informative Direct
Biological Process (BP) nuclear import 0.000003354 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.000004394 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.000004949 Highly Informative Direct
Biological Process (BP) learning or memory 0.00001855 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00003811 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.00004071 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00004364 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.00004527 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00005803 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.00005967 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.00006081 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0000662 Highly Informative Direct
Biological Process (BP) wound healing 0.0001076 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0001118 Highly Informative Direct
Biological Process (BP) innate immune response 0.0001259 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0001426 Highly Informative Direct
Biological Process (BP) protein import 0.0001441 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.0001532 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0002151 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0003297 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0005499 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0006343 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.2109 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2803 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.1328 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.4766 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2426 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.006019 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.1281 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.01204 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.01704 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.1268 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.001421 Highly Informative Inherited
Biological Process (BP) renal system development 0.3356 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.08004 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.07612 Highly Informative Inherited
Biological Process (BP) placenta development 0.6851 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01397 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.007787 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.08196 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.008374 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.002138 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.02102 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.05486 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.008985 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.3312 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.07238 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1017 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.7056 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated cytotoxicity 0.005017 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.1309 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.41 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.0598 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.2396 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.05161 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.1575 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.9042 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.002426 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.2575 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.005566 Highly Informative Inherited
Biological Process (BP) response to UV 0.08576 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.02872 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.001655 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.06295 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.9502 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01298 Highly Informative Inherited
Biological Process (BP) muscle organ development 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.9198 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.04679 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 1 Highly Informative Inherited
Biological Process (BP) hemostasis 0.1666 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.9613 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.4874 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4705 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.001939 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9999 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.6832 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.09566 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.1159 Highly Informative Inherited
Biological Process (BP) exocytosis 0.4387 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.9088 Highly Informative Inherited
Biological Process (BP) response to fungus 0.2964 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.004977 Highly Informative Inherited
Biological Process (BP) gonad development 0.4125 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000000000001728 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.000002432 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.8347 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.00000000000004974 Informative Direct
Molecular Function (MF) DNA binding 0.00002371 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00003338 Informative Direct
Molecular Function (MF) enzyme binding 0.00006493 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.00006717 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) protein domain specific binding 0.000000000000001562 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000000005215 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.0000002626 Highly Informative Direct
Molecular Function (MF) heme binding 0.000002283 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0000294 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00003617 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0004292 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.000538 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.1661 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3819 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.08628 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.00192 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.3606 Highly Informative Inherited
Cellular Component (CC) membrane 0.0000007937 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0001043 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6624 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000000004761 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0003787 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.003215 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9091 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.03037 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0.00000000000003157 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000000134 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) adherens junction 0.00000000004162 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 0.00001318 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00006671 Highly Informative Direct
Cellular Component (CC) centrosome 0.4217 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0003158Least InformativeDirect
Disease Ontology (DO)immune system disease0.01372Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05628Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8574Moderately InformativeInherited
Disease Ontology (DO)in situ carcinoma0.0002942InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3129InformativeInherited
Disease Ontology (DO)polycythemia0.00000000868Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.0000008275Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.00002877Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of leukocytes0.009221InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000000004219Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.00000000009903Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.09283Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1372Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0000000002597Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.00000509Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.00008951Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0001157Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.0001987Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0003314Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.004604Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.007786Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.1332Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.604Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000001924InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000006234InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.00007362InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.002697InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.007853InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.02575InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.03577InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.06144InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.06528InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.1215InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1394InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.1412InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1719InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.2249InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2333InformativeInherited
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0000001175Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00002762Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.000437Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005318Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0009187Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.02771Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03499Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01539Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.3188InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0003212Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0002348InformativeDirect
Fly Phenotype (FP)size defective0.000584InformativeDirect
Fly Phenotype (FP)planar polarity defective0.000861Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.005584Least InformativeInherited
Fly Anatomy (FA)anatomical group0.01288Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.02728Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.03085Least InformativeInherited
Fly Anatomy (FA)organ system0.1271Least InformativeInherited
Fly Anatomy (FA)cell0.861Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.00005469Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.001515Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.007488Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.03587Moderately InformativeInherited
Fly Anatomy (FA)adult head0.04481Moderately InformativeInherited
Fly Anatomy (FA)appendage0.05285Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05725Moderately InformativeInherited
Fly Anatomy (FA)neuron0.07047Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1079Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1661Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.2239Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.2598Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.2703Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.5538Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.7664Moderately InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.0001027InformativeDirect
Fly Anatomy (FA)optic lobe neuron0.000146InformativeDirect
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.0002326InformativeDirect
Fly Anatomy (FA)ommatidium0.0006333InformativeDirect
Fly Anatomy (FA)ovariole0.00159InformativeInherited
Fly Anatomy (FA)germline stem cell0.01504InformativeInherited
Fly Anatomy (FA)germline cyst0.03595InformativeInherited
Fly Anatomy (FA)male germline cell0.1254InformativeInherited
Fly Anatomy (FA)male reproductive system0.4287InformativeInherited
Fly Anatomy (FA)somatic stem cell0.7826InformativeInherited
Fly Anatomy (FA)male germline stem cell0.0007495Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.5099Least InformativeInherited
Zebrafish Anatomy (ZA)lymphoid progenitor cell0.00001198InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0001511Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000003869Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00008057InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001577InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000009442Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.00000000000002123Moderately InformativeDirect
Biological processApoptosis0.00000000009495Moderately InformativeDirect
Biological processHost-virus interaction0.00008786Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processCell adhesion0.00000000012InformativeDirect
Biological processEndocytosis0.00000001661InformativeDirect
Biological processInflammatory response0.000001102InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0.0000000000003397Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane6.436e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000000000004925Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000002131Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000006015Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene0.00001019Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.000000000000182InformativeDirect
Molecular functionNucleotide-binding0.000007891Least InformativeDirect
Molecular functionATP-binding0.0000000001425Moderately InformativeDirect
Molecular functionCalcium0.00005344Moderately InformativeDirect
Molecular functionLipid-binding0.00000000005104InformativeDirect
Molecular functionActin-binding0.0000001339InformativeDirect
Post-translational modificationTransferase0.000000003553Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator4.449e-16Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000000000005694Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationProtein phosphatase0.00000002265InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000000355Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]