SUPERFAMILY 1.75 HMM library and genome assignments server


SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (398) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 12,665 12,244 94
Proteins 11,389 11,001 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.347e-070Least InformativeDirect
Biological Process (BP)protein metabolic process0.0008140Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0008660Least InformativeDirect
Biological Process (BP)regulation of cellular process0.94377.129e-08Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.57170.6997Least InformativeInherited
Biological Process (BP)developmental process0.05440Least InformativeInherited
Biological Process (BP)multicellular organismal process0.10720Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0042082.289e-12Least InformativeInherited
Biological Process (BP)immune system process3.302e-070Moderately InformativeDirect
Biological Process (BP)cellular protein modification process1.313e-050Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process9.312e-050Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00040350Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0032972.395e-05Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.030951.287e-09Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.069190.4996Moderately InformativeInherited
Biological Process (BP)organ development0.00080290.001719Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.19191.389e-12Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.013170.2536Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.34322.452e-10Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.44587.952e-13Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.066461Moderately InformativeInherited
Biological Process (BP)regulation of immune effector process6.132e-060.0001033InformativeDirect
Biological Process (BP)gland development0.00013120.0008148InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.0002570.0007482InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.00035651.589e-07InformativeDirect
Biological Process (BP)protein phosphorylation0.00049640InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development0.00072910InformativeDirect
Biological Process (BP)regulation of protein phosphorylation4.746e-070.02966InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.0027751.018e-06InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.015150InformativeInherited
Biological Process (BP)negative regulation of signaling0.017772.351e-11InformativeInherited
Biological Process (BP)negative regulation of cell communication0.018465.458e-11InformativeInherited
Biological Process (BP)negative regulation of cellular metabolic process0.080441InformativeInherited
Biological Process (BP)regulation of response to stress0.0025711InformativeInherited
Biological Process (BP)regulation of immune response0.0034932.81e-12InformativeInherited
Biological Process (BP)regulation of cell killing3.89e-136.583e-05Highly InformativeDirect
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation1.203e-101.352e-13Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine phosphorylation2.574e-060Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process4.451e-056.946e-07Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process0.00015111.889e-07Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.0020550.008499Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.0024280.003575Highly InformativeInherited
Biological Process (BP)negative regulation of signal transduction0.096328.952e-05Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte mediated immunity01Highly InformativeInherited
Biological Process (BP)regulation of innate immune response6.187e-061Highly InformativeInherited
Molecular Function (MF)binding3.788e-060Least InformativeDirect
Molecular Function (MF)protein binding3.658e-090Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.289e-12 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 7.835e-15 Least Informative Direct
Biological Process (BP) regulation of cellular process 7.129e-08 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.6997 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2442 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 2.395e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.287e-09 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 2.316e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 2.812e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.389e-12 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 2.452e-10 Moderately Informative Direct
Biological Process (BP) regulation of signaling 7.952e-13 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.6e-10 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 8.551e-10 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 4.445e-06 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 9.576e-06 Moderately Informative Direct
Biological Process (BP) reproduction 3.702e-05 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0001924 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0.0009364 Moderately Informative Direct
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001868 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7816 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8968 Moderately Informative Inherited
Biological Process (BP) organ development 0.001719 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1915 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.1541 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3157 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3301 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.4001 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.6901 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.4996 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2536 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7048 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.8392 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.04779 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1047 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0001033 Informative Direct
Biological Process (BP) gland development 0.0008148 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0007482 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.589e-07 Informative Direct
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 1.018e-06 Informative Direct
Biological Process (BP) regulation of immune response 2.81e-12 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) negative regulation of signaling 2.351e-11 Informative Direct
Biological Process (BP) negative regulation of cell communication 5.458e-11 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0004294 Informative Direct
Biological Process (BP) intracellular signal transduction 3.329e-14 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0 Informative Direct
Biological Process (BP) response to organic nitrogen 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.258e-14 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 8.164e-14 Informative Direct
Biological Process (BP) glycerolipid metabolic process 2.357e-13 Informative Direct
Biological Process (BP) localization of cell 4.549e-13 Informative Direct
Biological Process (BP) defense response 4.917e-13 Informative Direct
Biological Process (BP) apoptotic process 2.61e-12 Informative Direct
Biological Process (BP) cell proliferation 2.471e-10 Informative Direct
Biological Process (BP) blood circulation 8.462e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 7.512e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 8.771e-09 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 2.019e-08 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 4.838e-08 Informative Direct
Biological Process (BP) negative regulation of developmental process 2.228e-07 Informative Direct
Biological Process (BP) regulation of cell proliferation 2.252e-07 Informative Direct
Biological Process (BP) response to wounding 2.448e-07 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 7.529e-07 Informative Direct
Biological Process (BP) cellular component movement 9.682e-07 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 2.461e-06 Informative Direct
Biological Process (BP) secretion 3.526e-06 Informative Direct
Biological Process (BP) cytoplasmic transport 6.518e-06 Informative Direct
Biological Process (BP) transcription, DNA-dependent 1.642e-05 Informative Direct
Biological Process (BP) cellular cation homeostasis 4.825e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 5.85e-05 Informative Direct
Biological Process (BP) generation of neurons 9.012e-05 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001969 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0006959 Informative Direct
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01202 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) chordate embryonic development 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.2381 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.4987 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.6802 Informative Inherited
Biological Process (BP) protein localization to organelle 0.001312 Informative Inherited
Biological Process (BP) protein transport 0.06554 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.004812 Informative Inherited
Biological Process (BP) actin filament-based process 0.08232 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9151 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.0597 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.003753 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.3403 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1485 Informative Inherited
Biological Process (BP) regulation of cell development 0.3758 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8738 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.001862 Informative Inherited
Biological Process (BP) regulation of secretion 0.05787 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.09492 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.02966 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 0.2337 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.2739 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) steroid metabolic process 0.3367 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.1327 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) immune effector process 0.8181 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.01109 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.05282 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.002358 Informative Inherited
Biological Process (BP) regulation of growth 0.002526 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) chromosome organization 0.9271 Informative Inherited
Biological Process (BP) dephosphorylation 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.001855 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8871 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001671 Informative Inherited
Biological Process (BP) cell projection organization 0.04845 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.3838 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.5765 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) response to other organism 0.0341 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.08127 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.154 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4145 Informative Inherited
Biological Process (BP) sexual reproduction 0.01261 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.315 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.01248 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01957 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.9189 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of cell killing 6.583e-05 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 1.352e-13 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 6.946e-07 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 1.889e-07 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 1.326e-08 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 4.008e-15 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 8.952e-05 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 7.835e-15 Highly Informative Direct
Biological Process (BP) phagocytosis 1.417e-13 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 2.044e-11 Highly Informative Direct
Biological Process (BP) lactation 2.679e-10 Highly Informative Direct
Biological Process (BP) coagulation 4.294e-10 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 1.564e-09 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 1.885e-09 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 5.148e-09 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 5.448e-09 Highly Informative Direct
Biological Process (BP) activation of immune response 2.083e-08 Highly Informative Direct
Biological Process (BP) feeding behavior 3.2e-08 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.42e-08 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 1.441e-07 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 2.811e-07 Highly Informative Direct
Biological Process (BP) lymphocyte differentiation 3.842e-07 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 3.85e-07 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 3.904e-07 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 3.969e-07 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 5.831e-07 Highly Informative Direct
Biological Process (BP) monoamine transport 1.034e-06 Highly Informative Direct
Biological Process (BP) eye morphogenesis 1.372e-06 Highly Informative Direct
Biological Process (BP) calcium ion transport 2.483e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 4.415e-06 Highly Informative Direct
Biological Process (BP) nuclear import 4.908e-06 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 5.058e-06 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.432e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 1.347e-05 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 5.427e-05 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 5.488e-05 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 6.72e-05 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 9.87e-05 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0001074 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.000149 Highly Informative Direct
Biological Process (BP) protein import 0.0001752 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0001801 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0002337 Highly Informative Direct
Biological Process (BP) innate immune response 0.0002874 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0004523 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0005736 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0005784 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.0008643 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.02889 Highly Informative Inherited
Biological Process (BP) regulation of blood coagulation 0.02365 Highly Informative Inherited
Biological Process (BP) kidney development 0.0249 Highly Informative Inherited
Biological Process (BP) embryonic placenta development 0.009105 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.8338 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.07135 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) gastrulation 0.06879 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.84 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.003575 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.1852 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.2603 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.04887 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.1027 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.001123 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6132 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.001065 Highly Informative Inherited
Biological Process (BP) T cell activation 0.2577 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.01899 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.01134 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.5014 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.2607 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.01166 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.009669 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.005051 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.09302 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.557 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.414 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.001996 Highly Informative Inherited
Biological Process (BP) learning or memory 0.007584 Highly Informative Inherited
Biological Process (BP) wound healing 0.001224 Highly Informative Inherited
Biological Process (BP) hemostasis 0.4058 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.2921 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.5571 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.002983 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) exocytosis 0.3039 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.897 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.008499 Highly Informative Inherited
Biological Process (BP) signal release 0.03782 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.008451 Highly Informative Inherited
Biological Process (BP) gonad development 0.3343 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.051e-11 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 6.285e-06 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.2741 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 1.459e-13 Informative Direct
Molecular Function (MF) DNA binding 0.0001242 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.0002098 Informative Direct
Molecular Function (MF) enzyme binding 0.01884 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) lipid binding 0.2865 Informative Inherited
Molecular Function (MF) phospholipase activity 1.023e-07 Highly Informative Direct
Molecular Function (MF) protein kinase activity 1.647e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 4.465e-06 Highly Informative Direct
Molecular Function (MF) heme binding 5.378e-06 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1.086e-05 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 4.666e-05 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0003736 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.1935 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.08218 Highly Informative Inherited
Cellular Component (CC) membrane 6.817e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3748 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.002493 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 7.538e-10 Moderately Informative Direct
Cellular Component (CC) vesicle 8.085e-05 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.4565 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.5002 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.2451 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.2162 Moderately Informative Inherited
Cellular Component (CC) cell junction 8.889e-09 Informative Direct
Cellular Component (CC) cell leading edge 9.571e-09 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.003901 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) membrane raft 1.217e-12 Highly Informative Direct
Cellular Component (CC) ruffle 2.663e-11 Highly Informative Direct
Cellular Component (CC) adherens junction 4.8e-11 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 2.649e-08 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 6.191e-06 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 9.433e-06 Highly Informative Direct
Cellular Component (CC) receptor complex 5.426e-05 Highly Informative Direct
Cellular Component (CC) actin filament 0.0009719 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.1368 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds6.817e-06Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases2.804e-06Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases7.356e-05Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C1.01e-14InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001467Least InformativeDirect
Disease Ontology (DO)immune system disease0.008251Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0002138Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.05402Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8891Moderately InformativeInherited
Disease Ontology (DO)in situ carcinoma0.0002323InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3885InformativeInherited
Disease Ontology (DO)polycythemia5.34e-09Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues2.507e-06Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system6.636e-05Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.0003187InformativeDirect
Phenotypic Abnormality (PA)Abnormality of leukocytes0.0129InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype7.267e-11Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype9.303e-05Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.1732Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation1.245e-14Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis1.755e-07Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology1.189e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development1.9e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0004119Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0004981Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.000754Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.007814Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01828Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.387Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.7957Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response7.079e-05InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.0009923InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.00528InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.01215InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.06646InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.071InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.1117InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.1695InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1909InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.3424InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.3518InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation4.285e-07Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity2.316e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0002494Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0005937Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.0009634Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.001481Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03499Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01539Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.3188InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0003212Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible6.688e-05Moderately InformativeDirect
Fly Phenotype (FP)size defective9.648e-05InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0003981InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.0421Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.04441Least InformativeInherited
Fly Anatomy (FA)organ system0.1202Least InformativeInherited
Fly Anatomy (FA)cell0.7635Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)portion of tissue0.006059Moderately InformativeInherited
Fly Anatomy (FA)gonad0.03581Moderately InformativeInherited
Fly Anatomy (FA)neuron0.04675Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.06149Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.07293Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1435Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.2032Moderately InformativeInherited
Fly Anatomy (FA)head0.3633Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.01446InformativeInherited
Fly Anatomy (FA)male germline cell0.1156InformativeInherited
Fly Anatomy (FA)testis0.5978InformativeInherited
Fly Anatomy (FA)somatic stem cell0.7634InformativeInherited
Fly Anatomy (FA)male germline stem cell0.0007763Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal pole2.18e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0005987Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases3.069e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases7.396e-05InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001757InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C1.069e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation4.522e-15Moderately InformativeDirect
Biological processApoptosis5.536e-11Moderately InformativeDirect
Biological processHost-virus interaction6.223e-05Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processCell adhesion3.053e-10InformativeDirect
Biological processEndocytosis1.519e-07InformativeDirect
Biological processInflammatory response1.494e-06InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity1.458e-12Highly InformativeDirect
Biological processPhagocytosis1.89e-12Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1.269e-15Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome3.791e-14Moderately InformativeDirect
Cellular componentCytoplasmic vesicle7.579e-10Moderately InformativeDirect
Cellular componentGolgi apparatus3.867e-09Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene1.94e-05Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding8.745e-10InformativeDirect
Molecular functionNucleotide-binding8.792e-06Least InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionZinc-finger4e-08Moderately InformativeDirect
Molecular functionCalcium6.753e-05Moderately InformativeDirect
Molecular functionLipid-binding1.003e-11InformativeDirect
Molecular functionActin-binding4.945e-08InformativeDirect
Post-translational modificationTransferase1.187e-09Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator2.225e-16Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.068e-15Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationGTPase activation1.321e-15InformativeDirect
Post-translational modificationProtein phosphatase2.138e-08InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation6.155e-07Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]