SUPERFAMILY 1.75 HMM library and genome assignments server


SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (400) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 12,856 12,244 94
Proteins 11,561 11,001 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.375e-070Least InformativeDirect
Biological Process (BP)protein metabolic process0.00010460Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.00078187.625e-12Least InformativeDirect
Biological Process (BP)regulation of cellular process0.90381.268e-08Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.64280.6704Least InformativeInherited
Biological Process (BP)multicellular organismal process0.039380Least InformativeInherited
Biological Process (BP)developmental process0.017550Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0035870Least InformativeInherited
Biological Process (BP)immune system process3.764e-070Moderately InformativeDirect
Biological Process (BP)cellular protein modification process6.912e-070Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process1.997e-050Moderately InformativeDirect
Biological Process (BP)organ development0.00012842.102e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00047270Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00065670Moderately InformativeDirect
Biological Process (BP)signal transduction0.00081380Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.010490.0002595Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0011960Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.079090.2809Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.010781.546e-09Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.086318.278e-14Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.044790.1109Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction17.256e-09Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.080911Moderately InformativeInherited
Biological Process (BP)regulation of immune effector process2.58e-060.0002941InformativeDirect
Biological Process (BP)positive regulation of immune system process6.015e-050InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development0.00011280InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00011460InformativeDirect
Biological Process (BP)phosphorylation0.00012690InformativeDirect
Biological Process (BP)cell activation0.00018680InformativeDirect
Biological Process (BP)gland development0.00025330.000838InformativeDirect
Biological Process (BP)regulation of protein phosphorylation2.603e-080.103InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.015293.068e-06InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.012541InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.036950.002997InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.0043950InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00067910.002634InformativeInherited
Biological Process (BP)negative regulation of cell communication0.067110.0002436InformativeInherited
Biological Process (BP)negative regulation of signaling0.081617.203e-05InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.095930.3172InformativeInherited
Biological Process (BP)regulation of immune response0.0037236.009e-08InformativeInherited
Biological Process (BP)regulation of defense response9.44e-140.02178InformativeInherited
Biological Process (BP)regulation of cell killing9.134e-157.315e-05Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification1.799e-130Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process1.697e-054.868e-06Highly InformativeDirect
Biological Process (BP)protein phosphorylation4.248e-050Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process7.538e-051.302e-06Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00070810Highly InformativeDirect
Biological Process (BP)positive regulation of peptidyl-tyrosine phosphorylation0.00071244.822e-05Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.0095030.0155Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.012330.002257Highly InformativeInherited
Biological Process (BP)positive regulation of defense response2.035e-070.401Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte mediated immunity0.0017321Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte mediated immunity01Highly InformativeInherited
Biological Process (BP)regulation of innate immune response3.524e-061Highly InformativeInherited
Molecular Function (MF)binding9.74e-080Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 7.625e-12 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.268e-08 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6704 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02305 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 2.102e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0002595 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.546e-09 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 8.278e-14 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 2.92e-07 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.032e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 3.361e-11 Moderately Informative Direct
Biological Process (BP) response to organic substance 8.558e-10 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 3.925e-09 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 7.256e-09 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 8.265e-07 Moderately Informative Direct
Biological Process (BP) reproduction 1.555e-06 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 1.097e-05 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.955e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0002049 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0002422 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0002571 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1109 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9488 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.825 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02641 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.6242 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.004296 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2809 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.03778 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.6482 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.01129 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0002941 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) gland development 0.000838 Informative Direct
Biological Process (BP) regulation of cytokine production 8.02e-06 Informative Direct
Biological Process (BP) regulation of immune response 6.009e-08 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 3.068e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002436 Informative Direct
Biological Process (BP) negative regulation of signaling 7.203e-05 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 7.333e-15 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.086e-14 Informative Direct
Biological Process (BP) transcription, DNA-dependent 1.884e-13 Informative Direct
Biological Process (BP) glycerolipid metabolic process 3.561e-13 Informative Direct
Biological Process (BP) response to hormone stimulus 3.444e-12 Informative Direct
Biological Process (BP) defense response 4.289e-11 Informative Direct
Biological Process (BP) cellular component movement 5.213e-11 Informative Direct
Biological Process (BP) blood circulation 9.813e-11 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.555e-10 Informative Direct
Biological Process (BP) response to wounding 4.786e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 6.89e-09 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 9.481e-09 Informative Direct
Biological Process (BP) negative regulation of developmental process 1.979e-08 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 2.216e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.83e-07 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 3.473e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 2.983e-06 Informative Direct
Biological Process (BP) cytoplasmic transport 3.14e-06 Informative Direct
Biological Process (BP) biological adhesion 1.772e-05 Informative Direct
Biological Process (BP) regulation of cellular component movement 3.692e-05 Informative Direct
Biological Process (BP) cell death 6.405e-05 Informative Direct
Biological Process (BP) generation of neurons 0.0001583 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0002331 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0003072 Informative Direct
Biological Process (BP) regulation of locomotion 0.0003235 Informative Direct
Biological Process (BP) response to bacterium 0.0003999 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004881 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0007828 Informative Direct
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01306 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.3078 Informative Inherited
Biological Process (BP) cation homeostasis 0.2261 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.6454 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.009322 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.02178 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.6869 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.6787 Informative Inherited
Biological Process (BP) protein transport 0.04883 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8348 Informative Inherited
Biological Process (BP) regulation of ion transport 0.3551 Informative Inherited
Biological Process (BP) actin filament-based process 0.0641 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.5068 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.00584 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.213 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7976 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.4338 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.103 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03086 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.3243 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.3172 Informative Inherited
Biological Process (BP) steroid metabolic process 0.2784 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.1393 Informative Inherited
Biological Process (BP) immune effector process 0.9594 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.002382 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.01578 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.002997 Informative Inherited
Biological Process (BP) regulation of growth 0.002034 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) chromosome organization 0.9331 Informative Inherited
Biological Process (BP) dephosphorylation 0.956 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.4907 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.003069 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9627 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.001325 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6744 Informative Inherited
Biological Process (BP) cell projection organization 0.06127 Informative Inherited
Biological Process (BP) lipid localization 0.007925 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.9652 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.0922 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3611 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3291 Informative Inherited
Biological Process (BP) sexual reproduction 0.01073 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.02089 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.002634 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01555 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) secretion by cell 0.1017 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.7923 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) regulation of cell killing 7.315e-05 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 4.868e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.302e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 4.822e-05 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 6.945e-09 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 1.086e-14 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) phagocytosis 3.443e-14 Highly Informative Direct
Biological Process (BP) coagulation 2.187e-13 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 3.065e-11 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 7.005e-11 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 1.696e-10 Highly Informative Direct
Biological Process (BP) cell proliferation 1.805e-10 Highly Informative Direct
Biological Process (BP) lactation 2.42e-10 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 1.671e-09 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 1.703e-09 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.033e-08 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 1.646e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 1.761e-08 Highly Informative Direct
Biological Process (BP) activation of immune response 1.738e-07 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 1.898e-07 Highly Informative Direct
Biological Process (BP) female gamete generation 2.467e-07 Highly Informative Direct
Biological Process (BP) leukocyte migration 2.773e-07 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 2.917e-07 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 2.942e-07 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 5.699e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 6.252e-07 Highly Informative Direct
Biological Process (BP) monoamine transport 8.005e-07 Highly Informative Direct
Biological Process (BP) eye morphogenesis 1.165e-06 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.466e-06 Highly Informative Direct
Biological Process (BP) nuclear import 1.656e-06 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 4.532e-06 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 6.925e-06 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 1.222e-05 Highly Informative Direct
Biological Process (BP) myeloid cell development 1.945e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 3.332e-05 Highly Informative Direct
Biological Process (BP) innate immune response 3.456e-05 Highly Informative Direct
Biological Process (BP) protein import 7.075e-05 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 8.503e-05 Highly Informative Direct
Biological Process (BP) wound healing 0.0001116 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0001278 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0.0001494 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0001897 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0002197 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0002893 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0003169 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0003183 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0004685 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.2013 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2663 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.3911 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.02038 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.02824 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.1145 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.001001 Highly Informative Inherited
Biological Process (BP) renal system development 0.2856 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.04741 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.4105 Highly Informative Inherited
Biological Process (BP) placenta development 0.6821 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.866 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.0398 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.003528 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1089 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.0155 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.002257 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.401 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.238 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.9494 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.03862 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.4891 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6184 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1062 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.07315 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.07299 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.3636 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.5163 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.123 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.01231 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.1695 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.7798 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.8972 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0495 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.2998 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.004499 Highly Informative Inherited
Biological Process (BP) response to UV 0.08491 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.001804 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.008011 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.8433 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.714 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.00716 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01269 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01051 Highly Informative Inherited
Biological Process (BP) muscle organ development 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.02216 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.423 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 1 Highly Informative Inherited
Biological Process (BP) hemostasis 0.1747 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.9895 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.5443 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4017 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.002609 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9017 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.6455 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) exocytosis 0.2806 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.9112 Highly Informative Inherited
Biological Process (BP) response to fungus 0.2766 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.006582 Highly Informative Inherited
Biological Process (BP) gonad development 0.3682 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 2.27e-11 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1.098e-06 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.834 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) DNA binding 5.087e-06 Informative Direct
Molecular Function (MF) tetrapyrrole binding 3.398e-05 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 5.597e-05 Informative Direct
Molecular Function (MF) enzyme binding 0.003117 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) protein kinase activity 1.824e-10 Highly Informative Direct
Molecular Function (MF) phospholipase activity 3.065e-08 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 2.491e-07 Highly Informative Direct
Molecular Function (MF) heme binding 1.382e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.378e-05 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 4.888e-05 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.000451 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0007473 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.2011 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.2585 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.08383 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.1465 Highly Informative Inherited
Cellular Component (CC) membrane 1.456e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.2373 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.07554 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 9.028e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.05857 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.4217 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9892 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.2362 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 7.259e-09 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.001115 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) membrane raft 0 Highly Informative Direct
Cellular Component (CC) ruffle 2.069e-11 Highly Informative Direct
Cellular Component (CC) adherens junction 2.343e-10 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.996e-06 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 1.005e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 5.188e-05 Highly Informative Direct
Cellular Component (CC) microtubule organizing center part 0.0001448 Highly Informative Direct
Cellular Component (CC) actin filament 0.0008962 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.03745 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1163 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds6.817e-06Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases2.804e-06Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases7.356e-05Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C1.01e-14InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer3.852e-05Least InformativeDirect
Disease Ontology (DO)immune system disease0.01003Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05745Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8582Moderately InformativeInherited
Disease Ontology (DO)in situ carcinoma0.0002306InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3221InformativeInherited
Disease Ontology (DO)polycythemia1.579e-08Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues9.112e-07Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system2.738e-05Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of humoral immunity9.925e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of leukocytes0.009603InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype3.705e-11Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype9.637e-11Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.08459Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1017Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis3.04e-10Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology3.212e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0001052Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0001373Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.0002255Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.001415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.005052Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.006619Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.154Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2222Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2285Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response1.743e-06InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation3.021e-05InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.0003117InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.002537InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.008393InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.01972InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.02797InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05541InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.06635InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.1177InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.125InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1791InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1974InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.2034InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2497InformativeInherited
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity1.367e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number3.13e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number3.288e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0004663Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0009841Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.002358Highly InformativeInherited
Mammalian Phenotype (MP)abnormal splenocyte number0.004941Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.02548Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03499Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01539Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.3188InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0003212Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible1.609e-05Moderately InformativeDirect
Fly Phenotype (FP)size defective8.591e-05InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0003052InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.02061Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.02168Least InformativeInherited
Fly Anatomy (FA)anatomical group0.03122Least InformativeInherited
Fly Anatomy (FA)organ system0.04852Least InformativeInherited
Fly Anatomy (FA)cell0.6893Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0007828Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.002523Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.002728Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.0031Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.01087Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.03031Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.03118Moderately InformativeInherited
Fly Anatomy (FA)neuron0.03582Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08036Moderately InformativeInherited
Fly Anatomy (FA)appendage0.08431Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.08481Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1253Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1565Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.2333Moderately InformativeInherited
Fly Anatomy (FA)head0.3372Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.6042Moderately InformativeInherited
Fly Anatomy (FA)egg chamber0.0001666InformativeDirect
Fly Anatomy (FA)germline stem cell0.01276InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.02634InformativeInherited
Fly Anatomy (FA)male germline cell0.1116InformativeInherited
Fly Anatomy (FA)testis0.6882InformativeInherited
Fly Anatomy (FA)somatic stem cell0.713InformativeInherited
Fly Anatomy (FA)male germline stem cell0.0005756Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0009114Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.3764Least InformativeInherited
Zebrafish Anatomy (ZA)lymphoid progenitor cell1.072e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases3.638e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases7.778e-05InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001628InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C1.079e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation6.64e-15Moderately InformativeDirect
Biological processApoptosis8.986e-11Moderately InformativeDirect
Biological processHost-virus interaction8.665e-05Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processCell adhesion1.074e-10InformativeDirect
Biological processEndocytosis1.906e-07InformativeDirect
Biological processInflammatory response8.673e-07InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity2.557e-13Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane6.373e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome4.041e-13Moderately InformativeDirect
Cellular componentCytoplasmic vesicle1.205e-09Moderately InformativeDirect
Cellular componentGolgi apparatus5.329e-09Moderately InformativeDirect
Cellular componentCell membrane0.0008538Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene1.295e-05Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding2.043e-13InformativeDirect
Molecular functionNucleotide-binding1.244e-05Least InformativeDirect
Molecular functionCalcium3.759e-05Moderately InformativeDirect
Molecular functionLipid-binding2.168e-11InformativeDirect
Molecular functionActin-binding1.193e-07InformativeDirect
Post-translational modificationTransferase3.401e-09Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator4.438e-16Moderately InformativeDirect
Post-translational modificationDevelopmental protein5.678e-15Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationGTPase activation2.197e-15InformativeDirect
Post-translational modificationProtein phosphatase2.37e-08InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation1.765e-11Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]