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Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)


Superfamily statistics
Genomes (3,216) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 41,169 130,592 143
Proteins 40,258 129,516 141


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.8811Least InformativeInherited
Biological Process (BP)single-organism cellular process10.8756Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)protein metabolic process0.0058970Least InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.25540.821Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.8021Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.15691Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.17641Moderately InformativeInherited
Biological Process (BP)reproduction0.20660.0000002505Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.47821Moderately InformativeInherited
Biological Process (BP)proteolysis0.000000000035210InformativeDirect
Biological Process (BP)cellular process involved in reproduction0.058310.004498InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.063531InformativeInherited
Biological Process (BP)single organism reproductive process0.10140.00000000000119InformativeInherited
Biological Process (BP)sexual reproduction0.13320.00005573InformativeInherited
Biological Process (BP)biological adhesion0.0013780.000001176InformativeInherited
Biological Process (BP)regulation of protein processing0.0000011960.000006696Highly InformativeDirect
Biological Process (BP)fertilization0.00027620.00002046Highly InformativeDirect
Biological Process (BP)cell adhesion0.00085090.000001442Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.001560.2241Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.000020520Least InformativeDirect
Molecular Function (MF)binding10.5054Least InformativeInherited
Molecular Function (MF)cation binding0.000088080Moderately InformativeDirect
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)metallopeptidase activity0.000000000000011360Highly InformativeDirect
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)vesicle0.50310.000000000000001589Moderately InformativeInherited
Cellular Component (CC)secretory granule0.0057480.5305InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0.0000004208 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8756 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0000002505 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000087 Moderately Informative Direct
Biological Process (BP) organ development 0.0002863 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.821 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2411 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9915 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6843 Moderately Informative Inherited
Biological Process (BP) system process 0.06386 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6117 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7262 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002501 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.9556 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.9415 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.771 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01991 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4734 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) biological adhesion 0.000001176 Informative Direct
Biological Process (BP) single organism reproductive process 0.00000000000119 Informative Direct
Biological Process (BP) sexual reproduction 0.00005573 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) blood circulation 0.000000000000001938 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0000000006354 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000000256 Informative Direct
Biological Process (BP) localization of cell 0.000000003883 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.0000002921 Informative Direct
Biological Process (BP) locomotion 0.0000004174 Informative Direct
Biological Process (BP) cellular component movement 0.000001512 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00009525 Informative Direct
Biological Process (BP) organ morphogenesis 0.0008324 Informative Direct
Biological Process (BP) regulation of locomotion 0.0009482 Informative Direct
Biological Process (BP) response to light stimulus 0.02511 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.004498 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6165 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) gland development 0.5889 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6965 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6664 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.8482 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.2365 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.004653 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.1982 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.4161 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001798 Informative Inherited
Biological Process (BP) immune effector process 0.8611 Informative Inherited
Biological Process (BP) reproductive system development 0.8429 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of protein processing 0.000006696 Highly Informative Direct
Biological Process (BP) fertilization 0.00002046 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000001442 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) renal system development 0.000000000001563 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.0000000006853 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000000001985 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.0000002653 Highly Informative Direct
Biological Process (BP) response to UV 0.0000006722 Highly Informative Direct
Biological Process (BP) ossification 0.000002066 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000002416 Highly Informative Direct
Biological Process (BP) gonad development 0.000005024 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.00006438 Highly Informative Direct
Biological Process (BP) skeletal system development 0.00009276 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.00009595 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0001148 Highly Informative Direct
Biological Process (BP) aging 0.0001395 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0001676 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0006374 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.0008034 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0008633 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.2241 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2133 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.4519 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.2349 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001723 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.1303 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.07829 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1702 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.6455 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4399 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.1135 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.03115 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5485 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.006442 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.5054 Least Informative Inherited
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.0007213 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.000000611 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.000000002281 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.000005125 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000000000001589 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0001308 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1117 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.01883 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) lytic vacuole 0.00000001755 Informative Direct
Cellular Component (CC) vacuolar part 0.00000008365 Informative Direct
Cellular Component (CC) synapse part 0.000008286 Informative Direct
Cellular Component (CC) secretory granule 0.5305 Informative Inherited
Cellular Component (CC) neuron projection 0.01383 Informative Inherited
Cellular Component (CC) coated vesicle 0.4945 Informative Inherited
Cellular Component (CC) brush border 0 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.00000002819 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.00000002888 Highly Informative Direct
Cellular Component (CC) dendrite 0.00000009014 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0009464 Highly Informative Direct
Cellular Component (CC) lysosome 0.02067 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01456Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5634Least InformativeInherited
Disease Ontology (DO)immune system disease0.5893Least InformativeInherited
Disease Ontology (DO)artery disease0.0000007765Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.0005915Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.001538Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.06373Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.3951Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.00000006607InformativeDirect
Disease Ontology (DO)Kawasaki disease0.00001427InformativeDirect
Disease Ontology (DO)endometrial cancer0.00005561InformativeDirect
Disease Ontology (DO)integumentary system cancer0.000266InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0004138InformativeDirect
Disease Ontology (DO)eye disease0.01777InformativeInherited
Disease Ontology (DO)connective tissue cancer0.09222InformativeInherited
Disease Ontology (DO)auditory system disease0.2911InformativeInherited
Disease Ontology (DO)heart disease0.2978InformativeInherited
Disease Ontology (DO)malignant glioma0.42InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.0000002093Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.00006557Highly InformativeDirect
Disease Ontology (DO)otitis media0.0005256Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03091Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4014Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.4088Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.5887Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6569Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7324Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.8911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01414InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.02719InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1161InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1397InformativeInherited
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.0000006265Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0002259Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0003485Highly InformativeDirect
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2461Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000004937InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.00003141Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00007748Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.01021Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.00003234Moderately InformativeDirect
Biological processApoptosis0.000224Moderately InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processAngiogenesis0.0000000000004568InformativeDirect
Biological processCell adhesion0.00000003099InformativeDirect
Biological processNotch signaling pathway0.000000001196Highly InformativeDirect
Biological processAdaptive immunity0.0007653Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.0000003139InformativeDirect
Coding sequence diversityPolymorphism0.0002109Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainSH3-binding0.0000000006225InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.000000000003523InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]