SUPERFAMILY 1.75 HMM library and genome assignments server


Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)


Superfamily statistics
Genomes (3,216) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 41,169 130,592 143
Proteins 40,258 129,516 141


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.87651Least InformativeInherited
Biological Process (BP)single-organism cellular process10.8832Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)protein metabolic process0.012450Least InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.24260.8477Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.79011Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.15031Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.17031Moderately InformativeInherited
Biological Process (BP)reproduction0.20582.24e-07Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.46261Moderately InformativeInherited
Biological Process (BP)proteolysis3.187e-100InformativeDirect
Biological Process (BP)cellular process involved in reproduction0.058040.004297InformativeInherited
Biological Process (BP)single organism reproductive process0.1018.683e-13InformativeInherited
Biological Process (BP)sexual reproduction0.1314.653e-05InformativeInherited
Biological Process (BP)biological adhesion0.0012771.146e-06InformativeInherited
Biological Process (BP)regulation of protein processing1.2e-066.718e-06Highly InformativeDirect
Biological Process (BP)fertilization0.00024081.722e-05Highly InformativeDirect
Biological Process (BP)cell adhesion0.00081741.488e-06Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.0015630.2221Highly InformativeInherited
Molecular Function (MF)hydrolase activity5.855e-050Least InformativeDirect
Molecular Function (MF)binding10.4325Least InformativeInherited
Molecular Function (MF)cation binding8.699e-050Moderately InformativeDirect
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)metallopeptidase activity1.386e-140Highly InformativeDirect
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)vesicle0.50211.594e-15Moderately InformativeInherited
Cellular Component (CC)secretory granule0.0057530.5224InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 5.795e-07 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8832 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 2.24e-07 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 1.016e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 5.457e-07 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 5.817e-10 Moderately Informative Direct
Biological Process (BP) organ development 0.0003492 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.8477 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2317 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9766 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7412 Moderately Informative Inherited
Biological Process (BP) system process 0.07453 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.768 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002355 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.9656 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.889 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8128 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02333 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4693 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) biological adhesion 1.146e-06 Informative Direct
Biological Process (BP) single organism reproductive process 8.683e-13 Informative Direct
Biological Process (BP) sexual reproduction 4.653e-05 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) blood circulation 1.931e-15 Informative Direct
Biological Process (BP) regulation of hormone levels 2.271e-09 Informative Direct
Biological Process (BP) localization of cell 3.636e-09 Informative Direct
Biological Process (BP) response to cytokine stimulus 2.498e-07 Informative Direct
Biological Process (BP) locomotion 4.205e-07 Informative Direct
Biological Process (BP) cellular component movement 1.53e-06 Informative Direct
Biological Process (BP) regulation of cellular component movement 9.454e-05 Informative Direct
Biological Process (BP) regulation of locomotion 0.0009125 Informative Direct
Biological Process (BP) response to light stimulus 0.02567 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.004297 Informative Inherited
Biological Process (BP) organ morphogenesis 0.003492 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6225 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) gland development 0.5687 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6961 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6349 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.8068 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.2363 Informative Inherited
Biological Process (BP) cardiovascular system development 0.004295 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.1918 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.4131 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001677 Informative Inherited
Biological Process (BP) immune effector process 0.8608 Informative Inherited
Biological Process (BP) reproductive system development 0.8312 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of protein processing 6.718e-06 Highly Informative Direct
Biological Process (BP) fertilization 1.722e-05 Highly Informative Direct
Biological Process (BP) cell adhesion 1.488e-06 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) renal system development 1.357e-12 Highly Informative Direct
Biological Process (BP) cellular response to radiation 5.364e-10 Highly Informative Direct
Biological Process (BP) ovulation cycle process 3.571e-09 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 2.675e-07 Highly Informative Direct
Biological Process (BP) response to UV 7.058e-07 Highly Informative Direct
Biological Process (BP) ossification 2.006e-06 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 2.425e-06 Highly Informative Direct
Biological Process (BP) gonad development 4.693e-06 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 6.461e-05 Highly Informative Direct
Biological Process (BP) skeletal system development 8.216e-05 Highly Informative Direct
Biological Process (BP) aging 8.899e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 9.626e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0001025 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0001682 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0006388 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.0008058 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0008336 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.2221 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1656 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.4601 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1724 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001123 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.1265 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.0799 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1705 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.6406 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4417 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.1064 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.0304 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5387 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.006512 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.4325 Least Informative Inherited
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.0006834 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 9.537e-07 Highly Informative Direct
Molecular Function (MF) protein complex binding 2.04e-09 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1.213e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) vesicle 1.594e-15 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0001504 Moderately Informative Direct
Cellular Component (CC) cell projection 0.09754 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.0265 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) lytic vacuole 1.399e-08 Informative Direct
Cellular Component (CC) vacuolar part 8.29e-08 Informative Direct
Cellular Component (CC) synapse part 4.777e-06 Informative Direct
Cellular Component (CC) secretory granule 0.5224 Informative Inherited
Cellular Component (CC) neuron projection 0.01248 Informative Inherited
Cellular Component (CC) coated vesicle 0.4813 Informative Inherited
Cellular Component (CC) brush border 0 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 2.59e-08 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 2.615e-08 Highly Informative Direct
Cellular Component (CC) dendrite 7.015e-08 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0008046 Highly Informative Direct
Cellular Component (CC) lysosome 0.01998 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01373Least InformativeInherited
Disease Ontology (DO)immune system disease0.5781Least InformativeInherited
Disease Ontology (DO)nervous system disease0.6295Least InformativeInherited
Disease Ontology (DO)artery disease7.622e-07Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.0006021Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0008319Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.001929Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1201Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.3971Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system cancer0.5065Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis6.507e-08InformativeDirect
Disease Ontology (DO)myopia1.363e-06InformativeDirect
Disease Ontology (DO)Kawasaki disease1.424e-05InformativeDirect
Disease Ontology (DO)chondrosarcoma2.304e-05InformativeDirect
Disease Ontology (DO)endometrial cancer5.551e-05InformativeDirect
Disease Ontology (DO)integumentary system cancer0.0002688InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0004138InformativeDirect
Disease Ontology (DO)auditory system disease0.214InformativeInherited
Disease Ontology (DO)heart disease0.298InformativeInherited
Disease Ontology (DO)malignant glioma0.4051InformativeInherited
Disease Ontology (DO)adult astrocytic tumour2.109e-07Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm6.571e-05Highly InformativeDirect
Disease Ontology (DO)otitis media0.000439Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02857Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3975Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.4123Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.5774Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6427Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.8856Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01236InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.02493InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1111InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1286InformativeInherited
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology4.918e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.000224Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0003488Highly InformativeDirect
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2523Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant4.937e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage3.175e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage7.827e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.00926Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation2.882e-05Moderately InformativeDirect
Biological processApoptosis0.000224Moderately InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processAngiogenesis4.648e-13InformativeDirect
Biological processCell adhesion1.354e-06InformativeDirect
Biological processNotch signaling pathway1.208e-09Highly InformativeDirect
Biological processAdaptive immunity0.0007699Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor3.115e-07InformativeDirect
Coding sequence diversityPolymorphism0.0001581Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainSH3-binding6.397e-10InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid3.697e-12InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]