SUPERFAMILY 1.75 HMM library and genome assignments server

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SRF-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SRF-like [ 55454]
Superfamily:   SRF-like [ 55455]
Families:   SRF-like [ 55456] (4)


Superfamily statistics
Genomes (457) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,098 9,626 7
Proteins 7,071 9,620 7


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.00000000000007996 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000001694 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.00002167 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.3425 Least Informative Inherited
Biological Process (BP) localization 0.9434 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.5898 Least Informative Inherited
Biological Process (BP) response to stimulus 0.03146 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.833 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1975 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1716 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.05007 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.429 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1242 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000000002458 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0000000000001736 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0000000005728 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.00000001306 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000002514 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0000001057 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000002621 Moderately Informative Direct
Biological Process (BP) organ development 0.0000003982 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0000004465 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000004684 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000004716 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0000005682 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000006404 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.00001437 Moderately Informative Direct
Biological Process (BP) tissue development 0.00004199 Moderately Informative Direct
Biological Process (BP) gene expression 0.00007538 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0001104 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001863 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.9805 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9259 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1403 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.001571 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3566 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6135 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9466 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2015 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1212 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1142 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2396 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06781 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.4971 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.009923 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.09314 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.000000000000003755 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.000000000000007347 Informative Direct
Biological Process (BP) reproductive system development 0.00000000000006071 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000000000007678 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0000000000003122 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0.000000000000339 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.000000000001033 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000005459 Informative Direct
Biological Process (BP) muscle structure development 0.0000000003549 Informative Direct
Biological Process (BP) response to light stimulus 0.000000009371 Informative Direct
Biological Process (BP) muscle tissue development 0.0000001807 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000004146 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.00002301 Informative Direct
Biological Process (BP) organelle assembly 0.00005456 Informative Direct
Biological Process (BP) response to inorganic substance 0.00008924 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0001688 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001825 Informative Direct
Biological Process (BP) actin filament-based process 0.0002373 Informative Direct
Biological Process (BP) response to lipid 0.0004342 Informative Direct
Biological Process (BP) organ morphogenesis 0.0004477 Informative Direct
Biological Process (BP) tube development 0.1092 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.09867 Informative Inherited
Biological Process (BP) regulation of defense response 0.1274 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.02476 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.001098 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1494 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1522 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.008852 Informative Inherited
Biological Process (BP) response to bacterium 0.04728 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.5552 Informative Inherited
Biological Process (BP) regulation of system process 0.04019 Informative Inherited
Biological Process (BP) regulation of growth 0.1476 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.07432 Informative Inherited
Biological Process (BP) organelle localization 0.08258 Informative Inherited
Biological Process (BP) regulation of cell activation 0.07264 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6281 Informative Inherited
Biological Process (BP) synaptic transmission 0.115 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.005753 Informative Inherited
Biological Process (BP) cell projection organization 0.4783 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1882 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.008344 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01455 Informative Inherited
Biological Process (BP) leukocyte activation 0.007185 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.001624 Informative Inherited
Biological Process (BP) generation of neurons 0.04442 Informative Inherited
Biological Process (BP) regulation of cell development 0.8606 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.1523 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.5265 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1411 Informative Inherited
Biological Process (BP) embryonic organ development 0.0186 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01361 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.3927 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.0319 Informative Inherited
Biological Process (BP) growth 0.002434 Informative Inherited
Biological Process (BP) single-organism behavior 0.002635 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01981 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001073 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.2639 Informative Inherited
Biological Process (BP) regulation of immune response 0.01699 Informative Inherited
Biological Process (BP) immune response 0.1197 Informative Inherited
Biological Process (BP) post-embryonic organ development 0 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) response to cold 0.000000000000001938 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000000000000161 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.00000000000004119 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.00000000000004447 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.000000000005204 Highly Informative Direct
Biological Process (BP) MAPK cascade 0.000000001991 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000004338 Highly Informative Direct
Biological Process (BP) response to UV 0.0000000827 Highly Informative Direct
Biological Process (BP) ossification 0.0000001341 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.0000005718 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.000002168 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.000003618 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.00000454 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000006168 Highly Informative Direct
Biological Process (BP) membrane fusion 0.000007448 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.0000123 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00002955 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00003085 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.00003226 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.00003258 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00003287 Highly Informative Direct
Biological Process (BP) connective tissue development 0.00003883 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00006887 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00007971 Highly Informative Direct
Biological Process (BP) humoral immune response 0.00014 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00017 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.000178 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0002527 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0002717 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0002789 Highly Informative Direct
Biological Process (BP) cell growth 0.0003249 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0003558 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0003857 Highly Informative Direct
Biological Process (BP) learning or memory 0.0004891 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0006517 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0006647 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.0008057 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0009561 Highly Informative Direct
Biological Process (BP) renal system development 0.3777 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.6793 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.001994 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.004112 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1545 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.1005 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.9731 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.01944 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.03401 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.05612 Highly Informative Inherited
Biological Process (BP) B cell activation 0.003955 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.006793 Highly Informative Inherited
Biological Process (BP) response to drug 0.003379 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.04334 Highly Informative Inherited
Biological Process (BP) stem cell development 0.1459 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2154 Highly Informative Inherited
Biological Process (BP) developmental growth 0.02212 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.003465 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.005026 Highly Informative Inherited
Molecular Function (MF) binding 0.000001297 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0.000000006149 Informative Direct
Molecular Function (MF) chromatin binding 0.0001437 Informative Direct
Molecular Function (MF) enzyme binding 0.02821 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000001734 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.03505 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1963 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1598 Informative Inherited
Cellular Component (CC) chromosome 0.1416 Informative Inherited
Cellular Component (CC) nuclear body 0.001461 Highly Informative Inherited
Cellular Component (CC) chromatin 0.00564 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.005745 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.0851Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.008495Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.01447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.01867Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)premature death0InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.00007822InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.0002229InformativeDirect
Mammalian Phenotype (MP)abnormal neuron physiology0.0008495InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.00991InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.08584InformativeInherited
Mammalian Phenotype (MP)abnormal long term potentiation0.00002609Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac muscle tissue morphology0.0000974Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myocardium layer morphology0.0002659Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0InformativeDirect
Xenopus ANatomical entity (XAN)trunk somite0Highly InformativeDirect
Xenopus ANatomical entity (XAN)myotome0Highly InformativeDirect
Xenopus ANatomical entity (XAN)trunk musculature0Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.05061Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.01658InformativeInherited
Plant ANatomical entity (PAN)root tip0.02058InformativeInherited
Plant ANatomical entity (PAN)embryo sac cell0Highly InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0001307Highly InformativeDirect
Plant ANatomical entity (PAN)plant ovule0.000548Highly InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis0.0000000001205Moderately InformativeDirect
Biological processNeurogenesis0.00000000000002611InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.0002619Least InformativeDirect
Post-translational modificationAcetylation0.0002916Least InformativeDirect
Post-translational modificationIsopeptide bond0.000000000004941Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000003771Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002100 SSF55455 Protein matches
Abstract Human serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [PubMed7637780], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins.

Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic alpha-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel beta-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SRF-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the SRF-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]