SUPERFAMILY 1.75 HMM library and genome assignments server


SRF-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SRF-like [ 55454]
Superfamily:   SRF-like [ 55455]
Families:   SRF-like [ 55456] (4)


Superfamily statistics
Genomes (404) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,591 7,436 7
Proteins 5,586 7,434 7


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 1.086e-14 Least Informative Direct
Biological Process (BP) multicellular organismal process 2.752e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 6.96e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.2307 Least Informative Inherited
Biological Process (BP) localization 0.9607 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.9778 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02504 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8794 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6118 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5685 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2545 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.07853 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) reproduction 9.142e-15 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 7.325e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 7.484e-12 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 2.656e-09 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 6.916e-08 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.794e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 2.261e-07 Moderately Informative Direct
Biological Process (BP) organ development 2.28e-07 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 3.271e-07 Moderately Informative Direct
Biological Process (BP) tissue development 3.287e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 5.914e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 8.679e-05 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 9.326e-05 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 9.672e-05 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0001006 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0002158 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0006904 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.277 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.8584 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9158 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1103 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.001 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3382 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6108 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9439 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1738 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.09524 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.06039 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.184 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9802 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04368 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.4568 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.009807 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.08678 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.001608 Moderately Informative Inherited
Biological Process (BP) gene expression 0.004276 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.02567 Moderately Informative Inherited
Biological Process (BP) reproductive structure development 1.431e-14 Informative Direct
Biological Process (BP) positive regulation of gene expression 2.337e-13 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 2.933e-13 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 3.447e-12 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.756e-10 Informative Direct
Biological Process (BP) muscle structure development 2.205e-10 Informative Direct
Biological Process (BP) transcription, DNA-dependent 6.16e-10 Informative Direct
Biological Process (BP) response to light stimulus 3.998e-08 Informative Direct
Biological Process (BP) muscle tissue development 1.504e-07 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 3.576e-06 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.764e-05 Informative Direct
Biological Process (BP) organelle assembly 2.735e-05 Informative Direct
Biological Process (BP) response to inorganic substance 8.786e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001804 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0001822 Informative Direct
Biological Process (BP) actin filament-based process 0.000226 Informative Direct
Biological Process (BP) organ morphogenesis 0.0003564 Informative Direct
Biological Process (BP) response to lipid 0.0004145 Informative Direct
Biological Process (BP) growth 0.0005023 Informative Direct
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.09091 Informative Inherited
Biological Process (BP) regulation of defense response 0.1415 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.0247 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.001047 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1601 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.171 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.00844 Informative Inherited
Biological Process (BP) response to bacterium 0.03914 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.5599 Informative Inherited
Biological Process (BP) regulation of system process 0.03721 Informative Inherited
Biological Process (BP) regulation of growth 0.2207 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.05868 Informative Inherited
Biological Process (BP) cell-cell signaling 0.3277 Informative Inherited
Biological Process (BP) organelle localization 0.08322 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.578 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.1664 Informative Inherited
Biological Process (BP) cell projection organization 0.4631 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2367 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.007842 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01283 Informative Inherited
Biological Process (BP) cell activation 0.02739 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00239 Informative Inherited
Biological Process (BP) generation of neurons 0.03357 Informative Inherited
Biological Process (BP) regulation of cell development 0.9238 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.1488 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.5291 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1365 Informative Inherited
Biological Process (BP) embryonic organ development 0.01784 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01043 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.302 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.008171 Informative Inherited
Biological Process (BP) single-organism behavior 0.001582 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01408 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001387 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.2671 Informative Inherited
Biological Process (BP) regulation of immune response 0.01442 Informative Inherited
Biological Process (BP) immune response 0.1084 Informative Inherited
Biological Process (BP) post-embryonic organ development 0 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) response to cold 3.746e-15 Highly Informative Direct
Biological Process (BP) response to UV 7.333e-15 Highly Informative Direct
Biological Process (BP) post-embryonic development 7.333e-15 Highly Informative Direct
Biological Process (BP) response to calcium ion 2.78e-14 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 8.915e-14 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 1.219e-12 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 1.444e-10 Highly Informative Direct
Biological Process (BP) MAPK cascade 2.148e-09 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 5.117e-08 Highly Informative Direct
Biological Process (BP) ossification 9.6e-08 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 8.518e-07 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 2.057e-06 Highly Informative Direct
Biological Process (BP) regulation of binding 3.458e-06 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 3.556e-06 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 4.401e-06 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 1.022e-05 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 1.84e-05 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 2.144e-05 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 2.197e-05 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 2.802e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 3.321e-05 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 3.787e-05 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 6.716e-05 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 0.0001208 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.000141 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0001501 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0001596 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0002068 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0002166 Highly Informative Direct
Biological Process (BP) cell growth 0.0002971 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0003268 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0003325 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0005239 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0006311 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0.0006763 Highly Informative Direct
Biological Process (BP) activation of immune response 0.0009307 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0009415 Highly Informative Direct
Biological Process (BP) renal system development 0.3832 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.1738 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.001441 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.00451 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.285 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.08629 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.9777 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.02063 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.06593 Highly Informative Inherited
Biological Process (BP) B cell activation 0.003763 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.008404 Highly Informative Inherited
Biological Process (BP) response to drug 0.003407 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1951 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.04324 Highly Informative Inherited
Biological Process (BP) stem cell development 0.1364 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2232 Highly Informative Inherited
Biological Process (BP) developmental growth 0.02327 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.003266 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.005521 Highly Informative Inherited
Molecular Function (MF) binding 7.618e-07 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 1.125e-08 Informative Direct
Molecular Function (MF) chromatin binding 0.0003142 Informative Direct
Molecular Function (MF) enzyme binding 0.01698 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.83e-06 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.07327 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1554 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.8246 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1842 Informative Inherited
Cellular Component (CC) chromosome 0.1184 Informative Inherited
Cellular Component (CC) nuclear body 0.001378 Highly Informative Inherited
Cellular Component (CC) chromatin 0.004185 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.004304 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.008158Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.0001977InformativeDirect
Mammalian Phenotype (MP)abnormal heart layer morphology0.08179InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle tissue morphology9.852e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myocardium layer morphology0.0002441Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0InformativeDirect
Xenopus ANatomical entity (XAN)trunk somite0Highly InformativeDirect
Xenopus ANatomical entity (XAN)myotome0Highly InformativeDirect
Xenopus ANatomical entity (XAN)trunk musculature0Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.05061Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.01658InformativeInherited
Plant ANatomical entity (PAN)root tip0.02058InformativeInherited
Plant ANatomical entity (PAN)embryo sac cell0Highly InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0001307Highly InformativeDirect
Plant ANatomical entity (PAN)plant ovule0.000548Highly InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis1.191e-10Moderately InformativeDirect
Biological processNeurogenesis2.029e-14InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.0002431Least InformativeDirect
Post-translational modificationAcetylation0.0002728Least InformativeDirect
Post-translational modificationIsopeptide bond3.344e-12Moderately InformativeDirect
Post-translational modificationUbl conjugation2.857e-08Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002100 SSF55455 Protein matches
Abstract Human serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [PubMed7637780], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins.

Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic alpha-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel beta-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SRF-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the SRF-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]