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FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CO dehydrogenase flavoprotein C-domain-like [ 55423] (2)
Superfamily:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55424]
Families:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55425] (11)


Superfamily statistics
Genomes (3,085) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,864 75,370 38
Proteins 13,850 75,361 38


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0000000003245 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.06309 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01653 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0008665 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0008168 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00005304 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.6259 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.003125 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2866 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0304 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000001437 Informative Direct
Biological Process (BP) response to oxidative stress 0.00000000000001604 Informative Direct
Biological Process (BP) response to inorganic substance 0.000000001909 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.6282 Informative Inherited
Biological Process (BP) apoptotic process 0.2708 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.02114 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1543 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.61 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0.00000002239 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.00000000000002112 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0001278 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0.00000000004342 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0002967 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.00000000000009864 Highly Informative Direct
Biological Process (BP) cell redox homeostasis 0.00000000000005413 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0.00000000002289 Highly Informative Direct
Molecular Function (MF) binding 0.4229 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001117 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 0.0000000000002879 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0002898 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000000004826 Least Informative Direct
Cellular Component (CC) protein complex 0.1786 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2163 Least Informative Inherited
Cellular Component (CC) membrane 0.02661 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.00001294 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.0000001251 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.04812 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.004809 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0.0000003411 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000003857InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.0000007596InformativeDirect
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000004479InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase0.000000001104Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000005443Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.00000003343Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00001239Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Cellular componentCytoplasm0.00000000000003514Least InformativeDirect
Cellular componentMitochondrion0.0000000000002587Moderately InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DomainTransit peptide0.000000000008129Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionMercury0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationOxidation0.000008647Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD-linked reductases, dimerisation (C-terminal) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]