|
GO term |
FDR (all) |
IC level |
SDFO level |
Annotation (direct or inherited) |
| Biological Process (BP) |
oxoacid metabolic process |
0 |
0.8297 |
-- |
DIRECT |
| Biological Process (BP) |
cell redox homeostasis |
0 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
sulfur compound metabolic process |
4.382e-14 |
1.252 |
-- |
DIRECT |
| Biological Process (BP) |
acetyl-CoA biosynthetic process |
9.02e-13 |
2.699 |
-- |
DIRECT |
| Biological Process (BP) |
acyl-CoA biosynthetic process |
2.584e-12 |
2.222 |
-- |
DIRECT |
| Biological Process (BP) |
peptide metabolic process |
3.047e-12 |
1.699 |
-- |
DIRECT |
| Biological Process (BP) |
carboxylic acid metabolic process |
3.385e-12 |
0.8416 |
-- |
DIRECT |
| Biological Process (BP) |
response to reactive oxygen species |
6.388e-12 |
1.699 |
-- |
DIRECT |
| Biological Process (BP) |
metabolic process |
8.723e-12 |
0.2411 |
-- |
DIRECT |
| Biological Process (BP) |
activation of cysteine-type endopeptidase activity |
9.381e-12 |
2.222 |
-- |
DIRECT |
| Biological Process (BP) |
apoptotic DNA fragmentation |
1.137e-10 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
acetyl-CoA metabolic process |
1.14e-10 |
2.699 |
-- |
DIRECT |
| Biological Process (BP) |
positive regulation of cysteine-type endopeptidase activity |
1.517e-10 |
2.222 |
-- |
DIRECT |
| Biological Process (BP) |
apoptotic nuclear changes |
2.261e-10 |
2.222 |
-- |
DIRECT |
| Biological Process (BP) |
positive regulation of endopeptidase activity |
3.076e-10 |
2.097 |
-- |
DIRECT |
| Biological Process (BP) |
organic acid metabolic process |
1.665e-09 |
0.8239 |
-- |
DIRECT |
| Biological Process (BP) |
pyruvate metabolic process |
4.941e-09 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
regulation of cysteine-type endopeptidase activity |
5.039e-09 |
1.921 |
-- |
DIRECT |
| Biological Process (BP) |
execution phase of apoptosis |
5.368e-09 |
2.097 |
-- |
DIRECT |
| Biological Process (BP) |
cellular homeostasis |
6.922e-09 |
1.284 |
-- |
DIRECT |
| Biological Process (BP) |
hydrogen peroxide catabolic process |
1.448e-08 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
reactive oxygen species metabolic process |
3.763e-08 |
1.854 |
-- |
DIRECT |
| Biological Process (BP) |
regulation of endopeptidase activity |
6.708e-08 |
1.745 |
-- |
DIRECT |
| Biological Process (BP) |
cellular response to oxidative stress |
6.924e-08 |
1.745 |
-- |
DIRECT |
| Biological Process (BP) |
programmed cell death |
1.273e-07 |
1.553 |
-- |
DIRECT |
| Biological Process (BP) |
regulation of peptidase activity |
1.422e-07 |
1.658 |
-- |
DIRECT |
| Biological Process (BP) |
thioester metabolic process |
1.89e-07 |
2.097 |
-- |
DIRECT |
| Biological Process (BP) |
cell death |
4.067e-07 |
1.553 |
-- |
DIRECT |
| Biological Process (BP) |
death |
4.569e-07 |
1.553 |
-- |
DIRECT |
| Biological Process (BP) |
organonitrogen compound metabolic process |
1.077e-06 |
0.699 |
-- |
DIRECT |
| Biological Process (BP) |
induction of apoptosis |
1.616e-06 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
induction of programmed cell death |
2e-06 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
7.327e-06 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
positive regulation of hydrolase activity |
1.221e-05 |
1.62 |
-- |
DIRECT |
| Biological Process (BP) |
regulation of mitochondrial membrane potential |
2.108e-05 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
cellular metabolic process |
3.026e-05 |
0.2708 |
-- |
DIRECT |
| Biological Process (BP) |
acetyl-CoA biosynthetic process from pyruvate |
4.013e-05 |
2.699 |
-- |
DIRECT |
| Biological Process (BP) |
cofactor biosynthetic process |
4.314e-05 |
1.252 |
-- |
DIRECT |
| Biological Process (BP) |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
9.313e-05 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
DNA catabolic process, endonucleolytic |
9.906e-05 |
2.222 |
-- |
DIRECT |
| Biological Process (BP) |
positive regulation of cell death |
0.0001134 |
1.854 |
-- |
DIRECT |
| Biological Process (BP) |
cellular respiration |
0.0001213 |
1.62 |
-- |
DIRECT |
| Biological Process (BP) |
cellular response to hydrogen peroxide |
0.0001584 |
2.222 |
-- |
DIRECT |
| Biological Process (BP) |
cellular process |
0.0005899 |
0.1415 |
-- |
DIRECT |
| Biological Process (BP) |
alpha-amino acid catabolic process |
0.0006993 |
1.658 |
-- |
DIRECT |
| Biological Process (BP) |
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
0.0007708 |
2.699 |
-- |
DIRECT |
| Biological Process (BP) |
cellular amino acid catabolic process |
0.1311 |
1.62 |
-- |
INHERITED FROM: alpha-amino acid catabolic process |
| Biological Process (BP) |
small molecule catabolic process |
0.2094 |
1.357 |
-- |
INHERITED FROM: alpha-amino acid catabolic process |
| Biological Process (BP) |
single-organism catabolic process |
0.2436 |
1.357 |
-- |
INHERITED FROM: alpha-amino acid catabolic process |
| Biological Process (BP) |
organic acid catabolic process |
0.2792 |
1.523 |
-- |
INHERITED FROM: alpha-amino acid catabolic process |
| Biological Process (BP) |
alpha-amino acid metabolic process |
1 |
1.18 |
-- |
INHERITED FROM: alpha-amino acid catabolic process |
| Biological Process (BP) |
positive regulation of molecular function |
0.007428 |
1.222 |
-- |
INHERITED FROM: activation of cysteine-type endopeptidase activity || positive regulation of endopeptidase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of hydrolase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || positive regulation of peptidase activity || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of cysteine-type endopeptidase activity |
| Biological Process (BP) |
nucleic acid metabolic process |
0.4804 |
0.9066 |
-- |
INHERITED FROM: nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
nucleobase-containing compound metabolic process |
0.9644 |
0.7305 |
-- |
INHERITED FROM: nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
cellular biosynthetic process |
1 |
0.5498 |
-- |
INHERITED FROM: acyl-CoA biosynthetic process || cofactor biosynthetic process || acetyl-CoA biosynthetic process from pyruvate || acetyl-CoA biosynthetic process || thioester biosynthetic process |
| Biological Process (BP) |
organic substance biosynthetic process |
1 |
0.5376 |
-- |
INHERITED FROM: acyl-CoA biosynthetic process || acetyl-CoA biosynthetic process from pyruvate || acetyl-CoA biosynthetic process || thioester biosynthetic process |
| Biological Process (BP) |
phosphorus metabolic process |
1 |
0.8013 |
-- |
INHERITED FROM: acyl-CoA biosynthetic process || acetyl-CoA biosynthetic process || acyl-CoA metabolic process || acetyl-CoA biosynthetic process from pyruvate || acetyl-CoA metabolic process |
| Biological Process (BP) |
coenzyme metabolic process |
0.0682 |
1.222 |
-- |
INHERITED FROM: acyl-CoA biosynthetic process || acetyl-CoA metabolic process || acyl-CoA metabolic process || acetyl-CoA biosynthetic process || acetyl-CoA biosynthetic process from pyruvate |
| Biological Process (BP) |
regulation of catalytic activity |
0.02837 |
1.155 |
-- |
INHERITED FROM: regulation of peptidase activity || activation of cysteine-type endopeptidase activity || regulation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of endopeptidase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || regulation of endopeptidase activity || regulation of cysteine-type endopeptidase activity || positive regulation of hydrolase activity || positive regulation of peptidase activity || regulation of hydrolase activity || positive regulation of cysteine-type endopeptidase activity |
| Biological Process (BP) |
cellular ion homeostasis |
0.001504 |
1.377 |
-- |
INHERITED FROM: mitochondrial depolarization || regulation of mitochondrial membrane potential || regulation of membrane potential |
| Biological Process (BP) |
ion homeostasis |
0.003123 |
1.337 |
-- |
INHERITED FROM: mitochondrial depolarization || regulation of mitochondrial membrane potential || regulation of membrane potential |
| Biological Process (BP) |
chemical homeostasis |
1 |
1.208 |
-- |
INHERITED FROM: mitochondrial depolarization || regulation of mitochondrial membrane potential || regulation of membrane potential |
| Biological Process (BP) |
cellular chemical homeostasis |
1 |
1.357 |
-- |
INHERITED FROM: mitochondrial depolarization || regulation of mitochondrial membrane potential || regulation of membrane potential |
| Biological Process (BP) |
membrane depolarization |
0.004531 |
2.699 |
-- |
INHERITED FROM: mitochondrial depolarization |
| Biological Process (BP) |
regulation of biological quality |
0.008541 |
0.8539 |
-- |
INHERITED FROM: cell redox homeostasis || regulation of mitochondrial membrane potential || cellular homeostasis || regulation of membrane potential || mitochondrial depolarization || homeostatic process |
| Biological Process (BP) |
generation of precursor metabolites and energy |
0.04535 |
1.268 |
-- |
INHERITED FROM: cellular respiration |
| Biological Process (BP) |
biological regulation |
1 |
0.4202 |
-- |
INHERITED FROM: regulation of cysteine-type endopeptidase activity involved in apoptotic process || induction of programmed cell death || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || regulation of cysteine-type endopeptidase activity || activation of cysteine-type endopeptidase activity || cell redox homeostasis || cellular homeostasis || regulation of mitochondrial membrane potential || mitochondrial depolarization || positive regulation of endopeptidase activity || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of cell death || regulation of endopeptidase activity || regulation of peptidase activity || positive regulation of hydrolase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of cysteine-type endopeptidase activity || positive regulation of peptidase activity || induction of apoptosis || homeostatic process || regulation of hydrolase activity || regulation of membrane potential |
| Biological Process (BP) |
regulation of biological process |
1 |
0.4486 |
-- |
INHERITED FROM: regulation of cysteine-type endopeptidase activity involved in apoptotic process || induction of programmed cell death || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || regulation of cysteine-type endopeptidase activity || activation of cysteine-type endopeptidase activity || cell redox homeostasis || positive regulation of endopeptidase activity || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of cell death || regulation of endopeptidase activity || regulation of peptidase activity || positive regulation of hydrolase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of cysteine-type endopeptidase activity || positive regulation of peptidase activity || induction of apoptosis || regulation of hydrolase activity |
| Biological Process (BP) |
single-organism process |
0.2387 |
0.3316 |
-- |
INHERITED FROM: regulation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || execution phase of apoptosis || cell redox homeostasis || cellular homeostasis || apoptotic process || regulation of mitochondrial membrane potential || mitochondrial depolarization || cellular response to reactive oxygen species || cellular component disassembly || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || cell death || mitochondrion organization || death || activation of cysteine-type endopeptidase activity involved in apoptotic process || apoptotic DNA fragmentation || cellular response to oxidative stress || cellular response to stress || cellular response to hydrogen peroxide || cellular component disassembly involved in execution phase of apoptosis || hydrogen peroxide catabolic process || apoptotic nuclear changes || regulation of membrane potential || programmed cell death |
| Biological Process (BP) |
response to chemical stimulus |
0.02878 |
0.8861 |
-- |
INHERITED FROM: cellular response to oxidative stress || response to oxygen-containing compound || hydrogen peroxide catabolic process || response to reactive oxygen species || response to hydrogen peroxide || cellular response to reactive oxygen species || response to inorganic substance || cellular response to hydrogen peroxide |
| Biological Process (BP) |
cellular response to stimulus |
0.3834 |
0.7645 |
-- |
INHERITED FROM: cellular response to oxidative stress || hydrogen peroxide catabolic process || cellular response to stress || cellular response to reactive oxygen species || cellular response to hydrogen peroxide |
| Biological Process (BP) |
organic substance metabolic process |
1 |
0.2676 |
-- |
INHERITED FROM: carboxylic acid metabolic process || cellular amino acid metabolic process || alpha-amino acid catabolic process || thioester biosynthetic process || DNA catabolic process || acyl-CoA biosynthetic process || acetyl-CoA biosynthetic process from pyruvate || apoptotic DNA fragmentation || pyruvate metabolic process || acetyl-CoA biosynthetic process || peptide metabolic process || organonitrogen compound metabolic process || acetyl-CoA metabolic process || DNA catabolic process, endonucleolytic || thioester metabolic process || glutathione metabolic process || nucleic acid phosphodiester bond hydrolysis || acyl-CoA metabolic process || cellular modified amino acid metabolic process |
| Biological Process (BP) |
small molecule metabolic process |
0.8266 |
0.6421 |
-- |
INHERITED FROM: carboxylic acid metabolic process || cellular amino acid metabolic process || alpha-amino acid catabolic process || glutathione metabolic process || acetyl-CoA biosynthetic process from pyruvate || pyruvate metabolic process || cellular modified amino acid metabolic process || oxoacid metabolic process || organic acid metabolic process |
| Biological Process (BP) |
biological_process |
1 |
0 |
-- |
INHERITED FROM: carboxylic acid metabolic process || cellular amino acid metabolic process || induction of programmed cell death || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || alpha-amino acid catabolic process || execution phase of apoptosis || DNA catabolic process || regulation of cysteine-type endopeptidase activity || pyruvate metabolic process || response to hydrogen peroxide || thioester metabolic process || nucleic acid phosphodiester bond hydrolysis || acyl-CoA metabolic process || cellular catabolic process || regulation of peptidase activity || mitochondrion organization || cellular amide metabolic process || thioester biosynthetic process || response to oxidative stress || acyl-CoA biosynthetic process || cellular response to oxidative stress || acetyl-CoA biosynthetic process || induction of apoptosis || organonitrogen compound metabolic process || cellular component disassembly involved in execution phase of apoptosis || apoptotic nuclear changes || metabolic process || cofactor metabolic process || homeostatic process || regulation of hydrolase activity || sulfur compound metabolic process || regulation of membrane potential || response to reactive oxygen species || single-organism metabolic process || cellular modified amino acid metabolic process || regulation of cysteine-type endopeptidase activity involved in apoptotic process || cofactor biosynthetic process || activation of cysteine-type endopeptidase activity || cell redox homeostasis || cellular homeostasis || acetyl-CoA biosynthetic process from pyruvate || response to oxygen-containing compound || apoptotic process || regulation of mitochondrial membrane potential || mitochondrial depolarization || positive regulation of endopeptidase activity || cellular response to reactive oxygen species || cellular component disassembly || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || cellular respiration || positive regulation of cell death || cellular process || regulation of endopeptidase activity || organic acid metabolic process || cell death || death || cellular metabolic process || hydrogen peroxide metabolic process || positive regulation of hydrolase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of cysteine-type endopeptidase activity || reactive oxygen species metabolic process || apoptotic DNA fragmentation || positive regulation of peptidase activity || peptide metabolic process || cellular response to stress || oxoacid metabolic process || cellular response to hydrogen peroxide || acetyl-CoA metabolic process || hydrogen peroxide catabolic process || DNA catabolic process, endonucleolytic || glutathione metabolic process || programmed cell death || response to inorganic substance |
| Biological Process (BP) |
positive regulation of biological process |
1 |
0.8182 |
-- |
INHERITED FROM: induction of programmed cell death || positive regulation of cell death || induction of apoptosis |
| Biological Process (BP) |
positive regulation of programmed cell death |
0.03886 |
1.921 |
-- |
INHERITED FROM: induction of programmed cell death || induction of apoptosis |
| Biological Process (BP) |
cellular component organization |
1 |
0.6819 |
-- |
INHERITED FROM: cellular component disassembly involved in execution phase of apoptosis || mitochondrion organization || apoptotic DNA fragmentation || apoptotic nuclear changes || cellular component disassembly |
| Biological Process (BP) |
regulation of programmed cell death |
0.87 |
1.319 |
-- |
INHERITED FROM: induction of apoptosis || induction of programmed cell death || regulation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| Biological Process (BP) |
regulation of cell death |
0.002421 |
1.301 |
-- |
INHERITED FROM: induction of apoptosis || positive regulation of cell death || induction of programmed cell death || regulation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| Biological Process (BP) |
cellular nitrogen compound metabolic process |
0.02975 |
0.585 |
-- |
INHERITED FROM: glutathione metabolic process || nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation || cellular amide metabolic process || peptide metabolic process || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
primary metabolic process |
1 |
0.2976 |
-- |
INHERITED FROM: cellular amino acid metabolic process || alpha-amino acid catabolic process || DNA catabolic process, endonucleolytic || DNA catabolic process || glutathione metabolic process || nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation || cellular modified amino acid metabolic process |
| Biological Process (BP) |
catabolic process |
0.001051 |
0.7852 |
-- |
INHERITED FROM: apoptotic DNA fragmentation || hydrogen peroxide catabolic process || alpha-amino acid catabolic process || cellular catabolic process || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
macromolecule catabolic process |
0.01133 |
1.252 |
-- |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process || DNA catabolic process, endonucleolytic |
| Biological Process (BP) |
organic cyclic compound catabolic process |
0.005262 |
1.237 |
-- |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
aromatic compound catabolic process |
0.02915 |
1.252 |
-- |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
heterocycle catabolic process |
0.07417 |
1.301 |
-- |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
cellular nitrogen compound catabolic process |
0.3724 |
1.301 |
-- |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
macromolecule metabolic process |
1 |
0.4634 |
-- |
INHERITED FROM: DNA catabolic process, endonucleolytic || DNA catabolic process || nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation |
| Biological Process (BP) |
response to stress |
0.002325 |
0.8125 |
-- |
INHERITED FROM: response to reactive oxygen species || response to hydrogen peroxide || cellular response to oxidative stress || cellular response to stress || cellular response to reactive oxygen species || cellular response to hydrogen peroxide || response to oxidative stress || hydrogen peroxide catabolic process |
| Biological Process (BP) |
single-organism metabolic process |
3.729e-08 |
0.5376 |
Least Informative |
DIRECT |
| Biological Process (BP) |
nitrogen compound metabolic process |
0.0321 |
0.5171 |
Least Informative |
INHERITED FROM: organonitrogen compound metabolic process || cellular amino acid metabolic process || cellular amide metabolic process || alpha-amino acid catabolic process || DNA catabolic process, endonucleolytic || DNA catabolic process || glutathione metabolic process || nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation || peptide metabolic process || cellular modified amino acid metabolic process |
| Biological Process (BP) |
heterocycle metabolic process |
1 |
0.6308 |
Least Informative |
INHERITED FROM: nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
biosynthetic process |
1 |
0.52 |
Least Informative |
INHERITED FROM: acyl-CoA biosynthetic process || cofactor biosynthetic process || acetyl-CoA biosynthetic process from pyruvate || acetyl-CoA biosynthetic process || thioester biosynthetic process |
| Biological Process (BP) |
regulation of metabolic process |
1 |
0.6946 |
Least Informative |
INHERITED FROM: regulation of peptidase activity || regulation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of hydrolase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || positive regulation of endopeptidase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process || regulation of cysteine-type endopeptidase activity || positive regulation of cysteine-type endopeptidase activity || activation of cysteine-type endopeptidase activity || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || regulation of hydrolase activity || positive regulation of peptidase activity || regulation of endopeptidase activity |
| Biological Process (BP) |
regulation of cellular process |
1 |
0.5317 |
Least Informative |
INHERITED FROM: regulation of cysteine-type endopeptidase activity involved in apoptotic process || induction of programmed cell death || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || activation of cysteine-type endopeptidase activity involved in apoptotic process || cell redox homeostasis || induction of apoptosis || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of cell death |
| Biological Process (BP) |
single-organism cellular process |
1 |
0.3915 |
Least Informative |
INHERITED FROM: regulation of cysteine-type endopeptidase activity involved in apoptotic process || cell death || mitochondrion organization || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || execution phase of apoptosis || activation of cysteine-type endopeptidase activity involved in apoptotic process || cell redox homeostasis || cellular homeostasis || apoptotic DNA fragmentation || cellular response to oxidative stress || apoptotic process || cellular response to stress || cellular response to hydrogen peroxide || regulation of mitochondrial membrane potential || cellular component disassembly involved in execution phase of apoptosis || hydrogen peroxide catabolic process || mitochondrial depolarization || apoptotic nuclear changes || cellular response to reactive oxygen species || cellular component disassembly || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || regulation of membrane potential || programmed cell death |
| Biological Process (BP) |
response to stimulus |
0.4309 |
0.5498 |
Least Informative |
INHERITED FROM: hydrogen peroxide catabolic process || response to hydrogen peroxide || cellular response to reactive oxygen species || response to oxidative stress || cellular response to oxidative stress || response to oxygen-containing compound || response to reactive oxygen species || cellular response to stress || response to inorganic substance || cellular response to hydrogen peroxide |
| Biological Process (BP) |
cellular component organization or biogenesis |
1 |
0.6536 |
Least Informative |
INHERITED FROM: cellular component disassembly involved in execution phase of apoptosis || mitochondrion organization || apoptotic DNA fragmentation || apoptotic nuclear changes || cellular component disassembly |
| Biological Process (BP) |
cellular macromolecule metabolic process |
1 |
0.4976 |
Least Informative |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
cellular aromatic compound metabolic process |
1 |
0.6271 |
Least Informative |
INHERITED FROM: DNA catabolic process, endonucleolytic || DNA catabolic process || nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation |
| Biological Process (BP) |
organic cyclic compound metabolic process |
1 |
0.5817 |
Least Informative |
INHERITED FROM: DNA catabolic process, endonucleolytic || DNA catabolic process || nucleic acid phosphodiester bond hydrolysis || apoptotic DNA fragmentation |
| Biological Process (BP) |
cellular amino acid metabolic process |
2.304e-12 |
1.036 |
Moderately Informative |
DIRECT |
| Biological Process (BP) |
response to oxygen-containing compound |
1.209e-05 |
1.108 |
Moderately Informative |
DIRECT |
| Biological Process (BP) |
homeostatic process |
2.113e-05 |
1.086 |
Moderately Informative |
DIRECT |
| Biological Process (BP) |
cellular catabolic process |
2.402e-05 |
0.8928 |
Moderately Informative |
DIRECT |
| Biological Process (BP) |
cofactor metabolic process |
0.0001599 |
1.131 |
Moderately Informative |
DIRECT |
| Biological Process (BP) |
cellular response to stress |
0.0004102 |
1.086 |
Moderately Informative |
DIRECT |
| Biological Process (BP) |
regulation of molecular function |
0.08514 |
1.056 |
Moderately Informative |
INHERITED FROM: regulation of peptidase activity || activation of cysteine-type endopeptidase activity || regulation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of peptidase activity || regulation of hydrolase activity || positive regulation of endopeptidase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process || regulation of endopeptidase activity || regulation of cysteine-type endopeptidase activity || positive regulation of hydrolase activity || positive regulation of cysteine-type endopeptidase activity |
| Biological Process (BP) |
oxidation-reduction process |
0.004442 |
1.237 |
Moderately Informative |
INHERITED FROM: cellular respiration |
| Biological Process (BP) |
cellular response to chemical stimulus |
0.03416 |
1.097 |
Moderately Informative |
INHERITED FROM: cellular response to oxidative stress || cellular response to reactive oxygen species || cellular response to hydrogen peroxide || hydrogen peroxide catabolic process |
| Biological Process (BP) |
positive regulation of cellular process |
0.9697 |
0.9066 |
Moderately Informative |
INHERITED FROM: positive regulation of cell death || induction of programmed cell death || induction of apoptosis |
| Biological Process (BP) |
organelle organization |
0.8085 |
0.8996 |
Moderately Informative |
INHERITED FROM: mitochondrion organization |
| Biological Process (BP) |
organic substance catabolic process |
0.03015 |
0.8297 |
Moderately Informative |
INHERITED FROM: apoptotic DNA fragmentation || alpha-amino acid catabolic process || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
monocarboxylic acid metabolic process |
0.9846 |
1.155 |
Moderately Informative |
INHERITED FROM: pyruvate metabolic process || acetyl-CoA biosynthetic process from pyruvate |
| Biological Process (BP) |
cellular amide metabolic process |
3.618e-13 |
1.469 |
Informative |
DIRECT |
| Biological Process (BP) |
response to oxidative stress |
6.025e-11 |
1.469 |
Informative |
DIRECT |
| Biological Process (BP) |
response to inorganic substance |
4.447e-10 |
1.42 |
Informative |
DIRECT |
| Biological Process (BP) |
apoptotic process |
3.26e-08 |
1.553 |
Informative |
DIRECT |
| Biological Process (BP) |
cellular component disassembly |
7.488e-06 |
1.745 |
Informative |
DIRECT |
| Biological Process (BP) |
cellular modified amino acid metabolic process |
1.83e-05 |
1.377 |
Informative |
DIRECT |
| Biological Process (BP) |
mitochondrion organization |
0.0001958 |
1.585 |
Informative |
DIRECT |
| Biological Process (BP) |
regulation of hydrolase activity |
0.0003757 |
1.42 |
Informative |
DIRECT |
| Biological Process (BP) |
carboxylic acid catabolic process |
0.1686 |
1.523 |
Informative |
INHERITED FROM: alpha-amino acid catabolic process |
| Biological Process (BP) |
organonitrogen compound catabolic process |
0.6106 |
1.268 |
Informative |
INHERITED FROM: alpha-amino acid catabolic process |
| Biological Process (BP) |
positive regulation of catalytic activity |
0.001981 |
1.337 |
Informative |
INHERITED FROM: activation of cysteine-type endopeptidase activity || positive regulation of endopeptidase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of hydrolase activity || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || positive regulation of peptidase activity || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process || positive regulation of cysteine-type endopeptidase activity |
| Biological Process (BP) |
coenzyme biosynthetic process |
0.02921 |
1.337 |
Informative |
INHERITED FROM: acyl-CoA biosynthetic process || acetyl-CoA biosynthetic process from pyruvate || acetyl-CoA biosynthetic process |
| Biological Process (BP) |
cellular response to oxygen-containing compound |
0.03011 |
1.319 |
Informative |
INHERITED FROM: cellular response to hydrogen peroxide || cellular response to reactive oxygen species || hydrogen peroxide catabolic process |
| Biological Process (BP) |
energy derivation by oxidation of organic compounds |
0.7929 |
1.469 |
Informative |
INHERITED FROM: cellular respiration |
| Biological Process (BP) |
regulation of apoptotic process |
0.002876 |
1.337 |
Informative |
INHERITED FROM: induction of apoptosis || regulation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process || activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c || positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| Biological Process (BP) |
nucleobase-containing compound catabolic process |
0.00444 |
1.377 |
Informative |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process || DNA catabolic process, endonucleolytic |
| Biological Process (BP) |
cellular macromolecule catabolic process |
0.01396 |
1.398 |
Informative |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process || DNA catabolic process, endonucleolytic |
| Biological Process (BP) |
DNA metabolic process |
0.0097 |
1.268 |
Informative |
INHERITED FROM: apoptotic DNA fragmentation || DNA catabolic process, endonucleolytic || DNA catabolic process |
| Biological Process (BP) |
hydrogen peroxide metabolic process |
2.896e-13 |
2.097 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
thioester biosynthetic process |
2.584e-12 |
2.222 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
glutathione metabolic process |
4.278e-11 |
1.854 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
DNA catabolic process |
3.47e-10 |
2.097 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
positive regulation of peptidase activity |
8.336e-10 |
2 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
cellular component disassembly involved in execution phase of apoptosis |
1.521e-09 |
2.097 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
acyl-CoA metabolic process |
4.89e-09 |
2.097 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
nucleic acid phosphodiester bond hydrolysis |
1.833e-06 |
2.097 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
regulation of cysteine-type endopeptidase activity involved in apoptotic process |
2.104e-06 |
2 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
regulation of membrane potential |
4.017e-06 |
1.854 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
cellular response to reactive oxygen species |
1.115e-05 |
1.854 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
response to hydrogen peroxide |
6.547e-05 |
1.921 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
positive regulation of apoptotic process |
0.02545 |
2 |
Highly Informative |
INHERITED FROM: induction of apoptosis |
| Molecular Function (MF) |
catalytic activity |
0 |
0.2686 |
-- |
DIRECT |
| Molecular Function (MF) |
oxidoreductase activity, acting on NAD(P)H |
0 |
1.9 |
-- |
DIRECT |
| Molecular Function (MF) |
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
0 |
2.679 |
-- |
DIRECT |
| Molecular Function (MF) |
antioxidant activity |
0 |
1.833 |
-- |
DIRECT |
| Molecular Function (MF) |
coenzyme binding |
1.61e-14 |
1.724 |
-- |
DIRECT |
| Molecular Function (MF) |
flavin adenine dinucleotide binding |
3.257e-13 |
2.679 |
-- |
DIRECT |
| Molecular Function (MF) |
apoptotic protease activator activity |
1.553e-11 |
2.679 |
-- |
DIRECT |
| Molecular Function (MF) |
peptidase activator activity |
1.003e-09 |
2.377 |
-- |
DIRECT |
| Molecular Function (MF) |
nucleoside phosphate binding |
1.945e-09 |
1.448 |
-- |
DIRECT |
| Molecular Function (MF) |
small molecule binding |
8.046e-09 |
1.317 |
-- |
DIRECT |
| Molecular Function (MF) |
thioredoxin-disulfide reductase activity |
9.499e-08 |
2.679 |
-- |
DIRECT |
| Molecular Function (MF) |
ion binding |
0.000101 |
0.8334 |
-- |
DIRECT |
| Molecular Function (MF) |
monovalent inorganic cation transmembrane transporter activity |
0.0001878 |
1.637 |
-- |
DIRECT |
| Molecular Function (MF) |
molecular_function |
0.04402 |
0 |
-- |
INHERITED FROM: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor || NADP binding || enzyme activator activity || NAD(P)+ transhydrogenase (B-specific) activity || anion binding || apoptotic protease activator activity || antioxidant activity || peptidase regulator activity || flavin adenine dinucleotide binding || peptide disulfide oxidoreductase activity || thioredoxin-disulfide reductase activity || glutathione-disulfide reductase activity || coenzyme binding || oxidoreductase activity, acting on a sulfur group of donors || NAD(P)+ transhydrogenase activity || monovalent inorganic cation transmembrane transporter activity || nucleotide binding || small molecule binding || peptidase activator activity || catalytic activity || hydrogen ion transmembrane transporter activity || ion binding || cysteine-type endopeptidase regulator activity involved in apoptotic process || oxidoreductase activity, acting on NAD(P)H || oxidoreductase activity || glutathione disulfide oxidoreductase activity || nucleoside phosphate binding || cysteine-type endopeptidase activator activity involved in apoptotic process || cofactor binding |
| Molecular Function (MF) |
disulfide oxidoreductase activity |
0.2303 |
2.679 |
-- |
INHERITED FROM: glutathione disulfide oxidoreductase activity || glutathione-disulfide reductase activity || peptide disulfide oxidoreductase activity |
| Molecular Function (MF) |
cation transmembrane transporter activity |
0.01201 |
1.423 |
-- |
INHERITED FROM: NAD(P)+ transhydrogenase (B-specific) activity || monovalent inorganic cation transmembrane transporter activity || hydrogen ion transmembrane transporter activity |
| Molecular Function (MF) |
ion transmembrane transporter activity |
0.05161 |
1.336 |
-- |
INHERITED FROM: NAD(P)+ transhydrogenase (B-specific) activity || monovalent inorganic cation transmembrane transporter activity || hydrogen ion transmembrane transporter activity |
| Molecular Function (MF) |
substrate-specific transmembrane transporter activity |
0.09496 |
1.281 |
-- |
INHERITED FROM: NAD(P)+ transhydrogenase (B-specific) activity || monovalent inorganic cation transmembrane transporter activity || hydrogen ion transmembrane transporter activity |
| Molecular Function (MF) |
substrate-specific transporter activity |
0.1448 |
1.134 |
-- |
INHERITED FROM: NAD(P)+ transhydrogenase (B-specific) activity || monovalent inorganic cation transmembrane transporter activity || hydrogen ion transmembrane transporter activity |
| Molecular Function (MF) |
transmembrane transporter activity |
0.1501 |
1.231 |
-- |
INHERITED FROM: NAD(P)+ transhydrogenase (B-specific) activity || monovalent inorganic cation transmembrane transporter activity || hydrogen ion transmembrane transporter activity |
| Molecular Function (MF) |
binding |
1 |
0.3952 |
Least Informative |
INHERITED FROM: coenzyme binding || flavin adenine dinucleotide binding || NADP binding || anion binding || ion binding || nucleoside phosphate binding || nucleotide binding || cofactor binding || small molecule binding |
| Molecular Function (MF) |
oxidoreductase activity |
0 |
0.9883 |
Moderately Informative |
DIRECT |
| Molecular Function (MF) |
anion binding |
0.0006481 |
1.076 |
Moderately Informative |
DIRECT |
| Molecular Function (MF) |
enzyme regulator activity |
0.0634 |
1.134 |
Moderately Informative |
INHERITED FROM: peptidase activator activity || cysteine-type endopeptidase regulator activity involved in apoptotic process || peptidase regulator activity || apoptotic protease activator activity || enzyme activator activity || cysteine-type endopeptidase activator activity involved in apoptotic process |
| Molecular Function (MF) |
transporter activity |
0.3409 |
1.087 |
Moderately Informative |
INHERITED FROM: NAD(P)+ transhydrogenase (B-specific) activity || monovalent inorganic cation transmembrane transporter activity || hydrogen ion transmembrane transporter activity |
| Molecular Function (MF) |
heterocyclic compound binding |
0.03777 |
0.8932 |
Moderately Informative |
INHERITED FROM: nucleotide binding || nucleoside phosphate binding || NADP binding || flavin adenine dinucleotide binding |
| Molecular Function (MF) |
organic cyclic compound binding |
0.04334 |
0.846 |
Moderately Informative |
INHERITED FROM: nucleotide binding || nucleoside phosphate binding || NADP binding || flavin adenine dinucleotide binding |
| Molecular Function (MF) |
cofactor binding |
2.564e-12 |
1.474 |
Informative |
DIRECT |
| Molecular Function (MF) |
nucleotide binding |
1.945e-09 |
1.448 |
Informative |
DIRECT |
| Molecular Function (MF) |
peptidase regulator activity |
2.019e-05 |
1.599 |
Informative |
DIRECT |
| Molecular Function (MF) |
enzyme activator activity |
0.0004531 |
1.679 |
Informative |
DIRECT |
| Molecular Function (MF) |
inorganic cation transmembrane transporter activity |
0.004095 |
1.502 |
Informative |
INHERITED FROM: hydrogen ion transmembrane transporter activity || NAD(P)+ transhydrogenase (B-specific) activity || monovalent inorganic cation transmembrane transporter activity |
| Molecular Function (MF) |
oxidoreductase activity, acting on a sulfur group of donors |
0 |
1.98 |
Highly Informative |
DIRECT |
| Molecular Function (MF) |
cysteine-type endopeptidase regulator activity involved in apoptotic process |
3.437e-09 |
2.076 |
Highly Informative |
DIRECT |
| Molecular Function (MF) |
hydrogen ion transmembrane transporter activity |
2.999e-07 |
1.98 |
Highly Informative |
DIRECT |
| Molecular Function (MF) |
NADP binding |
0.0004594 |
2.201 |
Highly Informative |
DIRECT |
| Cellular Component (CC) |
mitochondrion |
0 |
0.7422 |
-- |
DIRECT |
| Cellular Component (CC) |
cytoplasm |
0 |
0.2515 |
-- |
DIRECT |
| Cellular Component (CC) |
pyruvate dehydrogenase complex |
1.256e-11 |
2.542 |
-- |
DIRECT |
| Cellular Component (CC) |
cell part |
1.499e-08 |
0.08068 |
-- |
DIRECT |
| Cellular Component (CC) |
cell |
1.528e-08 |
0.08068 |
-- |
DIRECT |
| Cellular Component (CC) |
organelle |
1.743e-08 |
0.1836 |
-- |
DIRECT |
| Cellular Component (CC) |
organelle envelope lumen |
2.438e-07 |
2.241 |
-- |
DIRECT |
| Cellular Component (CC) |
intracellular |
2.61e-06 |
0.1266 |
-- |
DIRECT |
| Cellular Component (CC) |
envelope |
4.074e-06 |
0.9288 |
-- |
DIRECT |
| Cellular Component (CC) |
intracellular part |
2.338e-05 |
0.1266 |
-- |
DIRECT |
| Cellular Component (CC) |
organelle part |
7.139e-05 |
0.3713 |
-- |
DIRECT |
| Cellular Component (CC) |
membrane-enclosed lumen |
7.77e-05 |
0.9395 |
-- |
DIRECT |
| Cellular Component (CC) |
membrane-bounded organelle |
0.000945 |
0.2912 |
-- |
DIRECT |
| Cellular Component (CC) |
macromolecular complex |
0.6443 |
0.4276 |
-- |
INHERITED FROM: pyruvate dehydrogenase complex |
| Cellular Component (CC) |
intracellular organelle |
0.6491 |
0.1875 |
-- |
INHERITED FROM: mitochondrial part || intracellular membrane-bounded organelle || mitochondrion || organelle envelope lumen || mitochondrial intermembrane space || organelle envelope |
| Cellular Component (CC) |
cellular_component |
0.1578 |
0 |
-- |
INHERITED FROM: mitochondrial part || cell || intracellular membrane-bounded organelle || envelope || cytoplasm || pyruvate dehydrogenase complex || organelle part || organelle envelope || cell part || membrane-bounded organelle || mitochondrion || organelle envelope lumen || cytoplasmic part || membrane-enclosed lumen || intracellular part || mitochondrial intermembrane space || intracellular || organelle |
| Cellular Component (CC) |
mitochondrial envelope |
0.1112 |
1.094 |
-- |
INHERITED FROM: mitochondrial intermembrane space |
| Cellular Component (CC) |
cytoplasmic part |
0 |
0.2605 |
Least Informative |
DIRECT |
| Cellular Component (CC) |
intracellular membrane-bounded organelle |
0.0008471 |
0.2961 |
Least Informative |
DIRECT |
| Cellular Component (CC) |
protein complex |
0.2101 |
0.5639 |
Least Informative |
INHERITED FROM: pyruvate dehydrogenase complex |
| Cellular Component (CC) |
intracellular organelle part |
0.2241 |
0.3893 |
Least Informative |
INHERITED FROM: mitochondrial part || organelle envelope lumen || mitochondrial intermembrane space || organelle envelope |
| Cellular Component (CC) |
mitochondrial part |
6.23e-07 |
1.01 |
Moderately Informative |
DIRECT |
| Cellular Component (CC) |
organelle envelope |
1.018e-05 |
0.9618 |
Moderately Informative |
DIRECT |
| Cellular Component (CC) |
mitochondrial intermembrane space |
0.000396 |
2.241 |
Highly Informative |
DIRECT |
0
