SUPERFAMILY 1.75 HMM library and genome assignments server


eIF4e-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   eIF4e-like [ 55417]
Superfamily:   eIF4e-like [ 55418] (2)
Families:   Translation initiation factor eIF4e [ 55419]
  BLES03-like [ 143583]


Superfamily statistics
Genomes (512) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,224 2,982 6
Proteins 2,207 2,969 6


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.12820.3715Least InformativeInherited
Biological Process (BP)developmental process1.118e-070.002395Least InformativeInherited
Biological Process (BP)multicellular organismal process2.846e-070.00382Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0022770.08282Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0078360.058Least InformativeInherited
Biological Process (BP)protein metabolic process0.00081320.00204Least InformativeInherited
Biological Process (BP)biosynthetic process0.016230.00425Least InformativeInherited
Biological Process (BP)gene expression1.149e-063.114e-06Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process5.09e-071.084e-06Moderately InformativeDirect
Biological Process (BP)single-organism developmental process1.684e-060.0002042Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process3.256e-111.762e-07Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process7.354e-100.001025Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process2.67e-090.001708Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression6.407e-090.00291Moderately InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching05.366e-12InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression02.334e-13InformativeDirect
Biological Process (BP)translational initiation00Highly InformativeDirect
Biological Process (BP)regulation of translation00Highly InformativeDirect
Biological Process (BP)post-embryonic development0.029570.03987Highly InformativeInherited
Molecular Function (MF)binding3e-091.467e-06Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)RNA binding00InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding3.135e-088.564e-11Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.00094040.03581Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.79880.132Least InformativeInherited
Cellular Component (CC)protein complex0.22010.2629Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.0002677.767e-05Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.3715 Least Informative Inherited
Biological Process (BP) developmental process 0.002395 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.00382 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.08282 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.058 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.00204 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.00425 Least Informative Inherited
Biological Process (BP) gene expression 3.114e-06 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 1.084e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0002042 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.762e-07 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.001025 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.001708 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.00291 Moderately Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 5.366e-12 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 2.334e-13 Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.03987 Highly Informative Inherited
Molecular Function (MF) binding 1.467e-06 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 8.564e-11 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.03581 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.132 Least Informative Inherited
Cellular Component (CC) protein complex 0.2629 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 7.767e-05 Moderately Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)brood size variant0InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processTranslation regulation0InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001040 SSF55418 Protein matches
Abstract Eukaryotic translation initiation factor 4E (eIF-4E) [PubMed1733496] is a protein that binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding [PubMed1672854].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a eIF4e-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the eIF4e-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]