SUPERFAMILY 1.75 HMM library and genome assignments server


eIF4e-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   eIF4e-like [ 55417]
Superfamily:   eIF4e-like [ 55418] (2)
Families:   Translation initiation factor eIF4e [ 55419]
  BLES03-like [ 143583]


Superfamily statistics
Genomes (461) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,035 2,180 6
Proteins 2,020 2,171 6


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.14120.3114Least InformativeInherited
Biological Process (BP)multicellular organismal process5.136e-070.01182Least InformativeInherited
Biological Process (BP)developmental process2.302e-070.008396Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0027350.06851Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.01390.08961Least InformativeInherited
Biological Process (BP)protein metabolic process0.0018510.004195Least InformativeInherited
Biological Process (BP)biosynthetic process0.02590.008339Least InformativeInherited
Biological Process (BP)gene expression4.633e-061.142e-05Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process3.644e-100.0008331Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process2.167e-064.409e-06Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.254e-111.086e-07Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process1.357e-090.00139Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.97161Moderately InformativeInherited
Biological Process (BP)single-organism developmental process4.352e-060.001005Moderately InformativeInherited
Biological Process (BP)regulation of gene expression2.748e-090.002229Moderately InformativeInherited
Biological Process (BP)translation1.492e-092.503e-13InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression01.376e-13InformativeDirect
Biological Process (BP)embryo development ending in birth or egg hatching1.406e-120.002116InformativeInherited
Biological Process (BP)translational initiation00Highly InformativeDirect
Biological Process (BP)regulation of translation00Highly InformativeDirect
Biological Process (BP)post-embryonic development0.023540.02218Highly InformativeInherited
Molecular Function (MF)binding9.636e-091.56e-06Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)RNA binding00InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding8.582e-104.155e-12Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0001790.01036Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.78210.1129Least InformativeInherited
Cellular Component (CC)protein complex0.21310.2456Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.00027558.128e-05Moderately InformativeDirect
Cellular Component (CC)RNA cap binding complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.3114 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.01182 Least Informative Inherited
Biological Process (BP) developmental process 0.008396 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.06851 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.08961 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.004195 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.008339 Least Informative Inherited
Biological Process (BP) gene expression 1.142e-05 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0008331 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 4.409e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.086e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.00139 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.001005 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.002229 Moderately Informative Inherited
Biological Process (BP) translation 2.503e-13 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.376e-13 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.002116 Informative Inherited
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.02218 Highly Informative Inherited
Molecular Function (MF) binding 1.56e-06 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 4.155e-12 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01036 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1129 Least Informative Inherited
Cellular Component (CC) protein complex 0.2456 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 8.128e-05 Moderately Informative Direct
Cellular Component (CC) RNA cap binding complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)brood size variant0InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processTranslation regulation0InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001040 SSF55418 Protein matches
Abstract Eukaryotic translation initiation factor 4E (eIF-4E) [PubMed1733496] is a protein that binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding [PubMed1672854].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a eIF4e-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the eIF4e-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]