SUPERFAMILY 1.75 HMM library and genome assignments server


eIF4e-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   eIF4e-like [ 55417]
Superfamily:   eIF4e-like [ 55418] (2)
Families:   Translation initiation factor eIF4e [ 55419]
  BLES03-like [ 143583]


Superfamily statistics
Genomes (512) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,224 2,982 6
Proteins 2,207 2,969 6


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.13050.3802Least InformativeInherited
Biological Process (BP)developmental process1.156e-070.002406Least InformativeInherited
Biological Process (BP)multicellular organismal process2.913e-070.003859Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0022230.0865Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0079050.05852Least InformativeInherited
Biological Process (BP)protein metabolic process0.00082560.002096Least InformativeInherited
Biological Process (BP)biosynthetic process0.016470.004311Least InformativeInherited
Biological Process (BP)gene expression1.157e-063.171e-06Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process5.041e-071.095e-06Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process3.82e-111.921e-07Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process8.026e-100.001066Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process2.937e-090.001773Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression7.451e-090.003141Moderately InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching05.005e-12InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression02.373e-13InformativeDirect
Biological Process (BP)translational initiation00Highly InformativeDirect
Biological Process (BP)regulation of translation00Highly InformativeDirect
Biological Process (BP)post-embryonic development0.02960.0397Highly InformativeInherited
Molecular Function (MF)binding3.119e-091.604e-06Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)RNA binding00InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding3.136e-089.06e-11Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.00093010.03582Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.80170.1334Least InformativeInherited
Cellular Component (CC)protein complex0.22180.2669Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.00026347.39e-05Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.3802 Least Informative Inherited
Biological Process (BP) developmental process 0.002406 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003859 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.0865 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.05852 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.002096 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.004311 Least Informative Inherited
Biological Process (BP) gene expression 3.171e-06 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 1.095e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.921e-07 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.001066 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.001773 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.003141 Moderately Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 5.005e-12 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 2.373e-13 Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0397 Highly Informative Inherited
Molecular Function (MF) binding 1.604e-06 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 9.06e-11 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.03582 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1334 Least Informative Inherited
Cellular Component (CC) protein complex 0.2669 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 7.39e-05 Moderately Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)brood size variant0InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processTranslation regulation0InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001040 SSF55418 Protein matches
Abstract Eukaryotic translation initiation factor 4E (eIF-4E) [PubMed1733496] is a protein that binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding [PubMed1672854].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a eIF4e-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the eIF4e-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]