SUPERFAMILY 1.75 HMM library and genome assignments server

Frataxin/Nqo15-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   N domain of copper amine oxidase-like [ 55382] (5)
Superfamily:   Frataxin/Nqo15-like [ 55387] (2)
Families:   Frataxin-like [ 55388] (2)
  Nqo15-like [ 143572]


Superfamily statistics
Genomes (1,054) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,124 5,055 7
Proteins 1,123 5,055 7


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.0051410.00005613Least InformativeInherited
Biological Process (BP)biosynthetic process0.0025430.00002443Least InformativeInherited
Biological Process (BP)cellular component biogenesis0.00003190.00004588Moderately InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly0.00000000017210Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00002443 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00005613 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.06818 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1212 Least Informative Inherited
Biological Process (BP) developmental process 0.07271 Least Informative Inherited
Biological Process (BP) response to stimulus 0.003491 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.005843 Least Informative Inherited
Biological Process (BP) cellular component biogenesis 0.00004588 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000002975 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.004626 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 0.00000003653 Informative Direct
Biological Process (BP) response to inorganic substance 0.0005004 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0000000006774 Informative Direct
Biological Process (BP) phosphorylation 0.00005207 Informative Direct
Biological Process (BP) regulation of growth 0.000001437 Informative Direct
Biological Process (BP) cation homeostasis 0.0000000000002373 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000000001581 Informative Direct
Biological Process (BP) oxidative phosphorylation 0.00000001666 Highly Informative Direct
Biological Process (BP) iron-sulfur cluster assembly 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Molecular Function (MF) binding 0.3048 Least Informative Inherited
Molecular Function (MF) cation binding 0.000001059 Moderately Informative Direct
Molecular Function (MF) iron ion binding 0.00000000000007842 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0003923 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000003161 Least Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000000000000007332Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHeme biosynthesis0Highly InformativeDirect
Cellular componentMitochondrion0.0000000000000267Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionIron0.000000000000005913Moderately InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationOxidoreductase0.0000000000001928Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002908 SSF55387 Protein matches
Abstract

This family is related to the globular C-terminus of frataxin the protein that is mutated in Friedreich's ataxia [PubMed8931268]. Friedreich ataxia is a progressive neurodegenerative disorder caused by loss of function mutations in the gene encoding frataxin (FRDA). Frataxin mRNA is predominantly expressed in tissues with a high metabolic rate (including liver, kidney, brown fat and heart). Mouse and yeast frataxin homologues contain a potential N-terminal mitochondrial targeting sequence, and human frataxin has been observed to co-localise with a mitochondrial protein. Furthermore, disruption of the yeast gene has been shown to result in mitochondrial dysfunction. Friedreich's ataxia is thus believed to be a mitochondrial disease caused by a mutation in the nuclear genome (specifically, expansion of an intronic GAA triplet repeat) [PubMed8596916, PubMed8815938, PubMed9241270].

This family is also found found in a number of bacterial proteins whose functions are currently unknown.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Frataxin/Nqo15-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Frataxin/Nqo15-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]