SUPERFAMILY 1.75 HMM library and genome assignments server

Tubulin C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Families:   Tubulin, C-terminal domain [ 55308] (3)


Superfamily statistics
Genomes (2,992) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,318 33,356 19
Proteins 9,294 33,322 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0004379 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.4193 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.0543 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5377 Least Informative Inherited
Biological Process (BP) developmental process 0.2922 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.007028 Least Informative Inherited
Biological Process (BP) cellular localization 0.00005532 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00000000001969 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.4553 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9189 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6546 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.05149 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.001387 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.05418 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.0000000000157 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00000001723 Informative Direct
Biological Process (BP) hexose metabolic process 0.000000003818 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) protein catabolic process 0.00004267 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0001618 Informative Direct
Biological Process (BP) cell division 0.00000000000006627 Informative Direct
Biological Process (BP) organelle localization 0.000003925 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0001559 Informative Direct
Biological Process (BP) cellular component movement 0.01419 Informative Inherited
Biological Process (BP) proteolysis 0.00124 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1044 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.00131 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) glucose metabolic process 0.000000000611 Highly Informative Direct
Biological Process (BP) protein folding 0.0000008358 Highly Informative Direct
Biological Process (BP) spindle organization 0.0000007521 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.0000001487 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.00000003423 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000004517 Highly Informative Direct
Biological Process (BP) protein polymerization 0.000000000000009016 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.287 Highly Informative Inherited
Molecular Function (MF) binding 0.1614 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.5028 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000796 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0002901 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0098 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00005324 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0005011 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000002466 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000001549 Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0000000000006468 Informative Direct
Cellular Component (CC) plastid 0.01619 Informative Inherited
Cellular Component (CC) spindle 0.00000000002394 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.00001573 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.1691 Highly Informative Inherited
Cellular Component (CC) cell body 0.002637 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.0297Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008798InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of brain morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skull size0InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental delay0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Polymicrogyria0Highly InformativeDirect
Phenotypic Abnormality (PA)Agenesis of corpus callosum0.000008345Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the brainstem0.00001979Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0000000004803Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001381Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.001908Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0000000001309Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000002374Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.00001454Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004282Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.03276Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.03697Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.09361Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.000000001179InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000000002493InformativeDirect
Worm Phenotype (WP)nicotine response variant0.0000001548InformativeDirect
Worm Phenotype (WP)exploded through vulva0.000007572InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0005179InformativeDirect
Worm Phenotype (WP)cell division variant0.002677InformativeInherited
Worm Phenotype (WP)copulation variant0.007935InformativeInherited
Worm Phenotype (WP)neuron development variant0.02841InformativeInherited
Worm Phenotype (WP)RNA expression variant0.06246InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)distal tip cell migration variant0.00000000002613Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.00000002393Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.0000005405Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.0000007067Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.000001355Highly InformativeDirect
Worm Phenotype (WP)presynaptic region morphology variant0.000005755Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.04514Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.06993Moderately InformativeInherited
Fly Phenotype (FP)male fertile0.00000001634Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0.1281Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1367Least InformativeInherited
Fly Anatomy (FA)reproductive system0.01177Moderately InformativeInherited
Fly Anatomy (FA)germline cyst0.01946InformativeInherited
Fly Anatomy (FA)male germline cell0.03375InformativeInherited
Fly Anatomy (FA)male reproductive system0.06327InformativeInherited
Fly Anatomy (FA)spermatid0.00006665Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cell0.1984Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.2567Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.374Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.557Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.6064Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.7531Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1428Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1808Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3358Moderately InformativeInherited
Xenopus ANatomical entity (XAN)endocrine system0.0008376InformativeDirect
Xenopus ANatomical entity (XAN)skin0.07262InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.000000113Highly InformativeDirect
Xenopus ANatomical entity (XAN)epidermis0.0001429Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.0002625Highly InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0003172Highly InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.0003872Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0004948Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.2603Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.003249InformativeInherited

Document: AP annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic agents0.000001685Moderately InformativeDirect
Drugbank ATC_code (DB)anthelmintics0.00001761InformativeDirect
Drugbank ATC_code (DB)vinca alkaloids and analogues0.000000000000006795Highly InformativeDirect
Drugbank ATC_code (DB)benzimidazole derivatives0.0000001921Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processAntibiotic resistance0.0001624InformativeDirect
Biological processSeptation0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationNitration0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008280 SSF55307 Protein matches
Abstract

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Tubulin C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]