SUPERFAMILY 1.75 HMM library and genome assignments server


Tubulin C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Families:   Tubulin, C-terminal domain [ 55308] (3)


Superfamily statistics
Genomes (2,946) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 8,704 20,376 19
Proteins 8,682 20,368 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 3.767e-10 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0.03202 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3288 Least Informative Inherited
Biological Process (BP) developmental process 0.2107 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4487 Least Informative Inherited
Biological Process (BP) localization 0.002517 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0009372 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 0.0001505 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.07355 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6329 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.07957 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01593 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 2.866e-12 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 1.17e-08 Informative Direct
Biological Process (BP) hexose metabolic process 1.219e-08 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) protein catabolic process 3.985e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0001113 Informative Direct
Biological Process (BP) organelle localization 3.481e-06 Informative Direct
Biological Process (BP) cellular component movement 0.1686 Informative Inherited
Biological Process (BP) proteolysis 0.001164 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.0002474 Highly Informative Direct
Biological Process (BP) protein folding 7.892e-07 Highly Informative Direct
Biological Process (BP) chromosome segregation 9.15e-07 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 1.687e-08 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 1.977e-07 Highly Informative Direct
Biological Process (BP) cell division 1.028e-06 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.5761 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.001251 Highly Informative Inherited
Molecular Function (MF) binding 0.1469 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.5876 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001284 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 2.93e-05 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.304e-06 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 7.948e-07 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.001513 Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1.872e-11 Informative Direct
Cellular Component (CC) plastid 0.0224 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.0219 Informative Inherited
Cellular Component (CC) cell wall 0.0001492 Highly Informative Direct
Cellular Component (CC) centrosome 0.0003286 Highly Informative Direct
Cellular Component (CC) spindle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 1.396e-05 Highly Informative Direct
Cellular Component (CC) microtubule organizing center part 3.551e-07 Highly Informative Direct
Cellular Component (CC) cell body 0.002211 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.02842Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008309InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skeletal system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of brain morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skull size0InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental delay0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Polymicrogyria0Highly InformativeDirect
Phenotypic Abnormality (PA)Agenesis of corpus callosum8.437e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the brainstem1.938e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant4.803e-10Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001381Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.001908Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant1.309e-10Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal2.374e-06Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant1.454e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004282Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.03276Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.03697Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.09361Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant1.179e-09InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant2.493e-09InformativeDirect
Worm Phenotype (WP)nicotine response variant1.548e-07InformativeDirect
Worm Phenotype (WP)exploded through vulva7.572e-06InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0005179InformativeDirect
Worm Phenotype (WP)cell division variant0.002677InformativeInherited
Worm Phenotype (WP)copulation variant0.007935InformativeInherited
Worm Phenotype (WP)neuron development variant0.02841InformativeInherited
Worm Phenotype (WP)RNA expression variant0.06246InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)distal tip cell migration variant2.613e-11Highly InformativeDirect
Worm Phenotype (WP)touch resistant2.393e-08Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant5.405e-07Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant7.067e-07Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb1.355e-06Highly InformativeDirect
Worm Phenotype (WP)presynaptic region morphology variant5.755e-06Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.04514Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.0684Least InformativeInherited
Fly Phenotype (FP)male fertile2.228e-08InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0.1333Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1494Least InformativeInherited
Fly Anatomy (FA)reproductive system0.01448Moderately InformativeInherited
Fly Anatomy (FA)male germline cell0.03465InformativeInherited
Fly Anatomy (FA)testis0.0718InformativeInherited
Fly Anatomy (FA)spermatid5.152e-05Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cell0.195Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.2562Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.3681Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.5577Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.5975Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.7521Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1408Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1728Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3159Moderately InformativeInherited
Xenopus ANatomical entity (XAN)endocrine system0.0008206InformativeDirect
Xenopus ANatomical entity (XAN)skin0.0724InformativeInherited
Xenopus ANatomical entity (XAN)neuron8.018e-08Highly InformativeDirect
Xenopus ANatomical entity (XAN)epidermis0.0001332Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.0001671Highly InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.0002226Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.000285Highly InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0003069Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.2603Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.003249InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processAntibiotic resistance0.000162InformativeDirect
Biological processSeptation0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationNitration0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008280 SSF55307 Protein matches
Abstract

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Tubulin C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]