SUPERFAMILY 1.75 HMM library and genome assignments server


DNA repair protein MutS, domain I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MutS N-terminal domain-like [ 55266] (2)
Superfamily:   DNA repair protein MutS, domain I [ 55271]
Families:   DNA repair protein MutS, domain I [ 55272]


Superfamily statistics
Genomes (2,000) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,866 8,358 7
Proteins 2,864 8,356 7


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 2.076e-15 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.896e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.498e-07 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 4.413e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.003207 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.02794 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.186 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1515 Least Informative Inherited
Biological Process (BP) developmental process 0.00471 Least Informative Inherited
Biological Process (BP) reproduction 1.021e-06 Moderately Informative Direct
Biological Process (BP) immune system process 0.0004728 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.009373 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.01262 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.002453 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell cycle process 0.0002401 Informative Direct
Biological Process (BP) cellular process involved in reproduction 3.21e-07 Informative Direct
Biological Process (BP) chromosome organization 5.049e-05 Informative Direct
Biological Process (BP) DNA repair 3.791e-08 Highly Informative Direct
Biological Process (BP) DNA recombination 0.0002211 Highly Informative Direct
Biological Process (BP) meiosis 4.163e-07 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 3.081e-12 Highly Informative Direct
Molecular Function (MF) binding 2.207e-05 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.04609 Least Informative Inherited
Molecular Function (MF) anion binding 0.0003396 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 1.589e-10 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 1.143e-10 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 3.074e-05 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0001396 Informative Direct
Molecular Function (MF) ATP binding 4.738e-07 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 3.118e-08 Highly Informative Direct
Cellular Component (CC) protein complex 0.0001122 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001482 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1233 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0002229 Moderately Informative Direct

Document: GO annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the DNA repair protein MutS, domain I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]