SUPERFAMILY 1.75 HMM library and genome assignments server

ThrRS/AlaRS common domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   RRF/tRNA synthetase additional domain-like [ 55185] (4)
Superfamily:   ThrRS/AlaRS common domain [ 55186] (2)
Families:   Threonyl-tRNA synthetase (ThrRS), second 'additional' domain [ 55187]
  AlaX-like [ 103051] (2)


Superfamily statistics
Genomes (3,224) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,872 40,495 6
Proteins 8,862 40,486 6


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

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GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0000000000006208 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000000000001939 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000001128 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000001811 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000002411 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00000006228 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000006235 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000008436 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.2998 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1262 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3594 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2164 Least Informative Inherited
Biological Process (BP) developmental process 0.249 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000000001151 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000004331 Moderately Informative Direct
Biological Process (BP) organ development 0.5937 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.237 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03615 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.06484 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1442 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.4814 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03264 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01958 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2159 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0895 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01603 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.003693 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.003774 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.00603 Moderately Informative Inherited
Biological Process (BP) ncRNA metabolic process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00000000000143 Informative Direct
Biological Process (BP) mitochondrion organization 0.00009321 Informative Direct
Biological Process (BP) response to acid chemical 0.0001425 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0004162 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0006633 Informative Direct
Biological Process (BP) neurological system process 0.0007388 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.005177 Informative Inherited
Biological Process (BP) central nervous system development 0.01079 Informative Inherited
Biological Process (BP) epithelium development 0.05315 Informative Inherited
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) hair cycle process 0.0000000003393 Highly Informative Direct
Biological Process (BP) response to amino acid 0.0000000009876 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.00000001001 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00000001131 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.00000004345 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.000000154 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0000002639 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000000281 Highly Informative Direct
Biological Process (BP) epidermis development 0.000004992 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.7796 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0000001156 Moderately Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0008627 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.1367 Least Informative Inherited
Cellular Component (CC) plastid 0.0004416 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Alanine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Threonine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functiontRNA-binding0InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ThrRS/AlaRS common domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the ThrRS/AlaRS common domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]