SUPERFAMILY 1.75 HMM library and genome assignments server

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ThrRS/AlaRS common domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   RRF/tRNA synthetase additional domain-like [ 55185] (4)
Superfamily:   ThrRS/AlaRS common domain [ 55186] (2)
Families:   Threonyl-tRNA synthetase (ThrRS), second 'additional' domain [ 55187]
  AlaX-like [ 103051] (2)


Superfamily statistics
Genomes (3,223) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,863 40,495 6
Proteins 8,853 40,486 6


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0000000000006073 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000000000001329 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000001088 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000001739 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000001995 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000002252 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000005867 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00000006261 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.4356 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2763 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) developmental process 0.2495 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1806 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000000001053 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000858 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.204 Moderately Informative Inherited
Biological Process (BP) system process 0.07759 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03402 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.06249 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1389 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.2732 Moderately Informative Inherited
Biological Process (BP) organ development 0.6166 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02947 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01879 Moderately Informative Inherited
Biological Process (BP) tissue development 0.08851 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3387 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2096 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.4799 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.005572 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.003796 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.009139 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.003466 Moderately Informative Inherited
Biological Process (BP) ncRNA metabolic process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000000000001413 Informative Direct
Biological Process (BP) mitochondrion organization 0.00009113 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0003106 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0004066 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.005018 Informative Inherited
Biological Process (BP) central nervous system development 0.009789 Informative Inherited
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0000000005656 Highly Informative Direct
Biological Process (BP) response to amino acid stimulus 0.000000001014 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.000000009934 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00000001159 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.00000003977 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.0000001557 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000002185 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0000002531 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0001284 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.7829 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0000001071 Moderately Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0007051 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.1977 Least Informative Inherited
Cellular Component (CC) plastid 0.0004013 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Alanine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Threonine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functiontRNA-binding0InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ThrRS/AlaRS common domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the ThrRS/AlaRS common domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]