SUPERFAMILY 1.75 HMM library and genome assignments server

CYTH-like phosphatases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CYTH-like phosphatases [ 55153]
Superfamily:   CYTH-like phosphatases [ 55154] (2)
Families:   mRNA triphosphatase CET1 [ 55155]
  CYTH domain [ 118007] (4)


Superfamily statistics
Genomes (2,257) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,201 15,747 5
Proteins 3,194 15,737 5


Functional annotation
General category Information
Detailed category Transcription

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00013890.0008027Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00013310.0006826Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00028380.001567Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.010750.02262Least InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0000033440.00004961Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.000015670.00002509Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.00000035810.00002308Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.0000069550.00005126Moderately InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.00000053280.0000006466InformativeDirect
Molecular Function (MF)hydrolase activity0.00024370.000001318Least InformativeDirect
Molecular Function (MF)binding0.47811Least InformativeInherited
Molecular Function (MF)cation binding0.000014450.0005397Moderately InformativeDirect
Molecular Function (MF)magnesium ion binding0.0000000068110.00000008717InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity0.27831InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0008027 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0006826 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.001567 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.02262 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.00004961 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00002509 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00002308 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00005126 Moderately Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0.0000006466 Informative Direct
Molecular Function (MF) hydrolase activity 0.000001318 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) cation binding 0.0005397 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 0.00000008717 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001559Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.3199Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.00155Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases9.368e-16Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000008156Moderately InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases4.839e-16Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.08619Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.00186Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.006138Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.09189Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000000000001971InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processmRNA capping0.000000000000005055Highly InformativeDirect
Cellular componentNucleus0.000001453Least InformativeDirect
Molecular functionNucleotide-binding0.03516Least InformativeInherited
Molecular functionS-adenosyl-L-methionine0.00013InformativeDirect
Molecular functionGTP-binding0.000403InformativeDirect
Post-translational modificationHydrolase0.00000000001421Least InformativeDirect
Post-translational modificationTransferase0.6429Least InformativeInherited
Post-translational modificationNucleotidyltransferase0.00002594Moderately InformativeDirect
Post-translational modificationMethyltransferase0.00005405InformativeDirect
Post-translational modificationAcetylation0.0001338Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.000000504Least InformativeDirect
UniPathway (UP)mRNA processing0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CYTH-like phosphatases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the CYTH-like phosphatases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]