SUPERFAMILY 1.75 HMM library and genome assignments server

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK [ 55083]
Families:   6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK [ 55084]


Superfamily statistics
Genomes (2,544) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,921 17,240 5
Proteins 2,894 17,174 5


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity00.000000001329Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00.003524Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00001132 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00004256 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00026 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000009899 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00001981 Least Informative Direct
Biological Process (BP) biosynthetic process 0.01484 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03026 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0000000001059 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000003528 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000000000002426 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.002537 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.004289 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.00168 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.002392 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.001835 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.00000000000001071 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.05201 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.05297 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.0001721 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.0000000001942 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000000001329 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003524 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.00000004998 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.03299Least InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.00000000007695InformativeDirect
Enzyme Commission (EC)2-amino-4-hydroxy-6-hydroxymethyldihydropteridine 0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.03769Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.00006156Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.0000000001028Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processFolate biosynthesis0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)pteridine biosynthesis0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)tetrahydrofolate biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000550 SSF55083 Protein matches
Abstract All organisms require reduced folate cofactors for the synthesis of a variety of metabolites. Most microorganisms must synthesise folate de novo because they lack the active transport system of higher vertebrate cells which allows these organisms to use dietary folates. Enzymes involved in folate biosynthesis are therefore targets for a variety of antimicrobial agents such as trimethoprim or sulphonamides. 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) catalyzes the attachment of pyrophosphate to 6-hydroxymethyl-7,8-dihydropterin to form 6-hydroxymethyl-7,8-dihydropteridine pyrophosphate. This is the first step in a three-step pathway leading to 7,8 dihydrofolate. Bacterial HPPK (gene folK or sulD) [PubMed1325970] is a protein of 160 to 270 amino acids. In the lower eukaryote Pneumocystis carinii, HPPK is the central domain of a multifunctional folate synthesis enzyme (gene fas) [PubMed1313386].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]