SUPERFAMILY 1.75 HMM library and genome assignments server

GHMP Kinase, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   GHMP Kinase, C-terminal domain [ 55060] (7)
Families:   Galactokinase [ 103011]
  Homoserine kinase [ 55061]
  Mevalonate kinase [ 75450]
  Phosphomevalonate kinase (PMK) [ 75454]
  Mevalonate 5-diphosphate decarboxylase [ 64281]
  4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase IspE [ 89950]
  Early switch protein XOL-1 [ 89953]


Superfamily statistics
Genomes (3,098) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,880 55,983 12
Proteins 9,852 55,952 12


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0004168 Least Informative Direct
Biological Process (BP) biosynthetic process 0.07205 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000000000002892 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0000000002096 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000003376 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.000006559 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00002032 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0008297 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.3945 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.359 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.2108 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.005703 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0000000002258 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.000000002354 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000000385 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.0000008811 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.000004521 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.00004456 Informative Direct
Biological Process (BP) phosphorylation 0.2472 Informative Inherited
Biological Process (BP) hexose metabolic process 0.09357 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.06244 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.002262 Informative Inherited
Biological Process (BP) galactose metabolic process 0 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0000000000003954 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.0000000005116 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 0.00000006911 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.000003191 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.00001651 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00000000000005253 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.04252 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.002976 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.00000000003322 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00004111 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00005732 Informative Direct
Molecular Function (MF) nucleotide binding 0.0005071 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.001718 Informative Inherited
Molecular Function (MF) carbohydrate kinase activity 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.0000000000001828 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000003586 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.03573 Least Informative Inherited
Cellular Component (CC) cytosol 0.0000001599 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0.8703Moderately InformativeInherited
Biological processSteroid metabolism0.000000000000002085InformativeDirect
Biological processLipid biosynthesis0.0004866InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0.000000006571Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.00000000002691Moderately InformativeDirect
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis0.001972InformativeInherited
UniPathway (UP)terpene metabolism0.08903InformativeInherited
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)galactose metabolism0Highly InformativeDirect
UniPathway (UP)cholesterol metabolism0.000000086Highly InformativeDirect
UniPathway (UP)sterol biosynthesis0.00002936Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GHMP Kinase, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the GHMP Kinase, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]