SUPERFAMILY 1.75 HMM library and genome assignments server


ACT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   ACT-like [ 55021] (14)
Families:   Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
  Allosteric threonine deaminase C-terminal domain [ 55025]
  Phenylalanine metabolism regulatory domain [ 55028] (2)
  Nickel responsive regulator NikR, C-terminal domain [ 102999]
  Glycine cleavage system transcriptional repressor [ 110980]
  IlvH-like [ 143376]
  SP0238-like [ 143381]
  Atu0741-like [ 143384]
  VC0802-like [ 143387]
  Aspartokinase allosteric domain-like [ 143390]
  BT0572-like [ 143395]
  AF1403 N-terminal domain-like [ 143398]
  NIL domain-like [ 160322] (2)
  TM1266-like [ 160329]


Superfamily statistics
Genomes (3,026) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 43,694 245,097 43
Proteins 32,468 191,922 32


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00084190Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.001490Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0027440Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process1.07e-050Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process2.068e-050Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process2.239e-050Moderately InformativeDirect
Molecular Function (MF)transferase activity0.016020.4686Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6854 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7817 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0003761 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9866 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2976 Moderately Informative Inherited
Biological Process (BP) organ development 0.5809 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2146 Moderately Informative Inherited
Biological Process (BP) system process 0.5975 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.01839 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.002285 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.0001094 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) gland development 0.01228 Informative Inherited
Biological Process (BP) reproductive system development 0.03243 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3087 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.005854 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2157 Informative Inherited
Biological Process (BP) response to light stimulus 0.001771 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.01171 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.008465 Informative Inherited
Biological Process (BP) single-organism behavior 0.004695 Informative Inherited
Biological Process (BP) mammary gland alveolus development 1.42e-08 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 3.919e-08 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 3.061e-07 Highly Informative Direct
Biological Process (BP) response to cold 5.956e-05 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.0001609 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0001865 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.09746 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.008314 Highly Informative Inherited
Biological Process (BP) response to UV 0.005272 Highly Informative Inherited
Biological Process (BP) learning or memory 0.06619 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.4686 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1.329e-09 Moderately Informative Direct
Molecular Function (MF) lyase activity 7.894e-07 Moderately Informative Direct
Molecular Function (MF) anion binding 0.008188 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001678 Moderately Informative Inherited
Molecular Function (MF) hydro-lyase activity 6.513e-13 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.08e-08 Informative Direct
Molecular Function (MF) kinase activity 0.5261 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.02934 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 3.071e-15 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1.524e-12 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2.96e-12 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6828 Least Informative Inherited
Cellular Component (CC) plastid 1.772e-08 Informative Direct
Cellular Component (CC) chloroplast stroma 2.13e-06 Highly Informative Direct
Cellular Component (CC) cell body 0.01335 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00038Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005559Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red3.708e-15Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.371e-07Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases2.527e-06Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.2547Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.05367Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases2.328e-15InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases2.234e-14InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep8.021e-08InformativeDirect
Enzyme Commission (EC)Transferring other groups0.001969InformativeInherited
Enzyme Commission (EC)Aspartate kinase0Highly InformativeDirect
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.03397Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.006621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01087Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat3.952e-05InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0007037InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.006162InformativeInherited
Mammalian Phenotype (MP)abnormal serotonin level0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thermal nociception7.703e-06Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)behavior defective0InformativeDirect
Fly Phenotype (FP)feeding behavior defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage6.776e-05Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0001663Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0001833Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0003187Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.001463Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005169Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors5.881e-06Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.09244Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen3.855e-14InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases2.55e-11InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor2.422e-08InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.884e-05InformativeDirect
Enzyme Commission (EC)In linear amides0.09992InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.3052InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ammonia-lyases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases9.6e-16Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor9.505e-10Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis1.858e-15Highly InformativeDirect
Biological processDiaminopimelate biosynthesis7.55e-12Highly InformativeDirect
Biological processPhenylalanine catabolism4.611e-09Highly InformativeDirect
Biological processAromatic amino acid biosynthesis0.1118Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane1.25e-06InformativeDirect
Coding sequence diversityAlternative initiation8.651e-09Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.0001246Moderately InformativeDirect
Molecular functionNucleotide-binding7.273e-08Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionDNA-binding2.067e-06Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase9.585e-15Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0.3561Moderately InformativeInherited
Post-translational modificationMonooxygenase4.508e-12Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.0001769Moderately InformativeDirect
UniPathway (UP)L-lysine biosynthesis via DAP pathway0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis8.03e-10InformativeDirect
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-phenylalanine biosynthesis8.214e-11Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]