ACT-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a+b) [ 53931] (376)
Fold:	Ferredoxin-like [ 54861] (59)
Superfamily:	ACT-like [ 55021] (14)
Families:	Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
	Allosteric threonine deaminase C-terminal domain [ 55025]
	Phenylalanine metabolism regulatory domain [ 55028] (2)
	Nickel responsive regulator NikR, C-terminal domain [ 102999]
	Glycine cleavage system transcriptional repressor [ 110980]
	IlvH-like [ 143376]
	SP0238-like [ 143381]
	Atu0741-like [ 143384]
	VC0802-like [ 143387]
	Aspartokinase allosteric domain-like [ 143390]
	BT0572-like [ 143395]
	AF1403 N-terminal domain-like [ 143398]
	NIL domain-like [ 160322] (2)
	TM1266-like [ 160329]

Superfamily statistics

	Genomes (2,356)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	33,461	104,530	43
Proteins	24,844	80,378	32

Functional annotation

General category	Metabolism
Detailed category	Amino acids metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	nitrogen compound metabolic process	0.001909	0	Least Informative	Inherited
Biological Process (BP)	biosynthetic process	0.001144	0	Least Informative	Inherited
Biological Process (BP)	single-organism metabolic process	0.003596	0	Least Informative	Inherited
Biological Process (BP)	cellular amino acid metabolic process	1.663e-05	0	Moderately Informative	Direct
Biological Process (BP)	small molecule biosynthetic process	2.69e-05	2.615e-14	Moderately Informative	Direct
Biological Process (BP)	organonitrogen compound biosynthetic process	3.055e-05	0	Moderately Informative	Direct
Molecular Function (MF)	transferase activity	0.0126	0.728	Least Informative	Inherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	biosynthetic process	0	Least Informative	Direct
Biological Process (BP)	nitrogen compound metabolic process	0	Least Informative	Direct
Biological Process (BP)	single-organism metabolic process	0	Least Informative	Direct
Biological Process (BP)	developmental process	1	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	1	Least Informative	Inherited
Biological Process (BP)	response to stimulus	1	Least Informative	Inherited
Biological Process (BP)	organic cyclic compound metabolic process	0.3192	Least Informative	Inherited
Biological Process (BP)	cellular aromatic compound metabolic process	0.1855	Least Informative	Inherited
Biological Process (BP)	cellular amino acid metabolic process	0	Moderately Informative	Direct
Biological Process (BP)	small molecule biosynthetic process	2.615e-14	Moderately Informative	Direct
Biological Process (BP)	organonitrogen compound biosynthetic process	0	Moderately Informative	Direct
Biological Process (BP)	aromatic compound biosynthetic process	8.911e-07	Moderately Informative	Direct
Biological Process (BP)	organic cyclic compound biosynthetic process	4.026e-05	Moderately Informative	Direct
Biological Process (BP)	multi-organism process	0.9518	Moderately Informative	Inherited
Biological Process (BP)	reproduction	0.4435	Moderately Informative	Inherited
Biological Process (BP)	organ development	0.5342	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	1	Moderately Informative	Inherited
Biological Process (BP)	organic hydroxy compound metabolic process	0.006051	Moderately Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0.2001	Moderately Informative	Inherited
Biological Process (BP)	system process	0.5896	Moderately Informative	Inherited
Biological Process (BP)	cellular biogenic amine metabolic process	0.0001375	Informative	Direct
Biological Process (BP)	aspartate family amino acid metabolic process	0.0004925	Informative	Direct
Biological Process (BP)	gland development	0.01564	Informative	Inherited
Biological Process (BP)	reproductive system development	0.07252	Informative	Inherited
Biological Process (BP)	developmental process involved in reproduction	0.4448	Informative	Inherited
Biological Process (BP)	organic hydroxy compound biosynthetic process	0.01009	Informative	Inherited
Biological Process (BP)	response to external stimulus	0.009377	Informative	Inherited
Biological Process (BP)	response to light stimulus	0.002053	Informative	Inherited
Biological Process (BP)	alpha-amino acid biosynthetic process	0.002342	Informative	Inherited
Biological Process (BP)	single-organism behavior	0.003097	Informative	Inherited
Biological Process (BP)	aromatic amino acid family biosynthetic process	0	Highly Informative	Direct
Biological Process (BP)	mammary gland alveolus development	2.551e-08	Highly Informative	Direct
Biological Process (BP)	phenol-containing compound metabolic process	2.144e-07	Highly Informative	Direct
Biological Process (BP)	dicarboxylic acid metabolic process	1.244e-05	Highly Informative	Direct
Biological Process (BP)	response to cold	9.566e-05	Highly Informative	Direct
Biological Process (BP)	multi-organism behavior	0.0001385	Highly Informative	Direct
Biological Process (BP)	diol metabolic process	0.0002608	Highly Informative	Direct
Biological Process (BP)	post-embryonic development	0.199	Highly Informative	Inherited
Biological Process (BP)	post-embryonic organ development	0.008014	Highly Informative	Inherited
Biological Process (BP)	response to UV	0.007174	Highly Informative	Inherited
Biological Process (BP)	branched-chain amino acid metabolic process	0.001265	Highly Informative	Inherited
Biological Process (BP)	learning or memory	0.06821	Highly Informative	Inherited
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	transferase activity	0.728	Least Informative	Inherited
Molecular Function (MF)	lyase activity	5.877e-13	Moderately Informative	Direct
Molecular Function (MF)	oxidoreductase activity	1.221e-06	Moderately Informative	Direct
Molecular Function (MF)	protein binding	1	Moderately Informative	Inherited
Molecular Function (MF)	anion binding	0.2395	Moderately Informative	Inherited
Molecular Function (MF)	transferase activity, transferring phosphorus-containing groups	0.003567	Moderately Informative	Inherited
Molecular Function (MF)	carboxylic acid binding	1.611e-06	Informative	Direct
Molecular Function (MF)	carbon-oxygen lyase activity	2.779e-05	Informative	Direct
Molecular Function (MF)	protein dimerization activity	0.0003394	Informative	Direct
Molecular Function (MF)	kinase activity	1	Informative	Inherited
Molecular Function (MF)	oxidoreductase activity, acting on CH-OH group of donors	0.128	Informative	Inherited
Molecular Function (MF)	monooxygenase activity	6.021e-15	Highly Informative	Direct
Molecular Function (MF)	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge	5.826e-12	Highly Informative	Direct
Molecular Function (MF)	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3.18e-08	Highly Informative	Direct
Cellular Component (CC)	intracellular organelle part	1	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	1	Least Informative	Inherited
Cellular Component (CC)	cytoplasmic part	0.7213	Least Informative	Inherited
Cellular Component (CC)	plastid	9.294e-08	Informative	Direct
Cellular Component (CC)	neuron part	0.07325	Informative	Inherited
Cellular Component (CC)	chloroplast stroma	4.223e-06	Highly Informative	Direct
Cellular Component (CC)	cell body	0.008401	Highly Informative	Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Nucleotidyltransferases	0	Least Informative	Direct
Enzyme Commission (EC)	Lyases	0.00038	Least Informative	Direct
Enzyme Commission (EC)	Isomerases	1	Least Informative	Inherited
Enzyme Commission (EC)	Acting on ester bonds	1	Least Informative	Inherited
Enzyme Commission (EC)	Oxidoreductases	0.005559	Least Informative	Inherited
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	3.708e-15	Moderately Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	7.371e-07	Moderately Informative	Direct
Enzyme Commission (EC)	Hydro-lyases	2.527e-06	Moderately Informative	Direct
Enzyme Commission (EC)	In linear amides	0.2547	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0.05367	Moderately Informative	Inherited
Enzyme Commission (EC)	Diphosphotransferases	2.328e-15	Informative	Direct
Enzyme Commission (EC)	Carbon-nitrogen lyases	2.234e-14	Informative	Direct
Enzyme Commission (EC)	Phosphotransferases with a carboxyl group as accep	8.021e-08	Informative	Direct
Enzyme Commission (EC)	Transferring other groups	0.001969	Informative	Inherited
Enzyme Commission (EC)	Aspartate kinase	0	Highly Informative	Direct
Enzyme Commission (EC)	Chorismate mutase	0	Highly Informative	Direct
Enzyme Commission (EC)	[Protein-PII] uridylyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	Phosphoglycerate dehydrogenase	0	Highly Informative	Direct
Enzyme Commission (EC)	Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase	0	Highly Informative	Direct
Enzyme Commission (EC)	Homoserine dehydrogenase	0	Highly Informative	Direct
Enzyme Commission (EC)	GTP diphosphokinase	0	Highly Informative	Direct
Enzyme Commission (EC)	Prephenate dehydratase	0	Highly Informative	Direct
Enzyme Commission (EC)	Transketolases and transaldolases	1	Highly Informative	Inherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	cognitive disorder	0	Moderately Informative	Direct

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal homeostasis	0	Least Informative	Direct
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.0357	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal hormone level	0	Moderately Informative	Direct
Mammalian Phenotype (MP)	behavior/neurological phenotype	0	Moderately Informative	Direct
Mammalian Phenotype (MP)	respiratory system phenotype	0.00699	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0.0113	Moderately Informative	Inherited
Mammalian Phenotype (MP)	integument phenotype	0.01332	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal heartbeat	3.696e-05	Informative	Direct
Mammalian Phenotype (MP)	abnormal respiration	0.0007696	Informative	Direct
Mammalian Phenotype (MP)	abnormal touch/ nociception	0.004339	Informative	Inherited
Mammalian Phenotype (MP)	abnormal serotonin level	0	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal thermal nociception	3.657e-06	Highly Informative	Direct

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)

	FP term	FDR (all)	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	behavior defective	0	Moderately Informative	Direct
Fly Phenotype (FP)	feeding behavior defective	0	Highly Informative	Direct

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	megasporophyll	0.0001751	Least Informative	Direct
Plant ANatomical entity (PAN)	leaf lamina	0.0001769	Least Informative	Direct
Plant ANatomical entity (PAN)	gynoecium	0.0001893	Least Informative	Direct
Plant ANatomical entity (PAN)	androecium	0.0002525	Least Informative	Direct
Plant ANatomical entity (PAN)	portion of meristem tissue	0.0005273	Least Informative	Direct
Plant ANatomical entity (PAN)	microsporophyll	0.002559	Least Informative	Inherited
Plant ANatomical entity (PAN)	vascular leaf	0.01628	Least Informative	Inherited
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	7.974e-05	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0.0001954	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0.0002153	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0.0003741	Least Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	Least Informative	Direct
Enzyme Commission (EC)	Lyases	0.0008516	Least Informative	Direct
Enzyme Commission (EC)	Oxidoreductases	0.00535	Least Informative	Inherited
Enzyme Commission (EC)	Hydrolases	1	Least Informative	Inherited
Enzyme Commission (EC)	Nucleotidyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on the CH-OH group of donors	4.732e-05	Moderately Informative	Direct
Enzyme Commission (EC)	Carbon-oxygen lyases	0.104	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Isomerases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen	1.023e-14	Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1.758e-07	Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	6.545e-05	Informative	Direct
Enzyme Commission (EC)	In linear amides	0.242	Informative	Inherited
Enzyme Commission (EC)	Intramolecular transferases (mutases)	0.3088	Informative	Inherited
Enzyme Commission (EC)	[Protein-PII] uridylyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	Ammonia-lyases	0	Highly Informative	Direct
Enzyme Commission (EC)	Diphosphoric monoester hydrolases	9.49e-16	Highly Informative	Direct
Enzyme Commission (EC)	Diphosphotransferases	2.359e-15	Highly Informative	Direct
Enzyme Commission (EC)	Phosphotransferases with a carboxyl group as acceptor	6.061e-08	Highly Informative	Direct
Enzyme Commission (EC)	Transketolases and transaldolases	1	Highly Informative	Inherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Transport	0	Least Informative	Direct
Biological process	Amino-acid biosynthesis	0	Moderately Informative	Direct
Biological process	Transcription regulation	0	Moderately Informative	Direct
Biological process	Nitrogen fixation	0	Informative	Direct
Biological process	Amino-acid transport	0	Highly Informative	Direct
Biological process	Branched-chain amino acid biosynthesis	9.192e-16	Highly Informative	Direct
Biological process	Diaminopimelate biosynthesis	2.953e-10	Highly Informative	Direct
Biological process	Phenylalanine catabolism	4.444e-09	Highly Informative	Direct
Biological process	Aromatic amino acid biosynthesis	0.08669	Highly Informative	Inherited
Cellular component	Membrane	0	Least Informative	Direct
Cellular component	Cell membrane	0	Moderately Informative	Direct
Cellular component	Cell inner membrane	3.755e-07	Informative	Direct
Coding sequence diversity	Alternative initiation	4.898e-09	Moderately Informative	Direct
Domain	Transit peptide	0.000528	Moderately Informative	Direct
Molecular function	Nucleotide-binding	0	Least Informative	Direct
Molecular function	DNA-binding	7.901e-14	Moderately Informative	Direct
Molecular function	Nickel	0	Informative	Direct
Post-translational modification	Hydrolase	0	Least Informative	Direct
Post-translational modification	Transferase	8.25e-13	Least Informative	Direct
Post-translational modification	Nucleotidyltransferase	0	Moderately Informative	Direct
Post-translational modification	Oxidoreductase	0.3689	Moderately Informative	Inherited
Post-translational modification	Monooxygenase	3.95e-12	Highly Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	amino-acid metabolism	0	Least Informative	Direct
UniPathway (UP)	aromatic compound metabolism	5.158e-13	Least Informative	Direct
UniPathway (UP)	proteinogenic amino-acid biosynthesis	0	Moderately Informative	Direct
UniPathway (UP)	aromatic compound biosynthesis	0	Moderately Informative	Direct
UniPathway (UP)	nucleotide metabolism	0.0001938	Moderately Informative	Direct
UniPathway (UP)	amine and polyamine metabolism	0.09305	Moderately Informative	Inherited
UniPathway (UP)	purine metabolism	0.4696	Moderately Informative	Inherited
UniPathway (UP)	amino-acid degradation	0.5941	Moderately Informative	Inherited
UniPathway (UP)	metabolic intermediate biosynthesis	1	Moderately Informative	Inherited
UniPathway (UP)	L-isoleucine biosynthesis	0	Informative	Direct
UniPathway (UP)	L-methionine biosynthesis	4.87e-13	Informative	Direct
UniPathway (UP)	aromatic amino-acid biosynthesis	9.867e-08	Informative	Direct
UniPathway (UP)	L-lysine biosynthesis	1.884e-05	Informative	Direct
UniPathway (UP)	amine and polyamine biosynthesis	0.0005053	Informative	Direct
UniPathway (UP)	tryptophan metabolism	0.9524	Informative	Inherited
UniPathway (UP)	L-lysine biosynthesis via DAP pathway	0	Highly Informative	Direct
UniPathway (UP)	L-threonine biosynthesis	0	Highly Informative	Direct
UniPathway (UP)	prephenate biosynthesis	0	Highly Informative	Direct
UniPathway (UP)	L-phenylalanine biosynthesis	0	Highly Informative	Direct
UniPathway (UP)	ppGpp biosynthesis	0	Highly Informative	Direct
UniPathway (UP)	L-tyrosine biosynthesis	4.007e-14	Highly Informative	Direct
UniPathway (UP)	L-tryptophan degradation	1.86e-12	Highly Informative	Direct
UniPathway (UP)	L-serine biosynthesis	4.481e-10	Highly Informative	Direct
UniPathway (UP)	catecholamine biosynthesis	1.437e-09	Highly Informative	Direct
UniPathway (UP)	L-valine biosynthesis	8.284e-08	Highly Informative	Direct
UniPathway (UP)	L-phenylalanine degradation	8.124e-06	Highly Informative	Direct

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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ACT-like superfamily