Dimeric alpha+beta barrel superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a+b) [ 53931] (376)
Fold:	Ferredoxin-like [ 54861] (59)
Superfamily:	Dimeric alpha+beta barrel [ 54909] (23)
Families:	Actinorhodin biosynthesis monooxygenase ActVa-Orf6 [ 82666]
	Plant stress-induced protein [ 89927] (3)
	PG130-like [ 102959] (5)
	Hypothetical protein YjcS [ 102962]
	YciI-like [ 102965]
	Muconalactone isomerase, MLI [ 54910]
	Lrp/AsnC-like transcriptional regulator C-terminal domain [ 69733] (4)
	Polyketide synthesis cyclase [ 110959]
	DGPF domain (Pfam 04946) [ 110962]
	Chlorite dismutase-like [ 110965] (2)
	PA3566-like [ 110970] (5)
	Hypothetical protein YdhR [ 117940]
	NIPSNAP [ 117943] (2)
	Dyp-type peroxidase-like [ 143265] (3)
	EthD-like [ 143272]
	Atu0297-like [ 143275]
	SOR-like [ 143278]
	YbaA-like [ 160289]
	MmlI-like [ 160292]
	Marine metagenome family DABB2 [ 160295]
	YiiL-like [ 160298]
	Marine metagenome family DABB1 [ 160301] (2)
	Marine metagenome family DABB3 [ 160306]

Superfamily statistics

	Genomes (2,091)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	22,782	66,440	47
Proteins	21,660	64,669	47

Functional annotation

General category	Metabolism
Detailed category	Secondary metabolism

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	single-organism metabolic process	1	Least Informative	Inherited
Biological Process (BP)	pigment metabolic process	0.0006913	Informative	Direct
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	heterocyclic compound binding	1	Moderately Informative	Inherited
Molecular Function (MF)	organic cyclic compound binding	1	Moderately Informative	Inherited
Molecular Function (MF)	oxidoreductase activity	0.2042	Moderately Informative	Inherited
Molecular Function (MF)	peroxidase activity	9.274e-08	Highly Informative	Direct
Molecular Function (MF)	heme binding	1.401e-06	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Isomerases	0	Least Informative	Direct
Enzyme Commission (EC)	Oxidoreductases	0.2323	Least Informative	Inherited
Enzyme Commission (EC)	Racemases and epimerases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	5.545e-15	Moderately Informative	Direct
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0	Informative	Direct
Enzyme Commission (EC)	Miscellaneous (requires further characterization)	0	Informative	Direct
Enzyme Commission (EC)	Transposing C==C bonds	1.622e-10	Informative	Direct

Document: EC annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	central nervous system	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	sensory system	0	Moderately Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot apex	0	Least Informative	Direct
Plant ANatomical entity (PAN)	shoot internode	0	Least Informative	Direct
Plant ANatomical entity (PAN)	root	0	Least Informative	Direct
Plant ANatomical entity (PAN)	plant embryo	0	Least Informative	Direct
Plant ANatomical entity (PAN)	seed	0	Least Informative	Direct
Plant ANatomical entity (PAN)	portion of meristem tissue	0	Least Informative	Direct
Plant ANatomical entity (PAN)	vascular leaf	0	Least Informative	Direct
Plant ANatomical entity (PAN)	megasporophyll	0	Least Informative	Direct
Plant ANatomical entity (PAN)	microsporophyll	0	Least Informative	Direct
Plant ANatomical entity (PAN)	sepal	0	Least Informative	Direct
Plant ANatomical entity (PAN)	petal	0	Least Informative	Direct
Plant ANatomical entity (PAN)	stem	0	Least Informative	Direct
Plant ANatomical entity (PAN)	pedicel	0	Least Informative	Direct
Plant ANatomical entity (PAN)	androecium	0	Least Informative	Direct
Plant ANatomical entity (PAN)	gynoecium	0	Least Informative	Direct
Plant ANatomical entity (PAN)	leaf lamina	0	Least Informative	Direct
Plant ANatomical entity (PAN)	collective leaf structure	0	Least Informative	Direct
Plant ANatomical entity (PAN)	stalk	0	Least Informative	Direct
Plant ANatomical entity (PAN)	sporangium	0	Least Informative	Direct
Plant ANatomical entity (PAN)	phyllome apex	0	Least Informative	Direct
Plant ANatomical entity (PAN)	microgametophyte	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	C globular stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	Least Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0.451	Least Informative	Inherited
Enzyme Commission (EC)	Isomerases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acyltransferases	0.2611	Moderately Informative	Inherited
Enzyme Commission (EC)	Racemases and epimerases	0	Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen	1.198e-09	Informative	Direct
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	Informative	Inherited
Enzyme Commission (EC)	Miscellaneous (requires further characterization)	0	Highly Informative	Direct
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0	Highly Informative	Direct
Enzyme Commission (EC)	Transposing C==C bonds	1.225e-09	Highly Informative	Direct
Enzyme Commission (EC)	Acyl groups converted into alkyl on transfer	3.675e-05	Highly Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Carbohydrate metabolism	0	Moderately Informative	Direct
Biological process	Transcription regulation	0	Moderately Informative	Direct
Biological process	Aromatic hydrocarbons catabolism	3.651e-09	Informative	Direct
Biological process	Rhamnose metabolism	0	Highly Informative	Direct
Cellular component	Cytoplasm	1.768e-07	Least Informative	Direct
Cellular component	Periplasm	6.553e-08	Informative	Direct
Molecular function	Metal-binding	0.7767	Least Informative	Inherited
Molecular function	DNA-binding	0	Moderately Informative	Direct
Molecular function	Iron	1.069e-07	Moderately Informative	Direct
Molecular function	Heme	0	Informative	Direct
Post-translational modification	Isomerase	0	Moderately Informative	Direct
Post-translational modification	Activator	6.484e-09	Moderately Informative	Direct
Post-translational modification	Oxidoreductase	2.768e-06	Moderately Informative	Direct
Post-translational modification	Repressor	0.0003593	Moderately Informative	Direct
Post-translational modification	Peroxidase	1.356e-13	Highly Informative	Direct
Post-translational modification	Monooxygenase	2.075e-11	Highly Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	carbohydrate metabolism	0	Least Informative	Direct
UniPathway (UP)	aromatic compound metabolism	1	Least Informative	Inherited
UniPathway (UP)	secondary metabolite metabolism	0.001032	Moderately Informative	Inherited
UniPathway (UP)	polyketide biosynthesis	3.386e-08	Informative	Direct
UniPathway (UP)	antibiotic biosynthesis	3.254e-06	Informative	Direct
UniPathway (UP)	L-rhamnose metabolism	0	Highly Informative	Direct
UniPathway (UP)	beta-ketoadipate pathway	0	Highly Informative	Direct

Document: UP annotation of SCOP domains

InterPro annotation

Cross references IPR011008 SSF54909 Protein matches

Abstract
Dimeric alpha-beta barrel domains exhibit an alpha+beta sandwich fold with an antiparallel beta sheet that forms a closed barrel. These domains dimerise through the beta-sheet, and in some cases these dimers may assemble into higher oligomers. Domains with this structure are found in proteins from several different families, including bacterial actinorhodin biosynthesis monooxygenase (ActVa-Orf6), which catalyses the oxidation of an aromatic intermediate of the actinorhodin biosynthetic pathway [ PubMed 12514126]; bacterial muconalactone isomerase, a decamer composed of five dimers [ PubMed 2926818]; and the C-terminal domain of archaeal LprA, a member of the Lrp/AqsnC family of transcription regulators [ PubMed 11230123].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 41 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Dimeric alpha+beta barrel domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 41 hidden Markov models representing the Dimeric alpha+beta barrel superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Dimeric alpha+beta barrel superfamily