SUPERFAMILY 1.75 HMM library and genome assignments server

GroEL-intermediate domain like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   GroEL-intermediate domain like [ 54848]
Superfamily:   GroEL-intermediate domain like [ 54849] (2)
Families:   GroEL-like chaperone, intermediate domain [ 54850]
  Group II chaperonin (CCT, TRIC), intermediate domain [ 54853]


Superfamily statistics
Genomes (3,011) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,831 26,660 29
Proteins 9,640 26,460 29


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000000000107 Least Informative Direct
Biological Process (BP) localization 0.000000006325 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000004481 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.0001058 Moderately Informative Direct
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00005573 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.00004762 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000000001668 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000885 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.714 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4438 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3451 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2687 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.007006 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.09376 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.03299 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.06321 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.00007343 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000007837 Informative Direct
Biological Process (BP) hexose metabolic process 0.00001649 Informative Direct
Biological Process (BP) sexual reproduction 0.0000004483 Informative Direct
Biological Process (BP) single organism reproductive process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0003401 Informative Direct
Biological Process (BP) cell cycle process 0.06554 Informative Inherited
Biological Process (BP) organelle assembly 0.1017 Informative Inherited
Biological Process (BP) response to inorganic substance 0.02273 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.001587 Informative Inherited
Biological Process (BP) microtubule-based process 0.001224 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.7178 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6068 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.1321 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.001767 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01793 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.002992 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.004954 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.002973 Informative Inherited
Biological Process (BP) organelle fission 0.03618 Informative Inherited
Biological Process (BP) cell division 0.01686 Informative Inherited
Biological Process (BP) nuclear division 0.0002992 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.000004067 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) spindle organization 0.000127 Highly Informative Direct
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0000009361 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00002374 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00003732 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00002167 Highly Informative Direct
Biological Process (BP) response to heat 0.0000001161 Highly Informative Direct
Biological Process (BP) fertilization 0 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.00008456 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.00003268 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000002072 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0002022 Highly Informative Direct
Molecular Function (MF) binding 0.000003478 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.7406 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.4977 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.2735 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.2115 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.00114 Informative Inherited
Molecular Function (MF) nucleotide binding 0.04364 Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0.007566 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.005734 Informative Inherited
Molecular Function (MF) ATP binding 0.0006791 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.00007712 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000000002101 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.001244 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000004792 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.01552 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01664 Moderately Informative Inherited
Cellular Component (CC) secretory granule 0.000000000083 Informative Direct
Cellular Component (CC) plastid 0.3921 Informative Inherited
Cellular Component (CC) chloroplast stroma 0.0001493 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)embryonic lethality0InformativeDirect
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000002487Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00006128Least InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.0000000001645Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0000000001818Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000001073Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0000002173Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0000005425Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000001838Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.002616Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.0229Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.2232Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000000152InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.00000000000196InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00000000004552InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0000000002187InformativeDirect
Worm Phenotype (WP)receptor mediated endocytosis defective0.0000000869InformativeDirect
Worm Phenotype (WP)pigmentation variant0.0000002813InformativeDirect
Worm Phenotype (WP)transgene expression increased0.000000441InformativeDirect
Worm Phenotype (WP)protruding vulva0.0000005867InformativeDirect
Worm Phenotype (WP)sick0.0001812InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.09631InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.1336InformativeInherited
Worm Phenotype (WP)cell division variant0.1777InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7481InformativeInherited
Worm Phenotype (WP)oocytes small0.00000000000000187Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000004889Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.000000655Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00004001Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0006864Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0.0109Least InformativeInherited
Zebrafish Anatomy (ZA)solid compound organ0.0008998Moderately InformativeDirect
Zebrafish Anatomy (ZA)liver and biliary system0.0009177Moderately InformativeDirect
Zebrafish Anatomy (ZA)immune system0.002578Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.07897Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.2518Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001547Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.04976Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.00002073InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.00008149InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.008532InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.00004337Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000002573InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.000184InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide0.00000009907Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.0003225Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL-intermediate domain like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the GroEL-intermediate domain like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]