SUPERFAMILY 1.75 HMM library and genome assignments server


GroEL-intermediate domain like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   GroEL-intermediate domain like [ 54848]
Superfamily:   GroEL-intermediate domain like [ 54849] (2)
Families:   GroEL-like chaperone, intermediate domain [ 54850]
  Group II chaperonin (CCT, TRIC), intermediate domain [ 54853]


Superfamily statistics
Genomes (3,002) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,631 0 29
Proteins 9,450 0 29


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0001512 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.259e-12 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 7.227e-05 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.556 Least Informative Inherited
Biological Process (BP) reproduction 5.546e-15 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0005134 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0006925 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0005106 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.06755 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4127 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.07608 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.06968 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.004744 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3224 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2536 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4322 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 0.0009827 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0001349 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 1.306e-05 Informative Direct
Biological Process (BP) hexose metabolic process 8.476e-05 Informative Direct
Biological Process (BP) sexual reproduction 7.994e-10 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 4.433e-07 Informative Direct
Biological Process (BP) single organism reproductive process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0002856 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0006611 Informative Direct
Biological Process (BP) response to inorganic substance 0.02914 Informative Inherited
Biological Process (BP) microtubule-based process 0.01006 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.695 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.5757 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.002949 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.001913 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.003562 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01291 Informative Inherited
Biological Process (BP) cell cycle process 0.2583 Informative Inherited
Biological Process (BP) protein complex assembly 0.3571 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.1007 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 2.225e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 6.677e-05 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 3.929e-05 Highly Informative Direct
Biological Process (BP) response to heat 8.015e-07 Highly Informative Direct
Biological Process (BP) fertilization 0 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 9.882e-05 Highly Informative Direct
Biological Process (BP) ATP metabolic process 3.481e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 5.877e-05 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 1.058e-06 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.00028 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.1833 Highly Informative Inherited
Molecular Function (MF) binding 6.351e-05 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.8364 Least Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.002091 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.0001351 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001779 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1.563e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.009372 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01589 Moderately Informative Inherited
Cellular Component (CC) secretory granule 7.658e-06 Informative Direct
Cellular Component (CC) plastid 0.4043 Informative Inherited
Cellular Component (CC) chloroplast stroma 0.0002147 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) sperm part 2.434e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant2.487e-06Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant6.128e-05Least InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant1.645e-10Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal1.818e-10Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.073e-07Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant2.173e-07Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant5.425e-07Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect1.838e-06Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.002616Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.0229Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.2232Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb1.52e-12InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant1.96e-12InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant4.552e-11InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant2.187e-10InformativeDirect
Worm Phenotype (WP)receptor mediated endocytosis defective8.69e-08InformativeDirect
Worm Phenotype (WP)pigmentation variant2.813e-07InformativeDirect
Worm Phenotype (WP)transgene expression increased4.41e-07InformativeDirect
Worm Phenotype (WP)protruding vulva5.867e-07InformativeDirect
Worm Phenotype (WP)sick0.0001812InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.09631InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.1336InformativeInherited
Worm Phenotype (WP)cell division variant0.1777InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7481InformativeInherited
Worm Phenotype (WP)oocytes small1.87e-15Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate4.889e-08Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses6.55e-07Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant4.001e-05Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0006864Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0.01134Least InformativeInherited
Zebrafish Anatomy (ZA)liver0.0009248Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.07786Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.2504Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001535Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.04728Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle2.069e-05InformativeDirect
Xenopus ANatomical entity (XAN)hematological system7.929e-05InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00813InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region4.513e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage2.573e-09InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.000184InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide9.79e-08Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.0002711Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL-intermediate domain like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the GroEL-intermediate domain like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]