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Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   dsRBD-like [ 54767] (5)
Superfamily:   Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain [ 54782]
Families:   Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain [ 54783]


Superfamily statistics
Genomes (2,488) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,660 13,587 3
Proteins 2,651 13,580 3


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0000001308 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000002069 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000002446 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000005037 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000001325 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.001056 Least Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000000000008501 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000006484 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000006717 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000000000006731 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000000002143 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000003085 Moderately Informative Direct
Biological Process (BP) pigment metabolic process 0 Informative Direct
Biological Process (BP) pigment biosynthetic process 0.000000000001578 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.00002915 Highly Informative Direct
Biological Process (BP) heme metabolic process 0.00004597 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000000005675 Least Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processHeme biosynthesis0.000000000005898Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000860 SSF54782 Protein matches
Abstract

This entry represents hydroxymethylbilane synthase (or porphobilinogen deaminase, ), which functions during the second stage of tetrapyrrole biosynthesis. This enzyme catalyses the polymerisation of four PBG molecules into the tetrapyrrole structure, preuroporphyrinogen, with the concomitant release of four molecules of ammonia. This enzyme uses a unique dipyrro-methane cofactor made from two molecules of PBG, which is covalently attached to a cysteine side chain. The tetrapyrrole product is synthesized in an ordered, sequential fashion, by initial attachment of the first pyrrole unit (ring A) to the cofactor, followed by subsequent additions of the remaining pyrrole units (rings B, C, D) to the growing pyrrole chain [PubMed11215515]. The link between the pyrrole ring and the cofactor is broken once all the pyrroles have been added. This enzyme is folded into three distinct domains that enclose a single, large active site that makes use of an aspartic acid as its one essential catalytic residue, acting as a general acid/base during catalysis [PubMed12555854, PubMed1522882]. A deficiency of hydroxymethylbilane synthase is implicated in the neuropathic disease, Acute Intermittent Porphyria (AIP) [PubMed16935474].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]