SUPERFAMILY 1.75 HMM library and genome assignments server

CO dehydrogenase molybdoprotein N-domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   alpha/beta-Hammerhead [ 54664] (5)
Superfamily:   CO dehydrogenase molybdoprotein N-domain-like [ 54665]
Families:   CO dehydrogenase molybdoprotein N-domain-like [ 54666] (6)


Superfamily statistics
Genomes (1,335) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,017 15,005 11
Proteins 3,999 14,994 11


Functional annotation
General category Metabolism
Detailed category E- transfer

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000003621 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0004959 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.1242 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01409 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01146 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5473 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.000001215 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0003328 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00000000001072 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00002028 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00000003699 Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Molecular Function (MF) binding 0.06088 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000000009637 Moderately Informative Direct
Molecular Function (MF) anion binding 0.2568 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00000000000004367 Informative Direct
Molecular Function (MF) electron carrier activity 0.00000002318 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.0000000000002142 Highly Informative Direct
Molecular Function (MF) metal cluster binding 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0000001077Moderately InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.000000001028Highly InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.00000000000003773InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.00000000009635Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000003733Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0.0002114Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0.01047Least InformativeInherited
UniPathway (UP)purine metabolism0.0002593Moderately InformativeDirect
UniPathway (UP)purine degradation0.00000000001165InformativeDirect
UniPathway (UP)purine base metabolism0.00000003291InformativeDirect
UniPathway (UP)purine biosynthesis via salvage pathway0.000001249InformativeDirect
UniPathway (UP)hypoxanthine degradation0.000000000000004228Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000674 SSF54665 Protein matches
Abstract Aldehyde oxidase catalyzes the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. The enzyme is a homodimer, and requires FAD, molybdenum and two 2FE-2S clusters as cofactors. Xanthine dehydrogenase catalyzes the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase activity too. The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulphhydryl groups.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CO dehydrogenase molybdoprotein N-domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the CO dehydrogenase molybdoprotein N-domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]