SUPERFAMILY 1.75 HMM library and genome assignments server


CBS-domain pair superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Families:   CBS-domain pair [ 54632] (20)


Superfamily statistics
Genomes (2,472) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 27,745 68,771 31
Proteins 25,123 66,054 26


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 1.779e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 0.5537 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1197 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) ion transport 1.274e-08 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.9375 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.003425 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.1567 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.6206 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2971 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.07158 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.05036 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.02874 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01239 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2471 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3134 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3227 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.5519 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.08506 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.5559 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2933 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1987 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.8072 Moderately Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 2.522e-07 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 5.45e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 1.404e-05 Informative Direct
Biological Process (BP) transmembrane transport 0.0001625 Informative Direct
Biological Process (BP) sulfur amino acid metabolic process 0.0003141 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0003651 Informative Direct
Biological Process (BP) response to external stimulus 0.0003914 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0005647 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0009396 Informative Direct
Biological Process (BP) purine nucleoside metabolic process 0.1905 Informative Inherited
Biological Process (BP) ribonucleoside metabolic process 0.008115 Informative Inherited
Biological Process (BP) regulation of response to stress 0.001133 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.00544 Informative Inherited
Biological Process (BP) metal ion transport 0.3604 Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.006065 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.001762 Informative Inherited
Biological Process (BP) anion transport 0.06754 Informative Inherited
Biological Process (BP) autophagy 1.021e-11 Highly Informative Direct
Biological Process (BP) cellular response to starvation 1.155e-10 Highly Informative Direct
Biological Process (BP) lipid homeostasis 5.546e-09 Highly Informative Direct
Biological Process (BP) maintenance of location 2.628e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 2.653e-06 Highly Informative Direct
Biological Process (BP) lipopolysaccharide biosynthetic process 3.697e-06 Highly Informative Direct
Biological Process (BP) inorganic anion transport 9.724e-05 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.0007857 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.00337 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.002078 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8731 Least Informative Inherited
Molecular Function (MF) transporter activity 1.084e-10 Moderately Informative Direct
Molecular Function (MF) anion binding 0.2274 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.1213 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.3065 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.294 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.05857 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 8.372e-12 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 7.816e-06 Informative Direct
Molecular Function (MF) nucleotide binding 0.04487 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.005539 Informative Inherited
Molecular Function (MF) kinase activity 0.01463 Informative Inherited
Molecular Function (MF) carbon-oxygen lyase activity 0.00347 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2.09e-06 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0008957 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.002256 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.005911 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.2832 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.08559 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.09812 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1649 Moderately Informative Inherited
Cellular Component (CC) endosome 6.839e-05 Informative Direct
Cellular Component (CC) vesicle membrane 0.0001628 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3306Least InformativeInherited
Enzyme Commission (EC)Lyases0.239Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006567Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001371Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003148InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1026Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3021Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.1431Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.0001351InformativeDirect
Phenotypic Abnormality (PA)Abnormality of renal physiology0.2295InformativeInherited
Phenotypic Abnormality (PA)Renal salt wasting4.096e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calcium homeostasis0.0002249Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine cation concentration0.0004534Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2217Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.02902Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.07558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.2165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.003998InformativeInherited
Mammalian Phenotype (MP)abnormal photoreceptor inner segment morphology5.617e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal photoreceptor outer segment morphology8.977e-05Highly InformativeDirect
Mammalian Phenotype (MP)retinal degeneration0.0001089Highly InformativeDirect
Mammalian Phenotype (MP)neurodegeneration0.0009373Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)electrophysiology variant4.398e-12InformativeDirect
Worm Phenotype (WP)nervous system physiology variant4.204e-10Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3168Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.0124Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.14Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.3827Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.008827InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0.003611Highly InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.03117Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0.01036Moderately InformativeInherited
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processFatty acid metabolism3.394e-07InformativeDirect
Biological processLipid biosynthesis0.0005665InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processVoltage-gated channel0Highly InformativeDirect
Biological processCysteine biosynthesis1.259e-09Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0004229Highly InformativeDirect
Biological processAmino-acid transport0.000576Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus5.075e-05Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.0006452Least InformativeDirect
DiseaseDisease mutation8.511e-08Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionCobalt1.306e-05InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationOxidoreductase4.828e-08Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationUbl conjugation0.0006617Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect
UniPathway (UP)L-cysteine metabolism1.516e-14Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the CBS-domain pair superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]