SUPERFAMILY 1.75 HMM library and genome assignments server


CBS-domain pair superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Families:   CBS-domain pair [ 54632] (20)


Superfamily statistics
Genomes (3,229) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 35,224 147,001 31
Proteins 32,084 143,363 26


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 6.339e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 0.572 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.212 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 1.41e-07 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.002202 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.009085 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2621 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01611 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5659 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2406 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.05215 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.05236 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.4777 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1127 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.3176 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.5397 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.54 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.5343 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.7743 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01182 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.3447 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5333 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6689 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.746 Moderately Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 2.716e-05 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0003827 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 9.01e-05 Informative Direct
Biological Process (BP) lipid localization 5.298e-09 Informative Direct
Biological Process (BP) response to nutrient levels 7.179e-10 Informative Direct
Biological Process (BP) regulation of ion transport 1.165e-09 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0001678 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 2.954e-05 Informative Direct
Biological Process (BP) transmembrane transport 0.0005305 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.67e-06 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 5.593e-05 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.08265 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.01766 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.007685 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.004474 Informative Inherited
Biological Process (BP) metal ion transport 0.3511 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.4921 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.5464 Informative Inherited
Biological Process (BP) anion transport 0.0316 Informative Inherited
Biological Process (BP) phosphorylation 0.04843 Informative Inherited
Biological Process (BP) protein phosphorylation 0.0006308 Highly Informative Direct
Biological Process (BP) autophagy 7.457e-11 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 7.626e-07 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 5.086e-05 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 8.803e-07 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate biosynthetic process 3.092e-07 Highly Informative Direct
Biological Process (BP) cellular response to starvation 4.209e-10 Highly Informative Direct
Biological Process (BP) inorganic anion transport 6.658e-05 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 7.656e-05 Highly Informative Direct
Biological Process (BP) maintenance of location 2.705e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 5.891e-06 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.0004837 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.001916 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.7047 Least Informative Inherited
Molecular Function (MF) transporter activity 2.902e-10 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1763 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.06174 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.1285 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.2708 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.01961 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 4.9e-13 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1.909e-07 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.0001003 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.008219 Informative Inherited
Molecular Function (MF) nucleotide binding 0.02709 Informative Inherited
Molecular Function (MF) kinase activity 0.004003 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.001249 Informative Inherited
Molecular Function (MF) protein kinase activity 4.481e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4.456e-08 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.001441 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.001628 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.2223 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.1457 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.4757 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0001256 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3306Least InformativeInherited
Enzyme Commission (EC)Lyases0.239Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006567Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001371Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003148InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09944Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.0001293InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calcium homeostasis0.0002282Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.02954Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2867Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4502Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.001266Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.04922Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.153Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1883Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.005211InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.3007InformativeInherited
Mammalian Phenotype (MP)abnormal renal protein reabsorption1.253e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal photoreceptor inner segment morphology8.07e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal photoreceptor outer segment morphology0.0001155Highly InformativeDirect
Mammalian Phenotype (MP)retinal degeneration0.0001724Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)electrophysiology variant4.398e-12InformativeDirect
Worm Phenotype (WP)nervous system physiology variant4.204e-10Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3114Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.01146Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.1323Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.3588Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.007832InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0.003191Highly InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.02971Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0.01193Moderately InformativeInherited
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processFatty acid metabolism3.603e-07InformativeDirect
Biological processLipid biosynthesis0.000623InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processCysteine biosynthesis1.414e-09Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0004449Highly InformativeDirect
Biological processAmino-acid transport0.0005495Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus7.443e-05Moderately InformativeDirect
Coding sequence diversityAlternative splicing1.128e-05Least InformativeDirect
DiseaseDisease mutation2.332e-07Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.008805Least InformativeInherited
DomainCBS domain0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionCobalt6.815e-06InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationOxidoreductase8.132e-08Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel1.762e-15Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism3.133e-05Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis6.487e-06Moderately InformativeDirect
UniPathway (UP)L-cysteine metabolism0InformativeDirect
UniPathway (UP)L-cysteine biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the CBS-domain pair superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]