SUPERFAMILY 1.75 HMM library and genome assignments server

CBS-domain pair superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Families:   CBS-domain pair [ 54632] (20)


Superfamily statistics
Genomes (3,230) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 35,267 147,001 31
Proteins 32,124 143,363 26


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000008349 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5668 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9392 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.000000006053 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.1392 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01189 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.3277 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.5252 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01138 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01473 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.02167 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.009239 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.03146 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.7451 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.5749 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.8064 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.3651 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.5798 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.003682 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5372 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.579 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2661 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.006425 Moderately Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.00002703 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0003708 Informative Direct
Biological Process (BP) anion transport 0.0003728 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00008683 Informative Direct
Biological Process (BP) lipid localization 0.000000005744 Informative Direct
Biological Process (BP) response to nutrient levels 0.000000001225 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000001414 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0003805 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00002215 Informative Direct
Biological Process (BP) cellular response to external stimulus 0.000000005819 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00000162 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.00005418 Informative Direct
Biological Process (BP) ion transmembrane transport 0.1156 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.01572 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.1149 Informative Inherited
Biological Process (BP) metal ion transport 0.5402 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.582 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.5594 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.004675 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.007503 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.004363 Informative Inherited
Biological Process (BP) lipopolysaccharide metabolic process 0.0000007354 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00005538 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate biosynthetic process 0.0000002976 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0.00001024 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00007332 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0009661 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000003792 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000008309 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.0005381 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.001216 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8949 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0000000002673 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.1104 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.05392 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.1289 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.178 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.2707 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.01887 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.06452 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.0000000000006354 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0000001831 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.0001198 Informative Direct
Molecular Function (MF) nucleotide binding 0.1177 Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0.008015 Informative Inherited
Molecular Function (MF) kinase activity 0.003748 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.001189 Informative Inherited
Molecular Function (MF) protein kinase activity 0.00004103 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.0000002462 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.00000004233 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.001522 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.09515 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.2252 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.02898 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.4828 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0001257 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3306Least InformativeInherited
Enzyme Commission (EC)Lyases0.239Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006567Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001371Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003148InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09928Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.0001277InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calcium homeostasis0.0002256Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.02946Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.3772Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3797Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.00252Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.04023Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.07083Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1582Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1923Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.007473InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.2997InformativeInherited
Mammalian Phenotype (MP)abnormal renal protein reabsorption0.000001262Highly InformativeDirect
Mammalian Phenotype (MP)abnormal photoreceptor inner segment morphology0.00001204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal photoreceptor outer segment morphology0.000179Highly InformativeDirect
Mammalian Phenotype (MP)retinal degeneration0.0002506Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)electrophysiology variant0.000000000004398InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0000000004204Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3101Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.01139Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.1315Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.3581Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.007795InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0.003175Highly InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.02973Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.008093Least InformativeInherited
Drugbank ATC_code (DB)blood and blood forming organs0.01104Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.03963Least InformativeInherited
Drugbank ATC_code (DB)other analgesics and antipyretics0.0005481Moderately InformativeDirect
Drugbank ATC_code (DB)stomatological preparations0.003226Moderately InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)acetylsalicylic acid0.000001864InformativeDirect
Drugbank ATC_code (DB)acetylsalicylic acid0.000001864InformativeDirect
Drugbank ATC_code (DB)other agents for local oral treatment0.00003444InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0.01219Moderately InformativeInherited
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processFatty acid metabolism0.0000003688InformativeDirect
Biological processLipid biosynthesis0.0006388InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processCysteine biosynthesis0.000000001443Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0004506Highly InformativeDirect
Biological processAmino-acid transport0.0006297Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00007941Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00002843Least InformativeDirect
DiseaseDisease mutation0.0000002657Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.009866Least InformativeInherited
DomainCBS domain0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionCobalt0.000006943InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationOxidoreductase0.00000009266Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0.00000000000002202Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect
UniPathway (UP)L-cysteine metabolism0.00000000000001623Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the CBS-domain pair superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]