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• Structural
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Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001

	GO term	FDR (singleton)	FDR (all)	IC level	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	positive regulation of adaptive immune response based on somatic recombination of immune receptors b	0	0	2.222	--	DIRECT
Biological Process (BP)	positive regulation of leukocyte mediated immunity	0	0	2.222	--	DIRECT
Biological Process (BP)	positive regulation of cell killing	0	0	2.398	--	DIRECT
Biological Process (BP)	regulation of leukocyte mediated immunity	0	0	1.854	--	DIRECT
Biological Process (BP)	regulation of leukocyte mediated cytotoxicity	0	0	2.398	--	DIRECT
Biological Process (BP)	regulation of adaptive immune response	0	2.076e-15	2.097	--	DIRECT
Biological Process (BP)	positive regulation of T cell mediated immunity	0	8.433e-13	2.222	--	DIRECT
Biological Process (BP)	regulation of T cell mediated immunity	0	2.181e-11	2.222	--	DIRECT
Biological Process (BP)	positive regulation of leukocyte mediated cytotoxicity	0	5.958e-11	2.398	--	DIRECT
Biological Process (BP)	positive regulation of lymphocyte mediated immunity	0	8.372e-11	2.222	--	DIRECT
Biological Process (BP)	positive regulation of T cell mediated cytotoxicity	0	2.332e-10	2.398	--	DIRECT
Biological Process (BP)	antigen processing and presentation of peptide antigen	0	1.444e-08	2.222	--	DIRECT
Biological Process (BP)	regulation of T cell mediated cytotoxicity	0	6.886e-08	2.398	--	DIRECT
Biological Process (BP)	ear development	9.05e-15	0	2.222	--	DIRECT
Biological Process (BP)	positive regulation of immune response	1.632e-11	0	1.796	--	DIRECT
Biological Process (BP)	positive regulation of response to stimulus	2.628e-08	0	1.284	--	DIRECT
Biological Process (BP)	regulation of immune system process	6.14e-08	0	1.398	--	DIRECT
Biological Process (BP)	antigen processing and presentation of endogenous antigen	1.829e-07	0.0004585	2.699	--	DIRECT
Biological Process (BP)	positive regulation of biological process	0.0006619	5.729e-12	0.8182	--	DIRECT
Biological Process (BP)	biological_process	0.01707	2.098e-10	0	--	INHERITED FROM: positive regulation of response to stimulus || immune system process || positive regulation of leukocyte mediated cytotoxicity || positive regulation of T cell mediated cytotoxicity || antigen processing and presentation of peptide antigen || positive regulation of leukocyte mediated immunity || antigen processing and presentation || positive regulation of immune effector process || regulation of immune system process || antigen processing and presentation of endogenous antigen || inner ear development || positive regulation of cell killing || positive regulation of lymphocyte mediated immunity || sensory organ development || regulation of leukocyte mediated immunity || regulation of T cell mediated cytotoxicity || positive regulation of immune response || positive regulation of adaptive immune response based on somatic recombination of immune receptors b || positive regulation of T cell mediated immunity || regulation of immune effector process || positive regulation of adaptive immune response || regulation of T cell mediated immunity || regulation of cell killing || regulation of response to stimulus || regulation of adaptive immune response || positive regulation of immune system process || ear development || positive regulation of biological process || regulation of immune response || regulation of lymphocyte mediated immunity || regulation of leukocyte mediated cytotoxicity
Biological Process (BP)	regulation of biological process	0.009857	0.0001374	0.4486	--	INHERITED FROM: positive regulation of response to stimulus || positive regulation of leukocyte mediated cytotoxicity || regulation of leukocyte mediated immunity || positive regulation of T cell mediated cytotoxicity || regulation of T cell mediated cytotoxicity || positive regulation of leukocyte mediated immunity || positive regulation of immune response || positive regulation of adaptive immune response based on somatic recombination of immune receptors b || positive regulation of T cell mediated immunity || regulation of immune effector process || positive regulation of adaptive immune response || regulation of T cell mediated immunity || regulation of cell killing || positive regulation of immune effector process || regulation of response to stimulus || regulation of adaptive immune response || positive regulation of immune system process || regulation of immune system process || positive regulation of biological process || regulation of immune response || regulation of lymphocyte mediated immunity || positive regulation of cell killing || regulation of leukocyte mediated cytotoxicity || positive regulation of lymphocyte mediated immunity
Biological Process (BP)	biological regulation	0.05557	0	0.4202	--	INHERITED FROM: positive regulation of response to stimulus || positive regulation of leukocyte mediated cytotoxicity || regulation of leukocyte mediated immunity || positive regulation of T cell mediated cytotoxicity || regulation of T cell mediated cytotoxicity || positive regulation of leukocyte mediated immunity || positive regulation of immune response || positive regulation of adaptive immune response based on somatic recombination of immune receptors b || positive regulation of T cell mediated immunity || regulation of immune effector process || positive regulation of adaptive immune response || regulation of T cell mediated immunity || regulation of cell killing || positive regulation of immune effector process || regulation of response to stimulus || regulation of adaptive immune response || positive regulation of immune system process || regulation of immune system process || positive regulation of biological process || regulation of immune response || regulation of lymphocyte mediated immunity || positive regulation of cell killing || regulation of leukocyte mediated cytotoxicity || positive regulation of lymphocyte mediated immunity
Biological Process (BP)	system development	0.0004175	0.221	0.8069	--	INHERITED FROM: sensory organ development || inner ear development || ear development
Biological Process (BP)	multicellular organismal development	0.001714	0.8857	0.7496	--	INHERITED FROM: sensory organ development || inner ear development || ear development
Biological Process (BP)	anatomical structure development	0.002034	0.9655	0.7212	--	INHERITED FROM: sensory organ development || inner ear development || ear development
Biological Process (BP)	single-multicellular organism process	0.007594	1	0.6383	--	INHERITED FROM: sensory organ development || ear development || inner ear development
Biological Process (BP)	single-organism process	0.6427	1	0.3316	--	INHERITED FROM: sensory organ development || ear development || inner ear development
Biological Process (BP)	developmental process	0.01007	1	0.6904	Least Informative	INHERITED FROM: sensory organ development || ear development || inner ear development
Biological Process (BP)	multicellular organismal process	0.02676	1	0.6091	Least Informative	INHERITED FROM: sensory organ development || ear development || inner ear development
Biological Process (BP)	immune system process	2.052e-14	0	1.076	Moderately Informative	DIRECT
Biological Process (BP)	regulation of response to stimulus	4.041e-05	0	0.9914	Moderately Informative	DIRECT
Biological Process (BP)	organ development	3.703e-05	0.001456	0.9355	Moderately Informative	INHERITED FROM: sensory organ development || inner ear development || ear development
Biological Process (BP)	single-organism developmental process	0.0009336	0.8757	0.7645	Moderately Informative	INHERITED FROM: sensory organ development || inner ear development || ear development
Biological Process (BP)	regulation of immune effector process	2.052e-14	4.607e-11	1.658	Informative	DIRECT
Biological Process (BP)	sensory organ development	8.207e-11	0	1.553	Informative	DIRECT
Biological Process (BP)	positive regulation of immune system process	1.288e-10	0	1.62	Informative	DIRECT
Biological Process (BP)	regulation of immune response	1.021e-09	0	1.553	Informative	DIRECT
Biological Process (BP)	positive regulation of immune effector process	0	0	1.921	Highly Informative	DIRECT
Biological Process (BP)	regulation of cell killing	0	0	2.097	Highly Informative	DIRECT
Biological Process (BP)	positive regulation of adaptive immune response	0	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	regulation of lymphocyte mediated immunity	0	0	1.921	Highly Informative	DIRECT
Biological Process (BP)	inner ear development	3.099e-15	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	antigen processing and presentation	4.244e-11	0	2.097	Highly Informative	DIRECT
Biological Process (BP)	regulation of adaptive immune response based on somatic recombination of immune receptors built from	1	0	2.097	Highly Informative	INHERITED FROM: positive regulation of adaptive immune response based on somatic recombination of immune receptors b || positive regulation of T cell mediated cytotoxicity || regulation of T cell mediated immunity || regulation of T cell mediated cytotoxicity || positive regulation of T cell mediated immunity
Cellular Component (CC)	plasma membrane part	1.187e-05	0	1.036	--	DIRECT
Cellular Component (CC)	membrane part	0.0001777	0	0.6842	--	DIRECT
Cellular Component (CC)	cell part	1	1.752e-10	0.08068	--	INHERITED FROM: external side of plasma membrane || plasma membrane part || cell surface
Cellular Component (CC)	cell	1	1.851e-10	0.08068	--	INHERITED FROM: external side of plasma membrane || plasma membrane part || cell surface
Cellular Component (CC)	cell periphery	0.01665	0	0.8256	--	INHERITED FROM: external side of plasma membrane || plasma membrane part
Cellular Component (CC)	cellular_component	0.3635	4.896e-09	0	--	INHERITED FROM: external side of plasma membrane || membrane part || plasma membrane part || cell surface
Cellular Component (CC)	membrane	0.03912	0	0.5731	Least Informative	INHERITED FROM: external side of plasma membrane || membrane part || plasma membrane part
Cellular Component (CC)	plasma membrane	0.007935	0	0.9734	Moderately Informative	INHERITED FROM: external side of plasma membrane || plasma membrane part
Cellular Component (CC)	cell surface	2.718e-06	0	1.542	Informative	DIRECT
Cellular Component (CC)	external side of plasma membrane	0.0003179	0	1.94	Highly Informative	DIRECT

Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001

	GO term	FDR (all)	IC level	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	positive regulation of adaptive immune response based on somatic recombination of immune receptors b	0	2.222	--	DIRECT
Biological Process (BP)	positive regulation of leukocyte mediated immunity	0	2.222	--	DIRECT
Biological Process (BP)	positive regulation of cell killing	0	2.398	--	DIRECT
Biological Process (BP)	regulation of leukocyte mediated immunity	0	1.854	--	DIRECT
Biological Process (BP)	regulation of leukocyte mediated cytotoxicity	0	2.398	--	DIRECT
Biological Process (BP)	regulation of adaptive immune response	2.076e-15	2.097	--	DIRECT
Biological Process (BP)	positive regulation of T cell mediated immunity	8.433e-13	2.222	--	DIRECT
Biological Process (BP)	regulation of T cell mediated immunity	2.181e-11	2.222	--	DIRECT
Biological Process (BP)	positive regulation of leukocyte mediated cytotoxicity	5.958e-11	2.398	--	DIRECT
Biological Process (BP)	positive regulation of lymphocyte mediated immunity	8.372e-11	2.222	--	DIRECT
Biological Process (BP)	positive regulation of T cell mediated cytotoxicity	2.332e-10	2.398	--	DIRECT
Biological Process (BP)	antigen processing and presentation of peptide antigen	1.444e-08	2.222	--	DIRECT
Biological Process (BP)	regulation of T cell mediated cytotoxicity	6.886e-08	2.398	--	DIRECT
Biological Process (BP)	ear development	0	2.222	--	DIRECT
Biological Process (BP)	positive regulation of immune response	0	1.796	--	DIRECT
Biological Process (BP)	positive regulation of response to stimulus	0	1.284	--	DIRECT
Biological Process (BP)	regulation of immune system process	0	1.398	--	DIRECT
Biological Process (BP)	antigen processing and presentation of endogenous antigen	0.0004585	2.699	--	DIRECT
Biological Process (BP)	positive regulation of biological process	5.729e-12	0.8182	--	DIRECT
Biological Process (BP)	regulation of biological process	0.0001374	0.4486	--	DIRECT
Biological Process (BP)	biological_process	2.098e-10	0	--	DIRECT
Biological Process (BP)	biological regulation	0	0.4202	--	DIRECT
Biological Process (BP)	response to stress	1.549e-12	0.8125	--	DIRECT
Biological Process (BP)	cellular response to interferon-gamma	0	2.699	--	DIRECT
Biological Process (BP)	immunoglobulin mediated immune response	0	2.699	--	DIRECT
Biological Process (BP)	'de novo' posttranslational protein folding	0	2.699	--	DIRECT
Biological Process (BP)	positive regulation of leukocyte differentiation	0	2.398	--	DIRECT
Biological Process (BP)	cellular response to type I interferon	0	2.699	--	DIRECT
Biological Process (BP)	chaperone-mediated protein folding	0	2.699	--	DIRECT
Biological Process (BP)	cellular response to organic substance	0	1.208	--	DIRECT
Biological Process (BP)	response to interferon-gamma	0	2.699	--	DIRECT
Biological Process (BP)	positive regulation of nitric oxide biosynthetic process	0	2.699	--	DIRECT
Biological Process (BP)	cell surface receptor signaling pathway	0	1.237	--	DIRECT
Biological Process (BP)	response to type I interferon	0	2.699	--	DIRECT
Biological Process (BP)	type I interferon-mediated signaling pathway	0	2.699	--	DIRECT
Biological Process (BP)	cellular response to cytokine stimulus	0	1.745	--	DIRECT
Biological Process (BP)	lymphocyte mediated immunity	0	2.398	--	DIRECT
Biological Process (BP)	lymphocyte activation	0	1.699	--	DIRECT
Biological Process (BP)	'de novo' protein folding	0	2.398	--	DIRECT
Biological Process (BP)	adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli	0	2.398	--	DIRECT
Biological Process (BP)	chaperone mediated protein folding requiring cofactor	0	2.699	--	DIRECT
Biological Process (BP)	regulation of cell activation	0	1.854	--	DIRECT
Biological Process (BP)	negative regulation of leukocyte proliferation	0	2.699	--	DIRECT
Biological Process (BP)	response to bacterium	5.966e-15	1.658	--	DIRECT
Biological Process (BP)	regulation of leukocyte proliferation	8.344e-13	2.222	--	DIRECT
Biological Process (BP)	detection of external stimulus	2.131e-12	1.854	--	DIRECT
Biological Process (BP)	regulation of peptide hormone secretion	8.101e-11	2.222	--	DIRECT
Biological Process (BP)	regulation of peptide secretion	9.407e-11	2.222	--	DIRECT
Biological Process (BP)	regulation of defense response	1.151e-10	1.658	--	DIRECT
Biological Process (BP)	regulation of peptide transport	1.262e-10	2.222	--	DIRECT
Biological Process (BP)	negative regulation of cell activation	3.533e-10	2.398	--	DIRECT
Biological Process (BP)	cell killing	4.794e-10	2.398	--	DIRECT
Biological Process (BP)	regulation of hormone secretion	9.456e-10	2.222	--	DIRECT
Biological Process (BP)	immune response-regulating cell surface receptor signaling pathway	1.261e-09	2.222	--	DIRECT
Biological Process (BP)	negative regulation of lymphocyte proliferation	1.968e-09	2.699	--	DIRECT
Biological Process (BP)	protein complex assembly	2.802e-09	1.319	--	DIRECT
Biological Process (BP)	protein complex biogenesis	3.489e-09	1.301	--	DIRECT
Biological Process (BP)	response to biotic stimulus	8.86e-09	1.377	--	DIRECT
Biological Process (BP)	negative regulation of mononuclear cell proliferation	2.014e-08	2.699	--	DIRECT
Biological Process (BP)	leukocyte differentiation	2.208e-08	1.854	--	DIRECT
Biological Process (BP)	regulation of insulin secretion involved in cellular response to glucose stimulus	6.539e-08	2.699	--	DIRECT
Biological Process (BP)	single organism signaling	9.721e-08	0.8601	--	DIRECT
Biological Process (BP)	antigen receptor-mediated signaling pathway	2.768e-07	2.699	--	DIRECT
Biological Process (BP)	macromolecular complex assembly	6.194e-07	1.252	--	DIRECT
Biological Process (BP)	cell communication	8.819e-07	0.8477	--	DIRECT
Biological Process (BP)	regulation of natural killer cell mediated immunity	1.29e-06	2.699	--	DIRECT
Biological Process (BP)	positive regulation of cytokine biosynthetic process	1.983e-06	2.398	--	DIRECT
Biological Process (BP)	T cell differentiation in thymus	2.16e-06	2.699	--	DIRECT
Biological Process (BP)	regulation of protein transport	8.422e-06	1.658	--	DIRECT
Biological Process (BP)	signaling	1.432e-05	0.8416	--	DIRECT
Biological Process (BP)	regulation of establishment of protein localization	1.94e-05	1.62	--	DIRECT
Biological Process (BP)	protein complex subunit organization	2.454e-05	1.194	--	DIRECT
Biological Process (BP)	hemopoiesis	5.26e-05	1.699	--	DIRECT
Biological Process (BP)	detection of stimulus	9.137e-05	1.854	--	DIRECT
Biological Process (BP)	negative regulation of defense response	0.0002044	2.699	--	DIRECT
Biological Process (BP)	T cell selection	0.0002264	2.699	--	DIRECT
Biological Process (BP)	regulation of cell differentiation	0.0002571	1.357	--	DIRECT
Biological Process (BP)	positive regulation of leukocyte activation	0.0004338	2.097	--	DIRECT
Biological Process (BP)	immune response-activating cell surface receptor signaling pathway	0.0004643	2.222	--	DIRECT
Biological Process (BP)	regulation of cytokine secretion	0.02554	2.222	--	INHERITED FROM: regulation of interleukin-10 secretion
Biological Process (BP)	regulation of cellular localization	0.12	1.357	--	INHERITED FROM: regulation of peptide hormone secretion || positive regulation of insulin secretion involved in cellular response to glucose stimulus || regulation of insulin secretion || positive regulation of peptide hormone secretion || regulation of hormone secretion || positive regulation of hormone secretion || regulation of protein secretion || regulation of insulin secretion involved in cellular response to glucose stimulus || regulation of interleukin-10 secretion || positive regulation of insulin secretion
Biological Process (BP)	cellular component assembly	0.006863	1.076	--	INHERITED FROM: macromolecular complex assembly || protein complex assembly || protein tetramerization
Biological Process (BP)	regulation of homeostatic process	0.00397	1.854	--	INHERITED FROM: regulation of insulin secretion involved in cellular response to glucose stimulus || positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process (BP)	macromolecule metabolic process	1	0.4634	--	INHERITED FROM: chaperone-mediated protein folding || protein folding || chaperone mediated protein folding requiring cofactor || 'de novo' posttranslational protein folding || 'de novo' protein folding
Biological Process (BP)	primary metabolic process	1	0.2976	--	INHERITED FROM: chaperone-mediated protein folding || protein folding || chaperone mediated protein folding requiring cofactor || 'de novo' posttranslational protein folding || 'de novo' protein folding
Biological Process (BP)	regulation of transport	0.2196	1.155	--	INHERITED FROM: regulation of protein transport || positive regulation of insulin secretion involved in cellular response to glucose stimulus || positive regulation of peptide secretion || positive regulation of hormone secretion || regulation of protein secretion || positive regulation of insulin secretion || regulation of peptide hormone secretion || regulation of peptide transport || regulation of insulin secretion || positive regulation of peptide hormone secretion || regulation of hormone secretion || positive regulation of secretion || regulation of secretion || regulation of insulin secretion involved in cellular response to glucose stimulus || regulation of interleukin-10 secretion || regulation of peptide secretion
Biological Process (BP)	regulation of alpha-beta T cell activation	1	2.222	--	INHERITED FROM: regulation of NK T cell activation || positive regulation of NK T cell activation
Biological Process (BP)	organic substance metabolic process	1	0.2676	--	INHERITED FROM: chaperone mediated protein folding requiring cofactor || 'de novo' posttranslational protein folding || chaperone-mediated protein folding || protein folding || 'de novo' protein folding
Biological Process (BP)	metabolic process	1	0.2411	--	INHERITED FROM: chaperone mediated protein folding requiring cofactor || 'de novo' posttranslational protein folding || chaperone-mediated protein folding || protein folding || 'de novo' protein folding
Biological Process (BP)	cellular metabolic process	1	0.2708	--	INHERITED FROM: chaperone mediated protein folding requiring cofactor || 'de novo' posttranslational protein folding || chaperone-mediated protein folding || protein folding || 'de novo' protein folding
Biological Process (BP)	cellular protein metabolic process	0.1958	0.6778	--	INHERITED FROM: 'de novo' posttranslational protein folding || chaperone-mediated protein folding || chaperone mediated protein folding requiring cofactor || 'de novo' protein folding || protein folding
Biological Process (BP)	immune response-activating signal transduction	0.03331	2.097	--	INHERITED FROM: antigen receptor-mediated signaling pathway || immune response-activating cell surface receptor signaling pathway || T cell receptor signaling pathway
Biological Process (BP)	negative regulation of leukocyte activation	1	2.398	--	INHERITED FROM: negative regulation of lymphocyte proliferation || negative regulation of T cell proliferation
Biological Process (BP)	regulation of lymphocyte proliferation	1	2.398	--	INHERITED FROM: negative regulation of lymphocyte proliferation || negative regulation of T cell proliferation
Biological Process (BP)	negative regulation of lymphocyte activation	1	2.398	--	INHERITED FROM: negative regulation of lymphocyte proliferation || negative regulation of T cell proliferation
Biological Process (BP)	system development	0.221	0.8069	--	INHERITED FROM: hematopoietic or lymphoid organ development || sensory organ development || thymic T cell selection || positive T cell selection || inner ear development || leukocyte differentiation || T cell selection || ear development || hemopoiesis || T cell differentiation in thymus || positive thymic T cell selection
Biological Process (BP)	multicellular organismal development	0.8857	0.7496	--	INHERITED FROM: hematopoietic or lymphoid organ development || sensory organ development || thymic T cell selection || positive T cell selection || inner ear development || leukocyte differentiation || T cell selection || ear development || hemopoiesis || T cell differentiation in thymus || positive thymic T cell selection
Biological Process (BP)	anatomical structure development	0.9655	0.7212	--	INHERITED FROM: hematopoietic or lymphoid organ development || sensory organ development || thymic T cell selection || positive T cell selection || inner ear development || leukocyte differentiation || T cell selection || ear development || hemopoiesis || T cell differentiation in thymus || positive thymic T cell selection
Biological Process (BP)	immune system development	1	1.585	--	INHERITED FROM: hematopoietic or lymphoid organ development || leukocyte differentiation || T cell selection || T cell differentiation in thymus || thymic T cell selection || hemopoiesis || positive thymic T cell selection || positive T cell selection
Biological Process (BP)	negative regulation of immune response	0.4834	2.398	--	INHERITED FROM: negative regulation of innate immune response
Biological Process (BP)	regulation of lymphocyte differentiation	0.02327	2.222	--	INHERITED FROM: positive regulation of lymphocyte differentiation || positive regulation of T cell differentiation
Biological Process (BP)	positive regulation of lymphocyte activation	0.001291	2.222	--	INHERITED FROM: positive regulation of lymphocyte differentiation || lymphocyte costimulation || positive regulation of T cell differentiation || positive regulation of NK T cell activation
Biological Process (BP)	regulation of leukocyte activation	0.00439	1.921	--	INHERITED FROM: positive regulation of lymphocyte differentiation || lymphocyte costimulation || positive regulation of T cell differentiation || negative regulation of lymphocyte proliferation || regulation of NK T cell activation || positive regulation of macrophage activation || negative regulation of T cell proliferation || regulation of macrophage activation || positive regulation of NK T cell activation || positive regulation of leukocyte activation || regulation of lymphocyte activation
Biological Process (BP)	regulation of T cell activation	0.00562	2.097	--	INHERITED FROM: positive regulation of T cell differentiation || positive regulation of NK T cell activation || regulation of NK T cell activation || negative regulation of T cell proliferation
Biological Process (BP)	positive regulation of T cell activation	0.02374	2.398	--	INHERITED FROM: positive regulation of T cell differentiation || positive regulation of NK T cell activation
Biological Process (BP)	regulation of multicellular organismal development	0.9569	1.268	--	INHERITED FROM: positive regulation of T cell differentiation || positive regulation of lymphocyte differentiation || positive regulation of leukocyte differentiation || regulation of leukocyte differentiation
Biological Process (BP)	regulation of T cell differentiation	0.03963	2.222	--	INHERITED FROM: positive regulation of T cell differentiation
Biological Process (BP)	positive regulation of biosynthetic process	0.3756	1.495	--	INHERITED FROM: positive regulation of nitric oxide biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-2 biosynthetic process || positive regulation of interleukin-4 biosynthetic process
Biological Process (BP)	regulation of cellular biosynthetic process	1	1.009	--	INHERITED FROM: regulation of interleukin-2 biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-4 biosynthetic process || positive regulation of nitric oxide biosynthetic process || positive regulation of interleukin-2 biosynthetic process || regulation of cytokine biosynthetic process || regulation of interleukin-4 biosynthetic process || regulation of nitric oxide biosynthetic process
Biological Process (BP)	regulation of primary metabolic process	1	0.7852	--	INHERITED FROM: regulation of interleukin-2 biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-4 biosynthetic process || positive regulation of interleukin-2 biosynthetic process || regulation of cytokine biosynthetic process || regulation of interleukin-4 biosynthetic process
Biological Process (BP)	regulation of macromolecule metabolic process	1	0.7959	--	INHERITED FROM: regulation of interleukin-2 biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-4 biosynthetic process || positive regulation of interleukin-2 biosynthetic process || regulation of cytokine biosynthetic process || regulation of interleukin-4 biosynthetic process
Biological Process (BP)	T cell differentiation	0.03317	2.097	--	INHERITED FROM: thymic T cell selection || positive T cell selection || T cell selection || positive thymic T cell selection || T cell differentiation in thymus
Biological Process (BP)	cellular developmental process	1	0.9666	--	INHERITED FROM: thymic T cell selection || positive T cell selection || leukocyte differentiation || T cell selection || T cell differentiation in thymus || positive thymic T cell selection
Biological Process (BP)	leukocyte activation	1	1.553	--	INHERITED FROM: T cell selection || T cell differentiation in thymus || thymic T cell selection || lymphocyte activation || positive thymic T cell selection || positive T cell selection
Biological Process (BP)	cellular component organization	1	0.6819	--	INHERITED FROM: macromolecular complex subunit organization || protein complex subunit organization || protein tetramerization || macromolecular complex assembly || protein complex assembly
Biological Process (BP)	cellular process	1	0.1415	--	INHERITED FROM: positive T cell selection || cell activation || interferon-gamma-mediated signaling pathway || T cell receptor signaling pathway || chaperone mediated protein folding requiring cofactor || T cell selection || immune response-regulating cell surface receptor signaling pathway || cellular response to chemical stimulus || thymic T cell selection || cell communication || type I interferon-mediated signaling pathway || lymphocyte activation || cellular response to organic substance || 'de novo' protein folding || cellular response to type I interferon || immune response-regulating signaling pathway || cellular response to cytokine stimulus || 'de novo' posttranslational protein folding || cytokine-mediated signaling pathway || leukocyte differentiation || cell surface receptor signaling pathway || immune response-activating cell surface receptor signaling pathway || T cell differentiation in thymus || positive thymic T cell selection || chaperone-mediated protein folding || protein folding || signal transduction || antigen receptor-mediated signaling pathway || cellular response to interferon-gamma
Biological Process (BP)	positive regulation of defense response	0.8977	2.398	--	INHERITED FROM: susceptibility to natural killer cell mediated cytotoxicity
Biological Process (BP)	positive regulation of innate immune response	1	2.699	--	INHERITED FROM: susceptibility to natural killer cell mediated cytotoxicity
Biological Process (BP)	leukocyte mediated cytotoxicity	0.01455	2.398	--	INHERITED FROM: natural killer cell mediated cytotoxicity
Biological Process (BP)	negative regulation of T cell activation	0.6902	2.699	--	INHERITED FROM: negative regulation of T cell proliferation
Biological Process (BP)	regulation of T cell proliferation	1	2.398	--	INHERITED FROM: negative regulation of T cell proliferation
Biological Process (BP)	positive regulation of cellular metabolic process	1	1.208	--	INHERITED FROM: positive regulation of cytokine biosynthetic process || positive regulation of interleukin-4 biosynthetic process || positive regulation of nitric oxide biosynthetic process || positive regulation of interleukin-2 biosynthetic process
Biological Process (BP)	positive regulation of macromolecule metabolic process	1	1.301	--	INHERITED FROM: positive regulation of cytokine biosynthetic process || positive regulation of interleukin-2 biosynthetic process || positive regulation of interleukin-4 biosynthetic process
Biological Process (BP)	adaptive immune response	0.6557	2.398	--	INHERITED FROM: T-helper 1 type immune response || immunoglobulin production involved in immunoglobulin mediated immune response || immunoglobulin mediated immune response || adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli
Biological Process (BP)	regulation of macromolecule biosynthetic process	1	1.066	--	INHERITED FROM: regulation of cytokine biosynthetic process || regulation of interleukin-2 biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-4 biosynthetic process || regulation of interleukin-4 biosynthetic process || positive regulation of interleukin-2 biosynthetic process
Biological Process (BP)	negative regulation of cytokine production	0.002991	2.398	--	INHERITED FROM: negative regulation of interferon-gamma production
Biological Process (BP)	response to chemical stimulus	0.5271	0.8861	--	INHERITED FROM: cytokine-mediated signaling pathway || cellular response to organic substance || cellular response to interferon-gamma || cellular response to type I interferon || interferon-gamma-mediated signaling pathway || response to type I interferon || type I interferon-mediated signaling pathway || response to organic substance || response to interferon-gamma || cellular response to cytokine stimulus || cellular response to chemical stimulus || response to cytokine stimulus
Biological Process (BP)	cellular response to stimulus	0.02002	0.7645	--	INHERITED FROM: cytokine-mediated signaling pathway || cellular response to organic substance || antigen receptor-mediated signaling pathway || cellular response to interferon-gamma || cellular response to type I interferon || interferon-gamma-mediated signaling pathway || immune response-regulating signaling pathway || cell surface receptor signaling pathway || type I interferon-mediated signaling pathway || signal transduction || immune response-activating cell surface receptor signaling pathway || immune response-regulating cell surface receptor signaling pathway || cellular response to cytokine stimulus || T cell receptor signaling pathway || cellular response to chemical stimulus
Biological Process (BP)	single-multicellular organism process	1	0.6383	--	INHERITED FROM: sensory organ development || positive T cell selection || leukocyte differentiation || T cell selection || ear development || T cell differentiation in thymus || positive thymic T cell selection || hematopoietic or lymphoid organ development || thymic T cell selection || inner ear development || hemopoiesis
Biological Process (BP)	single-organism process	1	0.3316	--	INHERITED FROM: sensory organ development || positive T cell selection || cell activation || interferon-gamma-mediated signaling pathway || T cell receptor signaling pathway || natural killer cell mediated cytotoxicity || T cell selection || immune response-regulating cell surface receptor signaling pathway || cellular response to chemical stimulus || hematopoietic or lymphoid organ development || thymic T cell selection || cell communication || type I interferon-mediated signaling pathway || lymphocyte activation || cellular response to organic substance || cellular response to type I interferon || immune response-regulating signaling pathway || cellular response to cytokine stimulus || cytokine-mediated signaling pathway || leukocyte differentiation || cell surface receptor signaling pathway || single organism signaling || immune response-activating cell surface receptor signaling pathway || ear development || T cell differentiation in thymus || positive thymic T cell selection || signal transduction || antigen receptor-mediated signaling pathway || inner ear development || cellular response to interferon-gamma || hemopoiesis
Biological Process (BP)	regulation of response to biotic stimulus	0.1266	2.699	--	INHERITED FROM: positive regulation of response to biotic stimulus || positive regulation of response to tumor cell || regulation of immune response to tumor cell || positive regulation of immune response to tumor cell || regulation of response to tumor cell
Biological Process (BP)	negative regulation of biological process	1	0.8665	--	INHERITED FROM: negative regulation of immune system process || negative regulation of interferon-gamma production || negative regulation of innate immune response || negative regulation of cell proliferation || negative regulation of cell killing || negative regulation of lymphocyte proliferation || negative regulation of multicellular organismal process || negative regulation of cell activation || negative regulation of defense response || negative regulation of mononuclear cell proliferation || negative regulation of leukocyte proliferation || negative regulation of T cell proliferation
Biological Process (BP)	antigen processing and presentation of peptide antigen via MHC class I	1	2.699	--	INHERITED FROM: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway || antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
Biological Process (BP)	antigen processing and presentation of exogenous antigen	0.0161	2.222	--	INHERITED FROM: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
Biological Process (BP)	antigen processing and presentation of exogenous peptide antigen	0.4929	2.398	--	INHERITED FROM: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
Biological Process (BP)	antigen processing and presentation of exogenous peptide antigen via MHC class I	0.9901	2.699	--	INHERITED FROM: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
Biological Process (BP)	B cell mediated immunity	0.334	2.699	--	INHERITED FROM: immunoglobulin production involved in immunoglobulin mediated immune response || immunoglobulin mediated immune response
Biological Process (BP)	response to stimulus	0	0.5498	Least Informative	DIRECT
Biological Process (BP)	protein metabolic process	0.5998	0.6383	Least Informative	INHERITED FROM: 'de novo' posttranslational protein folding || chaperone-mediated protein folding || protein folding || chaperone mediated protein folding requiring cofactor || 'de novo' protein folding
Biological Process (BP)	cellular macromolecule metabolic process	1	0.4976	Least Informative	INHERITED FROM: 'de novo' posttranslational protein folding || chaperone-mediated protein folding || protein folding || chaperone mediated protein folding requiring cofactor || 'de novo' protein folding
Biological Process (BP)	regulation of cellular process	1	0.5317	Least Informative	INHERITED FROM: regulation of interleukin-2 biosynthetic process || positive regulation of NK T cell activation || interferon-gamma-mediated signaling pathway || immune response-regulating signaling pathway || positive regulation of insulin secretion involved in cellular response to glucose stimulus || T cell receptor signaling pathway || positive regulation of leukocyte activation || positive regulation of leukocyte differentiation || regulation of nitric oxide biosynthetic process || positive regulation of peptide hormone secretion || regulation of hormone secretion || positive regulation of cell differentiation || positive regulation of T cell differentiation || cytokine-mediated signaling pathway || positive regulation of lymphocyte differentiation || regulation of peptide hormone secretion || regulation of insulin secretion || cell surface receptor signaling pathway || regulation of cell development || positive regulation of interleukin-2 biosynthetic process || immune response-activating cell surface receptor signaling pathway || regulation of mononuclear cell proliferation || regulation of cytokine biosynthetic process || immune response-regulating cell surface receptor signaling pathway || regulation of cell differentiation || negative regulation of mononuclear cell proliferation || negative regulation of leukocyte proliferation || regulation of leukocyte proliferation || regulation of insulin secretion involved in cellular response to glucose stimulus || positive regulation of macrophage activation || lymphocyte costimulation || positive regulation of interleukin-4 biosynthetic process || positive regulation of nitric oxide biosynthetic process || type I interferon-mediated signaling pathway || signal transduction || positive regulation of hormone secretion || regulation of macrophage activation || regulation of cell activation || regulation of lymphocyte activation || negative regulation of cell proliferation || antigen receptor-mediated signaling pathway || positive regulation of cytokine biosynthetic process || negative regulation of lymphocyte proliferation || regulation of protein secretion || positive regulation of insulin secretion || negative regulation of cell activation || regulation of NK T cell activation || regulation of interleukin-10 secretion || negative regulation of T cell proliferation || regulation of interleukin-4 biosynthetic process || positive regulation of cell activation || regulation of leukocyte differentiation
Biological Process (BP)	regulation of metabolic process	1	0.6946	Least Informative	INHERITED FROM: regulation of interleukin-2 biosynthetic process || positive regulation of interleukin-4 biosynthetic process || positive regulation of nitric oxide biosynthetic process || regulation of nitric oxide biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-2 biosynthetic process || regulation of cytokine biosynthetic process || regulation of interleukin-4 biosynthetic process
Biological Process (BP)	cellular component organization or biogenesis	1	0.6536	Least Informative	INHERITED FROM: macromolecular complex subunit organization || protein complex subunit organization || protein tetramerization || protein complex biogenesis || macromolecular complex assembly || protein complex assembly
Biological Process (BP)	single-organism cellular process	1	0.3915	Least Informative	INHERITED FROM: positive T cell selection || cell activation || cellular response to type I interferon || interferon-gamma-mediated signaling pathway || immune response-regulating signaling pathway || cellular response to cytokine stimulus || T cell receptor signaling pathway || cytokine-mediated signaling pathway || leukocyte differentiation || cell surface receptor signaling pathway || T cell selection || immune response-activating cell surface receptor signaling pathway || immune response-regulating cell surface receptor signaling pathway || cellular response to chemical stimulus || T cell differentiation in thymus || positive thymic T cell selection || thymic T cell selection || cell communication || type I interferon-mediated signaling pathway || signal transduction || lymphocyte activation || cellular response to organic substance || antigen receptor-mediated signaling pathway || cellular response to interferon-gamma
Biological Process (BP)	developmental process	1	0.6904	Least Informative	INHERITED FROM: sensory organ development || positive T cell selection || leukocyte differentiation || T cell selection || ear development || T cell differentiation in thymus || positive thymic T cell selection || hematopoietic or lymphoid organ development || thymic T cell selection || inner ear development || hemopoiesis
Biological Process (BP)	multicellular organismal process	1	0.6091	Least Informative	INHERITED FROM: sensory organ development || positive T cell selection || leukocyte differentiation || T cell selection || ear development || T cell differentiation in thymus || positive thymic T cell selection || hematopoietic or lymphoid organ development || thymic T cell selection || inner ear development || hemopoiesis
Biological Process (BP)	immune system process	0	1.076	Moderately Informative	DIRECT
Biological Process (BP)	regulation of response to stimulus	0	0.9914	Moderately Informative	DIRECT
Biological Process (BP)	response to organic substance	0	1.018	Moderately Informative	DIRECT
Biological Process (BP)	cellular response to chemical stimulus	0	1.097	Moderately Informative	DIRECT
Biological Process (BP)	multi-organism process	1.06e-10	1.086	Moderately Informative	DIRECT
Biological Process (BP)	signal transduction	1.226e-09	0.9914	Moderately Informative	DIRECT
Biological Process (BP)	macromolecular complex subunit organization	0.0007262	1.131	Moderately Informative	DIRECT
Biological Process (BP)	regulation of multicellular organismal process	0.0009783	0.9666	Moderately Informative	DIRECT
Biological Process (BP)	cellular component biogenesis	0.05954	0.983	Moderately Informative	INHERITED FROM: protein tetramerization || protein complex biogenesis || macromolecular complex assembly || protein complex assembly
Biological Process (BP)	regulation of localization	1	1.066	Moderately Informative	INHERITED FROM: regulation of protein transport || positive regulation of peptide secretion || regulation of protein secretion || positive regulation of insulin secretion || regulation of peptide hormone secretion || regulation of peptide transport || regulation of insulin secretion || regulation of secretion || regulation of interleukin-10 secretion || positive regulation of insulin secretion involved in cellular response to glucose stimulus || regulation of establishment of protein localization || positive regulation of hormone secretion || positive regulation of peptide hormone secretion || regulation of hormone secretion || positive regulation of secretion || regulation of insulin secretion involved in cellular response to glucose stimulus || regulation of peptide secretion || regulation of protein localization
Biological Process (BP)	organ development	0.001456	0.9355	Moderately Informative	INHERITED FROM: hematopoietic or lymphoid organ development || sensory organ development || thymic T cell selection || positive T cell selection || inner ear development || leukocyte differentiation || T cell selection || ear development || hemopoiesis || T cell differentiation in thymus || positive thymic T cell selection
Biological Process (BP)	single-organism developmental process	0.8757	0.7645	Moderately Informative	INHERITED FROM: hematopoietic or lymphoid organ development || sensory organ development || thymic T cell selection || positive T cell selection || inner ear development || leukocyte differentiation || T cell selection || ear development || hemopoiesis || T cell differentiation in thymus || positive thymic T cell selection
Biological Process (BP)	regulation of developmental process	0.9712	1.155	Moderately Informative	INHERITED FROM: positive regulation of T cell differentiation || positive regulation of lymphocyte differentiation || regulation of cell development || regulation of cell differentiation || positive regulation of leukocyte differentiation || regulation of leukocyte differentiation || positive regulation of cell differentiation
Biological Process (BP)	positive regulation of cellular process	0.7619	0.9066	Moderately Informative	INHERITED FROM: positive regulation of T cell differentiation || positive regulation of macrophage activation || positive regulation of cytokine biosynthetic process || lymphocyte costimulation || positive regulation of interleukin-4 biosynthetic process || positive regulation of NK T cell activation || positive regulation of insulin secretion || positive regulation of lymphocyte differentiation || positive regulation of nitric oxide biosynthetic process || positive regulation of interleukin-2 biosynthetic process || positive regulation of insulin secretion involved in cellular response to glucose stimulus || positive regulation of hormone secretion || positive regulation of leukocyte activation || positive regulation of leukocyte differentiation || positive regulation of peptide hormone secretion || positive regulation of cell activation || positive regulation of cell differentiation
Biological Process (BP)	regulation of nitrogen compound metabolic process	1	0.9914	Moderately Informative	INHERITED FROM: positive regulation of nitric oxide biosynthetic process || regulation of nitric oxide biosynthetic process
Biological Process (BP)	regulation of cellular metabolic process	1	0.7905	Moderately Informative	INHERITED FROM: regulation of interleukin-2 biosynthetic process || positive regulation of interleukin-4 biosynthetic process || positive regulation of nitric oxide biosynthetic process || regulation of nitric oxide biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-2 biosynthetic process || regulation of cytokine biosynthetic process || regulation of interleukin-4 biosynthetic process
Biological Process (BP)	regulation of biosynthetic process	1	0.9914	Moderately Informative	INHERITED FROM: regulation of interleukin-2 biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-4 biosynthetic process || positive regulation of nitric oxide biosynthetic process || positive regulation of interleukin-2 biosynthetic process || regulation of cytokine biosynthetic process || regulation of interleukin-4 biosynthetic process || regulation of nitric oxide biosynthetic process
Biological Process (BP)	cell differentiation	1	1.009	Moderately Informative	INHERITED FROM: thymic T cell selection || positive T cell selection || leukocyte differentiation || T cell selection || T cell differentiation in thymus || positive thymic T cell selection
Biological Process (BP)	positive regulation of metabolic process	1	1.167	Moderately Informative	INHERITED FROM: positive regulation of cytokine biosynthetic process || positive regulation of interleukin-4 biosynthetic process || positive regulation of nitric oxide biosynthetic process || positive regulation of interleukin-2 biosynthetic process
Biological Process (BP)	regulation of protein metabolic process	1	1.119	Moderately Informative	INHERITED FROM: regulation of cytokine biosynthetic process || regulation of interleukin-2 biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-4 biosynthetic process || regulation of interleukin-4 biosynthetic process || positive regulation of interleukin-2 biosynthetic process
Biological Process (BP)	regulation of cell communication	1	1.066	Moderately Informative	INHERITED FROM: positive regulation of insulin secretion || regulation of peptide hormone secretion || regulation of insulin secretion || positive regulation of insulin secretion involved in cellular response to glucose stimulus || positive regulation of hormone secretion || positive regulation of peptide hormone secretion || regulation of hormone secretion || regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process (BP)	regulation of signaling	1	1.076	Moderately Informative	INHERITED FROM: positive regulation of insulin secretion || regulation of peptide hormone secretion || regulation of insulin secretion || positive regulation of insulin secretion involved in cellular response to glucose stimulus || positive regulation of hormone secretion || positive regulation of peptide hormone secretion || regulation of hormone secretion || regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process (BP)	negative regulation of cellular process	1	0.9355	Moderately Informative	INHERITED FROM: negative regulation of cell proliferation || negative regulation of lymphocyte proliferation || negative regulation of cell activation || negative regulation of mononuclear cell proliferation || negative regulation of leukocyte proliferation || negative regulation of T cell proliferation
Biological Process (BP)	regulation of immune effector process	4.607e-11	1.658	Informative	DIRECT
Biological Process (BP)	sensory organ development	0	1.553	Informative	DIRECT
Biological Process (BP)	positive regulation of immune system process	0	1.62	Informative	DIRECT
Biological Process (BP)	regulation of immune response	0	1.553	Informative	DIRECT
Biological Process (BP)	defense response	0	1.357	Informative	DIRECT
Biological Process (BP)	immune response	0	1.495	Informative	DIRECT
Biological Process (BP)	response to cytokine stimulus	0	1.658	Informative	DIRECT
Biological Process (BP)	regulation of cytokine production	7.145e-14	1.62	Informative	DIRECT
Biological Process (BP)	cell activation	1.954e-13	1.495	Informative	DIRECT
Biological Process (BP)	response to other organism	4.073e-12	1.398	Informative	DIRECT
Biological Process (BP)	regulation of cell development	3.53e-11	1.469	Informative	DIRECT
Biological Process (BP)	hematopoietic or lymphoid organ development	0.0001734	1.585	Informative	DIRECT
Biological Process (BP)	regulation of protein localization	0.000176	1.585	Informative	DIRECT
Biological Process (BP)	regulation of secretion	0.0003347	1.658	Informative	DIRECT
Biological Process (BP)	protein oligomerization	0.1035	1.658	Informative	INHERITED FROM: protein tetramerization
Biological Process (BP)	regulation of cell proliferation	0.4961	1.42	Informative	INHERITED FROM: negative regulation of lymphocyte proliferation || regulation of leukocyte proliferation || negative regulation of T cell proliferation || negative regulation of cell proliferation || regulation of mononuclear cell proliferation || negative regulation of mononuclear cell proliferation || negative regulation of leukocyte proliferation
Biological Process (BP)	positive regulation of developmental process	0.02113	1.553	Informative	INHERITED FROM: positive regulation of lymphocyte differentiation || positive regulation of T cell differentiation || positive regulation of leukocyte differentiation || positive regulation of cell differentiation
Biological Process (BP)	positive regulation of cellular biosynthetic process	0.3595	1.495	Informative	INHERITED FROM: positive regulation of nitric oxide biosynthetic process || positive regulation of cytokine biosynthetic process || positive regulation of interleukin-2 biosynthetic process || positive regulation of interleukin-4 biosynthetic process
Biological Process (BP)	positive regulation of nitrogen compound metabolic process	0.993	1.523	Informative	INHERITED FROM: positive regulation of nitric oxide biosynthetic process
Biological Process (BP)	positive regulation of protein metabolic process	0.7137	1.469	Informative	INHERITED FROM: positive regulation of cytokine biosynthetic process || positive regulation of interleukin-2 biosynthetic process || positive regulation of interleukin-4 biosynthetic process
Biological Process (BP)	positive regulation of macromolecule biosynthetic process	1	1.585	Informative	INHERITED FROM: positive regulation of cytokine biosynthetic process || positive regulation of interleukin-2 biosynthetic process || positive regulation of interleukin-4 biosynthetic process
Biological Process (BP)	positive regulation of transport	0.7178	1.495	Informative	INHERITED FROM: positive regulation of insulin secretion involved in cellular response to glucose stimulus || positive regulation of peptide hormone secretion || positive regulation of peptide secretion || positive regulation of secretion || positive regulation of hormone secretion || positive regulation of insulin secretion
Biological Process (BP)	positive regulation of multicellular organismal process	0.6166	1.585	Informative	INHERITED FROM: positive regulation of interferon-gamma production
Biological Process (BP)	negative regulation of response to stimulus	1	1.585	Informative	INHERITED FROM: negative regulation of defense response || negative regulation of innate immune response
Biological Process (BP)	regulation of response to stress	1	1.42	Informative	INHERITED FROM: regulation of defense response || negative regulation of defense response || regulation of natural killer cell mediated immunity || susceptibility to natural killer cell mediated cytotoxicity || negative regulation of innate immune response
Biological Process (BP)	response to external stimulus	1	1.319	Informative	INHERITED FROM: detection of external stimulus || detection of bacterium
Biological Process (BP)	immune effector process	1	1.658	Informative	INHERITED FROM: leukocyte mediated immunity || natural killer cell mediated cytotoxicity || immunoglobulin production involved in immunoglobulin mediated immune response || immunoglobulin mediated immune response || lymphocyte mediated immunity || natural killer cell mediated immunity
Biological Process (BP)	response to wounding	1	1.495	Informative	INHERITED FROM: inflammatory response to antigenic stimulus
Biological Process (BP)	positive regulation of immune effector process	0	1.921	Highly Informative	DIRECT
Biological Process (BP)	regulation of cell killing	0	2.097	Highly Informative	DIRECT
Biological Process (BP)	positive regulation of adaptive immune response	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	regulation of lymphocyte mediated immunity	0	1.921	Highly Informative	DIRECT
Biological Process (BP)	inner ear development	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	antigen processing and presentation	0	2.097	Highly Informative	DIRECT
Biological Process (BP)	cytokine-mediated signaling pathway	0	1.921	Highly Informative	DIRECT
Biological Process (BP)	regulation of nitric oxide biosynthetic process	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	positive regulation of cell activation	0	2	Highly Informative	DIRECT
Biological Process (BP)	regulation of adaptive immune response based on somatic recombination of immune receptors built from	0	2.097	Highly Informative	DIRECT
Biological Process (BP)	protein folding	0	1.796	Highly Informative	DIRECT
Biological Process (BP)	regulation of lymphocyte activation	0	2	Highly Informative	DIRECT
Biological Process (BP)	protein tetramerization	2.067e-13	2.097	Highly Informative	DIRECT
Biological Process (BP)	regulation of mononuclear cell proliferation	5.776e-13	2.222	Highly Informative	DIRECT
Biological Process (BP)	regulation of insulin secretion	3.034e-11	2.222	Highly Informative	DIRECT
Biological Process (BP)	positive regulation of cell differentiation	8.128e-10	1.854	Highly Informative	DIRECT
Biological Process (BP)	leukocyte mediated immunity	1.377e-09	1.921	Highly Informative	DIRECT
Biological Process (BP)	regulation of protein secretion	1.652e-09	2	Highly Informative	DIRECT
Biological Process (BP)	positive regulation of secretion	1.393e-07	2	Highly Informative	DIRECT
Biological Process (BP)	negative regulation of immune system process	3.324e-06	1.854	Highly Informative	DIRECT
Biological Process (BP)	negative regulation of multicellular organismal process	1.436e-05	1.854	Highly Informative	DIRECT
Biological Process (BP)	negative regulation of cell proliferation	2.641e-05	1.854	Highly Informative	DIRECT
Biological Process (BP)	regulation of leukocyte differentiation	3.207e-05	2	Highly Informative	DIRECT
Biological Process (BP)	regulation of cytokine biosynthetic process	4.4e-05	2.222	Highly Informative	DIRECT
Biological Process (BP)	immune response-regulating signaling pathway	0.0002076	2	Highly Informative	DIRECT
Biological Process (BP)	activation of immune response	1	1.921	Highly Informative	INHERITED FROM: antigen receptor-mediated signaling pathway || immune response-activating cell surface receptor signaling pathway || T cell receptor signaling pathway
Biological Process (BP)	T cell activation	0.1687	2	Highly Informative	INHERITED FROM: thymic T cell selection || T cell selection || positive thymic T cell selection || positive T cell selection || T cell differentiation in thymus
Biological Process (BP)	lymphocyte differentiation	0.3674	1.854	Highly Informative	INHERITED FROM: thymic T cell selection || T cell selection || positive thymic T cell selection || positive T cell selection || T cell differentiation in thymus
Biological Process (BP)	regulation of innate immune response	1	2.097	Highly Informative	INHERITED FROM: susceptibility to natural killer cell mediated cytotoxicity || negative regulation of innate immune response || regulation of natural killer cell mediated immunity
Biological Process (BP)	innate immune response	0.001075	1.921	Highly Informative	INHERITED FROM: response to type I interferon || natural killer cell mediated cytotoxicity || type I interferon-mediated signaling pathway || cellular response to interferon-gamma || cellular response to type I interferon || response to interferon-gamma || interferon-gamma-mediated signaling pathway || natural killer cell mediated immunity
Biological Process (BP)	positive regulation of cytokine production	0.005068	1.921	Highly Informative	INHERITED FROM: positive regulation of interferon-gamma production
Biological Process (BP)	inflammatory response	1	1.921	Highly Informative	INHERITED FROM: inflammatory response to antigenic stimulus
Molecular Function (MF)	antigen binding	0	2.679	--	DIRECT
Molecular Function (MF)	amide binding	0	1.775	--	DIRECT
Molecular Function (MF)	molecular_function	0.7173	0	--	INHERITED FROM: peptide binding || antigen binding || amide binding || MHC class II receptor activity || receptor binding || beta-2-microglobulin binding || peptide antigen binding || natural killer cell lectin-like receptor binding || lipid antigen binding || binding
Molecular Function (MF)	transmembrane signaling receptor activity	0.00122	1.724	--	INHERITED FROM: MHC class II receptor activity
Molecular Function (MF)	signaling receptor activity	0.01863	1.724	--	INHERITED FROM: MHC class II receptor activity
Molecular Function (MF)	signal transducer activity	0.06236	1.599	--	INHERITED FROM: MHC class II receptor activity
Molecular Function (MF)	binding	0	0.3952	Least Informative	DIRECT
Molecular Function (MF)	protein binding	0.07198	0.77	Moderately Informative	INHERITED FROM: receptor binding || natural killer cell lectin-like receptor binding || beta-2-microglobulin binding
Molecular Function (MF)	receptor binding	2.728e-05	1.565	Informative	DIRECT
Molecular Function (MF)	receptor activity	0.01133	1.637	Informative	INHERITED FROM: MHC class II receptor activity
Molecular Function (MF)	molecular transducer activity	0.06247	1.565	Informative	INHERITED FROM: MHC class II receptor activity
Molecular Function (MF)	lipid binding	0.5192	1.377	Informative	INHERITED FROM: lipid antigen binding
Molecular Function (MF)	peptide binding	0	1.833	Highly Informative	DIRECT
Cellular Component (CC)	plasma membrane part	0	1.036	--	DIRECT
Cellular Component (CC)	membrane part	0	0.6842	--	DIRECT
Cellular Component (CC)	cell periphery	0	0.8256	--	DIRECT
Cellular Component (CC)	cellular_component	4.896e-09	0	--	DIRECT
Cellular Component (CC)	lysosomal membrane	0	2.542	--	DIRECT
Cellular Component (CC)	intrinsic to organelle membrane	0	1.763	--	DIRECT
Cellular Component (CC)	coated vesicle membrane	0	2.542	--	DIRECT
Cellular Component (CC)	endoplasmic reticulum part	0	1.365	--	DIRECT
Cellular Component (CC)	cytoplasmic membrane-bounded vesicle	0	1.241	--	DIRECT
Cellular Component (CC)	vacuolar part	0	1.696	--	DIRECT
Cellular Component (CC)	ER to Golgi transport vesicle	0	2.542	--	DIRECT
Cellular Component (CC)	endocytic vesicle membrane	0	2.542	--	DIRECT
Cellular Component (CC)	nuclear outer membrane-endoplasmic reticulum membrane network	0	1.365	--	DIRECT
Cellular Component (CC)	cytoplasmic vesicle	0	1.18	--	DIRECT
Cellular Component (CC)	transport vesicle membrane	0	2.542	--	DIRECT
Cellular Component (CC)	integral to endoplasmic reticulum membrane	0	2.241	--	DIRECT
Cellular Component (CC)	endosome membrane	0	2.241	--	DIRECT
Cellular Component (CC)	Golgi apparatus part	0	1.763	--	DIRECT
Cellular Component (CC)	lytic vacuole	0	1.696	--	DIRECT
Cellular Component (CC)	cytoplasmic vesicle membrane	0	2.064	--	DIRECT
Cellular Component (CC)	organelle part	4.307e-11	0.3713	--	DIRECT
Cellular Component (CC)	multivesicular body	1.071e-10	2.542	--	DIRECT
Cellular Component (CC)	cell part	1.752e-10	0.08068	--	DIRECT
Cellular Component (CC)	cell	1.851e-10	0.08068	--	DIRECT
Cellular Component (CC)	cytoplasm	5.951e-10	0.2515	--	DIRECT
Cellular Component (CC)	clathrin-coated endocytic vesicle	1.367e-08	2.542	--	DIRECT
Cellular Component (CC)	anchored to plasma membrane	8.578e-07	2.241	--	DIRECT
Cellular Component (CC)	membrane-bounded organelle	9.247e-07	0.2912	--	DIRECT
Cellular Component (CC)	membrane-bounded vesicle	6.861e-06	1.219	--	DIRECT
Cellular Component (CC)	intracellular organelle	6.113e-05	0.1875	--	DIRECT
Cellular Component (CC)	organelle	0.09375	0.1836	--	INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || cytoplasmic membrane-bounded vesicle || lysosome || endocytic vesicle membrane || transport vesicle membrane || coated vesicle || Golgi apparatus part || Golgi membrane || membrane-bounded organelle || transport vesicle || vesicle membrane || endosome || intracellular membrane-bounded organelle || coated vesicle membrane || intracellular organelle part || vesicle || vacuolar part || trans-Golgi network membrane || vacuole || endoplasmic reticulum || cytoplasmic vesicle || organelle membrane || lytic vacuole || late endosome || intrinsic to endoplasmic reticulum membrane || Golgi apparatus || lysosomal membrane || trans-Golgi network || intrinsic to organelle membrane || integral to lumenal side of endoplasmic reticulum membrane || endosomal part || organelle part || ER to Golgi transport vesicle || cytoplasmic vesicle part || integral to endoplasmic reticulum membrane || clathrin-coated endocytic vesicle || cytoplasmic vesicle membrane || early endosome membrane || endocytic vesicle || vacuolar membrane || ER to Golgi transport vesicle membrane || intracellular organelle || multivesicular body || phagocytic vesicle membrane || endoplasmic reticulum membrane || endosome membrane || early endosome || membrane-bounded vesicle
Cellular Component (CC)	intracellular	1	0.1266	--	INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || cytoplasmic membrane-bounded vesicle || lysosome || endocytic vesicle membrane || transport vesicle membrane || coated vesicle || Golgi apparatus part || Golgi membrane || transport vesicle || endosome || intracellular membrane-bounded organelle || coated vesicle membrane || intracellular organelle part || vacuolar part || trans-Golgi network membrane || vacuole || endoplasmic reticulum || cytoplasmic vesicle || lytic vacuole || late endosome || cytoplasm || intrinsic to endoplasmic reticulum membrane || Golgi apparatus || lysosomal membrane || trans-Golgi network || intrinsic to organelle membrane || integral to lumenal side of endoplasmic reticulum membrane || endosomal part || ER to Golgi transport vesicle || cytoplasmic vesicle part || cytoplasmic part || integral to endoplasmic reticulum membrane || clathrin-coated endocytic vesicle || cytoplasmic vesicle membrane || early endosome membrane || endocytic vesicle || vacuolar membrane || ER to Golgi transport vesicle membrane || intracellular organelle || multivesicular body || phagocytic vesicle membrane || endoplasmic reticulum membrane || endosome membrane || early endosome
Cellular Component (CC)	intracellular part	1	0.1266	--	INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || cytoplasmic membrane-bounded vesicle || lysosome || endocytic vesicle membrane || transport vesicle membrane || coated vesicle || Golgi apparatus part || Golgi membrane || transport vesicle || endosome || intracellular membrane-bounded organelle || coated vesicle membrane || intracellular organelle part || vacuolar part || trans-Golgi network membrane || vacuole || endoplasmic reticulum || cytoplasmic vesicle || lytic vacuole || late endosome || cytoplasm || intrinsic to endoplasmic reticulum membrane || Golgi apparatus || lysosomal membrane || trans-Golgi network || intrinsic to organelle membrane || integral to lumenal side of endoplasmic reticulum membrane || endosomal part || ER to Golgi transport vesicle || cytoplasmic vesicle part || cytoplasmic part || integral to endoplasmic reticulum membrane || clathrin-coated endocytic vesicle || cytoplasmic vesicle membrane || early endosome membrane || endocytic vesicle || vacuolar membrane || ER to Golgi transport vesicle membrane || intracellular organelle || multivesicular body || phagocytic vesicle membrane || endoplasmic reticulum membrane || endosome membrane || early endosome
Cellular Component (CC)	macromolecular complex	1	0.4276	--	INHERITED FROM: MHC protein complex
Cellular Component (CC)	membrane	0	0.5731	Least Informative	DIRECT
Cellular Component (CC)	intracellular organelle part	0	0.3893	Least Informative	DIRECT
Cellular Component (CC)	cytoplasmic part	0	0.2605	Least Informative	DIRECT
Cellular Component (CC)	intracellular membrane-bounded organelle	7.114e-07	0.2961	Least Informative	DIRECT
Cellular Component (CC)	protein complex	0.6269	0.5639	Least Informative	INHERITED FROM: MHC protein complex
Cellular Component (CC)	plasma membrane	0	0.9734	Moderately Informative	DIRECT
Cellular Component (CC)	intrinsic to membrane	5.443e-06	1.18	Moderately Informative	DIRECT
Cellular Component (CC)	vesicle	0	1.144	Moderately Informative	DIRECT
Cellular Component (CC)	endomembrane system	0	1.11	Moderately Informative	DIRECT
Cellular Component (CC)	endoplasmic reticulum	0	1.127	Moderately Informative	DIRECT
Cellular Component (CC)	organelle membrane	0	0.8514	Moderately Informative	DIRECT
Cellular Component (CC)	cell surface	0	1.542	Informative	DIRECT
Cellular Component (CC)	Golgi apparatus	0	1.542	Informative	DIRECT
Cellular Component (CC)	endosome	0	1.462	Informative	DIRECT
Cellular Component (CC)	vacuole	0	1.337	Informative	DIRECT
Cellular Component (CC)	coated vesicle	0	1.696	Informative	DIRECT
Cellular Component (CC)	endoplasmic reticulum membrane	0	1.462	Informative	DIRECT
Cellular Component (CC)	integral to membrane	0.9385	1.286	Informative	INHERITED FROM: integral to lumenal side of endoplasmic reticulum membrane || integral to endoplasmic reticulum membrane || integral to organelle membrane
Cellular Component (CC)	intrinsic to plasma membrane	1	1.696	Informative	INHERITED FROM: anchored to plasma membrane
Cellular Component (CC)	external side of plasma membrane	0	1.94	Highly Informative	DIRECT
Cellular Component (CC)	transport vesicle	0	2.064	Highly Informative	DIRECT
Cellular Component (CC)	trans-Golgi network	0	1.843	Highly Informative	DIRECT
Cellular Component (CC)	vesicle membrane	0	1.94	Highly Informative	DIRECT
Cellular Component (CC)	endosomal part	0	2.064	Highly Informative	DIRECT
Cellular Component (CC)	integral to organelle membrane	0	1.94	Highly Informative	DIRECT
Cellular Component (CC)	endocytic vesicle	0	2.064	Highly Informative	DIRECT
Cellular Component (CC)	lysosome	0	1.94	Highly Informative	DIRECT
Cellular Component (CC)	vacuolar membrane	0	1.843	Highly Informative	DIRECT
Cellular Component (CC)	cytoplasmic vesicle part	0	1.94	Highly Informative	DIRECT
Cellular Component (CC)	Golgi membrane	0	2.241	Highly Informative	DIRECT
Cellular Component (CC)	intrinsic to endoplasmic reticulum membrane	0	2.241	Highly Informative	DIRECT
Cellular Component (CC)	late endosome	3.129e-15	2.064	Highly Informative	DIRECT
Cellular Component (CC)	anchored to membrane	0.07259	1.843	Highly Informative	INHERITED FROM: anchored to plasma membrane
Cellular Component (CC)	clathrin-coated vesicle	1	1.843	Highly Informative	INHERITED FROM: clathrin-coated endocytic vesicle

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	demyelinating disease	9.192e-13	1.429	--	DIRECT
Disease Ontology (DO)	Behcet's disease	2.11e-08	1.73	--	DIRECT
Disease Ontology (DO)	Kawasaki disease	6.28e-08	1.633	--	DIRECT
Disease Ontology (DO)	hyperthyroidism	9.481e-08	1.73	--	DIRECT
Disease Ontology (DO)	lymph node disease	1.064e-07	1.633	--	DIRECT
Disease Ontology (DO)	psoriatic arthritis	4.196e-07	2.332	--	DIRECT
Disease Ontology (DO)	diabetes mellitus	7.811e-07	1.633	--	DIRECT
Disease Ontology (DO)	bone inflammation disease	6.72e-06	1.186	--	DIRECT
Disease Ontology (DO)	hypotrichosis	3.421e-05	1.73	--	DIRECT
Disease Ontology (DO)	hemochromatosis	5.762e-05	2.332	--	DIRECT
Disease Ontology (DO)	vascular hemostatic disease	8.403e-05	2.332	--	DIRECT
Disease Ontology (DO)	uveitis	9.063e-05	2.332	--	DIRECT
Disease Ontology (DO)	peripheral vascular disease	9.516e-05	1.554	--	DIRECT
Disease Ontology (DO)	neuromyelitis optica	0.000205	2.332	--	DIRECT
Disease Ontology (DO)	rheumatic fever	0.0003872	2.332	--	DIRECT
Disease Ontology (DO)	nasal cavity disease	0.0004674	1.429	--	DIRECT
Disease Ontology (DO)	leukemia	0.0005654	1.128	--	DIRECT
Disease Ontology (DO)	nose disease	0.0006114	1.429	--	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type I disease	0.0006199	2.332	--	DIRECT
Disease Ontology (DO)	autoimmune disease of endocrine system	0.0008621	1.855	--	DIRECT
Disease Ontology (DO)	integumentary system disease	0.001186	0.87	--	INHERITED FROM: alopecia || pemphigus || hypotrichosis || Kawasaki disease || skin disease
Disease Ontology (DO)	musculoskeletal system disease	0.001655	0.8273	--	INHERITED FROM: rheumatic fever || bone inflammation disease || spondylitis
Disease Ontology (DO)	uveal disease	0.00404	2.332	--	INHERITED FROM: uveitis
Disease Ontology (DO)	lymphatic system disease	0.004352	1.633	--	INHERITED FROM: lymph node disease || Kawasaki disease
Disease Ontology (DO)	hepatobiliary disease	0.007102	1.429	--	INHERITED FROM: liver disease || intrahepatic cholestasis
Disease Ontology (DO)	hair disease	0.007992	1.73	--	INHERITED FROM: alopecia || hypotrichosis
Disease Ontology (DO)	biliary tract disease	0.008162	2.031	--	INHERITED FROM: intrahepatic cholestasis
Disease Ontology (DO)	disease of anatomical entity	0.01333	0.2119	--	INHERITED FROM: hypersensitivity reaction type I disease || gastrointestinal system disease || Kawasaki disease || uveitis || autoimmune disease of endocrine system || multiple sclerosis || demyelinating disease || autoimmune disease of cardiovascular system || liver disease || hemorrhagic disease || pemphigus || rheumatic fever || neuromyelitis optica || bone inflammation disease || hypersensitivity reaction type II disease || hypotrichosis || hyperthyroidism || spondylitis || peripheral vascular disease || alopecia || vasculitis || nose disease || vascular hemostatic disease || nasal cavity disease || Behcet's disease || sarcoidosis || endocrine system disease || immune system disease || lymph node disease || Graves' disease || allergic rhinitis || intrahepatic cholestasis || skin disease
Disease Ontology (DO)	polyarteritis nodosa	0.01342	1.633	--	INHERITED FROM: Kawasaki disease
Disease Ontology (DO)	immune system cancer	0.01397	0.8853	--	INHERITED FROM: leukemia
Disease Ontology (DO)	central nervous system disease	0.02208	0.801	--	INHERITED FROM: neuromyelitis optica || demyelinating disease || multiple sclerosis
Disease Ontology (DO)	eye and adnexa disease	0.02572	1.102	--	INHERITED FROM: uveitis
Disease Ontology (DO)	respiratory system disease	0.02846	0.8853	--	INHERITED FROM: nasal cavity disease || allergic rhinitis || nose disease
Disease Ontology (DO)	upper respiratory tract disease	0.02962	1.378	--	INHERITED FROM: nose disease || nasal cavity disease || allergic rhinitis
Disease Ontology (DO)	autosomal genetic disease	0.04079	1.054	--	INHERITED FROM: sickle cell anemia
Disease Ontology (DO)	monogenic disease	0.04713	1.054	--	INHERITED FROM: sickle cell anemia
Disease Ontology (DO)	bullous skin disease	0.06211	1.218	--	INHERITED FROM: pemphigus
Disease Ontology (DO)	dermatitis	0.1001	1.128	--	INHERITED FROM: pemphigus
Disease Ontology (DO)	carbohydrate metabolism disease	0.1136	1.429	--	INHERITED FROM: diabetes mellitus
Disease Ontology (DO)	bacterial infectious disease	0.1156	1.186	--	INHERITED FROM: leprosy || primary bacterial infectious disease
Disease Ontology (DO)	cardiovascular system disease	0.1413	0.7884	--	INHERITED FROM: Kawasaki disease || peripheral vascular disease || Behcet's disease || vasculitis
Disease Ontology (DO)	hypersensitivity reaction disease	0.1574	0.8139	--	INHERITED FROM: Behcet's disease || autoimmune disease of endocrine system || Graves' disease || sarcoidosis || hypersensitivity reaction type I disease || hypersensitivity reaction type II disease || autoimmune disease of cardiovascular system
Disease Ontology (DO)	acquired metabolic disease	0.1684	1.156	--	INHERITED FROM: diabetes mellitus
Disease Ontology (DO)	cancer	0.3355	0.3031	--	INHERITED FROM: leukemia
Disease Ontology (DO)	disease of cellular proliferation	0.3732	0.268	--	INHERITED FROM: leukemia
Disease Ontology (DO)	cholestasis	0.3735	2.031	--	INHERITED FROM: intrahepatic cholestasis
Disease Ontology (DO)	blood coagulation disease	0.4814	1.332	--	INHERITED FROM: hemorrhagic disease || vascular hemostatic disease
Disease Ontology (DO)	spondyloarthropathy	0.5063	1.633	--	INHERITED FROM: spondylitis
Disease Ontology (DO)	inherited metabolic disorder	0.6962	1.218	--	INHERITED FROM: hemochromatosis
Disease Ontology (DO)	globe disease	1	1.128	--	INHERITED FROM: uveitis
Disease Ontology (DO)	bile duct disease	1	2.031	--	INHERITED FROM: intrahepatic cholestasis
Disease Ontology (DO)	rhinitis	1	1.429	--	INHERITED FROM: allergic rhinitis
Disease Ontology (DO)	eye disease	1	1.128	--	INHERITED FROM: uveitis
Disease Ontology (DO)	immune system disease	8.215e-06	0.6792	Least Informative	DIRECT
Disease Ontology (DO)	nervous system disease	0.01456	0.5766	Least Informative	INHERITED FROM: neuromyelitis optica || uveitis || multiple sclerosis || demyelinating disease
Disease Ontology (DO)	organ system cancer	0.05798	0.5263	Least Informative	INHERITED FROM: leukemia
Disease Ontology (DO)	hypersensitivity reaction type II disease	2e-07	0.8411	Moderately Informative	DIRECT
Disease Ontology (DO)	disease by infectious agent	7.661e-07	0.8273	Moderately Informative	DIRECT
Disease Ontology (DO)	disease of metabolism	4.101e-06	0.9522	Moderately Informative	DIRECT
Disease Ontology (DO)	gastrointestinal system disease	4.478e-05	0.8139	Moderately Informative	DIRECT
Disease Ontology (DO)	skin disease	7.977e-05	0.9011	Moderately Informative	DIRECT
Disease Ontology (DO)	endocrine system disease	0.0007035	1.128	Moderately Informative	DIRECT
Disease Ontology (DO)	hematologic cancer	0.002436	0.9011	Moderately Informative	INHERITED FROM: leukemia
Disease Ontology (DO)	vascular disease	0.006932	0.8853	Moderately Informative	INHERITED FROM: peripheral vascular disease || Behcet's disease || Kawasaki disease || vasculitis
Disease Ontology (DO)	hematopoietic system disease	0.01066	1.01	Moderately Informative	INHERITED FROM: hemorrhagic disease || vascular hemostatic disease
Disease Ontology (DO)	neurodegenerative disease	0.01208	1.077	Moderately Informative	INHERITED FROM: demyelinating disease || multiple sclerosis
Disease Ontology (DO)	genetic disease	0.075	1.01	Moderately Informative	INHERITED FROM: sickle cell anemia
Disease Ontology (DO)	bone disease	0.09422	1.128	Moderately Informative	INHERITED FROM: spondylitis || bone inflammation disease
Disease Ontology (DO)	syndrome	0.1672	1.186	Moderately Informative	INHERITED FROM: psoriatic arthritis
Disease Ontology (DO)	sensory system disease	0.5014	1.054	Moderately Informative	INHERITED FROM: uveitis
Disease Ontology (DO)	multiple sclerosis	7.752e-13	1.429	Informative	DIRECT
Disease Ontology (DO)	liver disease	1.9e-08	1.429	Informative	DIRECT
Disease Ontology (DO)	alopecia	1.79e-05	1.73	Informative	DIRECT
Disease Ontology (DO)	vasculitis	6.043e-05	1.633	Informative	DIRECT
Disease Ontology (DO)	primary bacterial infectious disease	0.0002583	1.291	Informative	DIRECT
Disease Ontology (DO)	hemorrhagic disease	0.0003656	1.487	Informative	DIRECT
Disease Ontology (DO)	allergic rhinitis	0.0004286	1.429	Informative	DIRECT
Disease Ontology (DO)	autoimmune disease of cardiovascular system	0.0005559	1.73	Informative	DIRECT
Disease Ontology (DO)	vascular skin disease	0.002224	1.554	Informative	INHERITED FROM: Kawasaki disease
Disease Ontology (DO)	autosomal recessive disease	0.002678	1.291	Informative	INHERITED FROM: sickle cell anemia
Disease Ontology (DO)	arthropathy	0.003328	1.554	Informative	INHERITED FROM: spondylitis
Disease Ontology (DO)	thyroid gland disease	0.008324	1.487	Informative	INHERITED FROM: hyperthyroidism || Graves' disease
Disease Ontology (DO)	hypersensitivity reaction type IV disease	0.01718	1.73	Informative	INHERITED FROM: sarcoidosis
Disease Ontology (DO)	connective tissue disease	0.09491	1.378	Informative	INHERITED FROM: rheumatic fever
Disease Ontology (DO)	lymphadenitis	1	1.633	Informative	INHERITED FROM: Kawasaki disease
Disease Ontology (DO)	glucose metabolism disease	1	1.487	Informative	INHERITED FROM: diabetes mellitus
Disease Ontology (DO)	Graves' disease	2.11e-08	1.855	Highly Informative	DIRECT
Disease Ontology (DO)	spondylitis	5.313e-06	1.855	Highly Informative	DIRECT
Disease Ontology (DO)	sickle cell anemia	6.32e-06	2.031	Highly Informative	DIRECT
Disease Ontology (DO)	pemphigus	9.351e-06	1.855	Highly Informative	DIRECT
Disease Ontology (DO)	sarcoidosis	1.363e-05	1.855	Highly Informative	DIRECT
Disease Ontology (DO)	intrahepatic cholestasis	6.468e-05	2.031	Highly Informative	DIRECT
Disease Ontology (DO)	leprosy	0.0005091	2.031	Highly Informative	DIRECT
Disease Ontology (DO)	metal metabolism disorder	0.001344	2.031	Highly Informative	INHERITED FROM: hemochromatosis

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Cardiac arrest	2.475e-05	2.207	--	DIRECT
Phenotypic Abnormality (PA)	Reduced consciousness/confusion	0.0006226	1.253	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1617	0.8266	--	INHERITED FROM: Cardiac arrest
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0.3111	0.7155	--	INHERITED FROM: Reduced consciousness/confusion
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.5423	0.3873	--	INHERITED FROM: Reduced consciousness/confusion
Phenotypic Abnormality (PA)	Abnormality of the central nervous system	0.4887	0.4287	Least Informative	INHERITED FROM: Reduced consciousness/confusion
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system physiology	0.02417	1.508	Informative	INHERITED FROM: Cardiac arrest
Phenotypic Abnormality (PA)	Arrhythmia	0.002509	1.906	Highly Informative	INHERITED FROM: Cardiac arrest

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal T cell number	3.567e-07	1.62	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	9.905e-07	1.235	--	DIRECT
Mammalian Phenotype (MP)	abnormal T cell morphology	3.53e-06	1.351	--	DIRECT
Mammalian Phenotype (MP)	absent CD8-positive T cells	8.093e-06	2.465	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	1.106e-05	0.7752	--	DIRECT
Mammalian Phenotype (MP)	hematopoietic system phenotype	1.652e-05	0.7578	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	2.381e-05	1.05	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoiesis	4.286e-05	0.8219	--	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.0002483	0.8972	--	DIRECT
Mammalian Phenotype (MP)	abnormal self tolerance	0.001665	1.424	--	INHERITED FROM: altered susceptibility to autoimmune disorder
Mammalian Phenotype (MP)	absent single-positive T cells	0.01493	2.465	--	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	absent T cells	0.02015	2.465	--	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	absent lymphocyte	0.06729	2.465	--	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal CD8-positive T cell physiology	0.08982	2.164	--	INHERITED FROM: abnormal cytotoxic T cell physiology
Mammalian Phenotype (MP)	abnormal immune tolerance	0.09349	1.424	--	INHERITED FROM: altered susceptibility to autoimmune disorder
Mammalian Phenotype (MP)	decreased single-positive T cell number	0.1217	2.164	--	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.124	1.21	--	INHERITED FROM: abnormal T cell number || abnormal lymphocyte cell number || absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal immune system morphology	0.2697	0.8026	--	INHERITED FROM: abnormal mononuclear cell morphology || abnormal lymphocyte cell number || abnormal lymphocyte morphology || absent CD8-positive T cells || abnormal T cell number || abnormal T cell morphology
Mammalian Phenotype (MP)	abnormal immune system physiology	0.3353	0.733	--	INHERITED FROM: altered susceptibility to autoimmune disorder || abnormal lymphocyte physiology || abnormal antigen presentation || abnormal cytotoxic T cell physiology || abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.4279	0.8219	--	INHERITED FROM: abnormal hematopoiesis || abnormal mononuclear cell morphology || abnormal lymphocyte cell number || abnormal lymphocyte morphology || abnormal T cell number || abnormal T cell morphology || absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal CD8-positive T cell morphology	0.5033	2.164	--	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.5477	0.8743	--	INHERITED FROM: abnormal mononuclear cell morphology || abnormal lymphocyte cell number || abnormal lymphocyte morphology || abnormal T cell number || abnormal T cell morphology || absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.5709	0.8633	--	INHERITED FROM: abnormal mononuclear cell morphology || abnormal lymphocyte cell number || abnormal lymphocyte morphology || abnormal T cell number || abnormal T cell morphology || absent CD8-positive T cells
Mammalian Phenotype (MP)	decreased CD8-positive T cell number	0.6402	2.465	--	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.6422	1.766	--	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.7266	1.687	--	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	immune system phenotype	0	0.5846	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	5.148e-05	1.034	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.1121	1.034	Moderately Informative	INHERITED FROM: abnormal lymphocyte physiology || abnormal cytotoxic T cell physiology || abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.117	1.034	Moderately Informative	INHERITED FROM: abnormal lymphocyte physiology || abnormal cytotoxic T cell physiology || abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.1275	1.018	Moderately Informative	INHERITED FROM: abnormal lymphocyte physiology || abnormal cytotoxic T cell physiology || abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.1345	1.123	Moderately Informative	INHERITED FROM: abnormal T cell number || abnormal lymphocyte cell number || absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	1.042e-05	1.465	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal antigen presentation	9.942e-05	1.687	Informative	DIRECT
Mammalian Phenotype (MP)	autoimmune response	0.001641	1.424	Informative	INHERITED FROM: altered susceptibility to autoimmune disorder
Mammalian Phenotype (MP)	abnormal effector T cell morphology	0.02337	1.62	Informative	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal T cell physiology	0.6473	1.465	Informative	INHERITED FROM: abnormal cytotoxic T cell physiology
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.72	1.465	Informative	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	altered susceptibility to autoimmune disorder	0.0005993	1.863	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cytotoxic T cell physiology	0.0007558	2.164	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased T cell number	0.395	1.988	Highly Informative	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal CD8-positive T cell number	0.5645	2.164	Highly Informative	INHERITED FROM: absent CD8-positive T cells
Mammalian Phenotype (MP)	abnormal single-positive T cell number	0.7081	1.988	Highly Informative	INHERITED FROM: absent CD8-positive T cells