SUPERFAMILY 1.75 HMM library and genome assignments server

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MoaD/ThiS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   MoaD/ThiS [ 54285] (4)
Families:   MoaD [ 54286] (2)
  ThiS [ 54289] (4)
  C9orf74 homolog [ 117833]
  HI0395-like [ 159931]


Superfamily statistics
Genomes (2,502) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,956 29,327 12
Proteins 5,956 29,327 12


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.00000019270.0000002652Least InformativeDirect
Biological Process (BP)biosynthetic process0.00014360.00003313Least InformativeDirect
Biological Process (BP)protein metabolic process0.0000018470.00001547Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.0000000062590.000008454Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00000019770.0000005852Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0000012780.000002486Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00000000030770.0000000002147Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00000005710.00000002708Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.0000000079970.0000000004289Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00000000000019260Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000000180.0000001545Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)gene expression0.75880.9885Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.65830.9855Moderately InformativeInherited
Biological Process (BP)RNA processing0.000059410.0007687InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.000024820.0000005453InformativeDirect
Biological Process (BP)RNA modification0.00017510.000009044InformativeDirect
Biological Process (BP)ncRNA metabolic process0.000005210.00005525InformativeDirect
Biological Process (BP)tRNA modification0.000000017160.00000001286Highly InformativeDirect
Biological Process (BP)molybdopterin cofactor metabolic process00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.0084470.01313Least InformativeInherited
Cellular Component (CC)cytosol0.000000027890.000000009196Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.0000002652 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00003313 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00001547 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000008454 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000005852 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000002486 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000002147 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000002708 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000000004289 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000001545 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0.9885 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9855 Moderately Informative Inherited
Biological Process (BP) RNA processing 0.0007687 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0000005453 Informative Direct
Biological Process (BP) RNA modification 0.000009044 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.00005525 Informative Direct
Biological Process (BP) tRNA modification 0.00000001286 Highly Informative Direct
Biological Process (BP) molybdopterin cofactor metabolic process 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.01313 Least Informative Inherited
Cellular Component (CC) cytosol 0.000000009196 Moderately Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processtRNA processing0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0.0007339Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.0000004095Least InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis0Highly InformativeDirect
UniPathway (UP)molybdopterin biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MoaD/ThiS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the MoaD/ThiS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]