SUPERFAMILY 1.75 HMM library and genome assignments server

MoaD/ThiS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   MoaD/ThiS [ 54285] (4)
Families:   MoaD [ 54286] (2)
  ThiS [ 54289] (4)
  C9orf74 homolog [ 117833]
  HI0395-like [ 159931]


Superfamily statistics
Genomes (2,502) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,956 29,327 12
Proteins 5,956 29,327 12


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.00000021460.0000002632Least InformativeDirect
Biological Process (BP)biosynthetic process0.00011780.00002684Least InformativeDirect
Biological Process (BP)protein metabolic process0.0000018450.00001631Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.000000004830.0000063Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00000025090.0000006052Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0000013790.000002611Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00000000062320.0000000004945Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.000000056560.00000002519Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.000000011460.0000000005837Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00000000000047220Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.00000017220.0000001449Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.65750.9901Moderately InformativeInherited
Biological Process (BP)gene expression0.80061Moderately InformativeInherited
Biological Process (BP)RNA processing0.000058620.0007688InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.000050350.000001082InformativeDirect
Biological Process (BP)RNA modification0.00016760.0000089InformativeDirect
Biological Process (BP)ncRNA metabolic process0.0000051610.00005533InformativeDirect
Biological Process (BP)tRNA modification0.000000017050.00000001309Highly InformativeDirect
Biological Process (BP)molybdopterin cofactor metabolic process00Highly InformativeDirect
Molecular Function (MF)transferase activity0.000016670.00008811Least InformativeDirect
Molecular Function (MF)transferase activity, transferring sulfur-containing groups00InformativeDirect
Molecular Function (MF)sulfurtransferase activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.0079580.01343Least InformativeInherited
Cellular Component (CC)cytosol0.000000025490.00000000973Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.0000002632 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00002684 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00001631 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000063 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000006052 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000002611 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000004945 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000002519 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000000005837 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000001449 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.9901 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA processing 0.0007688 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.000001082 Informative Direct
Biological Process (BP) RNA modification 0.0000089 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.00005533 Informative Direct
Biological Process (BP) tRNA modification 0.00000001309 Highly Informative Direct
Biological Process (BP) molybdopterin cofactor metabolic process 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00008811 Least Informative Direct
Molecular Function (MF) transferase activity, transferring sulfur-containing groups 0 Informative Direct
Molecular Function (MF) sulfurtransferase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.01343 Least Informative Inherited
Cellular Component (CC) cytosol 0.00000000973 Moderately Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processtRNA processing0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0.0007339Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.0000004095Least InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis0Highly InformativeDirect
UniPathway (UP)molybdopterin biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MoaD/ThiS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the MoaD/ThiS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]