SUPERFAMILY 1.75 HMM library and genome assignments server


MoaD/ThiS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   MoaD/ThiS [ 54285] (4)
Families:   MoaD [ 54286] (2)
  ThiS [ 54289] (4)
  C9orf74 homolog [ 117833]
  HI0395-like [ 159931]


Superfamily statistics
Genomes (2,502) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,959 29,327 12
Proteins 5,959 29,327 12


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process3.774e-075.312e-07Least InformativeDirect
Biological Process (BP)biosynthetic process0.0002576.449e-05Least InformativeDirect
Biological Process (BP)protein metabolic process5.918e-074.548e-06Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process5.784e-108.931e-07Least InformativeDirect
Biological Process (BP)heterocycle metabolic process3.625e-081.179e-07Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process2.415e-075.119e-07Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process2.836e-102.504e-10Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process1.25e-084.731e-09Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process2.255e-091.514e-10Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process4.86e-140Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process4.16e-083.006e-08Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process3.321e-150Moderately InformativeDirect
Biological Process (BP)gene expression0.76330.9888Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.66560.9859Moderately InformativeInherited
Biological Process (BP)RNA processing6.642e-050.0008043InformativeDirect
Biological Process (BP)coenzyme biosynthetic process2.4e-054.531e-07InformativeDirect
Biological Process (BP)RNA modification0.00017499.038e-06InformativeDirect
Biological Process (BP)ncRNA metabolic process5.923e-065.84e-05InformativeDirect
Biological Process (BP)tRNA modification1.802e-081.371e-08Highly InformativeDirect
Biological Process (BP)molybdopterin cofactor metabolic process00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.009840.01464Least InformativeInherited
Cellular Component (CC)cytosol3.324e-081.022e-08Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 5.312e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 6.449e-05 Least Informative Direct
Biological Process (BP) protein metabolic process 4.548e-06 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 8.931e-07 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.179e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 5.119e-07 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 2.504e-10 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 4.731e-09 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.514e-10 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 3.006e-08 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0.9888 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9859 Moderately Informative Inherited
Biological Process (BP) RNA processing 0.0008043 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 4.531e-07 Informative Direct
Biological Process (BP) RNA modification 9.038e-06 Informative Direct
Biological Process (BP) ncRNA metabolic process 5.84e-05 Informative Direct
Biological Process (BP) tRNA modification 1.371e-08 Highly Informative Direct
Biological Process (BP) molybdopterin cofactor metabolic process 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.01464 Least Informative Inherited
Cellular Component (CC) cytosol 1.022e-08 Moderately Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processtRNA processing0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0.000737Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism4.112e-07Least InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)molybdopterin biosynthesis0Highly InformativeDirect
UniPathway (UP)5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MoaD/ThiS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the MoaD/ThiS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]