SUPERFAMILY 1.75 HMM library and genome assignments server

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CAD & PB1 domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   CAD & PB1 domains [ 54277] (2)
Families:   CAD domain [ 54278] (3)
  PB1 domain [ 64225] (10)


Superfamily statistics
Genomes (468) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,259 7,672 23
Proteins 9,231 7,661 23


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.0025770.0000001186Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00002066 Least Informative Direct
Biological Process (BP) developmental process 0.000008438 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000002177 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.7822 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.152 Least Informative Inherited
Biological Process (BP) localization 0.9889 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002604 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.001123 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9671 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000000000002282 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0006998 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0468 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9336 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.002758 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.5687 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.02106 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.417 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2192 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1997 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5726 Moderately Informative Inherited
Biological Process (BP) organ development 0.4646 Moderately Informative Inherited
Biological Process (BP) reproduction 0.002636 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.7242 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.987 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8831 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8391 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.06401 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.3044 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.617 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.6377 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.002212 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.3767 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3055 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1385 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.5785 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1617 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5394 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.000231 Informative Direct
Biological Process (BP) response to hormone stimulus 0 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0000002004 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0005297 Informative Direct
Biological Process (BP) apoptotic process 0.09694 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.061 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.8867 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.06197 Informative Inherited
Biological Process (BP) reproductive system development 0.03788 Informative Inherited
Biological Process (BP) sensory organ development 0.1951 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.006599 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.1826 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.06142 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.05192 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.07975 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.634 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.001244 Informative Inherited
Biological Process (BP) phosphorylation 0.001147 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.4074 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.1895 Informative Inherited
Biological Process (BP) DNA metabolic process 0.5205 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.01547 Informative Inherited
Biological Process (BP) organ morphogenesis 0.225 Informative Inherited
Biological Process (BP) DNA catabolic process 0.0000636 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.00008094 Highly Informative Direct
Biological Process (BP) autophagy 0.00000004773 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.00002853 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0002096 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0000003009 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0002928 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0001076 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.0005373 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0004308 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0.00000000004762 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.03375 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.0871 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.2602 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.005404 Highly Informative Inherited
Molecular Function (MF) binding 0.0000001186 Least Informative Direct
Molecular Function (MF) transferase activity 0.001401 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000002116 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.03677 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.06963 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.0000000005598 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000004634 Informative Direct
Molecular Function (MF) enzyme binding 0.0003341 Informative Direct
Molecular Function (MF) enzyme activator activity 0.05802 Informative Inherited
Molecular Function (MF) lipid binding 0.04202 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000000000005667 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.0001359 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0001976 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0002035 Highly Informative Direct
Cellular Component (CC) membrane 0.4696 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1562 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.03316 Least Informative Inherited
Cellular Component (CC) cytosol 0.0003386 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0778 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.00000002115 Informative Direct
Cellular Component (CC) cell junction 0.0000009149 Informative Direct
Cellular Component (CC) apical plasma membrane 0.00000000003403 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000000005968Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000008198Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.7636Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.06154Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.06315Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.0005428InformativeDirect
Mammalian Phenotype (MP)abnormal fatty acid level0.0005182Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001063Least InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.0003339Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0003483Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000485Moderately InformativeDirect
Worm Phenotype (WP)receptor mediated endocytosis defective0.00008736InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue0.1354Least InformativeInherited
Plant ANatomical entity (PAN)root system0.3886Least InformativeInherited
Plant ANatomical entity (PAN)root meristem0.01088Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000000007108Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.0005379Moderately InformativeDirect
Biological processAuxin signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndosome0.00000000001472Moderately InformativeDirect
Cellular componentCell junction0.00000002916Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00003119Moderately InformativeDirect
Cellular componentLysosome0.00000005322InformativeDirect
Cellular componentLipid droplet0.00000000002355Highly InformativeDirect
Cellular componentTight junction0.00000004861Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0005725Least InformativeDirect
DiseaseProto-oncogene0.0001273Moderately InformativeDirect
DomainZinc-finger0.0000005564Moderately InformativeDirect
DomainSH3 domain0.000000000000446InformativeDirect
DomainTPR repeat0.0000003388Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator0.00009635Moderately InformativeDirect
Post-translational modificationKinase0.0003482Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000000000001985InformativeDirect
Post-translational modificationPhosphoprotein0.000000002047Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CAD & PB1 domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the CAD & PB1 domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]