SUPERFAMILY 1.75 HMM library and genome assignments server


Ubiquitin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Families:   Ubiquitin-related [ 54237] (38)
  UBX domain [ 54250] (5)
  GABARAP-like [ 54253] (3)
  First domain of FERM [ 54256] (6)
  Ras-binding domain, RBD [ 54263] (13)
  BM-002-like [ 75362] (3)
  APG12-like [ 142972]
  DIX domain [ 159926]


Superfamily statistics
Genomes (623) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,637 52,964 156
Proteins 40,135 45,363 155


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process7.753e-100Least InformativeDirect
Biological Process (BP)response to stimulus0.16886.452e-06Least InformativeInherited
Biological Process (BP)regulation of cellular process0.12721.169e-05Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.016740.896Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)developmental process0.095351.545e-06Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)localization0.2422.14e-05Least InformativeInherited
Biological Process (BP)single-organism cellular process0.71327.424e-11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.60890.0002917Least InformativeInherited
Biological Process (BP)macromolecule localization0.00083882.669e-11Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.59410.7015Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.52231Moderately InformativeInherited
Biological Process (BP)response to organic substance0.47760.06781Moderately InformativeInherited
Biological Process (BP)regulation of localization0.44960.3483Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.64111Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.96030.08663Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0025731Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.04261Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.021040Moderately InformativeInherited
Biological Process (BP)cellular protein modification process7.821e-080.0959Moderately InformativeInherited
Biological Process (BP)ion transport0.6461Moderately InformativeInherited
Biological Process (BP)organic substance transport0.42611Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.048080.0119Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.60510.4641Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.046867.09e-12Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.77771Moderately InformativeInherited
Biological Process (BP)system process0.70160.5004Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal00InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.0063810InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.29220.3627InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.20470.1581InformativeInherited
Biological Process (BP)nitrogen compound transport0.32421InformativeInherited
Biological Process (BP)regulation of system process0.10270.5056InformativeInherited
Biological Process (BP)regulation of secretion0.0007470.1896InformativeInherited
Biological Process (BP)dephosphorylation0.094030.2111InformativeInherited
Biological Process (BP)synaptic transmission0.022870.1365InformativeInherited
Biological Process (BP)autophagy01.085e-14Highly InformativeDirect
Biological Process (BP)monoamine transport6.136e-051.115e-05Highly InformativeDirect
Biological Process (BP)regulation of proteolysis3.31e-050Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination7.29e-080Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process0.00043710Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.0028490.02153Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0067724.113e-05Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.0025343.606e-06Highly InformativeInherited
Biological Process (BP)protein dephosphorylation0.46770.1526Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.0018460.06308Highly InformativeInherited
Biological Process (BP)neuromuscular process0.00024240.1096Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.0022580.4754Highly InformativeInherited
Biological Process (BP)neurotransmitter transport0.0018460.02298Highly InformativeInherited
Molecular Function (MF)binding0.001730Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.64320.825Moderately InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds1.994e-152.072e-09InformativeDirect
Molecular Function (MF)enzyme binding0.01375.319e-09InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.14130.09827InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.00071971.289e-05Highly InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity7.683e-153.015e-11Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0023011Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.09181Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.4621Least InformativeInherited
Cellular Component (CC)nuclear part0.02040.4431Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen2.149e-050.5752Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.0022011InformativeInherited
Cellular Component (CC)nuclear body5.527e-070.0003245Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0002917 Least Informative Direct
Biological Process (BP) developmental process 1.545e-06 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 7.424e-11 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.169e-05 Least Informative Direct
Biological Process (BP) response to stimulus 6.452e-06 Least Informative Direct
Biological Process (BP) localization 2.14e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.896 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 7.637e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 1.105e-06 Moderately Informative Direct
Biological Process (BP) nervous system development 3.552e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 2.669e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 4.96e-06 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 7.09e-12 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 3.752e-15 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0001085 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 5.197e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.9222 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3483 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.0959 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.7015 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.06781 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08172 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.001015 Moderately Informative Inherited
Biological Process (BP) system process 0.5004 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.005511 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5062 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.04971 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0119 Moderately Informative Inherited
Biological Process (BP) reproduction 0.06653 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1576 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.08663 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.007046 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.9063 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.4217 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4641 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2081 Moderately Informative Inherited
Biological Process (BP) proteolysis 5.778e-09 Informative Direct
Biological Process (BP) phospholipid metabolic process 5.34e-08 Informative Direct
Biological Process (BP) cytoskeleton organization 1.902e-10 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0003382 Informative Direct
Biological Process (BP) cellular membrane organization 0.0003186 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1.356e-08 Informative Direct
Biological Process (BP) actin filament-based process 4.07e-10 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 1.602e-06 Informative Direct
Biological Process (BP) locomotion 0.0002755 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.247e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 2.606e-11 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.472e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0002149 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 5.967e-06 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001354 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.1189 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.3578 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.007525 Informative Inherited
Biological Process (BP) generation of neurons 0.7557 Informative Inherited
Biological Process (BP) regulation of cell development 0.06888 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4734 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001222 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.03036 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.3627 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.8531 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.004481 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.5849 Informative Inherited
Biological Process (BP) embryonic organ development 0.6617 Informative Inherited
Biological Process (BP) cell projection organization 0.01056 Informative Inherited
Biological Process (BP) apoptotic process 0.715 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.7239 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1581 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.2818 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9308 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.6777 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8148 Informative Inherited
Biological Process (BP) phosphorylation 0.001719 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03517 Informative Inherited
Biological Process (BP) regulation of system process 0.5056 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8218 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1325 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3306 Informative Inherited
Biological Process (BP) synaptic transmission 0.1365 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8593 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.4348 Informative Inherited
Biological Process (BP) cell cycle process 0.6313 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.004367 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.4688 Informative Inherited
Biological Process (BP) sexual reproduction 0.01204 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3739 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4239 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1175 Informative Inherited
Biological Process (BP) cellular component movement 0.05548 Informative Inherited
Biological Process (BP) localization of cell 0.006762 Informative Inherited
Biological Process (BP) regulation of secretion 0.1896 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.04105 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1123 Informative Inherited
Biological Process (BP) organ morphogenesis 0.04131 Informative Inherited
Biological Process (BP) leukocyte activation 0.008841 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.3003 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) dephosphorylation 0.2111 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.08985 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4337 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01468 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.003756 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01399 Informative Inherited
Biological Process (BP) central nervous system development 0.2766 Informative Inherited
Biological Process (BP) sensory organ development 0.009635 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.7773 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.9006 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.2515 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) growth 0.9431 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8941 Informative Inherited
Biological Process (BP) epithelium development 0.04179 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6753 Informative Inherited
Biological Process (BP) response to nutrient levels 0.007547 Informative Inherited
Biological Process (BP) organelle assembly 0.7547 Informative Inherited
Biological Process (BP) leukocyte homeostasis 4.453e-06 Highly Informative Direct
Biological Process (BP) autophagy 1.085e-14 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 3.752e-15 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 4.911e-06 Highly Informative Direct
Biological Process (BP) hemostasis 0.0005049 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 8.219e-06 Highly Informative Direct
Biological Process (BP) monoamine transport 1.115e-05 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) lipid modification 0.0007945 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0003815 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 2.336e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 1.368e-07 Highly Informative Direct
Biological Process (BP) cell junction organization 1.417e-05 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 1.141e-06 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 3.401e-05 Highly Informative Direct
Biological Process (BP) B cell activation 0.0001071 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 2.432e-06 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 3.606e-06 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0006766 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0005183 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0002066 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 4.113e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0002015 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.07178 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.8528 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.002349 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.1007 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.02153 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.03687 Highly Informative Inherited
Biological Process (BP) ear development 0.9134 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.7353 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.3644 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) meiosis 0.1112 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.02065 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.06263 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1538 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.0121 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.9308 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.2654 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1777 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1658 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.007615 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001901 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.5603 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.005413 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0039 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.1526 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.1175 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.9757 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.9404 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.002527 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.5 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.005692 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.005018 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01665 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.03269 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.1659 Highly Informative Inherited
Biological Process (BP) DNA modification 0.7021 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.6636 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.05394 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.06308 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.07888 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.5218 Highly Informative Inherited
Biological Process (BP) wound healing 0.05069 Highly Informative Inherited
Biological Process (BP) coagulation 0.003867 Highly Informative Inherited
Biological Process (BP) cell growth 0.1608 Highly Informative Inherited
Biological Process (BP) developmental growth 0.3339 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.0497 Highly Informative Inherited
Biological Process (BP) protein folding 0.815 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1096 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.001031 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.4754 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.02298 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.3253 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 6.849e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.189e-14 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.5161 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.825 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 4.848e-08 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 2.072e-09 Informative Direct
Molecular Function (MF) enzyme binding 5.319e-09 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.1007 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01395 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.9646 Informative Inherited
Molecular Function (MF) peptidase activity 0.1309 Informative Inherited
Molecular Function (MF) lipid binding 0.5364 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.09827 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.8846 Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1.289e-05 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002157 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0003692 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 3.015e-11 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 1.009e-11 Highly Informative Direct
Molecular Function (MF) protein complex binding 3.886e-06 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.1176 Highly Informative Inherited
Molecular Function (MF) ribonucleoprotein complex binding 0.00193 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.01955 Highly Informative Inherited
Molecular Function (MF) adenylyltransferase activity 0.002146 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 2.225e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.4621 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01049 Least Informative Inherited
Cellular Component (CC) protein complex 0.01068 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 2.847e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.2451 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.5752 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.5145 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.008564 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.7186 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4431 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.0003677 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0001371 Informative Direct
Cellular Component (CC) cell cortex 2.617e-14 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0002618 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) synapse part 0.03762 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0006598 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0003245 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0004277 Highly Informative Direct
Cellular Component (CC) cell division site part 0.003205 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.003473 Highly Informative Inherited
Cellular Component (CC) spliceosomal complex 0.2995 Highly Informative Inherited
Cellular Component (CC) chromatin 0.6662 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)5.609e-14Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0102Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases4.359e-12Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases4.443e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep3.067e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00289Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase1.949e-13InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase3.66e-06InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase6.12e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.01421Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.6628Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.8921InformativeInherited
Phenotypic Abnormality (PA)Alveolar cell carcinoma0.0001442Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal tumor incidence0.2212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.0005241Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.006354Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant1.573e-05Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.05939InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.2714Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9154Least InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.02423Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.0008178InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.0003732Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.001382Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.224Least InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.009171Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spleen0.0001293InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell1.031e-06InformativeDirect
Plant ANatomical entity (PAN)gamete0.0003164InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage4.841e-06Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases4.513e-12Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.312e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases6.772e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor2.099e-06Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase2.888e-06InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases6.043e-06InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1.517e-05InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.06057InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase4.105e-13Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C4.149e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport8.808e-07Least InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processAngiogenesis2.37e-16InformativeDirect
Biological processEndocytosis8.37e-08InformativeDirect
Biological processNeurogenesis0.0002213InformativeDirect
Biological processmRNA splicing0.0008555InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Biological processmRNA transport1.674e-13Highly InformativeDirect
Biological processCilium biogenesis/degradation1.611e-07Highly InformativeDirect
Biological processExocytosis9.97e-06Highly InformativeDirect
Biological processAntiviral defense3.027e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane4.43e-15Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentGolgi apparatus3.207e-06Moderately InformativeDirect
Cellular componentEndosome0.0003371Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentProteasome1.929e-09Highly InformativeDirect
Cellular componentLipid droplet2.577e-09Highly InformativeDirect
Coding sequence diversityAlternative splicing8.95e-05Least InformativeDirect
DiseaseTumor suppressor5.968e-09Moderately InformativeDirect
DiseaseProto-oncogene6.425e-06Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain5.766e-10InformativeDirect
DomainSH3 domain4.62e-05InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding9.154e-08InformativeDirect
Molecular functionLipid-binding7.312e-06InformativeDirect
Molecular functioncAMP-binding2.77e-06Highly InformativeDirect
Molecular functioncAMP0.0001101Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0.002338Moderately InformativeInherited
Post-translational modificationKinase0.04397Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationProtein phosphatase2.624e-12InformativeDirect
Post-translational modificationChromatin regulator3.984e-07InformativeDirect
Post-translational modificationSerine/threonine-protein kinase2.218e-05InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationActin capping6.297e-06Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor8.914e-06Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0007001Highly InformativeDirect
Post-translational modificationPhosphoprotein5.683e-13Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.03058Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism2.461e-10InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation3.158e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the Ubiquitin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]