SUPERFAMILY 1.75 HMM library and genome assignments server


Ubiquitin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Families:   Ubiquitin-related [ 54237] (38)
  UBX domain [ 54250] (5)
  GABARAP-like [ 54253] (3)
  First domain of FERM [ 54256] (6)
  Ras-binding domain, RBD [ 54263] (13)
  BM-002-like [ 75362] (3)
  APG12-like [ 142972]
  DIX domain [ 159926]


Superfamily statistics
Genomes (572) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 42,794 37,436 156
Proteins 35,971 31,486 155


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process3.14e-150Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process8.308e-090Least InformativeDirect
Biological Process (BP)response to stimulus0.1837.294e-06Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0065046.124e-07Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0010910.6396Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)localization0.22341.872e-05Least InformativeInherited
Biological Process (BP)multicellular organismal process0.25220.000258Least InformativeInherited
Biological Process (BP)single-organism cellular process0.70281.735e-11Least InformativeInherited
Biological Process (BP)macromolecule localization0.00075322.241e-11Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.77580.8813Moderately InformativeInherited
Biological Process (BP)response to organic substance0.63460.05058Moderately InformativeInherited
Biological Process (BP)regulation of localization0.81890.7292Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.94420.9528Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.95950.09469Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.00037321Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.015221Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.019520Moderately InformativeInherited
Biological Process (BP)cellular protein modification process5.541e-070.2256Moderately InformativeInherited
Biological Process (BP)ion transport0.65881Moderately InformativeInherited
Biological Process (BP)organic substance transport0.4291Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.028125.035e-12Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.72811Moderately InformativeInherited
Biological Process (BP)system process0.83690.4706Moderately InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.077167.533e-06InformativeInherited
Biological Process (BP)nitrogen compound transport0.33461InformativeInherited
Biological Process (BP)regulation of system process0.048250.5845InformativeInherited
Biological Process (BP)regulation of secretion0.046320.5724InformativeInherited
Biological Process (BP)dephosphorylation0.10120.2306InformativeInherited
Biological Process (BP)transmission of nerve impulse0.098740.684InformativeInherited
Biological Process (BP)cell-cell signaling0.29590.8982InformativeInherited
Biological Process (BP)autophagy05.591e-15Highly InformativeDirect
Biological Process (BP)monoamine transport6.154e-059.315e-06Highly InformativeDirect
Biological Process (BP)regulation of proteolysis3.226e-050Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination5.594e-080Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process0.00029370Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.0027770.01797Highly InformativeInherited
Biological Process (BP)regulation of transmission of nerve impulse0.0077050.5544Highly InformativeInherited
Biological Process (BP)protein dephosphorylation0.40080.152Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.0018990.05284Highly InformativeInherited
Biological Process (BP)neuromuscular process0.00016680.0798Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.0025110.3836Highly InformativeInherited
Biological Process (BP)neurotransmitter transport0.0019640.0185Highly InformativeInherited
Molecular Function (MF)binding0.01230Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.64530.7344Moderately InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds1.962e-151.178e-09InformativeDirect
Molecular Function (MF)enzyme binding0.025874.327e-09InformativeInherited
Molecular Function (MF)phosphatase activity0.10020.117InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.00073367.451e-06Highly InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity7.523e-152.293e-11Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.012331Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.092181Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.03093Least InformativeInherited
Cellular Component (CC)nuclear part0.0031981Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.00010471Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.0044581InformativeInherited
Cellular Component (CC)nuclear body4.452e-070.0002213Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000258 Least Informative Direct
Biological Process (BP) developmental process 1.271e-06 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.735e-11 Least Informative Direct
Biological Process (BP) regulation of cellular process 6.124e-07 Least Informative Direct
Biological Process (BP) response to stimulus 7.294e-06 Least Informative Direct
Biological Process (BP) localization 1.872e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.6396 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 5.95e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 9.065e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 2.241e-11 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 5.035e-12 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 5.243e-14 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0001571 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0001723 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.2611 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7876 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.2256 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05058 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8813 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1592 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.001845 Moderately Informative Inherited
Biological Process (BP) system process 0.4706 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7292 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9873 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.3678 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.007141 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.3157 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.01648 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001398 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02753 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9528 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0845 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.07186 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.09469 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.003602 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.9435 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.419 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4468 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2212 Moderately Informative Inherited
Biological Process (BP) proteolysis 1.087e-09 Informative Direct
Biological Process (BP) phospholipid metabolic process 1.274e-07 Informative Direct
Biological Process (BP) cytoskeleton organization 4.694e-10 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 3.337e-09 Informative Direct
Biological Process (BP) actin filament-based process 9.052e-10 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 2.011e-06 Informative Direct
Biological Process (BP) locomotion 0.0003989 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 7.274e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 5.977e-11 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.337e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001661 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 7.533e-06 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 1.597e-06 Informative Direct
Biological Process (BP) membrane organization 4.639e-05 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.07039 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.2533 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.007306 Informative Inherited
Biological Process (BP) generation of neurons 0.2377 Informative Inherited
Biological Process (BP) regulation of cell development 0.01234 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8778 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.08345 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.8151 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.005462 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.5801 Informative Inherited
Biological Process (BP) embryonic organ development 0.7077 Informative Inherited
Biological Process (BP) cell projection organization 0.004881 Informative Inherited
Biological Process (BP) cell death 0.001499 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.5623 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.3348 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9645 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1745 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8267 Informative Inherited
Biological Process (BP) phosphorylation 0.001245 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03417 Informative Inherited
Biological Process (BP) regulation of system process 0.5845 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.05148 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5463 Informative Inherited
Biological Process (BP) cell-cell signaling 0.8982 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.684 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2791 Informative Inherited
Biological Process (BP) cell cycle process 0.5435 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.00325 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.5168 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.06009 Informative Inherited
Biological Process (BP) cellular component movement 0.05481 Informative Inherited
Biological Process (BP) localization of cell 0.009345 Informative Inherited
Biological Process (BP) regulation of secretion 0.5724 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0631 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1562 Informative Inherited
Biological Process (BP) organ morphogenesis 0.0688 Informative Inherited
Biological Process (BP) cell activation 0.01201 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.05284 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1042 Informative Inherited
Biological Process (BP) dephosphorylation 0.2306 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.9234 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.7863 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.004883 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3354 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01857 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005153 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01537 Informative Inherited
Biological Process (BP) central nervous system development 0.5868 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.9191 Informative Inherited
Biological Process (BP) sensory organ development 0.0224 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.3281 Informative Inherited
Biological Process (BP) growth 0.5597 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8918 Informative Inherited
Biological Process (BP) epithelium development 0.03528 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.675 Informative Inherited
Biological Process (BP) response to nutrient levels 0.003751 Informative Inherited
Biological Process (BP) organelle assembly 0.6183 Informative Inherited
Biological Process (BP) leukocyte homeostasis 6.028e-06 Highly Informative Direct
Biological Process (BP) autophagy 5.591e-15 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 6.329e-06 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 1.433e-05 Highly Informative Direct
Biological Process (BP) monoamine transport 9.315e-06 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0006619 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) lipid modification 0.000731 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0004125 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 1.327e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 2.774e-05 Highly Informative Direct
Biological Process (BP) cell junction organization 1.266e-05 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 9.949e-06 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 2.51e-05 Highly Informative Direct
Biological Process (BP) B cell activation 0.0001013 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 8.043e-07 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0007363 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0007741 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0001283 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0007181 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.07149 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.8671 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.744 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.002438 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.01797 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.02888 Highly Informative Inherited
Biological Process (BP) inner ear development 0.2865 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.7897 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.1186 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.3638 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.8818 Highly Informative Inherited
Biological Process (BP) meiosis 0.07474 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.009513 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.07382 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1305 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.3559 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.004538 Highly Informative Inherited
Biological Process (BP) regulation of transmission of nerve impulse 0.5544 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.3614 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.09443 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.004479 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.002317 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.2619 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.003684 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.005596 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.009399 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.152 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.2039 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.3666 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 1 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 1 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.9144 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.06873 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.3788 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.001988 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.009041 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.003699 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01489 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.06619 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.1587 Highly Informative Inherited
Biological Process (BP) DNA modification 0.6408 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.5981 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.04768 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.05284 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6732 Highly Informative Inherited
Biological Process (BP) hemostasis 0.001113 Highly Informative Inherited
Biological Process (BP) wound healing 0.06134 Highly Informative Inherited
Biological Process (BP) coagulation 0.008441 Highly Informative Inherited
Biological Process (BP) cell growth 0.1318 Highly Informative Inherited
Biological Process (BP) developmental growth 0.2865 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.05162 Highly Informative Inherited
Biological Process (BP) protein folding 0.7239 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.0798 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.3836 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.0185 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.2487 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 4.816e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.888e-14 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3602 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.7344 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1.577e-07 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.178e-09 Informative Direct
Molecular Function (MF) enzyme binding 4.327e-09 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.1273 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0219 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.873 Informative Inherited
Molecular Function (MF) peptidase activity 0.1255 Informative Inherited
Molecular Function (MF) lipid binding 0.5161 Informative Inherited
Molecular Function (MF) phosphatase activity 0.117 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.8375 Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 7.451e-06 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002247 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000527 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 2.293e-11 Highly Informative Direct
Molecular Function (MF) protein complex binding 4.223e-06 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.07826 Highly Informative Inherited
Molecular Function (MF) ribonucleoprotein complex binding 0.001686 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.01602 Highly Informative Inherited
Molecular Function (MF) adenylyltransferase activity 0.001539 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0001239 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.03093 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.0243 Least Informative Inherited
Cellular Component (CC) protein complex 0.01125 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 5.415e-08 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.2218 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.00758 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.7405 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.0001988 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0001613 Informative Direct
Cellular Component (CC) cell cortex 5.824e-15 Informative Direct
Cellular Component (CC) actin cytoskeleton 7.461e-05 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) synapse part 0.04888 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) ruffle 2.306e-08 Highly Informative Direct
Cellular Component (CC) microvillus 1.13e-07 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 0.000112 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0003935 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0002213 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 5.623e-07 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0004245 Highly Informative Direct
Cellular Component (CC) axon part 0.9654 Highly Informative Inherited
Cellular Component (CC) spliceosomal complex 0.1371 Highly Informative Inherited
Cellular Component (CC) chromatin 0.5257 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)5.609e-14Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0102Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases4.359e-12Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases4.443e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep3.067e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00289Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase1.949e-13InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase3.66e-06InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase6.12e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.02011Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.553Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.8872InformativeInherited
Phenotypic Abnormality (PA)Alveolar cell carcinoma0.0001662Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)tumorigenesis0.2788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.0005615Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.006354Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant1.573e-05Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.05939InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0007307InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.0003662Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.001252Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.2233Least InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.00921Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spleen0.0001302InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell1.031e-06InformativeDirect
Plant ANatomical entity (PAN)gamete0.0003164InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage4.841e-06Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases6.584e-12Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.348e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases6.22e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1.955e-06Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase2.977e-06InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases6.216e-06InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1.568e-05InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.05938InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase4.594e-13Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C4.366e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport8.243e-07Least InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processAngiogenesis2.365e-16InformativeDirect
Biological processEndocytosis7.973e-08InformativeDirect
Biological processNeurogenesis0.0001919InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Biological processmRNA transport1.701e-13Highly InformativeDirect
Biological processCilium biogenesis/degradation1.33e-07Highly InformativeDirect
Biological processExocytosis1.02e-05Highly InformativeDirect
Biological processAntiviral defense3.065e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane6.564e-15Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentGolgi apparatus3.117e-06Moderately InformativeDirect
Cellular componentEndosome0.00033Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLipid droplet1.857e-09Highly InformativeDirect
Cellular componentProteasome2.09e-09Highly InformativeDirect
Coding sequence diversityAlternative splicing4.573e-05Least InformativeDirect
DiseaseTumor suppressor3.31e-09Moderately InformativeDirect
DiseaseProto-oncogene4.119e-06Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain6.258e-10InformativeDirect
DomainSH3 domain4.993e-05InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding9.526e-08InformativeDirect
Molecular functionLipid-binding3.597e-06InformativeDirect
Molecular functioncAMP-binding2.813e-06Highly InformativeDirect
Molecular functioncAMP0.0001143Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0.002209Moderately InformativeInherited
Post-translational modificationKinase0.04269Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationProtein phosphatase2.861e-12InformativeDirect
Post-translational modificationChromatin regulator3.584e-07InformativeDirect
Post-translational modificationSerine/threonine-protein kinase2.304e-05InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationActin capping6.413e-06Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor8.749e-06Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0007263Highly InformativeDirect
Post-translational modificationPhosphoprotein6.425e-13Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.03056Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism2.421e-10InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation3.11e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the Ubiquitin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]