SUPERFAMILY 1.73 HMM library and genome assignments server


Ribosomal protein S5 domain 2-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (334)
  Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold:   Ribosomal protein S5 domain 2-like [ 54210]
  core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
Superfamily:   Ribosomal protein S5 domain 2-like [ 54211] (12)
Families:   Translational machinery components [ 54212] (4)
  RNase P protein [ 54220]
  DNA gyrase/MutL, second domain [ 54224] (6)
  Hsp90 middle domain [ 102755]
  related to the DNA gyrase/MutL family; contains extra C-terminal alpha/beta subdomain
  Ribonuclease PH domain 1-like [ 54229] (2)
  GHMP Kinase, N-terminal domain [ 54232] (6)
  Early switch protein XOL-1, N-terminal domain [ 89824]
  diverged from the GHMP Kinase family; lost the ATP-binding site
  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC [ 89827]
  duplication; there are two structural repeats of this fold; each repeat is elaborated with additional structures forming the active site
  Imidazole glycerol phosphate dehydratase [ 102766]
  duplication; there are two structural repeats of this fold
  ATP-dependent protease Lon (La), catalytic domain [ 102769]
  contains extra C-terminal alpha/beta subdomain
  YigZ N-terminal domain-like [ 102772] (2)
  modification of the common fold; contains extra alpha-beta unit after strand 2, the extra strand is inserted between strands 3 and 4
  Formaldehyde-activating enzyme, FAE [ 117795]
  modification of the common fold; contains extra alpha-beta unit after strand 2, the extra strand extends beta-sheet antiparallel to strand 3


Superfamily statistics
Genomes (1,235) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 28,474 35,737 81
Proteins 25,950 32,701 73


Functional annotation
General category Information
Detailed category Translation

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ribosomal protein S5 domain 2-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Ribosomal protein S5 domain 2-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]