SUPERFAMILY 1.75 HMM library and genome assignments server


Ribosomal protein S5 domain 2-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ribosomal protein S5 domain 2-like [ 54210]
Superfamily:   Ribosomal protein S5 domain 2-like [ 54211] (12)
Families:   Translational machinery components [ 54212] (4)
  RNase P protein [ 54220]
  DNA gyrase/MutL, second domain [ 54224] (6)
  Hsp90 middle domain [ 102755]
  Ribonuclease PH domain 1-like [ 54229] (10)
  GHMP Kinase, N-terminal domain [ 54232] (6)
  Early switch protein XOL-1, N-terminal domain [ 89824]
  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC [ 89827]
  Imidazole glycerol phosphate dehydratase [ 102766]
  ATP-dependent protease Lon (La), catalytic domain [ 102769]
  YigZ N-terminal domain-like [ 102772] (2)
  Formaldehyde-activating enzyme, FAE [ 117795]


Superfamily statistics
Genomes (3,253) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 73,051 363,446 102
Proteins 66,195 325,948 93


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.018814.821e-13Least InformativeInherited
Biological Process (BP)biosynthetic process0.1161.098e-06Least InformativeInherited
Biological Process (BP)protein metabolic process0.04560.3606Least InformativeInherited
Biological Process (BP)gene expression1.05e-050Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.00051529.877e-12Moderately InformativeDirect
Molecular Function (MF)structural molecule activity9.038e-073.688e-06Moderately InformativeDirect
Molecular Function (MF)structural constituent of ribosome5.508e-086.759e-14InformativeDirect
Cellular Component (CC)intracellular organelle part0.061680.5894Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.00029510.00185Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.34560.1078Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex2.804e-098.572e-14Moderately InformativeDirect
Cellular Component (CC)cytosol0.030710.01815Moderately InformativeInherited
Cellular Component (CC)small ribosomal subunit1.265e-120InformativeDirect
Cellular Component (CC)cytosolic ribosome0.13510.2866InformativeInherited
Cellular Component (CC)cytosolic small ribosomal subunit0.00028978.73e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 4.821e-13 Least Informative Direct
Biological Process (BP) biosynthetic process 1.098e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 2.12e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0002707 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3606 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 9.877e-12 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 2.621e-11 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 5.669e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0002122 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3815 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.5254 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.509 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.955 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6224 Moderately Informative Inherited
Biological Process (BP) reproduction 0.8138 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.6562 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.03369 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 8.733e-08 Informative Direct
Biological Process (BP) isoprenoid metabolic process 7.348e-07 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 4.667e-06 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.045e-05 Informative Direct
Biological Process (BP) DNA metabolic process 4.348e-05 Informative Direct
Biological Process (BP) cell cycle process 0.0004431 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0006924 Informative Direct
Biological Process (BP) protein localization to organelle 0.04341 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.2754 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.6074 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.001403 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1137 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) organelle localization 0.6083 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.8241 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.2651 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.804 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9369 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.597 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.07221 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.6532 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.07377 Informative Inherited
Biological Process (BP) immune effector process 0.3513 Informative Inherited
Biological Process (BP) immune response 0.75 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.001126 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.001609 Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 2.123e-13 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 6.731e-13 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 1.785e-11 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 8.751e-11 Highly Informative Direct
Biological Process (BP) meiosis 1.215e-10 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 2.415e-08 Highly Informative Direct
Biological Process (BP) sterol metabolic process 1.069e-07 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 2.949e-06 Highly Informative Direct
Biological Process (BP) chromosome segregation 5.153e-06 Highly Informative Direct
Biological Process (BP) response to heat 1.52e-05 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 2.446e-05 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.0001091 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0001456 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0005185 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.0009235 Highly Informative Direct
Biological Process (BP) DNA recombination 0.1501 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.01004 Highly Informative Inherited
Biological Process (BP) B cell activation 0.01668 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.2325 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.03993 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate catabolic process 1 Highly Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0.1777 Highly Informative Inherited
Biological Process (BP) rRNA processing 0.02993 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.002872 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 3.688e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 1.387e-09 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 6.713e-08 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01096 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.003931 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.465 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.2038 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) structural constituent of ribosome 6.759e-14 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) nuclease activity 5.322e-14 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 2.853e-10 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 9.93e-10 Informative Direct
Molecular Function (MF) RNA binding 2.743e-08 Informative Direct
Molecular Function (MF) nucleotide binding 7.272e-07 Informative Direct
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.02932 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.147 Informative Inherited
Molecular Function (MF) hydro-lyase activity 0.003248 Informative Inherited
Molecular Function (MF) kinase activity 0.6659 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.8052 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) translation factor activity, nucleic acid binding 0 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 7.995e-16 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 1.53e-05 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 2.719e-05 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0003386 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.004343 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5894 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1284 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1078 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.00185 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 8.572e-14 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 9.249e-05 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.000825 Moderately Informative Direct
Cellular Component (CC) cytosol 0.01815 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.9851 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.04229 Moderately Informative Inherited
Cellular Component (CC) small ribosomal subunit 0 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.0009043 Informative Direct
Cellular Component (CC) cytosolic ribosome 0.2866 Informative Inherited
Cellular Component (CC) plastid 0.002527 Informative Inherited
Cellular Component (CC) cell junction 0.5587 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.02458 Informative Inherited
Cellular Component (CC) chromosome 0.04655 Informative Inherited
Cellular Component (CC) cytosolic small ribosomal subunit 8.73e-06 Highly Informative Direct
Cellular Component (CC) symplast 0.0003328 Highly Informative Direct
Cellular Component (CC) mitochondrial ribosome 0.001569 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.4313 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.03273Least InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.3584InformativeInherited
Enzyme Commission (EC)Endopeptidase La0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)Polyribonucleotide nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ribonuclease P0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.01209Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1998Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.02968Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.1745Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2517Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.3172Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.01127InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.02238InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0226InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.02538InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1296InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.3039InformativeInherited
Phenotypic Abnormality (PA)Uterine neoplasm1.921e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the large intestine4.309e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0003392Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.0003904Highly InformativeDirect
Phenotypic Abnormality (PA)Sarcoma0.0003904Highly InformativeDirect
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.04241Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.09133Moderately InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.009311InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.009471InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.01375InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01943InformativeInherited
Mammalian Phenotype (MP)azoospermia0.0004602Highly InformativeDirect
Mammalian Phenotype (MP)abnormal meiosis0.0005444Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.3432Least InformativeInherited
Worm Phenotype (WP)growth variant0.3714Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.01511Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.03872Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.07052Moderately InformativeInherited
Worm Phenotype (WP)germ cell compartment expansion variant0.0001344InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0001353InformativeDirect
Worm Phenotype (WP)rachis morphology variant0.0001518InformativeDirect
Worm Phenotype (WP)diplotene progression during oogenesis variant0.0001846InformativeDirect
Worm Phenotype (WP)early larval arrest6.174e-05Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.0001192Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.02299Moderately InformativeInherited
Xenopus ANatomical entity (XAN)endocrine system0.001273InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000278Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.02021Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Polyribonucleotide nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ribonuclease P0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.4317Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processLipid metabolism1.95e-12Moderately InformativeDirect
Biological processCarbohydrate metabolism0.001139Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processProtein biosynthesis0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processSteroid metabolism0.09696InformativeInherited
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis6.117e-09Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome0.0002647InformativeDirect
DomainTransit peptide5.099e-06Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationLyase4.071e-11Moderately InformativeDirect
Post-translational modificationProtease4.661e-05Moderately InformativeDirect
Post-translational modificationIsomerase1Moderately InformativeInherited
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)chorismate biosynthesis3.027e-06InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ribosomal protein S5 domain 2-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the Ribosomal protein S5 domain 2-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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