SUPERFAMILY 1.75 HMM library and genome assignments server


HIT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   HIT-like [ 54196] (2)
Superfamily:   HIT-like [ 54197] (4)
Families:   HIT (HINT, histidine triad) family of protein kinase-interacting proteins [ 54198] (7)
  Hexose-1-phosphate uridylyltransferase [ 54207]
  mRNA decapping enzyme DcpS C-terminal domain [ 102745]
  CDH-like [ 159882]


Superfamily statistics
Genomes (2,456) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 10,004 23,825 25
Proteins 8,929 21,037 20


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process2.934e-055.43e-14Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.00033283.828e-10Least InformativeDirect
Biological Process (BP)heterocycle metabolic process2.399e-051.896e-14Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00011546.511e-10Least InformativeDirect
Biological Process (BP)response to stimulus0.9441Least InformativeInherited
Biological Process (BP)regulation of cellular process0.74511Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.014170.3617Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process1.15e-050.0004774Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process1.78e-084.383e-06Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process1.352e-098.039e-07Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00018660.0004557Moderately InformativeDirect
Biological Process (BP)signal transduction0.020130.9105Moderately InformativeInherited
Biological Process (BP)apoptotic process2.486e-070.0003097InformativeDirect
Biological Process (BP)ribose phosphate metabolic process0.00047630.0003226InformativeDirect
Biological Process (BP)intracellular signal transduction2.784e-050.02568InformativeInherited
Biological Process (BP)signal transduction by p53 class mediator4.012e-142.892e-11Highly InformativeDirect
Biological Process (BP)apoptotic signaling pathway2.176e-116.328e-08Highly InformativeDirect
Molecular Function (MF)hydrolase activity1.376e-056.235e-10Least InformativeDirect
Molecular Function (MF)transferase activity0.95980.704Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.18010.000263Moderately InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity0.00070480InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.006010.03527Least InformativeInherited
Cellular Component (CC)protein complex0.44711Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)nuclear part0.089250.4618Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.020350.4614Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00051770.2468InformativeInherited
Cellular Component (CC)histone deacetylase complex2.317e-124.675e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 5.43e-14 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 3.828e-10 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.896e-14 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 6.511e-10 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.3617 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7258 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0004774 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0003107 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 4.383e-06 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0001567 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 8.039e-07 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0004557 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0002242 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.2397 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9105 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5893 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9223 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.009466 Moderately Informative Inherited
Biological Process (BP) gene expression 0.2804 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0008392 Informative Direct
Biological Process (BP) apoptotic process 0.0003097 Informative Direct
Biological Process (BP) hexose metabolic process 1.431e-06 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0.0003226 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 5.211e-05 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.02882 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.02568 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.03153 Informative Inherited
Biological Process (BP) RNA splicing, via transesterification reactions 1.297e-06 Highly Informative Direct
Biological Process (BP) signal transduction by p53 class mediator 2.892e-11 Highly Informative Direct
Biological Process (BP) apoptotic signaling pathway 6.328e-08 Highly Informative Direct
Biological Process (BP) mRNA processing 0.1413 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 6.235e-10 Least Informative Direct
Molecular Function (MF) transferase activity 0.704 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000263 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.2298 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.2095 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.0003889 Informative Direct
Molecular Function (MF) nuclease activity 3.551e-08 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.03527 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.4618 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.4614 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.2468 Informative Inherited
Cellular Component (CC) histone deacetylase complex 4.675e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases8.856e-13Least InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases2.399e-16Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.000401Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases2.586e-11Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processApoptosis1.183e-14Moderately InformativeDirect
Biological processCarbohydrate metabolism1.759e-12Moderately InformativeDirect
Biological processDNA damage1.026e-06Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processmRNA splicing4.666e-07InformativeDirect
Biological processPhospholipid biosynthesis0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.06126Least InformativeInherited
Cellular componentCell membrane2.86e-07Moderately InformativeDirect
Cellular componentCell inner membrane8.856e-10InformativeDirect
DomainTransmembrane6.745e-06Least InformativeDirect
Molecular functionZinc2.464e-11Least InformativeDirect
Molecular functionMetal-binding0.04163Least InformativeInherited
Molecular functionZinc-finger7.364e-08Moderately InformativeDirect
Molecular functionDNA-binding6.74e-05Moderately InformativeDirect
Molecular functionIron0.0004279Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase2.699e-12Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.0001726Least InformativeDirect
Post-translational modificationAcetylation0.0001678Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism2.243e-16Least InformativeDirect
UniPathway (UP)carbohydrate metabolism2.826e-06Least InformativeDirect
UniPathway (UP)phospholipid metabolism0InformativeDirect
UniPathway (UP)galactose metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011146 SSF54197 Protein matches
Abstract

The histidine triad motif (HIT) is related to the sequence H-phi-H-phi-H-phi-phi (where phi is a hydrophobic amino acid). Proteins containing HIT domains form a superfamily of nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides [PubMed12119013]. HIT-containing proteins fall into three families:

  • Hint family of protein kinase-interacting proteins. These include adenosine 5'-monophosphoramide hydrolases (e.g. HIT-nucleotide-binding protein, or HINT) and diadenosine polyphosphate hydrolases (e.g. fragile HIT protein, or FINT). These HIT domains have a topology similar to that found in the N-terminal of protein kinases [PubMed15904496].
  • GalT family. These include specific nucleoside monophosphate transferases (e.g. galactose-1-phosphate uridylyltransferase, diadenosine tetraphosphate phosphorylase, and adenylyl sulphate:phosphate adenylytransferase). These HIT domains are a duplication consisting of 2 HIT-like motifs. This family binds zinc and iron.
  • mRNA decapping enzyme family. These include enzymes such as DcpS and Dcp2. The HIT-domain is usually C-terminal in these proteins [PubMed15273322].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HIT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the HIT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]