SUPERFAMILY 1.75 HMM library and genome assignments server


DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNA-binding domain [ 54170]
Superfamily:   DNA-binding domain [ 54171] (4)
Families:   DNA-binding domain from tn916 integrase [ 54172]
  lambda integrase N-terminal domain [ 75344]
  GCC-box binding domain [ 54175]
  Methyl-CpG-binding domain, MBD [ 54178] (2)


Superfamily statistics
Genomes (355) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 11,434 10,632 10
Proteins 9,770 9,680 10


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 2.698e-10 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.04011 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01864 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.135 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1506 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3243 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4995 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.09176 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.08662 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.009849 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1293 Least Informative Inherited
Biological Process (BP) developmental process 0.05172 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8235 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9482 Least Informative Inherited
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 5.953e-14 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.03e-11 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.423e-07 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 2.628e-07 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1.39e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 7.354e-05 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.0001291 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.007085 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.6928 Moderately Informative Inherited
Biological Process (BP) reproduction 0.003701 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8233 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.01461 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.04417 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2644 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01234 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.003193 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01864 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.03648 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.2226 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5607 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.001897 Moderately Informative Inherited
Biological Process (BP) organ development 0.6259 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2462 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.3393 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to hormone stimulus 2.494e-12 Informative Direct
Biological Process (BP) chromosome organization 1.478e-10 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 2.192e-07 Informative Direct
Biological Process (BP) reproductive system development 1.613e-05 Informative Direct
Biological Process (BP) negative regulation of cellular metabolic process 1.704e-05 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 2.02e-05 Informative Direct
Biological Process (BP) response to inorganic substance 0.00024 Informative Direct
Biological Process (BP) immune effector process 0.0002736 Informative Direct
Biological Process (BP) DNA metabolic process 0.0004171 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0009522 Informative Direct
Biological Process (BP) cardiovascular system development 0.8613 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.001954 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.2122 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1343 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.9657 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.05053 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3434 Informative Inherited
Biological Process (BP) protein transport 0.2101 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.03728 Informative Inherited
Biological Process (BP) response to lipid 0.01065 Informative Inherited
Biological Process (BP) response to other organism 0.01433 Informative Inherited
Biological Process (BP) tube development 0.4553 Informative Inherited
Biological Process (BP) organ morphogenesis 0.4587 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5052 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.5544 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) defense response 0.2549 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.6828 Informative Inherited
Biological Process (BP) response to water deprivation 0 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) protein deacylation 5.545e-10 Highly Informative Direct
Biological Process (BP) post-embryonic development 7.866e-10 Highly Informative Direct
Biological Process (BP) response to cold 2.224e-09 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 1.702e-08 Highly Informative Direct
Biological Process (BP) DNA packaging 5.017e-07 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 1.043e-06 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 1.172e-06 Highly Informative Direct
Biological Process (BP) response to osmotic stress 2.737e-06 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 1.591e-05 Highly Informative Direct
Biological Process (BP) negative regulation of gene expression 3.494e-05 Highly Informative Direct
Biological Process (BP) response to fungus 4.157e-05 Highly Informative Direct
Biological Process (BP) nuclear import 6.124e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 7.969e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0001087 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0001684 Highly Informative Direct
Biological Process (BP) response to heat 0.0003083 Highly Informative Direct
Biological Process (BP) protein import 0.0003325 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 0.0003618 Highly Informative Direct
Biological Process (BP) protein methylation 0.1013 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.009022 Highly Informative Inherited
Biological Process (BP) chromatin assembly or disassembly 0.01582 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.04146 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.005032 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.6985 Least Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 7.973e-16 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 5.028e-09 Informative Direct
Molecular Function (MF) DNA binding 5.946e-09 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0001104 Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) methyltransferase activity 5.597e-05 Highly Informative Direct
Molecular Function (MF) chromatin binding 7.947e-05 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.8559 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 2.426e-06 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2454 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01904 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 9.535e-05 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.475 Moderately Informative Inherited
Cellular Component (CC) chromosome 1.207e-09 Informative Direct
Cellular Component (CC) nucleoplasm part 0.42 Informative Inherited
Cellular Component (CC) histone deacetylase complex 1.65e-08 Highly Informative Direct
Cellular Component (CC) chromatin 7.678e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups3.701e-10Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.03861Least InformativeInherited

Document: MP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit9.043e-05InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups3.824e-10Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.991Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processMitosis0.0003461InformativeDirect
Biological processEthylene signaling pathway0Highly InformativeDirect
Biological processViral genome integration1.09e-10Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome6.397e-16InformativeDirect
Coding sequence diversityAlternative splicing4.196e-06Least InformativeDirect
DomainCoiled coil2.757e-05Moderately InformativeDirect
DomainBromodomain5.275e-11Highly InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor1.103e-15Moderately InformativeDirect
Post-translational modificationDevelopmental protein8.496e-06Moderately InformativeDirect
Post-translational modificationChromatin regulator7.181e-13InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]