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RNase A-like superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Information |
| Detailed category | RNA processing |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR001427 SSF54076 Protein matches |
| Abstract | Pancreatic ribonucleases (RNAse) are pyrimidine-specific endonucleases
found in high quantity in the pancreas of certain mammals and of
some reptiles [ 3940901]. Specifically, the enzymes are involved in endonucleolytic
cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending
in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can
unwind the DNA helix by complexing with single-stranded DNA; the complex
arises by an extended multi-site cation-anion interaction between lysine
and arginine residues of the enzyme and phosphate groups of the nucleotides.
Other proteins belonging to the pancreatic RNAse family include: bovine
seminal vesicle and brain ribonucleases; kidney non-secretory ribonucleases
[2734298]; liver-type ribonucleases [2611266]; angiogenin, which induces vascularisation
of normal and malignant tissues; eosinophil cationic protein [2473157], a
cytotoxin and helminthotoxin with ribonuclease activity; and frog liver
ribonuclease and frog sialic acid-binding lectin.
The sequence of pancreatic RNases contains four conserved disulphide bonds and
three amino acid residues involved in the catalytic activity. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 16 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a RNase A-like domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 16 hidden Markov models representing the RNase A-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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