SUPERFAMILY 1.75 HMM library and genome assignments server

RNase A-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   RNase A-like [ 54075]
Superfamily:   RNase A-like [ 54076]
Families:   Ribonuclease A-like [ 54077] (8)


Superfamily statistics
Genomes (61) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 619 1,267 61
Proteins 619 1,256 61


Functional annotation
General category Information
Detailed category RNA processing

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00.0000000000001879Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.0000000000000063590.00000000002979Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00.000000001892Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00.0000000000001132Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.0000052570.000008005Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00.00000000000162Least InformativeDirect
Biological Process (BP)regulation of cellular process0.15640.1667Least InformativeInherited
Biological Process (BP)developmental process0.0000052140.01264Least InformativeInherited
Biological Process (BP)biosynthetic process0.045420.0308Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.000016590.1823Least InformativeInherited
Biological Process (BP)response to stimulus0.000000041310.001844Least InformativeInherited
Biological Process (BP)single-organism cellular process0.96261Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0002270.01145Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.53590.6015Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000010420.0146Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0000015170.0000001307Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.000014460.00002577Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.000000090820.0000001387Moderately InformativeDirect
Biological Process (BP)RNA metabolic process00Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00058420.0007912Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.00013490.0006923Moderately InformativeDirect
Biological Process (BP)regulation of localization0.0000000000056870.000000000000003707Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.00002110.0004689Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.000000000013840.0000262Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.00000000014090.00002431Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.0000000000000063590.0000000001717Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00036140.0005764Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000000087450.0000007509Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.000000000002390.000000005855Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization0.000000000006320.0000004628Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000000034830.001567Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.00000000016460.003502Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.043820.1095Moderately InformativeInherited
Biological Process (BP)defense response0.93940.8489Moderately InformativeInherited
Biological Process (BP)multi-organism process0.030430.01916Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.95891Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0012930.002513Moderately InformativeInherited
Biological Process (BP)gene expression0.00070850.003213Moderately InformativeInherited
Biological Process (BP)transcription, DNA-templated0.0000000000000048440.00000000003211InformativeDirect
Biological Process (BP)cytoskeleton organization00.00000000002841InformativeDirect
Biological Process (BP)response to bacterium0.000022430.000226InformativeDirect
Biological Process (BP)actin filament-based process00.000000000000007248InformativeDirect
Biological Process (BP)regulation of protein localization00.00001521InformativeDirect
Biological Process (BP)cellular macromolecular complex assembly00InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0000000000000032510.0000000001125InformativeDirect
Biological Process (BP)glycerolipid metabolic process00InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis00.0000000001023InformativeDirect
Biological Process (BP)regulation of secretion00InformativeDirect
Biological Process (BP)positive regulation of transport00.000000000007078InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity00InformativeDirect
Biological Process (BP)cardiovascular system development0.0000000000000032510.00000000001944InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis00InformativeDirect
Biological Process (BP)defense response to other organism0.0016210.001746InformativeInherited
Biological Process (BP)cellular response to external stimulus0.027760.01697InformativeInherited
Biological Process (BP)response to nutrient levels0.0001140.001829InformativeInherited
Biological Process (BP)angiogenesis00Highly InformativeDirect
Biological Process (BP)response to hypoxia0.00000000000020380.0000000000001285Highly InformativeDirect
Biological Process (BP)acylglycerol metabolic process00Highly InformativeDirect
Biological Process (BP)actin filament organization00Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation00Highly InformativeDirect
Biological Process (BP)regulation of phospholipase activity00Highly InformativeDirect
Biological Process (BP)defense response to bacterium0.00000077920.000006118Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation00Highly InformativeDirect
Biological Process (BP)positive regulation of epithelial cell proliferation00Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion00Highly InformativeDirect
Biological Process (BP)protein polymerization00Highly InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.025430.8499Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000000000052440.00000000003772Moderately InformativeDirect
Molecular Function (MF)cation binding0.0000000000040110.000000000004547Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000000000018830.000000000000009169Moderately InformativeDirect
Molecular Function (MF)nuclease activity00InformativeDirect
Molecular Function (MF)receptor binding00.00000000000004367InformativeDirect
Molecular Function (MF)cytoskeletal protein binding00.000000000000003138InformativeDirect
Molecular Function (MF)sulfur compound binding00InformativeDirect
Molecular Function (MF)copper ion binding00Highly InformativeDirect
Molecular Function (MF)heparin binding00Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0000082220.0005276Least InformativeDirect
Cellular Component (CC)protein complex0.0000012120.0007947Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00014730.03697Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)nuclear part0.000000000047770.000004851Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.000000000027470.000001517Moderately InformativeDirect
Cellular Component (CC)extracellular matrix00InformativeDirect
Cellular Component (CC)proteinaceous extracellular matrix00.0000000006809Highly InformativeDirect
Cellular Component (CC)extracellular matrix part00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0000000000001879 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00000000002979 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000001892 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000000000001132 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.000008005 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000000162 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.1667 Least Informative Inherited
Biological Process (BP) developmental process 0.01264 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.0308 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1823 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001844 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01145 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6015 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.0146 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.0000001307 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00002577 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000001387 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0007912 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0006923 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0004689 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0000262 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.00002431 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000001717 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0005764 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000007509 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000005855 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.0000004628 Moderately Informative Direct
Biological Process (BP) defense response 0.8489 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001567 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.003502 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.1095 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01916 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.1779 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.002513 Moderately Informative Inherited
Biological Process (BP) gene expression 0.003213 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-templated 0.00000000003211 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000002841 Informative Direct
Biological Process (BP) response to bacterium 0.000226 Informative Direct
Biological Process (BP) biological adhesion 0.0001104 Informative Direct
Biological Process (BP) actin filament-based process 0.000000000000007248 Informative Direct
Biological Process (BP) regulation of protein localization 0.00001521 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.00007708 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000000001125 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000000001023 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.000000000007078 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00005075 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) cardiovascular system development 0.00000000001944 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0 Informative Direct
Biological Process (BP) defense response to other organism 0.001746 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.01697 Informative Inherited
Biological Process (BP) response to nutrient levels 0.001829 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1834 Informative Inherited
Biological Process (BP) reproductive structure development 0.1127 Informative Inherited
Biological Process (BP) angiogenesis 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.0000000000001285 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0.00002569 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0 Highly Informative Direct
Biological Process (BP) gonad development 0.000136 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000001901 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.000006118 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0000003856 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0 Highly Informative Direct
Biological Process (BP) protein polymerization 0 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.0000002837 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.8499 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000000003772 Moderately Informative Direct
Molecular Function (MF) cation binding 0.000000000004547 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000000009169 Moderately Informative Direct
Molecular Function (MF) nuclease activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.00000000000004367 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000000000003138 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0005276 Least Informative Direct
Cellular Component (CC) protein complex 0.0007947 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.03697 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.000004851 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.000001517 Moderately Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.0000000006809 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing other than 5'-phosphom0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)citric acid0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processStress response0.00000000003498InformativeDirect
Biological processCell adhesion0.00001412InformativeDirect
Biological processFertilization0.00000000000005028Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentExtracellular matrix0.00004399InformativeDirect
Cellular componentBasement membrane0Highly InformativeDirect
Coding sequence diversityPolymorphism0.0006831Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000000001208Moderately InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationNitration0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001427 SSF54076 Protein matches
Abstract Pancreatic ribonucleases (RNAse) are pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles [PubMed3940901]. Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can unwind the DNA helix by complexing with single-stranded DNA; the complex arises by an extended multi-site cation-anion interaction between lysine and arginine residues of the enzyme and phosphate groups of the nucleotides. Other proteins belonging to the pancreatic RNAse family include: bovine seminal vesicle and brain ribonucleases; kidney non-secretory ribonucleases [PubMed2734298]; liver-type ribonucleases [PubMed2611266]; angiogenin, which induces vascularisation of normal and malignant tissues; eosinophil cationic protein [PubMed2473157], a cytotoxin and helminthotoxin with ribonuclease activity; and frog liver ribonuclease and frog sialic acid-binding lectin. The sequence of pancreatic RNases contains four conserved disulphide bonds and three amino acid residues involved in the catalytic activity.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNase A-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the RNase A-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]