SUPERFAMILY 1.75 HMM library and genome assignments server


His-Me finger endonucleases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   His-Me finger endonucleases [ 54059]
Superfamily:   His-Me finger endonucleases [ 54060] (6)
Families:   Endonuclease I [ 102726]
  HNH-motif [ 54061] (2)
  DNA/RNA non-specific endonuclease [ 54066] (2)
  Intron-encoded homing endonucleases [ 54069] (2)
  Recombination endonuclease VII, N-terminal domain [ 68915]
  Caspase-activated DNase, CAD (DffB, DFF40) [ 110778]


Superfamily statistics
Genomes (1,247) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 4,251 9,998 24
Proteins 4,169 9,672 24


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 1.062e-05 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.005098 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7989 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4583 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.5436 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01042 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.006672 Least Informative Inherited
Biological Process (BP) cellular catabolic process 9.269e-11 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 6.902e-10 Moderately Informative Direct
Biological Process (BP) DNA metabolic process 1.612e-07 Informative Direct
Biological Process (BP) apoptotic process 7.141e-07 Informative Direct
Biological Process (BP) cellular component disassembly 9.921e-09 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 2.151e-12 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 1.633e-07 Informative Direct
Biological Process (BP) DNA catabolic process 1.53e-14 Highly Informative Direct
Biological Process (BP) cellular component disassembly involved in execution phase of apoptosis 2.584e-12 Highly Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 7.26e-10 Highly Informative Direct
Molecular Function (MF) hydrolase activity 9.164e-07 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 2.457e-09 Moderately Informative Direct
Molecular Function (MF) nuclease activity 6.105e-09 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) phospholipase activity 9.811e-09 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 4.07e-10 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0.05464 Highly Informative Inherited
Cellular Component (CC) extracellular region 0.005401 Moderately Informative Inherited
Cellular Component (CC) extracellular space 5.646e-05 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0196Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases6.077e-14Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides4.777e-13Moderately InformativeDirect
Enzyme Commission (EC)Nucleotide diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Phosphodiesterase I8.244e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.01934Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases6.148e-14InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides4.49e-13InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.001037Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis8.539e-07Moderately InformativeDirect
Cellular componentSecreted5.747e-13Moderately InformativeDirect
Cellular componentMitochondrion5.502e-06Moderately InformativeDirect
DiseaseObesity1.302e-10InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor4.272e-10Moderately InformativeDirect
DomainTransit peptide0.0001975Moderately InformativeDirect
Molecular functionMetal-binding4.198e-09Least InformativeDirect
Molecular functionZinc0.0008023Least InformativeDirect
Molecular functionManganese1.07e-05Moderately InformativeDirect
Molecular functionCalcium0.0005173Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationAntimicrobial1.41e-09InformativeDirect
Post-translational modificationEndonuclease0.0007175InformativeDirect
Post-translational modificationAntibiotic9.121e-12Highly InformativeDirect
Post-translational modificationGlycoprotein9.019e-05Least InformativeDirect
Post-translational modificationDisulfide bond9.448e-05Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a His-Me finger endonucleases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the His-Me finger endonucleases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]