SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (2,990) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 58,159 89,135 132
Proteins 57,342 88,440 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.90430Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.90580.8944Least InformativeInherited
Biological Process (BP)multicellular organismal process9.458e-090.9573Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.2292Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.90071Least InformativeInherited
Biological Process (BP)response to stimulus0.19580.2517Least InformativeInherited
Biological Process (BP)regulation of cellular process10.00165Least InformativeInherited
Biological Process (BP)developmental process4.667e-100.2164Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.27371Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.3564Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.61960.8183Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.12461Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.15460.9413Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.16071Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0042110.9534Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.79080.2257Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.076080Moderately InformativeInherited
Biological Process (BP)signal transduction0.27031Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0016740.001053Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0013820.3224Moderately InformativeInherited
Biological Process (BP)tissue development1.729e-070.4806Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.055751Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0059460.792Moderately InformativeInherited
Biological Process (BP)homeostatic process1.792e-050.6502Moderately InformativeInherited
Biological Process (BP)single-organism developmental process2.86e-120.3684Moderately InformativeInherited
Biological Process (BP)organ development0.00023031Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0039970.6466Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.12710.1037Moderately InformativeInherited
Biological Process (BP)gene expression0.078081Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0071620.7804Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process2.939e-050.001361Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0003290.1452Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.034781Moderately InformativeInherited
Biological Process (BP)regulation of localization0.11091Moderately InformativeInherited
Biological Process (BP)reproduction0.00010831Moderately InformativeInherited
Biological Process (BP)multi-organism process0.013430.04665Moderately InformativeInherited
Biological Process (BP)immune system process6.528e-051Moderately InformativeInherited
Biological Process (BP)proteolysis3.499e-086.895e-08InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression2.17e-102.515e-10InformativeDirect
Biological Process (BP)cellular amide metabolic process5.9e-085.206e-05InformativeDirect
Biological Process (BP)regulation of peptidase activity9.508e-119.544e-06InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.85511InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.096030.01601InformativeInherited
Biological Process (BP)regulation of organelle organization0.00018340.04165InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.23630.2519InformativeInherited
Biological Process (BP)response to hormone stimulus0.33541InformativeInherited
Biological Process (BP)intracellular signal transduction0.00093860.09043InformativeInherited
Biological Process (BP)tissue morphogenesis3.009e-100.1195InformativeInherited
Biological Process (BP)epithelium development0.79220.8201InformativeInherited
Biological Process (BP)single organism reproductive process4.377e-071InformativeInherited
Biological Process (BP)multicellular organismal reproductive process1.101e-080.5828InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0025120.01297InformativeInherited
Biological Process (BP)positive regulation of developmental process2.803e-050.001087InformativeInherited
Biological Process (BP)organ morphogenesis4.685e-070.8907InformativeInherited
Biological Process (BP)response to lipid9.246e-050.1556InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity5.267e-070.09433InformativeInherited
Biological Process (BP)regulation of locomotion2.235e-060.6439InformativeInherited
Biological Process (BP)regulation of cellular component movement2e-070.7507InformativeInherited
Biological Process (BP)regulation of immune response0.0016320.6121InformativeInherited
Biological Process (BP)immune response5.8e-080.3667InformativeInherited
Biological Process (BP)immune effector process0.00086810.2179InformativeInherited
Biological Process (BP)placenta development4.695e-152.642e-07Highly InformativeDirect
Biological Process (BP)tissue homeostasis07.563e-06Highly InformativeDirect
Biological Process (BP)hair follicle development3.985e-070.0007217Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity4.814e-090.0004063Highly InformativeDirect
Biological Process (BP)immune response-regulating signaling pathway4.273e-120.0002647Highly InformativeDirect
Biological Process (BP)female pregnancy1.61e-154.655e-05Highly InformativeDirect
Biological Process (BP)positive regulation of peptidase activity3.206e-092.593e-05Highly InformativeDirect
Biological Process (BP)protein processing00Highly InformativeDirect
Biological Process (BP)lung development2.791e-090.0007465Highly InformativeDirect
Biological Process (BP)regulation of protein stability4.695e-150Highly InformativeDirect
Biological Process (BP)collagen metabolic process1.118e-070.0008945Highly InformativeDirect
Biological Process (BP)multicellular organismal catabolic process2.486e-080.0004055Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.0001572.24e-07Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization8.062e-081Highly InformativeInherited
Biological Process (BP)developmental maturation0.00019360.3315Highly InformativeInherited
Biological Process (BP)MAPK cascade2.854e-100.3224Highly InformativeInherited
Biological Process (BP)morphogenesis of a branching epithelium1.496e-140.001027Highly InformativeInherited
Biological Process (BP)epithelial tube morphogenesis4.984e-130.1639Highly InformativeInherited
Biological Process (BP)regulation of angiogenesis9.797e-130.01003Highly InformativeInherited
Biological Process (BP)cellular component disassembly5.336e-050.026Highly InformativeInherited
Biological Process (BP)extracellular matrix organization4.764e-060.3662Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0042941Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration9.288e-120.003987Highly InformativeInherited
Biological Process (BP)renal system development5.004e-090.03097Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.93261Least InformativeInherited
Molecular Function (MF)enzyme regulator activity1.983e-071.59e-09Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00031175.799e-12InformativeDirect
Molecular Function (MF)peptidase regulator activity2.787e-145.019e-10InformativeDirect
Molecular Function (MF)receptor activity5.639e-051InformativeInherited
Molecular Function (MF)molecular transducer activity0.00015661InformativeInherited
Molecular Function (MF)enzyme activator activity1.12e-070.06582InformativeInherited
Molecular Function (MF)thiolester hydrolase activity7.468e-060Highly InformativeDirect
Molecular Function (MF)hormone binding01.454e-08Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process9.359e-122.383e-07Highly InformativeDirect
Molecular Function (MF)exopeptidase activity4.223e-051Highly InformativeInherited
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity1.146e-060.00401Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.034521Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0015311Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)extracellular region part7.841e-148.485e-05Moderately InformativeDirect
Cellular Component (CC)vesicle1.235e-090.005376Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.31810.07567Moderately InformativeInherited
Cellular Component (CC)lytic vacuole1.254e-076.536e-06InformativeDirect
Cellular Component (CC)extracellular space1.199e-050.0003229InformativeDirect
Cellular Component (CC)secretory granule1.994e-119.467e-09InformativeDirect
Cellular Component (CC)endosome0.035670.01624InformativeInherited
Cellular Component (CC)vacuolar part0.017120.879InformativeInherited
Cellular Component (CC)vacuolar lumen1.381e-085.798e-07Highly InformativeDirect
Cellular Component (CC)alveolar lamellar body00Highly InformativeDirect
Cellular Component (CC)endosomal part0.00025080.007634Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2517 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8944 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9573 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.00165 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2292 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.2164 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0007098 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.169e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001227 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.8183 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2257 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9534 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7936 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1393 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.015 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.3224 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.7804 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.6401 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2786 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1037 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.7698 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4806 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9413 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6502 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.3684 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3564 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.1243 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.6466 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001361 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.792 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8507 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001053 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04665 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1452 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.518 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 7.328e-05 Informative Direct
Biological Process (BP) proteolysis 6.895e-08 Informative Direct
Biological Process (BP) cell death 4.947e-05 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 2.515e-10 Informative Direct
Biological Process (BP) actin filament-based process 0.0004099 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0001588 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0009295 Informative Direct
Biological Process (BP) cellular amide metabolic process 5.206e-05 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000106 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 4.519e-10 Informative Direct
Biological Process (BP) regulation of cell cycle 0.0001733 Informative Direct
Biological Process (BP) regulation of peptidase activity 9.544e-06 Informative Direct
Biological Process (BP) muscle structure development 3.411e-07 Informative Direct
Biological Process (BP) organelle assembly 2.12e-09 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.01601 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2519 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.9619 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.09043 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8779 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8274 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1195 Informative Inherited
Biological Process (BP) epithelium development 0.8201 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.6121 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.04165 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.7274 Informative Inherited
Biological Process (BP) cell cycle process 0.3745 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.4902 Informative Inherited
Biological Process (BP) regulation of growth 0.002205 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5828 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9655 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.001684 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.145 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.003034 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.001087 Informative Inherited
Biological Process (BP) organ morphogenesis 0.8907 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01297 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.4264 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.8389 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9542 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) gland development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.8872 Informative Inherited
Biological Process (BP) response to lipid 0.1556 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03356 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.397 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1155 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.09433 Informative Inherited
Biological Process (BP) regulation of locomotion 0.6439 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.7507 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.005575 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.01439 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.3826 Informative Inherited
Biological Process (BP) chromosome organization 0.001221 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.2103 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.3667 Informative Inherited
Biological Process (BP) immune effector process 0.2179 Informative Inherited
Biological Process (BP) placenta development 2.642e-07 Highly Informative Direct
Biological Process (BP) tissue homeostasis 7.563e-06 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0007217 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0004063 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0.0002647 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) autophagy 4.33e-07 Highly Informative Direct
Biological Process (BP) female pregnancy 4.655e-05 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 2.629e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 2.16e-09 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 7.117e-09 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 2.593e-05 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 5.211e-05 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) lung development 0.0007465 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 1.931e-15 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0002345 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0.0008945 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 0.0004055 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 5.019e-06 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.32e-08 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 3.54e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 4.386e-07 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 1.036e-07 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0005744 Highly Informative Direct
Biological Process (BP) regulation of wound healing 1.552e-10 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 2.24e-07 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.3315 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.06023 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.001361 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.003348 Highly Informative Inherited
Biological Process (BP) response to acid 0.004442 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.3224 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.001267 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.9986 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.001027 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.481 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.4608 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.0113 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.9494 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1639 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1675 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.005566 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.002744 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.003979 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.1213 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.9553 Highly Informative Inherited
Biological Process (BP) amide biosynthetic process 0.02587 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.2751 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.08668 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01003 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01055 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5993 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.02491 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1452 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.4096 Highly Informative Inherited
Biological Process (BP) regulation of response to biotic stimulus 0.2926 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.8743 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.5445 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.026 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.3662 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.9934 Highly Informative Inherited
Biological Process (BP) stem cell development 0.1271 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.07546 Highly Informative Inherited
Biological Process (BP) interaction with host 0.1241 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.7832 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.003987 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.001556 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.008301 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1457 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.5177 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.09499 Highly Informative Inherited
Biological Process (BP) gene silencing 0.003212 Highly Informative Inherited
Biological Process (BP) renal system development 0.03097 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0001911 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.59e-09 Moderately Informative Direct
Molecular Function (MF) cation binding 2.485e-07 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 5.799e-12 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.0001608 Informative Direct
Molecular Function (MF) peptidase regulator activity 5.019e-10 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.001527 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.06582 Informative Inherited
Molecular Function (MF) transition metal ion binding 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 4.914e-08 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 1.454e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 2.383e-07 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.00401 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.1845 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.8626 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01002 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 5.642e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 8.485e-05 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.5509 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.005376 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.07567 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 6.536e-06 Informative Direct
Cellular Component (CC) extracellular space 0.0003229 Informative Direct
Cellular Component (CC) secretory granule 9.467e-09 Informative Direct
Cellular Component (CC) contractile fiber part 1.286e-07 Informative Direct
Cellular Component (CC) endosome 0.01624 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.04625 Informative Inherited
Cellular Component (CC) vacuolar part 0.879 Informative Inherited
Cellular Component (CC) chromosome 0.9528 Informative Inherited
Cellular Component (CC) chromatin 0.0001801 Highly Informative Direct
Cellular Component (CC) lysosome 0.0001416 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 5.798e-07 Highly Informative Direct
Cellular Component (CC) centrosome 0.0003476 Highly Informative Direct
Cellular Component (CC) midbody 2.749e-05 Highly Informative Direct
Cellular Component (CC) sarcolemma 4.351e-14 Highly Informative Direct
Cellular Component (CC) alveolar lamellar body 0 Highly Informative Direct
Cellular Component (CC) endosomal part 0.007634 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.006199 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.738e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase6.359e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1777Least InformativeInherited
Disease Ontology (DO)skin disease0.006472Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5777Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis3.12e-07InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.1822Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02298InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001155Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.9928Moderately InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant2.959e-07Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9645Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant7.096e-15Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant2.651e-08Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0803Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant2.184e-09InformativeDirect
Worm Phenotype (WP)osmotic integrity variant6.743e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0001254InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1.853e-09Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In linear amides3.507e-06InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase5.761e-08Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0.1307Highly InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processHost-virus interaction1.748e-07Moderately InformativeDirect
Biological processCell cycle3.447e-07Moderately InformativeDirect
Biological processDifferentiation0.00542Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processMitosis8.181e-12InformativeDirect
Biological processEndocytosis4.217e-08InformativeDirect
Biological processWnt signaling pathway5.185e-07InformativeDirect
Biological processViral RNA replication4.672e-05InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response2.69e-08Highly InformativeDirect
Biological processSpermatogenesis1.695e-07Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted2.576e-11Moderately InformativeDirect
Cellular componentEndoplasmic reticulum9.527e-11Moderately InformativeDirect
Cellular componentEndosome4.518e-07Moderately InformativeDirect
Cellular componentCytoskeleton3.049e-05Moderately InformativeDirect
Cellular componentCell projection0.172Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentVacuole2.258e-05InformativeDirect
Cellular componentProteasome4.614e-07Highly InformativeDirect
Cellular componentHost cytoplasmic vesicle1.891e-06Highly InformativeDirect
Cellular componentCilium0.0001085Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger8.757e-06Moderately InformativeDirect
Molecular functionZinc1.16e-06Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCadmium5.402e-10Highly InformativeDirect
Molecular functionChloride9.755e-05Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase8.845e-16InformativeDirect
Post-translational modificationExonuclease2.13e-13InformativeDirect
Post-translational modificationAntimicrobial0.03399InformativeInherited
Post-translational modificationIon channel0.7848InformativeInherited
Post-translational modificationViral ion channel4.308e-06Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase2.772e-05Highly InformativeDirect
Post-translational modificationDisulfide bond0.0003025Least InformativeDirect
Post-translational modificationUbl conjugation9.019e-05Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage1.785e-13InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]