SUPERFAMILY 1.75 HMM library and genome assignments server

Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,033) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,273 208,755 132
Proteins 63,261 207,593 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.79380Least InformativeInherited
Biological Process (BP)regulation of cellular process0.99170.06683Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000000037380.8721Least InformativeInherited
Biological Process (BP)developmental process0.0000000021020.09611Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.074711Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.96761Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.1886Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.3020.4381Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.000073130.00000553Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.19291Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.81881Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.072140.0863Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.052051Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.83370.3248Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0035880.9024Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.050260Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.98171Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0062030.0001331Moderately InformativeInherited
Biological Process (BP)tissue development0.00000017881Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0048290.3998Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.016460.8183Moderately InformativeInherited
Biological Process (BP)multi-organism process0.059030.903Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.079921Moderately InformativeInherited
Biological Process (BP)organ development0.00058431Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.69971Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.028151Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00038630.007073Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.03981Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0025850.6308Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.36121Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.22250.00001062Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.96571Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00006480.004032Moderately InformativeInherited
Biological Process (BP)regulation of localization0.25551Moderately InformativeInherited
Biological Process (BP)cell differentiation0.32010.7749Moderately InformativeInherited
Biological Process (BP)gene expression0.1891Moderately InformativeInherited
Biological Process (BP)signal transduction0.41151Moderately InformativeInherited
Biological Process (BP)immune system process0.00022730.9522Moderately InformativeInherited
Biological Process (BP)reproductive process0.0000023121Moderately InformativeInherited
Biological Process (BP)proteolysis0.0000000015910.00000000000002922InformativeDirect
Biological Process (BP)peptide metabolic process0.000000000033590.000002124InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression0.0000000078940.0000000002099InformativeDirect
Biological Process (BP)positive regulation of cell death0.0000000000022520.0000000004315InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00018120.00004217InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.0000000017810.0001155InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00012820.0006973InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal0.00000000000028610InformativeDirect
Biological Process (BP)regulation of organelle organization0.00027790.1758InformativeInherited
Biological Process (BP)positive regulation of gene expression0.0010751InformativeInherited
Biological Process (BP)regulation of response to wounding0.065690.0001813InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.033760.9871InformativeInherited
Biological Process (BP)phosphorylation0.0064671InformativeInherited
Biological Process (BP)intracellular signal transduction0.0023830.3251InformativeInherited
Biological Process (BP)tissue morphogenesis0.0000000001440.1425InformativeInherited
Biological Process (BP)tube development0.00029441InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.00025110.6752InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.00000000030280.008943InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0065261InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0030221InformativeInherited
Biological Process (BP)apoptotic process11InformativeInherited
Biological Process (BP)response to acid chemical0.0000069550.01942InformativeInherited
Biological Process (BP)response to lipid0.0002730.1895InformativeInherited
Biological Process (BP)epithelium development0.039920.2947InformativeInherited
Biological Process (BP)organ morphogenesis0.00000032540.9243InformativeInherited
Biological Process (BP)regulation of cell proliferation0.000000025151InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.03351InformativeInherited
Biological Process (BP)regulation of locomotion0.000011770.7684InformativeInherited
Biological Process (BP)regulation of cellular component movement0.0000015630.8237InformativeInherited
Biological Process (BP)multi-multicellular organism process0.000000014740.005233InformativeInherited
Biological Process (BP)regulation of peptidase activity0.0000000028760.08584InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00000043550.2626InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.000030590.522InformativeInherited
Biological Process (BP)protein maturation0.000000000000044930.001757InformativeInherited
Biological Process (BP)regulation of immune response0.0036040.04354InformativeInherited
Biological Process (BP)immune response0.00000018050.4011InformativeInherited
Biological Process (BP)immune effector process0.0023540.271InformativeInherited
Biological Process (BP)single organism reproductive process0.000000061851InformativeInherited
Biological Process (BP)reproductive structure development0.00002240.0811InformativeInherited
Biological Process (BP)placenta development00.0000001841Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity0.000000055380.0005916Highly InformativeDirect
Biological Process (BP)female pregnancy0.000000000081810.000006959Highly InformativeDirect
Biological Process (BP)hair cycle process0.00000000000095270.00002518Highly InformativeDirect
Biological Process (BP)respiratory tube development0.0000000060130.0007845Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.000000000000090140Highly InformativeDirect
Biological Process (BP)multicellular organismal catabolic process0.00000002920.000594Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.000000000081070.000005676Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue0.0000000000000063590.00000000000001587Highly InformativeDirect
Biological Process (BP)positive regulation of response to wounding0.000025580Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization0.00000013451Highly InformativeInherited
Biological Process (BP)MAPK cascade0.0000000050.009229Highly InformativeInherited
Biological Process (BP)branching morphogenesis of an epithelial tube0.00000000000016890.001472Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity0.0000019230.01779Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process0.0000010710.008541Highly InformativeInherited
Biological Process (BP)collagen metabolic process0.00000013120.001298Highly InformativeInherited
Biological Process (BP)respiratory system development0.00000058940.0382Highly InformativeInherited
Biological Process (BP)cellular component disassembly0.000059420.02578Highly InformativeInherited
Biological Process (BP)extracellular matrix organization10.4083Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0036421Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.0000000002480.006677Highly InformativeInherited
Biological Process (BP)zymogen activation0.51610.9531Highly InformativeInherited
Biological Process (BP)epidermis development0.029540.01229Highly InformativeInherited
Biological Process (BP)kidney development0.0000000022170.02763Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.00000039880.000000000005486Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00014070.00000000001093InformativeDirect
Molecular Function (MF)peptidase regulator activity0.000000000001130.00000008571InformativeDirect
Molecular Function (MF)receptor activity0.00042041InformativeInherited
Molecular Function (MF)molecular transducer activity0.0009941InformativeInherited
Molecular Function (MF)enzyme activator activity0.0000019520.5232InformativeInherited
Molecular Function (MF)thiolester hydrolase activity0.0000094650Highly InformativeDirect
Molecular Function (MF)hormone binding0.000000000000011470.00000007105Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.00000000018370.000001965Highly InformativeDirect
Molecular Function (MF)transmembrane signaling receptor activity0.000066751Highly InformativeInherited
Molecular Function (MF)exopeptidase activity0.00024211Highly InformativeInherited
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity0.0000002640.002145Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.023381Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00043480.1206Least InformativeInherited
Cellular Component (CC)extracellular region part0.000000000022460.0003725Moderately InformativeDirect
Cellular Component (CC)vesicle0.000000076070.03871Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0022220.0000166Moderately InformativeInherited
Cellular Component (CC)lytic vacuole0.000000085070.00000009346InformativeDirect
Cellular Component (CC)extracellular space0.000016460.0006052InformativeDirect
Cellular Component (CC)secretory granule0.0000000026680.00000001982InformativeDirect
Cellular Component (CC)endosome0.082030.05692InformativeInherited
Cellular Component (CC)vacuolar part0.026170.9611InformativeInherited
Cellular Component (CC)endosomal part0.00063780.01617Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.06683 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8721 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4381 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 0.09611 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1886 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001331 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00002303 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00001062 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00002658 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000553 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000005361 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.6852 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.0863 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.5188 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.07035 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9024 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8313 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.6308 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004032 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7749 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8205 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.3998 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8183 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.903 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.007073 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001172 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.4531 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3248 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9522 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000000000002922 Informative Direct
Biological Process (BP) peptide metabolic process 0.000002124 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0000000002099 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0000000004315 Informative Direct
Biological Process (BP) actin filament-based process 0.0003844 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00004604 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00001266 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00000004827 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00004217 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0001155 Informative Direct
Biological Process (BP) regulation of cell activation 0.00003478 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0006973 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0001421 Informative Direct
Biological Process (BP) muscle structure development 0.000000163 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) organelle assembly 0.00000009929 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0001813 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.003572 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.9871 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.978 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.6117 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8539 Informative Inherited
Biological Process (BP) response to acid chemical 0.01942 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8798 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3251 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) negative regulation of protein processing 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1425 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6752 Informative Inherited
Biological Process (BP) gland development 0.7267 Informative Inherited
Biological Process (BP) regulation of immune response 0.04354 Informative Inherited
Biological Process (BP) cell cycle process 0.02887 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1008 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.6728 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7088 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002596 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.008943 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03789 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1758 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.005687 Informative Inherited
Biological Process (BP) response to nutrient levels 0.02245 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9801 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.04992 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.282 Informative Inherited
Biological Process (BP) regulation of growth 0.004644 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.9711 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1357 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8622 Informative Inherited
Biological Process (BP) response to lipid 0.1895 Informative Inherited
Biological Process (BP) epithelium development 0.2947 Informative Inherited
Biological Process (BP) organ morphogenesis 0.9243 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.4319 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) chromosome organization 0.001444 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.4714 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7684 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8237 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.4422 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.005233 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.2626 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.08584 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.522 Informative Inherited
Biological Process (BP) protein maturation 0.001757 Informative Inherited
Biological Process (BP) protein catabolic process 0.2639 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.001156 Informative Inherited
Biological Process (BP) DNA repair 0.06173 Informative Inherited
Biological Process (BP) immune response 0.4011 Informative Inherited
Biological Process (BP) immune effector process 0.271 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) reproductive structure development 0.0811 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) ribonucleoprotein complex biogenesis 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) placenta development 0.0000001841 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0005916 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) female pregnancy 0.000006959 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00004937 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0000000000513 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000003149 Highly Informative Direct
Biological Process (BP) macroautophagy 0.0002112 Highly Informative Direct
Biological Process (BP) histone modification 0.0000007055 Highly Informative Direct
Biological Process (BP) hair cycle process 0.00002518 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.0007845 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.000000000000005526 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.000707 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 0.000594 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.000005676 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000000973 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00007572 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 0.00000000000001587 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0000006097 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.000000003421 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.000001433 Highly Informative Direct
Biological Process (BP) positive regulation of response to wounding 0 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.00001861 Highly Informative Direct
Biological Process (BP) negative regulation of chromosome organization 0.000009197 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.7314 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.7209 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.005426 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3771 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.005227 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.002609 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.006946 Highly Informative Inherited
Biological Process (BP) response to amino acid 0.001717 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.7075 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.009229 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.7157 Highly Informative Inherited
Biological Process (BP) negative regulation of protein catabolic process 0.03203 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.002873 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.04385 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.001472 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.2245 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.005392 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.006529 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.002905 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.00693 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3301 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.08182 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.1388 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.6271 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.5382 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.001159 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.01779 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.008541 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1812 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01344 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.03415 Highly Informative Inherited
Biological Process (BP) regulation of protein targeting 0.04715 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.2143 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1257 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2323 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.004116 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.006125 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.4171 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.7294 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.4967 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.7623 Highly Informative Inherited
Biological Process (BP) stem cell development 0.281 Highly Informative Inherited
Biological Process (BP) negative regulation of cell division 0.09572 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.07099 Highly Informative Inherited
Biological Process (BP) collagen metabolic process 0.001298 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.0382 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.02578 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.4083 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.8625 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.006677 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.03539 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.006025 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.07286 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01857 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.08553 Highly Informative Inherited
Biological Process (BP) zymogen activation 0.9531 Highly Informative Inherited
Biological Process (BP) gene silencing 0.002623 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.3613 Highly Informative Inherited
Biological Process (BP) epidermis development 0.01229 Highly Informative Inherited
Biological Process (BP) kidney development 0.02763 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1977 Highly Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.5841 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.04429 Highly Informative Inherited
Biological Process (BP) mRNA catabolic process 0.1594 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0006445 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000000000005486 Moderately Informative Direct
Molecular Function (MF) cation binding 0.000004232 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00000000001093 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00000008571 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.004581 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.5232 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0.00000002501 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00000007105 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.000001965 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.002145 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.972 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.007038 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1206 Least Informative Inherited
Cellular Component (CC) cytosol 0.000008367 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0003725 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000166 Moderately Informative Direct
Cellular Component (CC) vesicle 0.03871 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.02707 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.00000009346 Informative Direct
Cellular Component (CC) extracellular space 0.0006052 Informative Direct
Cellular Component (CC) secretory granule 0.00000001982 Informative Direct
Cellular Component (CC) contractile fiber part 0.000001887 Informative Direct
Cellular Component (CC) endosome 0.05692 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.03919 Informative Inherited
Cellular Component (CC) vacuolar part 0.9611 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) chromatin 0.0005615 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.0002306 Highly Informative Direct
Cellular Component (CC) midbody 0.00009094 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0000000000001065 Highly Informative Direct
Cellular Component (CC) endosomal part 0.01617 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.009049 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000001738Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0.00000006359Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1501Least InformativeInherited
Disease Ontology (DO)skin disease0.01546Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5772Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis0.00001033InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.179Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02254InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.000141Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.2699Highly InformativeInherited