SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (2,337) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 53,474 89,135 132
Proteins 52,703 88,440 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process3.172e-110Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.99340Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.25140.1309Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.00065191Least InformativeInherited
Biological Process (BP)response to stimulus0.46270.6789Least InformativeInherited
Biological Process (BP)developmental process0.00091660.9485Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of cellular process0.80250.02195Least InformativeInherited
Biological Process (BP)response to endogenous stimulus0.10281Moderately InformativeInherited
Biological Process (BP)response to organic substance0.002571Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.63470.3624Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.010560Moderately InformativeInherited
Biological Process (BP)signal transduction0.071721Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.02980.001981Moderately InformativeInherited
Biological Process (BP)tissue development0.00037231Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0086010.03494Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.0094490.009787Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00022240.4198Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0032391Moderately InformativeInherited
Biological Process (BP)homeostatic process5.698e-050.9081Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0027850.9981Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.10630.1042Moderately InformativeInherited
Biological Process (BP)single-organism developmental process9.73e-060.5259Moderately InformativeInherited
Biological Process (BP)organ development0.0035511Moderately InformativeInherited
Biological Process (BP)gene expression0.44591Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.018590.03513Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.1311Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.13781Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0086240.9515Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0023310.0538Moderately InformativeInherited
Biological Process (BP)immune system process6.317e-051Moderately InformativeInherited
Biological Process (BP)proteolysis4.142e-132.805e-08InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression1.129e-105.379e-08InformativeDirect
Biological Process (BP)cellular amide metabolic process6.361e-080.0002341InformativeDirect
Biological Process (BP)multicellular organismal homeostasis1.373e-131.012e-05InformativeDirect
Biological Process (BP)positive regulation of developmental process8.725e-088.886e-05InformativeDirect
Biological Process (BP)negative regulation of cell death2.833e-050.0001657InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal2.709e-110InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.21880.7984InformativeInherited
Biological Process (BP)response to hormone stimulus0.36741InformativeInherited
Biological Process (BP)intracellular signal transduction0.0011780.09451InformativeInherited
Biological Process (BP)tissue morphogenesis1.776e-060.6542InformativeInherited
Biological Process (BP)epithelium development0.0090280.7481InformativeInherited
Biological Process (BP)organ morphogenesis0.00048581InformativeInherited
Biological Process (BP)tube development1.586e-060.8117InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.00041191InformativeInherited
Biological Process (BP)anatomical structure homeostasis6.33e-120.002537InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0020240.006596InformativeInherited
Biological Process (BP)response to lipid9.341e-050.1206InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.00013361InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.0094221InformativeInherited
Biological Process (BP)regulation of locomotion6.64e-080.348InformativeInherited
Biological Process (BP)regulation of cellular component movement3.001e-080.3913InformativeInherited
Biological Process (BP)regulation of immune response3.944e-060.5059InformativeInherited
Biological Process (BP)immune response8.977e-080.1471InformativeInherited
Biological Process (BP)immune effector process0.001310.1266InformativeInherited
Biological Process (BP)leukocyte mediated immunity1.205e-080.0001749Highly InformativeDirect
Biological Process (BP)immune response-regulating signaling pathway6.482e-128.335e-05Highly InformativeDirect
Biological Process (BP)positive regulation of peptidase activity3.099e-157.657e-06Highly InformativeDirect
Biological Process (BP)protein processing00Highly InformativeDirect
Biological Process (BP)lung development8.489e-120.0001508Highly InformativeDirect
Biological Process (BP)regulation of protein stability3.099e-150Highly InformativeDirect
Biological Process (BP)multicellular organismal metabolic process5.285e-090.0002901Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue02.081e-14Highly InformativeDirect
Biological Process (BP)MAPK cascade6.396e-100.1023Highly InformativeInherited
Biological Process (BP)morphogenesis of a branching epithelium6.09e-150.001296Highly InformativeInherited
Biological Process (BP)epithelial tube morphogenesis2.981e-130.1686Highly InformativeInherited
Biological Process (BP)regulation of angiogenesis1.189e-120.00921Highly InformativeInherited
Biological Process (BP)feeding behavior4.342e-060.08326Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration7.945e-120.003667Highly InformativeInherited
Biological Process (BP)kidney development7.975e-130.002587Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity7.363e-050.0002634Moderately InformativeDirect
Molecular Function (MF)protein binding0.75580.8556Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.9852Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00070096.937e-11InformativeDirect
Molecular Function (MF)peptidase regulator activity1.97e-090.0005633InformativeDirect
Molecular Function (MF)receptor activity9.154e-051InformativeInherited
Molecular Function (MF)molecular transducer activity0.00030171InformativeInherited
Molecular Function (MF)enzyme activator activity8.147e-070.7657InformativeInherited
Molecular Function (MF)thiolester hydrolase activity1.081e-060Highly InformativeDirect
Molecular Function (MF)hormone binding06.725e-09Highly InformativeDirect
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)exopeptidase activity0.008731Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity1.543e-060.003423Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.080150.9689Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.11211Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)vesicle8.074e-050.1806Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0033910.01781Moderately InformativeInherited
Cellular Component (CC)extracellular region1.347e-090.00116Moderately InformativeInherited
Cellular Component (CC)extracellular space3.198e-100.0004696InformativeDirect
Cellular Component (CC)vacuole00InformativeDirect
Cellular Component (CC)secretory granule9.319e-112.859e-08InformativeDirect
Cellular Component (CC)endosome0.011780.06132InformativeInherited
Cellular Component (CC)vacuolar lumen3.165e-071.781e-06Highly InformativeDirect
Cellular Component (CC)alveolar lamellar body00Highly InformativeDirect
Cellular Component (CC)endosomal part0.00011690.2097Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 0.9485 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6789 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1309 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02195 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6016 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.734e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0002097 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3624 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8072 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.04793 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.009787 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6782 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.4034 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1042 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9771 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9081 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.0538 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.7359 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4166 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9515 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9981 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.3452 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.69 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001981 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4198 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9866 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5259 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03494 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.03513 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6535 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.002111 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 2.805e-08 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0002642 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 5.379e-08 Informative Direct
Biological Process (BP) actin filament-based process 0.0002515 Informative Direct
Biological Process (BP) negative regulation of cellular metabolic process 1.739e-06 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 7.539e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0005715 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0001187 Informative Direct
Biological Process (BP) cellular amide metabolic process 0.0002341 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 1.012e-05 Informative Direct
Biological Process (BP) positive regulation of developmental process 8.886e-05 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 4.208e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 1.002e-10 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001657 Informative Direct
Biological Process (BP) muscle structure development 6.603e-07 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of response to stress 0.00045 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.7984 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.09451 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6865 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.6542 Informative Inherited
Biological Process (BP) cell cycle process 0.2168 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.7799 Informative Inherited
Biological Process (BP) epithelium development 0.7481 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) tube development 0.8117 Informative Inherited
Biological Process (BP) protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5916 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.0917 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2907 Informative Inherited
Biological Process (BP) microtubule-based process 0.9271 Informative Inherited
Biological Process (BP) regulation of ion transport 0.3387 Informative Inherited
Biological Process (BP) protein oligomerization 1 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.002537 Informative Inherited
Biological Process (BP) regulation of growth 0.008113 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.6024 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9492 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.04341 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.006596 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01064 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.06541 Informative Inherited
Biological Process (BP) regulation of protein localization 0.8563 Informative Inherited
Biological Process (BP) gland development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9067 Informative Inherited
Biological Process (BP) response to lipid 0.1206 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8655 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.005826 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.3192 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1415 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.348 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.3913 Informative Inherited
Biological Process (BP) response to external stimulus 0.9899 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.005761 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.9212 Informative Inherited
Biological Process (BP) protein catabolic process 0.3625 Informative Inherited
Biological Process (BP) chromosome organization 0.001691 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.1891 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.5059 Informative Inherited
Biological Process (BP) immune response 0.1471 Informative Inherited
Biological Process (BP) immune effector process 0.1266 Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.0001749 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 8.335e-05 Highly Informative Direct
Biological Process (BP) autophagy 7.637e-05 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 8.449e-07 Highly Informative Direct
Biological Process (BP) pathogenesis 0.0004002 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 3.935e-10 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 7.657e-06 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) lung development 0.0001508 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0003269 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0005142 Highly Informative Direct
Biological Process (BP) signal transduction in response to DNA damage 0.0001674 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0004187 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0.0002901 Highly Informative Direct
Biological Process (BP) positive regulation of growth 2.023e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 2.502e-06 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 2.081e-14 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 9.024e-08 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 1.138e-07 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.000122 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0009815 Highly Informative Direct
Biological Process (BP) signal transduction by p53 class mediator 8.568e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 2.449e-05 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.02432 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.03167 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.001144 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.002509 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.1023 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.00594 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.001296 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1739 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.3635 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.02067 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1686 Highly Informative Inherited
Biological Process (BP) lipid homeostasis 0.04541 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.003132 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.00555 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3679 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.9205 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.007866 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.06267 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.00921 Highly Informative Inherited
Biological Process (BP) feeding behavior 0.08326 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.017 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6515 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.01946 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1167 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.518 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.5624 Highly Informative Inherited
Biological Process (BP) stem cell development 0.1245 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.003667 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.004046 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.04418 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.5294 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.02193 Highly Informative Inherited
Biological Process (BP) DNA repair 0.04689 Highly Informative Inherited
Biological Process (BP) kidney development 0.002587 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0007033 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0002634 Moderately Informative Direct
Molecular Function (MF) cation binding 3.028e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.9852 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.8556 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 6.937e-11 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.000511 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0005633 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.002763 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.7657 Informative Inherited
Molecular Function (MF) transition metal ion binding 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) chromatin binding 0.0006315 Highly Informative Direct
Molecular Function (MF) calcium ion binding 3.049e-07 Highly Informative Direct
Molecular Function (MF) zinc ion binding 0.0006255 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 6.725e-09 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.003423 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.1909 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0002483 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.7737 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9689 Least Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.1806 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region 0.00116 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.207 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01781 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0004696 Informative Direct
Cellular Component (CC) vacuole 0 Informative Direct
Cellular Component (CC) secretory granule 2.859e-08 Informative Direct
Cellular Component (CC) contractile fiber part 8.208e-08 Informative Direct
Cellular Component (CC) endosome 0.06132 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0447 Informative Inherited
Cellular Component (CC) chromosome 0.9604 Informative Inherited
Cellular Component (CC) proteasome complex 0.0003428 Highly Informative Direct
Cellular Component (CC) chromatin 0.0001346 Highly Informative Direct
Cellular Component (CC) lysosome 2.896e-05 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 1.781e-06 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.0008161 Highly Informative Direct
Cellular Component (CC) midbody 1.478e-05 Highly Informative Direct
Cellular Component (CC) sarcolemma 3.48e-14 Highly Informative Direct
Cellular Component (CC) alveolar lamellar body 0 Highly Informative Direct
Cellular Component (CC) endosomal part 0.2097 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.006312 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.03281 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.738e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase6.359e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.154Least InformativeInherited
Disease Ontology (DO)skin disease0.009261Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.6057Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis2.637e-07InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm by histology0.01811InformativeInherited
Phenotypic Abnormality (PA)Melanoma3.718e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal gland morphology0.9022Moderately InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant2.959e-07Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9645Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant7.096e-15Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant2.651e-08Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0803Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant2.184e-09InformativeDirect
Worm Phenotype (WP)osmotic integrity variant6.743e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective8.42e-05Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1.719e-09Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In linear amides2.385e-06InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase6.126e-08Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0.1253Highly InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle1.854e-07Moderately InformativeDirect
Biological processHost-virus interaction6.073e-06Moderately InformativeDirect
Biological processDifferentiation0.003598Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processMitosis4.017e-12InformativeDirect
Biological processEndocytosis2.658e-08InformativeDirect
Biological processWnt signaling pathway3.836e-07InformativeDirect
Biological processViral RNA replication0.0002046InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processFlagellar rotation4.677e-11Highly InformativeDirect
Biological processUnfolded protein response9.916e-09Highly InformativeDirect
Biological processSpermatogenesis1.462e-07Highly InformativeDirect
Biological processViral ion channel2.973e-06Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted4.955e-11Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.495e-09Moderately InformativeDirect
Cellular componentEndosome3.694e-06Moderately InformativeDirect
Cellular componentCell projection0.09897Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentVirion0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentHost cytoplasm9.661e-14InformativeDirect
Cellular componentVacuole1.93e-05InformativeDirect
Cellular componentProteasome4.395e-07Highly InformativeDirect
Cellular componentHost cytoplasmic vesicle1.362e-06Highly InformativeDirect
Cellular componentCilium5.397e-05Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainWD repeat0.000674InformativeDirect
Molecular functionZinc3.355e-07Least InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Molecular functionCadmium5.079e-10Highly InformativeDirect
Molecular functionChloride8.754e-05Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationExonuclease1.526e-13InformativeDirect
Post-translational modificationAntimicrobial0.02952InformativeInherited
Post-translational modificationRNA-directed RNA polymerase0.0001311Highly InformativeDirect
Post-translational modificationDisulfide bond0.0005821Least InformativeDirect
Post-translational modificationUbl conjugation6.059e-05Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage2.204e-13InformativeDirect
Post-translational modificationOxidation0.0008253Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]