SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,031) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 63,958 208,755 132
Proteins 62,952 207,593 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.88540Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.90370.9377Least InformativeInherited
Biological Process (BP)regulation of cellular process10.06954Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process8.907e-081Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.1979Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.84661Least InformativeInherited
Biological Process (BP)response to stimulus0.29270.4126Least InformativeInherited
Biological Process (BP)developmental process1.703e-090.238Least InformativeInherited
Biological Process (BP)negative regulation of cellular process7.76e-050.0004749Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.43631Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.6623Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.060981Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.14231Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.030891Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.048911Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0029680.8617Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.8190.2888Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.050420Moderately InformativeInherited
Biological Process (BP)signal transduction0.3971Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0060110.0009424Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0049980.4346Moderately InformativeInherited
Biological Process (BP)tissue development1.782e-060.6349Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.014780.7817Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.12121Moderately InformativeInherited
Biological Process (BP)homeostatic process0.00016990.8462Moderately InformativeInherited
Biological Process (BP)organ development0.00075391Moderately InformativeInherited
Biological Process (BP)single-organism developmental process1.244e-120.3271Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0021960.5852Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.13190.064Moderately InformativeInherited
Biological Process (BP)gene expression0.14151Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00072540.01878Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.064911Moderately InformativeInherited
Biological Process (BP)regulation of localization0.22681Moderately InformativeInherited
Biological Process (BP)cell differentiation0.36210.8096Moderately InformativeInherited
Biological Process (BP)reproduction8.536e-051Moderately InformativeInherited
Biological Process (BP)multi-organism process0.029140.05846Moderately InformativeInherited
Biological Process (BP)immune system process0.00023540.9582Moderately InformativeInherited
Biological Process (BP)proteolysis8.45e-097.661e-13InformativeDirect
Biological Process (BP)peptide metabolic process1.021e-101.744e-06InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression6.4e-091.813e-11InformativeDirect
Biological Process (BP)positive regulation of developmental process8.996e-050.0002923InformativeDirect
Biological Process (BP)regulation of peptidase activity2.929e-091.78e-05InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal2.519e-130InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.90721InformativeInherited
Biological Process (BP)regulation of organelle organization0.00014310.08356InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity4.528e-050.5165InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.52260.2214InformativeInherited
Biological Process (BP)response to hormone stimulus0.13961InformativeInherited
Biological Process (BP)intracellular signal transduction0.0019420.2341InformativeInherited
Biological Process (BP)tissue morphogenesis4.668e-090.1781InformativeInherited
Biological Process (BP)epithelium development0.84570.9156InformativeInherited
Biological Process (BP)tube development0.00019380.9016InformativeInherited
Biological Process (BP)multi-multicellular organism process1.331e-080.005081InformativeInherited
Biological Process (BP)single organism reproductive process6.348e-071InformativeInherited
Biological Process (BP)multicellular organismal reproductive process5.31e-060.7432InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.003140.003763InformativeInherited
Biological Process (BP)organ morphogenesis3.732e-061InformativeInherited
Biological Process (BP)response to lipid0.00022240.1679InformativeInherited
Biological Process (BP)regulation of cell proliferation1.537e-081InformativeInherited
Biological Process (BP)regulation of locomotion1.126e-050.7572InformativeInherited
Biological Process (BP)regulation of cellular component movement1.053e-060.815InformativeInherited
Biological Process (BP)regulation of apoptotic process4.111e-070.2779InformativeInherited
Biological Process (BP)apoptotic process11InformativeInherited
Biological Process (BP)regulation of immune response0.0045720.04908InformativeInherited
Biological Process (BP)immune response1.936e-070.4208InformativeInherited
Biological Process (BP)immune effector process0.0023460.2746InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.013680.9507InformativeInherited
Biological Process (BP)placenta development3.256e-153.861e-07Highly InformativeDirect
Biological Process (BP)hair follicle development7.379e-070.0006436Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity5.64e-080.0005347Highly InformativeDirect
Biological Process (BP)female pregnancy3.256e-153.509e-05Highly InformativeDirect
Biological Process (BP)protein processing00Highly InformativeDirect
Biological Process (BP)regulation of protein stability9.299e-140Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue7.943e-151.776e-14Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00020545.119e-07Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.367e-071Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity2.695e-060.02032Highly InformativeInherited
Biological Process (BP)developmental maturation0.00025470.3632Highly InformativeInherited
Biological Process (BP)MAPK cascade4.511e-090.09021Highly InformativeInherited
Biological Process (BP)branching morphogenesis of an epithelial tube1.73e-130.001671Highly InformativeInherited
Biological Process (BP)respiratory system development5.53e-070.04046Highly InformativeInherited
Biological Process (BP)respiratory tube development4.038e-080.001076Highly InformativeInherited
Biological Process (BP)regulation of angiogenesis2.328e-110.02278Highly InformativeInherited
Biological Process (BP)multicellular organismal metabolic process4.15e-070.002815Highly InformativeInherited
Biological Process (BP)cellular component disassembly6.032e-050.03193Highly InformativeInherited
Biological Process (BP)extracellular matrix organization6.129e-060.4171Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0037291Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration1.833e-100.006557Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process1.242e-060.008446Highly InformativeInherited
Biological Process (BP)renal system development3.939e-080.04948Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity1.93e-067.371e-09Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00012991.048e-11InformativeDirect
Molecular Function (MF)peptidase regulator activity1.152e-125.607e-10InformativeDirect
Molecular Function (MF)receptor activity0.00042281InformativeInherited
Molecular Function (MF)molecular transducer activity0.0010011InformativeInherited
Molecular Function (MF)enzyme activator activity2.49e-070.06636InformativeInherited
Molecular Function (MF)thiolester hydrolase activity9.48e-060Highly InformativeDirect
Molecular Function (MF)hormone binding1.139e-144.828e-08Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process4.597e-111.731e-07Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00027811Highly InformativeInherited
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity2.41e-070.002058Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00092710.5013Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.020581Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10.0005655Least InformativeInherited
Cellular Component (CC)extracellular region part1.639e-110.0002904Moderately InformativeDirect
Cellular Component (CC)vesicle7.871e-080.02758Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0032710.000247Moderately InformativeInherited
Cellular Component (CC)nuclear part0.073540.1018Moderately InformativeInherited
Cellular Component (CC)lytic vacuole6.4e-082.038e-06InformativeDirect
Cellular Component (CC)extracellular space1.517e-050.0006182InformativeDirect
Cellular Component (CC)nucleolus0.00030740.0009849InformativeDirect
Cellular Component (CC)secretory granule3.652e-102.276e-08InformativeDirect
Cellular Component (CC)endosome0.073110.04041InformativeInherited
Cellular Component (CC)vacuolar part0.029210.9614InformativeInherited
Cellular Component (CC)endosomal part0.00058770.01359Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4126 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9377 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.06954 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1979 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.238 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0005764 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0009424 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 2.444e-06 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0009887 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0004749 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5625 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8617 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8001 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2888 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2105 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.008425 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4346 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8323 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5484 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.064 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1924 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6349 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7817 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8462 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.3271 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6623 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5852 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8096 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.05846 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01878 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9582 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 0.0001731 Informative Direct
Biological Process (BP) proteolysis 7.661e-13 Informative Direct
Biological Process (BP) peptide metabolic process 1.744e-06 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.813e-11 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0008578 Informative Direct
Biological Process (BP) actin filament-based process 0.0008103 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.891e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000638 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0002923 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0002303 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 8.353e-09 Informative Direct
Biological Process (BP) regulation of peptidase activity 1.78e-05 Informative Direct
Biological Process (BP) muscle structure development 1.839e-06 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) organelle assembly 2.526e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.5165 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2214 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.9826 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2341 Informative Inherited
Biological Process (BP) response to inorganic substance 0.841 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8783 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1781 Informative Inherited
Biological Process (BP) cell cycle process 0.3715 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.7525 Informative Inherited
Biological Process (BP) epithelium development 0.9156 Informative Inherited
Biological Process (BP) tube development 0.9016 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.005081 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.04908 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.08356 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02436 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8605 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6485 Informative Inherited
Biological Process (BP) regulation of growth 0.006016 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03838 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7432 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4344 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.003734 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9461 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.003763 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6615 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002049 Informative Inherited
Biological Process (BP) negative regulation of transport 0.9596 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.9411 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.845 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) gland development 1 Informative Inherited
Biological Process (BP) response to lipid 0.1679 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.0201 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5621 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1887 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7572 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.815 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01276 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.2779 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.002015 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.2765 Informative Inherited
Biological Process (BP) chromosome organization 0.002861 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.1597 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.4208 Informative Inherited
Biological Process (BP) immune effector process 0.2746 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9507 Informative Inherited
Biological Process (BP) placenta development 3.861e-07 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0006436 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0005347 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) autophagy 4.396e-09 Highly Informative Direct
Biological Process (BP) female pregnancy 3.509e-05 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 4.32e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 9.671e-12 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 2.472e-08 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 7.341e-15 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0002566 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 1.776e-14 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0006196 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.000972 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 2.368e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 3.099e-08 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 8.065e-05 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 1.776e-14 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.469e-06 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 1.022e-08 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0009039 Highly Informative Direct
Biological Process (BP) regulation of wound healing 2.575e-09 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 5.119e-07 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.02032 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.3632 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3444 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.004355 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.002617 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.006062 Highly Informative Inherited
Biological Process (BP) response to amino acid stimulus 0.001447 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.09021 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.004964 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.4393 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.8551 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.5312 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.5101 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.01688 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.951 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.001671 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.04046 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001076 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.009592 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.002894 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.002214 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.07144 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.006716 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3175 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.02278 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.0156 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.3624 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.633 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.5301 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002815 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.008911 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5547 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.03069 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.184 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.09866 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3817 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.6789 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2577 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.6354 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.001387 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.03193 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.4171 Highly Informative Inherited
Biological Process (BP) axon development 0.2426 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2138 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2433 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.006557 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002705 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01703 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1839 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.1058 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.008446 Highly Informative Inherited
Biological Process (BP) gene silencing 0.004325 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.1289 Highly Informative Inherited
Biological Process (BP) renal system development 0.04948 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0006518 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 7.371e-09 Moderately Informative Direct
Molecular Function (MF) cation binding 3.684e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0.0007456 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1.048e-11 Informative Direct
Molecular Function (MF) peptidase regulator activity 5.607e-10 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.004753 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.06636 Informative Inherited
Molecular Function (MF) transition metal ion binding 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 2.584e-08 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 4.828e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 1.731e-07 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.002058 Highly Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.2976 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0005655 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5013 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.0004189 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0002904 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.000247 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1018 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.02758 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 2.038e-06 Informative Direct
Cellular Component (CC) extracellular space 0.0006182 Informative Direct
Cellular Component (CC) nucleolus 0.0009849 Informative Direct
Cellular Component (CC) secretory granule 2.276e-08 Informative Direct
Cellular Component (CC) contractile fiber part 1.248e-06 Informative Direct
Cellular Component (CC) endosome 0.04041 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.03271 Informative Inherited
Cellular Component (CC) vacuolar part 0.9614 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) chromatin 0.0006118 Highly Informative Direct
Cellular Component (CC) centrosome 0.0001722 Highly Informative Direct
Cellular Component (CC) midbody 6.514e-05 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.285e-13 Highly Informative Direct
Cellular Component (CC) endosomal part 0.01359 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.008944 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.738e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase6.359e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1483Least InformativeInherited
Disease Ontology (DO)skin disease0.01535Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.575Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis1.034e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.179Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0226InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001429Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.2771Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant2.959e-07Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9645Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant7.096e-15Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant2.651e-08Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0803Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant2.184e-09InformativeDirect
Worm Phenotype (WP)osmotic integrity variant6.743e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0002474InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1.533e-09Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase2.795e-06InformativeDirect
Enzyme Commission (EC)In linear amides3.13e-06InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.839InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase5.693e-08Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase6.33e-06Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processHost-virus interaction1.592e-09Moderately InformativeDirect
Biological processCell cycle3.804e-07Moderately InformativeDirect
Biological processDifferentiation0.006123Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processMitosis8.138e-12InformativeDirect
Biological processViral RNA replication2.734e-08InformativeDirect
Biological processEndocytosis4.674e-08InformativeDirect
Biological processWnt signaling pathway5.209e-07InformativeDirect
Biological processVirus entry into host cell0.042InformativeInherited
Biological processAutophagy0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response2.7e-08Highly InformativeDirect
Biological processSpermatogenesis1.982e-07Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host1.235e-06Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum2.059e-11Moderately InformativeDirect
Cellular componentSecreted6.773e-11Moderately InformativeDirect
Cellular componentEndosome5.375e-07Moderately InformativeDirect
Cellular componentCytoskeleton3.829e-05Moderately InformativeDirect
Cellular componentCell projection0.1955Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentVacuole2.422e-05InformativeDirect
Cellular componentHost membrane0.0004452InformativeDirect
Cellular componentHost cytoplasmic vesicle4.256e-12Highly InformativeDirect
Cellular componentProteasome4.886e-07Highly InformativeDirect
Cellular componentCilium0.0001353Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger1.212e-05Moderately InformativeDirect
DomainWD repeat6.122e-05InformativeDirect
Molecular functionZinc1.767e-06Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCadmium5.449e-10Highly InformativeDirect
Molecular functionChloride0.0001002Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase8.845e-16InformativeDirect
Post-translational modificationExonuclease3.602e-13InformativeDirect
Post-translational modificationAntimicrobial0.03743InformativeInherited
Post-translational modificationIon channel0.1696InformativeInherited
Post-translational modificationViral ion channel1.893e-11Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase1.227e-08Highly InformativeDirect
Post-translational modificationDisulfide bond0.0002441Least InformativeDirect
Post-translational modificationUbl conjugation1.547e-05Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage2.579e-13InformativeDirect
Post-translational modificationMyristate0.0001336InformativeDirect
Post-translational modificationCovalent protein-RNA linkage1.687e-06Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]