SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,026) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 62,545 0 132
Proteins 61,547 0 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.88030Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.92110.9516Least InformativeInherited
Biological Process (BP)regulation of cellular process10.0833Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process3.365e-071Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.2423Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.96311Least InformativeInherited
Biological Process (BP)response to stimulus0.36430.4735Least InformativeInherited
Biological Process (BP)developmental process1.919e-080.4166Least InformativeInherited
Biological Process (BP)negative regulation of cellular process9.531e-050.0005917Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.44011Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.6702Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.063681Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.15571Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.15191Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0056170.8763Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.74860.3234Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.05340Moderately InformativeInherited
Biological Process (BP)signal transduction0.35651Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0024650.002799Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0062910.4511Moderately InformativeInherited
Biological Process (BP)tissue development4.535e-070.67Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.017570.8181Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.12851Moderately InformativeInherited
Biological Process (BP)homeostatic process0.00017130.867Moderately InformativeInherited
Biological Process (BP)single-organism developmental process2.236e-110.396Moderately InformativeInherited
Biological Process (BP)organ development0.00049241Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0068560.7078Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.12380.06208Moderately InformativeInherited
Biological Process (BP)gene expression0.11961Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.030531Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00080340.02062Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.078211Moderately InformativeInherited
Biological Process (BP)regulation of localization0.22991Moderately InformativeInherited
Biological Process (BP)reproduction0.00026661Moderately InformativeInherited
Biological Process (BP)multi-organism process0.02340.04731Moderately InformativeInherited
Biological Process (BP)immune system process0.00029390.9709Moderately InformativeInherited
Biological Process (BP)proteolysis2.138e-082.788e-12InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression5.609e-091.278e-11InformativeDirect
Biological Process (BP)cellular amide metabolic process7.321e-070.0001325InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00010780.0003336InformativeDirect
Biological Process (BP)regulation of peptidase activity3.152e-092.392e-05InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal1.296e-130InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.89681InformativeInherited
Biological Process (BP)regulation of apoptotic process4.351e-070.2719InformativeInherited
Biological Process (BP)regulation of organelle organization0.00013970.06489InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.24170.2323InformativeInherited
Biological Process (BP)response to hormone stimulus0.26721InformativeInherited
Biological Process (BP)intracellular signal transduction0.0022990.2658InformativeInherited
Biological Process (BP)tissue morphogenesis1.705e-090.1512InformativeInherited
Biological Process (BP)epithelium development0.86040.838InformativeInherited
Biological Process (BP)tube development0.00013580.8797InformativeInherited
Biological Process (BP)single organism reproductive process4.38e-071InformativeInherited
Biological Process (BP)multicellular organismal reproductive process3.009e-080.7755InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.003510.003006InformativeInherited
Biological Process (BP)organ morphogenesis1.398e-060.9706InformativeInherited
Biological Process (BP)response to lipid0.00026010.2368InformativeInherited
Biological Process (BP)cellular component disassembly9.499e-050.03419InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity4.504e-050.5358InformativeInherited
Biological Process (BP)regulation of cell proliferation2.037e-081InformativeInherited
Biological Process (BP)regulation of locomotion1.285e-050.7521InformativeInherited
Biological Process (BP)regulation of cellular component movement1.111e-060.8087InformativeInherited
Biological Process (BP)regulation of immune response0.0040740.0442InformativeInherited
Biological Process (BP)immune response2.476e-070.4127InformativeInherited
Biological Process (BP)immune effector process0.0024290.2949InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.019680.9611InformativeInherited
Biological Process (BP)placenta development3.3e-153.161e-07Highly InformativeDirect
Biological Process (BP)tissue homeostasis1.422e-141.267e-05Highly InformativeDirect
Biological Process (BP)hair follicle development7.131e-070.0006202Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity7.062e-080.0006495Highly InformativeDirect
Biological Process (BP)immune response-regulating signaling pathway1.083e-100.0005336Highly InformativeDirect
Biological Process (BP)female pregnancy3.3e-153.656e-05Highly InformativeDirect
Biological Process (BP)positive regulation of peptidase activity1.085e-098.861e-06Highly InformativeDirect
Biological Process (BP)protein processing00Highly InformativeDirect
Biological Process (BP)respiratory tube development2.719e-080.00093Highly InformativeDirect
Biological Process (BP)regulation of protein stability1.186e-130Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00020965.902e-07Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.336e-071Highly InformativeInherited
Biological Process (BP)developmental maturation0.00016450.3276Highly InformativeInherited
Biological Process (BP)MAPK cascade5.083e-090.08912Highly InformativeInherited
Biological Process (BP)branching morphogenesis of an epithelial tube2.277e-130.002026Highly InformativeInherited
Biological Process (BP)respiratory system development4.847e-070.04656Highly InformativeInherited
Biological Process (BP)regulation of angiogenesis2.982e-110.02286Highly InformativeInherited
Biological Process (BP)multicellular organismal metabolic process4.233e-070.003097Highly InformativeInherited
Biological Process (BP)extracellular matrix organization6.972e-060.4411Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0038151Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration2.345e-100.007215Highly InformativeInherited
Biological Process (BP)renal system development3.378e-080.05576Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity2.391e-061.209e-08Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00049263.247e-11InformativeDirect
Molecular Function (MF)peptidase regulator activity1.399e-125.925e-10InformativeDirect
Molecular Function (MF)receptor activity0.00047821InformativeInherited
Molecular Function (MF)molecular transducer activity0.0011321InformativeInherited
Molecular Function (MF)enzyme activator activity2.479e-070.0621InformativeInherited
Molecular Function (MF)thiolester hydrolase activity1.005e-050Highly InformativeDirect
Molecular Function (MF)hormone binding1.493e-147.553e-08Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process4.87e-111.864e-07Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00013381Highly InformativeInherited
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity1.899e-060.006149Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0035220.6242Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.024971Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)extracellular region part7.297e-120.0003122Moderately InformativeDirect
Cellular Component (CC)vesicle1.662e-080.01137Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0038470.0005323Moderately InformativeInherited
Cellular Component (CC)lytic vacuole1.414e-075.331e-06InformativeDirect
Cellular Component (CC)secretory granule4.842e-102.739e-08InformativeDirect
Cellular Component (CC)endosome0.06270.03765InformativeInherited
Cellular Component (CC)vacuolar part0.026580.9594InformativeInherited
Cellular Component (CC)vacuolar lumen2.316e-073.025e-06Highly InformativeDirect
Cellular Component (CC)alveolar lamellar body00Highly InformativeDirect
Cellular Component (CC)endosomal part0.0004650.01335Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4735 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9516 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.0833 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2423 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.4166 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000857 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.649e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0005917 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3234 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8763 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8566 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2221 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.008744 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4511 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8412 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06208 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.3636 Moderately Informative Inherited
Biological Process (BP) tissue development 0.67 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.867 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.396 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6702 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7078 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8181 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9667 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002799 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04731 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02062 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.648 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.00193 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9709 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 0.0003061 Informative Direct
Biological Process (BP) proteolysis 2.788e-12 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.278e-11 Informative Direct
Biological Process (BP) actin filament-based process 0.0005241 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.601e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0007112 Informative Direct
Biological Process (BP) cellular amide metabolic process 0.0001325 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0003336 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0002137 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 8.593e-09 Informative Direct
Biological Process (BP) regulation of peptidase activity 2.392e-05 Informative Direct
Biological Process (BP) muscle structure development 1.281e-06 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) organelle assembly 5.23e-09 Informative Direct
Biological Process (BP) regulation of response to stress 1.827e-05 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.2719 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2323 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2658 Informative Inherited
Biological Process (BP) response to inorganic substance 0.9098 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.882 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1512 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.7081 Informative Inherited
Biological Process (BP) epithelium development 0.838 Informative Inherited
Biological Process (BP) tube development 0.8797 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.0442 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.06489 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.03004 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8592 Informative Inherited
Biological Process (BP) cell cycle process 0.3503 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6422 Informative Inherited
Biological Process (BP) regulation of growth 0.005478 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7755 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4304 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.003351 Informative Inherited
Biological Process (BP) organ morphogenesis 0.9706 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.003006 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6329 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.001838 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.9334 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8253 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) gland development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) response to lipid 0.2368 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01385 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5403 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1418 Informative Inherited
Biological Process (BP) cellular component disassembly 0.03419 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.5358 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7521 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8087 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01293 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.00197 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.2261 Informative Inherited
Biological Process (BP) chromosome organization 0.003174 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.1374 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.4127 Informative Inherited
Biological Process (BP) immune effector process 0.2949 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9611 Informative Inherited
Biological Process (BP) placenta development 3.161e-07 Highly Informative Direct
Biological Process (BP) tissue homeostasis 1.267e-05 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0006202 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0006495 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0.0005336 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) autophagy 9.265e-09 Highly Informative Direct
Biological Process (BP) female pregnancy 3.656e-05 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 4.539e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 9.773e-12 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 9.64e-09 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 8.861e-06 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.00093 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 5.546e-15 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0002436 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 2.766e-14 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0005012 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.0007538 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 2.11e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 5.321e-08 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001168 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.59e-06 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 1.09e-08 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0009994 Highly Informative Direct
Biological Process (BP) regulation of wound healing 3.824e-09 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 5.902e-07 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.3276 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3285 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.004509 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.001626 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.003254 Highly Informative Inherited
Biological Process (BP) response to acid 0.004459 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.08912 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.004145 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.4667 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.8777 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.5202 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.4951 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.0152 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.9478 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.002026 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.04656 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.02826 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.009315 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.00264 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.002642 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.07299 Highly Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03357 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3258 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.02286 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.003097 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.009385 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.582 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.03277 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1934 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.09397 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.386 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.8796 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) stem cell development 0.1746 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.6414 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.001084 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.4411 Highly Informative Inherited
Biological Process (BP) axon development 0.2696 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.1457 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2366 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.007215 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002584 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01292 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1531 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.09939 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.1163 Highly Informative Inherited
Biological Process (BP) renal system development 0.05576 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0007595 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.209e-08 Moderately Informative Direct
Molecular Function (MF) cation binding 3.11e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0.0008473 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 3.247e-11 Informative Direct
Molecular Function (MF) peptidase regulator activity 5.925e-10 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.005347 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0621 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 3.785e-08 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 7.553e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 1.864e-07 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.006149 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0003057 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6242 Least Informative Inherited
Cellular Component (CC) cytosol 0.0003607 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0003122 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0005323 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.102 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01137 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 5.331e-06 Informative Direct
Cellular Component (CC) secretory granule 2.739e-08 Informative Direct
Cellular Component (CC) contractile fiber part 7.586e-07 Informative Direct
Cellular Component (CC) endosome 0.03765 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.03516 Informative Inherited
Cellular Component (CC) vacuolar part 0.9594 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) chromatin 0.0006848 Highly Informative Direct
Cellular Component (CC) lysosome 0.0001274 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 3.025e-06 Highly Informative Direct
Cellular Component (CC) centrosome 0.0001859 Highly Informative Direct
Cellular Component (CC) midbody 5.925e-05 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.531e-13 Highly Informative Direct
Cellular Component (CC) alveolar lamellar body 0 Highly Informative Direct
Cellular Component (CC) endosomal part 0.01335 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.007592 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.738e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase6.359e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1778Least InformativeInherited
Disease Ontology (DO)skin disease0.006423Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5735Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis3.116e-07InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.1821Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02281InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001154Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant2.959e-07Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9645Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant7.096e-15Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant2.651e-08Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0803Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant2.184e-09InformativeDirect
Worm Phenotype (WP)osmotic integrity variant6.743e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.000263InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1.385e-09Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase2.833e-06InformativeDirect
Enzyme Commission (EC)In linear amides3.163e-06InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.839InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase5.725e-08Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase6.398e-06Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processHost-virus interaction1.561e-09Moderately InformativeDirect
Biological processCell cycle3.742e-07Moderately InformativeDirect
Biological processDifferentiation0.006089Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processMitosis8.207e-12InformativeDirect
Biological processViral RNA replication2.728e-08InformativeDirect
Biological processEndocytosis4.66e-08InformativeDirect
Biological processWnt signaling pathway5.198e-07InformativeDirect
Biological processVirus entry into host cell0.04176InformativeInherited
Biological processAutophagy0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response2.695e-08Highly InformativeDirect
Biological processSpermatogenesis1.989e-07Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host1.233e-06Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum2.129e-11Moderately InformativeDirect
Cellular componentSecreted6.403e-11Moderately InformativeDirect
Cellular componentEndosome5.456e-07Moderately InformativeDirect
Cellular componentCytoskeleton3.803e-05Moderately InformativeDirect
Cellular componentCell projection0.1962Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentVacuole2.449e-05InformativeDirect
Cellular componentHost membrane0.0004448InformativeDirect
Cellular componentHost cytoplasmic vesicle3.859e-12Highly InformativeDirect
Cellular componentProteasome4.871e-07Highly InformativeDirect
Cellular componentCilium0.0001352Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger1.205e-05Moderately InformativeDirect
DomainWD repeat6.112e-05InformativeDirect
Molecular functionZinc1.672e-06Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCadmium5.442e-10Highly InformativeDirect
Molecular functionChloride9.999e-05Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase8.838e-16InformativeDirect
Post-translational modificationExonuclease3.167e-13InformativeDirect
Post-translational modificationAntimicrobial0.03749InformativeInherited
Post-translational modificationIon channel0.1701InformativeInherited
Post-translational modificationViral ion channel1.889e-11Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase1.225e-08Highly InformativeDirect
Post-translational modificationDisulfide bond0.0002343Least InformativeDirect
Post-translational modificationUbl conjugation1.171e-05Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage2.541e-13InformativeDirect
Post-translational modificationMyristate0.000136InformativeDirect
Post-translational modificationCovalent protein-RNA linkage1.698e-06Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]