SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,032) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 63,962 208,755 132
Proteins 62,956 207,593 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.82210Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.90540.9645Least InformativeInherited
Biological Process (BP)regulation of cellular process10.07252Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process9.004e-080.879Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.1039Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.77881Least InformativeInherited
Biological Process (BP)response to stimulus0.30420.4141Least InformativeInherited
Biological Process (BP)developmental process1.786e-090.1026Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00010240.0008009Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.062331Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.4691Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.6208Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.14771Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.027381Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.049471Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0031040.8837Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.82540.3115Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.049960Moderately InformativeInherited
Biological Process (BP)signal transduction0.37811Moderately InformativeInherited
Biological Process (BP)tissue development1.726e-060.7688Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0063550.0001025Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0047780.4216Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.016470.7971Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.13111Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.38381Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0024720.6105Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.13170.06261Moderately InformativeInherited
Biological Process (BP)gene expression0.14091Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00038090.008841Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.044381Moderately InformativeInherited
Biological Process (BP)regulation of localization0.23891Moderately InformativeInherited
Biological Process (BP)cell differentiation0.34090.7902Moderately InformativeInherited
Biological Process (BP)reproduction8.783e-051Moderately InformativeInherited
Biological Process (BP)multi-organism process0.031870.06834Moderately InformativeInherited
Biological Process (BP)immune system process0.00023140.9481Moderately InformativeInherited
Biological Process (BP)organ development0.00079991Moderately InformativeInherited
Biological Process (BP)proteolysis2.175e-093.956e-14InformativeDirect
Biological Process (BP)peptide metabolic process1.55e-101.933e-06InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression5.95e-091.315e-11InformativeDirect
Biological Process (BP)positive regulation of developmental process8.242e-050.0002558InformativeDirect
Biological Process (BP)regulation of peptidase activity2.912e-091.836e-05InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal2.248e-130InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.90761InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.08310.02606InformativeInherited
Biological Process (BP)regulation of organelle organization0.00012310.082InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity2.622e-050.4861InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.5220.2365InformativeInherited
Biological Process (BP)response to hormone stimulus0.13921InformativeInherited
Biological Process (BP)intracellular signal transduction0.0018440.1915InformativeInherited
Biological Process (BP)tissue morphogenesis4.193e-090.2355InformativeInherited
Biological Process (BP)epithelium development0.84840.9215InformativeInherited
Biological Process (BP)tube development0.00019030.938InformativeInherited
Biological Process (BP)multi-multicellular organism process1.355e-080.00515InformativeInherited
Biological Process (BP)regulation of defense response0.041671InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.13840.0007853InformativeInherited
Biological Process (BP)single organism reproductive process6.38e-071InformativeInherited
Biological Process (BP)multicellular organismal reproductive process5.077e-060.7386InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0033690.003564InformativeInherited
Biological Process (BP)organ morphogenesis4.545e-061InformativeInherited
Biological Process (BP)response to lipid0.00028150.1804InformativeInherited
Biological Process (BP)regulation of cell proliferation1.596e-081InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.032511InformativeInherited
Biological Process (BP)regulation of locomotion1.177e-050.7533InformativeInherited
Biological Process (BP)regulation of cellular component movement1.107e-060.8066InformativeInherited
Biological Process (BP)apoptotic process11InformativeInherited
Biological Process (BP)regulation of immune response0.004050.0449InformativeInherited
Biological Process (BP)immune response1.843e-070.4057InformativeInherited
Biological Process (BP)immune effector process0.0023720.2642InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.013871InformativeInherited
Biological Process (BP)placenta development3.261e-155.204e-07Highly InformativeDirect
Biological Process (BP)hair follicle development3.317e-070.0003548Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity5.605e-080.0005313Highly InformativeDirect
Biological Process (BP)female pregnancy3.261e-153.686e-05Highly InformativeDirect
Biological Process (BP)protein processing00Highly InformativeDirect
Biological Process (BP)regulation of protein stability9.206e-140Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue6.398e-151.61e-14Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.0002865.484e-07Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.363e-071Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity1.929e-060.01764Highly InformativeInherited
Biological Process (BP)MAPK cascade5.047e-090.08472Highly InformativeInherited
Biological Process (BP)branching morphogenesis of an epithelial tube1.722e-130.001459Highly InformativeInherited
Biological Process (BP)respiratory system development5.405e-070.03748Highly InformativeInherited
Biological Process (BP)respiratory tube development3.931e-080.001396Highly InformativeInherited
Biological Process (BP)positive regulation of defense response6.474e-080.002201Highly InformativeInherited
Biological Process (BP)positive regulation of response to external stimulus0.00042110.08996Highly InformativeInherited
Biological Process (BP)regulation of angiogenesis2.318e-110.02139Highly InformativeInherited
Biological Process (BP)multicellular organismal metabolic process2.6e-070.002739Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process1.078e-060.008578Highly InformativeInherited
Biological Process (BP)cellular component disassembly6.022e-050.03182Highly InformativeInherited
Biological Process (BP)extracellular matrix organization10.4087Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0033571Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration2.518e-100.006487Highly InformativeInherited
Biological Process (BP)renal system development3.847e-080.04739Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity2.028e-067.443e-09Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00013199.358e-12InformativeDirect
Molecular Function (MF)peptidase regulator activity1.131e-125.199e-10InformativeDirect
Molecular Function (MF)receptor activity0.00043891InformativeInherited
Molecular Function (MF)molecular transducer activity0.0010341InformativeInherited
Molecular Function (MF)enzyme activator activity2.685e-070.06927InformativeInherited
Molecular Function (MF)thiolester hydrolase activity9.437e-060Highly InformativeDirect
Molecular Function (MF)hormone binding1.136e-144.486e-08Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process4.342e-111.629e-07Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00024061Highly InformativeInherited
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity2.511e-070.002018Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00093310.4608Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.021591Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)extracellular region part2.466e-110.0003257Moderately InformativeDirect
Cellular Component (CC)vesicle8.099e-080.03459Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0031970.0004848Moderately InformativeInherited
Cellular Component (CC)lytic vacuole6.341e-086.314e-08InformativeDirect
Cellular Component (CC)extracellular space1.567e-050.0006408InformativeDirect
Cellular Component (CC)secretory granule3.586e-102.297e-08InformativeDirect
Cellular Component (CC)endosome0.074690.04744InformativeInherited
Cellular Component (CC)vacuolar part0.029050.9691InformativeInherited
Cellular Component (CC)endosomal part0.00058150.0144Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4141 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9645 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.879 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.07252 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1039 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.1026 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0005721 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001025 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 3.958e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0008009 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3034 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8837 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.824 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3115 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1002 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.009086 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7688 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4216 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8123 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.16 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5009 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06261 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7971 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6208 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.6105 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7902 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06834 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.008841 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001074 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9481 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 3.956e-14 Informative Direct
Biological Process (BP) peptide metabolic process 1.933e-06 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.315e-11 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0007445 Informative Direct
Biological Process (BP) actin filament-based process 0.0007906 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.969e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0007853 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0008994 Informative Direct
Biological Process (BP) regulation of cell activation 2.982e-05 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0002558 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0003163 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 4.52e-09 Informative Direct
Biological Process (BP) regulation of peptidase activity 1.836e-05 Informative Direct
Biological Process (BP) muscle structure development 4.21e-06 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) organelle assembly 7.848e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.02606 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.4861 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2365 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.9751 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1915 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8492 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.881 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2355 Informative Inherited
Biological Process (BP) cell cycle process 0.3615 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.749 Informative Inherited
Biological Process (BP) epithelium development 0.9215 Informative Inherited
Biological Process (BP) tube development 0.938 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.00515 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.0449 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.082 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02167 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8626 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.658 Informative Inherited
Biological Process (BP) protein oligomerization 1 Informative Inherited
Biological Process (BP) regulation of growth 0.006043 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03774 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7386 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4383 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.003287 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.2369 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01574 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.948 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.003564 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6829 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002105 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.9663 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.843 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) gland development 0.4784 Informative Inherited
Biological Process (BP) response to lipid 0.1804 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03678 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5459 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2618 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7533 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8066 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01662 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.2561 Informative Inherited
Biological Process (BP) chromosome organization 0.002972 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.1489 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.4057 Informative Inherited
Biological Process (BP) immune effector process 0.2642 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) ribonucleoprotein complex biogenesis 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) placenta development 5.204e-07 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0003548 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0005313 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) autophagy 6.549e-09 Highly Informative Direct
Biological Process (BP) female pregnancy 3.686e-05 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 4.903e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 1.992e-11 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 6.522e-08 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 7.347e-15 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0002366 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 2.119e-14 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0005772 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 2.221e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 3.391e-08 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 7.132e-05 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 1.61e-14 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.0008411 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.259e-06 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 1.094e-08 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0009718 Highly Informative Direct
Biological Process (BP) regulation of wound healing 1.991e-09 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 5.484e-07 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.01764 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3596 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.005273 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.002636 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.006787 Highly Informative Inherited
Biological Process (BP) response to amino acid stimulus 0.001704 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.08472 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.005016 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.7947 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.522 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.5004 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.03546 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.9535 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.001459 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.03748 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001396 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.01013 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.00297 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.002201 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.08996 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.00689 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3212 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.02139 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.2286 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.6198 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.5278 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002739 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.008578 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.008914 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5501 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.03167 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1807 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.09192 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.004092 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3953 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.7391 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2552 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.6312 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.002145 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.03182 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.4087 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.004774 Highly Informative Inherited
Biological Process (BP) interaction with host 0.01141 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2368 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.006487 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002673 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01802 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1825 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.1002 Highly Informative Inherited
Biological Process (BP) gene silencing 0.004455 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.1254 Highly Informative Inherited
Biological Process (BP) renal system development 0.04739 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1946 Highly Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.2761 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.04351 Highly Informative Inherited
Biological Process (BP) mRNA catabolic process 0.1612 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0006304 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 7.443e-09 Moderately Informative Direct
Molecular Function (MF) cation binding 3.868e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0.0008656 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.0009488 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 9.358e-12 Informative Direct
Molecular Function (MF) peptidase regulator activity 5.199e-10 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.004442 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.06927 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 2.511e-08 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 4.486e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 1.629e-07 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.002018 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4608 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.9899 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001991 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosol 9.937e-06 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0003257 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0004848 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1373 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.03459 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 6.314e-08 Informative Direct
Cellular Component (CC) extracellular space 0.0006408 Informative Direct
Cellular Component (CC) secretory granule 2.297e-08 Informative Direct
Cellular Component (CC) contractile fiber part 1.415e-06 Informative Direct
Cellular Component (CC) endosome 0.04744 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.03859 Informative Inherited
Cellular Component (CC) vacuolar part 0.9691 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) chromatin 0.0005391 Highly Informative Direct
Cellular Component (CC) centrosome 0.0003275 Highly Informative Direct
Cellular Component (CC) midbody 6.976e-05 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.187e-13 Highly Informative Direct
Cellular Component (CC) endosomal part 0.0144 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.008934 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.738e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase6.359e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1501Least InformativeInherited
Disease Ontology (DO)skin disease0.01546Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5772Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis1.033e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.179Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02254InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.000141Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.2699Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant2.959e-07Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9645Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant7.096e-15Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant2.651e-08Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0803Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant2.184e-09InformativeDirect
Worm Phenotype (WP)osmotic integrity variant6.743e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0004467InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1.626e-09Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase2.807e-06InformativeDirect
Enzyme Commission (EC)In linear amides9.973e-06InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.8387InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase3.421e-08Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase6.35e-06Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)