SUPERFAMILY 1.75 HMM library and genome assignments server

Periplasmic binding protein-like I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Periplasmic binding protein-like I [ 53821]
Superfamily:   Periplasmic binding protein-like I [ 53822]
Families:   L-arabinose binding protein-like [ 53823] (16)


Superfamily statistics
Genomes (2,627) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 45,761 226,237 47
Proteins 45,156 225,457 47


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.00014590.0002862Least InformativeDirect
Biological Process (BP)regulation of cellular process0.2240.00001059Least InformativeInherited
Biological Process (BP)response to stimulus0.87150Least InformativeInherited
Biological Process (BP)multicellular organismal process0.68540.000004807Least InformativeInherited
Biological Process (BP)single-organism cellular process0.25210Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.09981Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.22260.0000003535Moderately InformativeInherited
Biological Process (BP)organic substance transport0.000037181Moderately InformativeInherited
Biological Process (BP)ion transport0.12090Moderately InformativeInherited
Biological Process (BP)defense response0.085670.2457Moderately InformativeInherited
Biological Process (BP)negative regulation of cell communication0.00019020.00006226InformativeDirect
Biological Process (BP)negative regulation of signaling0.00029130.00005661InformativeDirect
Biological Process (BP)synaptic transmission0.00045390InformativeDirect
Biological Process (BP)anion transport0.00000049891InformativeInherited
Biological Process (BP)organic acid transport0.000063040.003827InformativeInherited
Biological Process (BP)nitrogen compound transport0.001550.4809InformativeInherited
Biological Process (BP)single-organism behavior0.0035530InformativeInherited
Biological Process (BP)amino acid transport0.000000000086540.000000002342Highly InformativeDirect
Biological Process (BP)behavioral fear response0.00000023820.00001576Highly InformativeDirect
Biological Process (BP)regulation of synaptic transmission0.00000042130Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.058651Least InformativeInherited
Molecular Function (MF)transporter activity0.00000032060Moderately InformativeDirect
Molecular Function (MF)receptor activity0.000021420InformativeDirect
Molecular Function (MF)molecular transducer activity0.000041530InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.011551InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.0000027880.6708InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances0.0000040731InformativeInherited
Molecular Function (MF)active transmembrane transporter activity0.031421InformativeInherited
Molecular Function (MF)amino acid transmembrane transporter activity0.000000000031610.000000009809Highly InformativeDirect
Molecular Function (MF)transmembrane signaling receptor activity10.00005841Highly InformativeInherited
Cellular Component (CC)protein complex0.017690Least InformativeInherited
Cellular Component (CC)membrane0.01110Least InformativeInherited
Cellular Component (CC)plasma membrane part0.0000036220Moderately InformativeDirect
Cellular Component (CC)cell projection0.012550Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.0011380Moderately InformativeInherited
Cellular Component (CC)transporter complex0.000000000016570InformativeDirect
Cellular Component (CC)synapse0.00000000085080InformativeDirect
Cellular Component (CC)integral component of membrane0.00057270InformativeDirect
Cellular Component (CC)neuron projection0.072930.00000000002323InformativeInherited
Cellular Component (CC)intrinsic component of plasma membrane0.0012040InformativeInherited
Cellular Component (CC)receptor complex0.000000000000031620Highly InformativeDirect
Cellular Component (CC)postsynaptic membrane0.0000000000019440.0001977Highly InformativeDirect
Cellular Component (CC)ion channel complex0.000000000040450Highly InformativeDirect
Cellular Component (CC)integral component of plasma membrane0.00086610Highly InformativeDirect
Cellular Component (CC)dendrite0.042020.0000000001125Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0002862 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00001059 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000004807 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000003535 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0007011 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3351 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4972 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.2306 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.006185 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5095 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.08705 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.3893 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4274 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4307 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4498 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.2548 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.08733 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.04147 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9959 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00591 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.006135 Moderately Informative Inherited
Biological Process (BP) defense response 0.2457 Moderately Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00006226 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00005661 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.000000000000003707 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00000000000005349 Informative Direct
Biological Process (BP) neurological system process 0.00000000001076 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.000000009371 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000000261 Informative Direct
Biological Process (BP) ion transmembrane transport 0.0000002708 Informative Direct
Biological Process (BP) regulation of secretion 0.00007546 Informative Direct
Biological Process (BP) response to light stimulus 0.00009191 Informative Direct
Biological Process (BP) positive regulation of transport 0.00009456 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0001367 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0001481 Informative Direct
Biological Process (BP) response to acid chemical 0.000177 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.9824 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2272 Informative Inherited
Biological Process (BP) metal ion transport 0.0108 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1722 Informative Inherited
Biological Process (BP) regulation of cell development 0.02725 Informative Inherited
Biological Process (BP) generation of neurons 0.2062 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7951 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.1315 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.5797 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.02327 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.8542 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.06016 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001458 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8342 Informative Inherited
Biological Process (BP) regulation of system process 0.1431 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.004255 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1891 Informative Inherited
Biological Process (BP) central nervous system development 0.1744 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 0.003827 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.4809 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1831 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) amino acid transport 0.000000002342 Highly Informative Direct
Biological Process (BP) behavioral fear response 0.00001576 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) response to amino acid 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0.0000000000002241 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0000000000003657 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.000000000001605 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.0000001498 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000004724 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00002134 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.00003511 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.00004756 Highly Informative Direct
Biological Process (BP) telencephalon development 0.00008539 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 0.0001512 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0002725 Highly Informative Direct
Biological Process (BP) regulation of ion transmembrane transport 0.9296 Highly Informative Inherited
Biological Process (BP) learning or memory 0.002484 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.001744 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.01768 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.004934 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.00544 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.06072 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.001461 Highly Informative Inherited
Biological Process (BP) detection of light stimulus 0.008442 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.002188 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.2587 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000001163 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0449 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.6 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.6708 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) amino acid transmembrane transporter activity 0.000000009809 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.00000003575 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.000002944 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.00005841 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0003304 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0006224 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0009609 Highly Informative Direct
Molecular Function (MF) cation channel activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.5263 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0000003016 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000004348 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000000005826 Moderately Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) integral component of membrane 0 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Informative Direct
Cellular Component (CC) cell surface 0.0008464 Informative Direct
Cellular Component (CC) neuron projection 0.00000000002323 Informative Direct
Cellular Component (CC) external encapsulating structure 0.5085 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) postsynaptic membrane 0.0001977 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) dendrite 0.0000000001125 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) cell envelope 0.00005181 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.0002349 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.00007704Least InformativeDirect
Disease Ontology (DO)disease of mental health0.000000008031Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.6968Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0000000001783InformativeDirect
Disease Ontology (DO)motor neuron disease0.00009409InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2851InformativeInherited
Disease Ontology (DO)temporal lobe epilepsy0.0000000005767Highly InformativeDirect
Disease Ontology (DO)amyotrophic lateral sclerosis0.0000001524Highly InformativeDirect
Disease Ontology (DO)autistic disorder0.0001123Highly InformativeDirect
Disease Ontology (DO)bipolar disorder0.0003648Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000003244Least InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0.007901Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.06584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.0003266InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0006072InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.0008859InformativeDirect
Mammalian Phenotype (MP)seizures0.001809InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.3719InformativeInherited
Mammalian Phenotype (MP)decreased alcohol consumption0.00003612Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.00009993Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.0009104Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.007137Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic depression0.2405Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.58Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000000267Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.6948Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.0004527Moderately InformativeDirect
Worm Phenotype (WP)chemotaxis variant0InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00001192InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.001162InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.00000182Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.000006777Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.000008007Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.00002023Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.009618Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.9973Highly InformativeInherited
Worm Phenotype (WP)negative chemotaxis variant1Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.00002341Least InformativeDirect
Drugbank ATC_code (DB)nervous system0.001234Least InformativeInherited
Drugbank ATC_code (DB)cardiovascular system0.8171Least InformativeInherited
Drugbank ATC_code (DB)psycholeptics0.001034Moderately InformativeInherited
Drugbank ATC_code (DB)musculo-skeletal system0.01627Moderately InformativeInherited
Drugbank ATC_code (DB)other nervous system drugs0.02314Moderately InformativeInherited
Drugbank ATC_code (DB)anesthetics0.09656Moderately InformativeInherited
Drugbank ATC_code (DB)cardiac therapy0.1262Moderately InformativeInherited
Drugbank ATC_code (DB)psychoanaleptics0.1512Moderately InformativeInherited
Drugbank ATC_code (DB)glutamic acid hydrochloride0InformativeDirect
Drugbank ATC_code (DB)pentobarbital0.000000001285InformativeDirect
Drugbank ATC_code (DB)acamprosate0.00000001021InformativeDirect
Drugbank ATC_code (DB)prasterone0.000001715InformativeDirect
Drugbank ATC_code (DB)opioids0.00000578InformativeDirect
Drugbank ATC_code (DB)muscle relaxants0.000007497InformativeDirect
Drugbank ATC_code (DB)other antidepressants0.00001661InformativeDirect
Drugbank ATC_code (DB)vasodilators used in cardiac diseases0.00003393InformativeDirect
Drugbank ATC_code (DB)anticholinergic agents0.00004147InformativeDirect
Drugbank ATC_code (DB)anesthetics, general0.0007852InformativeDirect
Drugbank ATC_code (DB)barbiturates and derivatives0.003147InformativeInherited
Drugbank ATC_code (DB)centrally acting sympathomimetics0.01266InformativeInherited
Drugbank ATC_code (DB)anti-dementia drugs0.04784InformativeInherited
Drugbank ATC_code (DB)other antiepileptics0.9543InformativeInherited
Drugbank ATC_code (DB)phenobarbital0.000000000000572Highly InformativeDirect
Drugbank ATC_code (DB)secobarbital0.00000000001621Highly InformativeDirect
Drugbank ATC_code (DB)milnacipran0.0000000001357Highly InformativeDirect
Drugbank ATC_code (DB)ketobemidone0.0000000003005Highly InformativeDirect
Drugbank ATC_code (DB)ethers chemically close to antihistamines0.00000188Highly InformativeDirect
Drugbank ATC_code (DB)memantine0.00000188Highly InformativeDirect
Drugbank ATC_code (DB)nesiritide0.000002515Highly InformativeDirect
Drugbank ATC_code (DB)gabapentin0.00001499Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processCell shape0.0000000001949InformativeDirect
Biological processChemotaxis0.00000006844InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processPeptidoglycan synthesis0.00000000007772Highly InformativeDirect
Biological processOsteogenesis0.00000007769Highly InformativeDirect
Biological processSugar transport0.0007678Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0.00000000002835Moderately InformativeDirect
Cellular componentCell membrane0.000000002519Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00009498Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentCell outer membrane0.00000000000007InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
Coding sequence diversityRNA editing0.0000005139Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionCalcium0.00000000000000501Moderately InformativeDirect
Molecular functionGTP-binding0.0004662InformativeDirect
Molecular functionChloride0.00002802Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.000372Least InformativeDirect
Post-translational modificationPalmitate9.055e-16Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Periplasmic binding protein-like I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Periplasmic binding protein-like I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]