SUPERFAMILY 1.75 HMM library and genome assignments server


ALDH-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   ALDH-like [ 53719]
Superfamily:   ALDH-like [ 53720] (2)
Families:   ALDH-like [ 53721] (5)
  L-histidinol dehydrogenase HisD [ 69602]


Superfamily statistics
Genomes (2,975) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 34,067 76,276 20
Proteins 33,643 75,813 20


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)developmental process0.49751Least InformativeInherited
Biological Process (BP)multicellular organismal process0.84971Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.67891Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.61330.4483Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.01958.577e-06Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process5.411e-110Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process4.57e-086.186e-06Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.66661Moderately InformativeInherited
Biological Process (BP)organ development0.06091Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.82351Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.011150.5782Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.76730.2961Moderately InformativeInherited
Biological Process (BP)system process0.09450.7291Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.046420.3245Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.13290.1613Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.67760.007378Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.0017828.799e-06Moderately InformativeInherited
Biological Process (BP)nervous system development0.069190.7446Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.069960.09153Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process11Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.1720.4218Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.62321Moderately InformativeInherited
Biological Process (BP)tissue development0.16111Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.44260.2501Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.39810.4152Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.44640.01729Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0021435.375e-07Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.90381Moderately InformativeInherited
Biological Process (BP)isoprenoid metabolic process3.152e-154.679e-12InformativeDirect
Biological Process (BP)central nervous system development0.00021740.0007772InformativeDirect
Biological Process (BP)regulation of hormone levels1.343e-129.213e-11InformativeDirect
Biological Process (BP)sensory organ development0.00017360.2426InformativeInherited
Biological Process (BP)embryonic organ development5.219e-060.0293InformativeInherited
Biological Process (BP)embryonic morphogenesis7.063e-050.2364InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.19670.1301InformativeInherited
Biological Process (BP)secondary metabolic process0.50521InformativeInherited
Biological Process (BP)cell-cell signaling0.30020.8954InformativeInherited
Biological Process (BP)transmission of nerve impulse0.052240.4539InformativeInherited
Biological Process (BP)alcohol metabolic process0.11630.9607InformativeInherited
Biological Process (BP)cellular amide metabolic process0.20130.03191InformativeInherited
Biological Process (BP)response to inorganic substance0.1870.03154InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.77930.0104InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.0047010.002706InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.027130.6099InformativeInherited
Biological Process (BP)organ morphogenesis0.0030750.8881InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.054291InformativeInherited
Biological Process (BP)tissue morphogenesis0.0010230.3662InformativeInherited
Biological Process (BP)epithelium development0.022950.8991InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process11InformativeInherited
Biological Process (BP)retinoid metabolic process00Highly InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process00Highly InformativeDirect
Biological Process (BP)amino-acid betaine metabolic process00Highly InformativeDirect
Biological Process (BP)polyamine metabolic process8.257e-059.178e-05Highly InformativeDirect
Biological Process (BP)isoprenoid biosynthetic process8.417e-073.229e-05Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process0.00024231.906e-06Highly InformativeDirect
Biological Process (BP)response to water deprivation0.00010691.086e-05Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process2.836e-111.004e-11Highly InformativeDirect
Biological Process (BP)imidazole-containing compound metabolic process0.00015134.159e-07Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis4.914e-080.002294Highly InformativeInherited
Biological Process (BP)eye morphogenesis3.166e-060.004875Highly InformativeInherited
Biological Process (BP)antibiotic biosynthetic process0.0012670.0001469Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.220.9337Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.029680.003048Highly InformativeInherited
Biological Process (BP)amide biosynthetic process0.005080.001096Highly InformativeInherited
Biological Process (BP)nucleobase metabolic process0.00094020.01058Highly InformativeInherited
Biological Process (BP)cellular biogenic amine catabolic process0.20250.05343Highly InformativeInherited
Biological Process (BP)branched-chain amino acid metabolic process0.00068330.1139Highly InformativeInherited
Biological Process (BP)glutamate metabolic process0.079380.0006863Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.00018990.003278Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.007320.02624Moderately InformativeInherited
Molecular Function (MF)cofactor binding1.068e-130InformativeDirect
Molecular Function (MF)nucleotide binding0.47150.5528InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors11InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors00Highly InformativeDirect
Molecular Function (MF)hormone binding9.486e-064.306e-05Highly InformativeDirect
Molecular Function (MF)NAD binding8.114e-102.237e-11Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.7660.2233Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.19620.3724Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0024821.487e-08Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 8.577e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4483 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 5.375e-07 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 8.799e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 6.186e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8555 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5782 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.2961 Moderately Informative Inherited
Biological Process (BP) system process 0.7291 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3245 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1613 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.007378 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.7446 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.09153 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.339 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.4218 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2501 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.4152 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01729 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) isoprenoid metabolic process 4.679e-12 Informative Direct
Biological Process (BP) central nervous system development 0.0007772 Informative Direct
Biological Process (BP) regulation of hormone levels 9.213e-11 Informative Direct
Biological Process (BP) protein complex assembly 0.109 Informative Inherited
Biological Process (BP) sensory organ development 0.2426 Informative Inherited
Biological Process (BP) embryonic organ development 0.0293 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.2364 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.6954 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.1301 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.8954 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.4539 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.9607 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.03191 Informative Inherited
Biological Process (BP) response to inorganic substance 0.03154 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.0104 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) pyrimidine-containing compound metabolic process 0.002706 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.6099 Informative Inherited
Biological Process (BP) organ morphogenesis 0.8881 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3662 Informative Inherited
Biological Process (BP) epithelium development 0.8991 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 1 Informative Inherited
Biological Process (BP) retinoid metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0 Highly Informative Direct
Biological Process (BP) glutamate metabolic process 0.0006863 Highly Informative Direct
Biological Process (BP) amino-acid betaine metabolic process 0 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 9.178e-05 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 3.229e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 1.906e-06 Highly Informative Direct
Biological Process (BP) response to water deprivation 1.086e-05 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0001469 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 1.004e-11 Highly Informative Direct
Biological Process (BP) protein tetramerization 1.534e-07 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 4.159e-07 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.05181 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.002294 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.004875 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.9337 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.003048 Highly Informative Inherited
Biological Process (BP) amide biosynthetic process 0.001096 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.01058 Highly Informative Inherited
Biological Process (BP) cellular biogenic amine catabolic process 0.05343 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.1139 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.003278 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02624 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.5528 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) hormone binding 4.306e-05 Highly Informative Direct
Molecular Function (MF) NAD binding 2.237e-11 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.2233 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0.004482 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.487e-08 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3724 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.0008758 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.0001789 Informative Direct
Cellular Component (CC) lipid particle 0.0002391 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.9278InformativeInherited
Enzyme Commission (EC)Histidinol dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase1.588e-10Highly InformativeDirect
Enzyme Commission (EC)Glutamate 5-kinase4.896e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye morphology0.001195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.006245InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.02043InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1734InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.0005522Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0.0002598Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.005805Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.008183Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.03173Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.1793Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.7602Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence meristem0.0007226Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor4.633e-05Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0.9024Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0.0009359InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis6.229e-11Highly InformativeDirect
Biological processLuminescence6.073e-09Highly InformativeDirect
Cellular componentCytoplasm1.583e-15Least InformativeDirect
Cellular componentMitochondrion0.0002964Moderately InformativeDirect
DomainTransit peptide8.788e-12Moderately InformativeDirect
Molecular functionZinc1.01e-05Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism3.405e-10Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)L-arginine metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.03259Moderately InformativeInherited
UniPathway (UP)L-arginine degradation0InformativeDirect
UniPathway (UP)betaine biosynthesis0InformativeDirect
UniPathway (UP)choline metabolism0InformativeDirect
UniPathway (UP)alcohol degradation0InformativeDirect
UniPathway (UP)isoprenoid metabolism1.045e-05InformativeDirect
UniPathway (UP)organic acid degradation0.0002149InformativeDirect
UniPathway (UP)putrescine metabolism0.004366InformativeInherited
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)betaine biosynthesis via choline pathway0Highly InformativeDirect
UniPathway (UP)ethanol metabolism0Highly InformativeDirect
UniPathway (UP)4-aminobutanoate metabolism3.794e-08Highly InformativeDirect
UniPathway (UP)L-proline degradation5.716e-05Highly InformativeDirect
UniPathway (UP)amine and polyamine degradation0.0002506Highly InformativeDirect
UniPathway (UP)nonprotein amino-acid degradation0.0116Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ALDH-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the ALDH-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]