SUPERFAMILY 1.75 HMM library and genome assignments server

ALDH-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   ALDH-like [ 53719]
Superfamily:   ALDH-like [ 53720] (2)
Families:   ALDH-like [ 53721] (5)
  L-histidinol dehydrogenase HisD [ 69602]


Superfamily statistics
Genomes (3,020) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,980 176,906 20
Proteins 34,519 176,078 20


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)developmental process0.62831Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0000014610.001214Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.061070.00008078Least InformativeInherited
Biological Process (BP)response to stimulus0.56781Least InformativeInherited
Biological Process (BP)biosynthetic process0.75270.5984Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00000000011820Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.000000028420.000003256Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.8631Moderately InformativeInherited
Biological Process (BP)organ development0.097371Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.66460.8944Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.84251Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.64951Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.45440.4984Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.89470.5459Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.042790.8603Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.28940.2274Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.019580.2357Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.66390.006034Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.82720.01658Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.15360.2167Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.47580.2755Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.45850.01729Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.3160.0009178Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.7640.8716Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.011130.8623Moderately InformativeInherited
Biological Process (BP)tissue development0.10441Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0035650.00001419Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.94241Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process00InformativeDirect
Biological Process (BP)isoprenoid metabolic process0.0000000000000094410.000000000001225InformativeDirect
Biological Process (BP)regulation of hormone levels0.0000000000020020.0000000001448InformativeDirect
Biological Process (BP)protein oligomerization0.0013620.000001298InformativeInherited
Biological Process (BP)embryonic morphogenesis0.00011670.2833InformativeInherited
Biological Process (BP)sensory organ development0.00028560.2937InformativeInherited
Biological Process (BP)organ morphogenesis0.0049970.9589InformativeInherited
Biological Process (BP)embryonic organ development0.000010370.04005InformativeInherited
Biological Process (BP)secondary metabolic process0.33390.704InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.23850.1937InformativeInherited
Biological Process (BP)synaptic transmission0.10160.5437InformativeInherited
Biological Process (BP)alcohol metabolic process0.048170.7495InformativeInherited
Biological Process (BP)amide biosynthetic process0.0049460.001546InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.0062780.003538InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.63310.003441InformativeInherited
Biological Process (BP)response to acid chemical0.016280.007273InformativeInherited
Biological Process (BP)response to inorganic substance0.29490.04467InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.002340.00001115InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process11InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.01650.4866InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.071951InformativeInherited
Biological Process (BP)tissue morphogenesis0.0015470.4371InformativeInherited
Biological Process (BP)epithelium development0.00350.6919InformativeInherited
Biological Process (BP)gland development0.00011730.09587InformativeInherited
Biological Process (BP)amino-acid betaine metabolic process0.0000000000000016820Highly InformativeDirect
Biological Process (BP)polyamine metabolic process0.000085090.0001134Highly InformativeDirect
Biological Process (BP)isoprenoid biosynthetic process0.00000085960.00003763Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process0.00024890.000001744Highly InformativeDirect
Biological Process (BP)response to water deprivation0.00011190.00001156Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process0.00000045220.0000000000064Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.000000000029490.00000000001297Highly InformativeDirect
Biological Process (BP)protein tetramerization0.000076030.00000000001493Highly InformativeDirect
Biological Process (BP)imidazole-containing compound metabolic process0.00012940.0000004008Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis0.00000010680.003102Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.021740.2241Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.031530.004163Highly InformativeInherited
Biological Process (BP)antibiotic biosynthetic process0.0020090.0002076Highly InformativeInherited
Biological Process (BP)cellular biogenic amine catabolic process0.18690.04944Highly InformativeInherited
Biological Process (BP)branched-chain amino acid metabolic process0.00075090.1161Highly InformativeInherited
Biological Process (BP)glutamate metabolic process0.072750.0004679Highly InformativeInherited
Biological Process (BP)nucleobase metabolic process0.00081210.009397Highly InformativeInherited
Biological Process (BP)retinoid metabolic process0.013620.006712Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.0000039680.006235Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.00018450.004039Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.00071550.0002885Moderately InformativeDirect
Molecular Function (MF)anion binding0.013370.0338Moderately InformativeInherited
Molecular Function (MF)cofactor binding0.000000000000090410InformativeDirect
Molecular Function (MF)sulfur compound binding0.00002050.0008573InformativeDirect
Molecular Function (MF)nucleotide binding0.07440.07854InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors11InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors00Highly InformativeDirect
Molecular Function (MF)hormone binding0.000015990.00008392Highly InformativeDirect
Molecular Function (MF)NAD binding0.00000000012720.000000000002689Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.73610.2228Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.24410.2876Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.010760.0000003143Least InformativeInherited
Cellular Component (CC)lipid particle0.00073190.000001276InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.00008078 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001214 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5984 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00001419 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0009178 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000003256 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8404 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8944 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.4984 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.5459 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.8603 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2274 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2357 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.006034 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.01658 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.2167 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2755 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01729 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.8716 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8623 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.000000000001225 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0000000001448 Informative Direct
Biological Process (BP) protein oligomerization 0.000001298 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00001115 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.2833 Informative Inherited
Biological Process (BP) sensory organ development 0.2937 Informative Inherited
Biological Process (BP) organ morphogenesis 0.9589 Informative Inherited
Biological Process (BP) embryonic organ development 0.04005 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.7786 Informative Inherited
Biological Process (BP) secondary metabolic process 0.704 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.1937 Informative Inherited
Biological Process (BP) synaptic transmission 0.5437 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.7495 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.001546 Informative Inherited
Biological Process (BP) pyrimidine-containing compound metabolic process 0.003538 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.003441 Informative Inherited
Biological Process (BP) response to acid chemical 0.007273 Informative Inherited
Biological Process (BP) response to inorganic substance 0.04467 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.4866 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4371 Informative Inherited
Biological Process (BP) epithelium development 0.6919 Informative Inherited
Biological Process (BP) gland development 0.09587 Informative Inherited
Biological Process (BP) glutamate metabolic process 0.0004679 Highly Informative Direct
Biological Process (BP) amino-acid betaine metabolic process 0 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 0.0001134 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.00003763 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.000001744 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.00001156 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0002076 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.0000000000064 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00000000001297 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.00000000001493 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.0000004008 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.003102 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.01131 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.2241 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.004163 Highly Informative Inherited
Biological Process (BP) cellular biogenic amine catabolic process 0.04944 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.1161 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.009397 Highly Informative Inherited
Biological Process (BP) retinoid metabolic process 0.006712 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.006235 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.004039 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0002885 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0338 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0008573 Informative Direct
Molecular Function (MF) nucleotide binding 0.07854 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00008392 Highly Informative Direct
Molecular Function (MF) NAD binding 0.000000000002689 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.2228 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0.005295 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0000003143 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.2876 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.0005749 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.0002244 Informative Direct
Cellular Component (CC) lipid particle 0.000001276 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.9278InformativeInherited
Enzyme Commission (EC)Histidinol dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0.0000000001588Highly InformativeDirect
Enzyme Commission (EC)Glutamate 5-kinase0.00004896Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0.2883Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.001298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.007017InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1812InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.0006208Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0.0002636Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.005805Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.008183Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.03173Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.1793Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.7602Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence meristem0.0007226Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.00004476Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0.8945Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.01564Least InformativeInherited
Drugbank ATC_code (DB)sensory organs0.06752Least InformativeInherited
Drugbank ATC_code (DB)nasal preparations0.005066Moderately InformativeInherited
Drugbank ATC_code (DB)retinoids for topical use in acne0.0000182InformativeDirect
Drugbank ATC_code (DB)vitamin a, plain0.000003914Highly InformativeDirect
Drugbank ATC_code (DB)retinol0.000003914Highly InformativeDirect
Drugbank ATC_code (DB)retinol0.000003914Highly InformativeDirect
Drugbank ATC_code (DB)retinol0.000003914Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0.0009361InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis0.00000000006686Highly InformativeDirect
Biological processLuminescence0.000000006497Highly InformativeDirect
Cellular componentCytoplasm0.000000000000005071Least InformativeDirect
Cellular componentMitochondrion0.0003908Moderately InformativeDirect
DomainTransit peptide0.00000000001817Moderately InformativeDirect
Molecular functionZinc0.00002583Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.000000000000001792Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.000058Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine degradation0InformativeDirect
UniPathway (UP)choline metabolism0InformativeDirect
UniPathway (UP)L-histidine biosynthesis0.0000000000313InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.0000000003219InformativeDirect
UniPathway (UP)organic acid degradation0.0000001519InformativeDirect
UniPathway (UP)putrescine metabolism0.789InformativeInherited
UniPathway (UP)amine and polyamine degradation1InformativeInherited
UniPathway (UP)polyol degradation1InformativeInherited
UniPathway (UP)myo-inositol degradation into acetyl-CoA0Highly InformativeDirect
UniPathway (UP)L-proline biosynthesis0Highly InformativeDirect
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)putrescine degradation0Highly InformativeDirect
UniPathway (UP)betaine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-proline degradation0.000000001212Highly InformativeDirect
UniPathway (UP)bacterial bioluminescence1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ALDH-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the ALDH-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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