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Formate dehydrogenase/DMSO reductase, domains 1-3 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Formate dehydrogenase/DMSO reductase, domains 1-3 [ 53705]
Superfamily:   Formate dehydrogenase/DMSO reductase, domains 1-3 [ 53706]
Families:   Formate dehydrogenase/DMSO reductase, domains 1-3 [ 53707] (10)


Superfamily statistics
Genomes (2,468) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,586 92,144 19
Proteins 11,562 92,013 19


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000004019 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.855 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.7534 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9388 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.03714 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02417 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0008883 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00002711 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00001604 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00003241 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.001809 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.004615 Moderately Informative Inherited
Biological Process (BP) apoptotic process 0.000000007601 Informative Direct
Biological Process (BP) mitochondrion organization 0.0000000000758 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0000000003788 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000000005225 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00000002542 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.00000000255 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000001443 Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.0000000002231 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.000000002908 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0000000003866 Highly Informative Direct
Molecular Function (MF) binding 0.417 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.004855 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.0000000000416 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.0000000007981 Informative Direct
Molecular Function (MF) NADH dehydrogenase activity 0.000001131 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.0002009 Highly Informative Direct
Molecular Function (MF) metal cluster binding 0.00000000001519 Highly Informative Direct
Cellular Component (CC) membrane 0.00005677 Least Informative Direct
Cellular Component (CC) protein complex 0.0000002173 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1389 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7367 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1818 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.000003154 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.00000001374 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.000000002185 Moderately Informative Direct
Cellular Component (CC) external encapsulating structure 0.0001413 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.0000000000001111 Informative Direct
Cellular Component (CC) respiratory chain 0.000000000000006088 Informative Direct
Cellular Component (CC) respiratory chain complex I 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000001207Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1Moderately InformativeInherited
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0InformativeDirect
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.474InformativeInherited
Enzyme Commission (EC)Nitrate reductase0Highly InformativeDirect
Enzyme Commission (EC)Formate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.3808Highly InformativeInherited

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000008625InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.8373InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)Formate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase0.000000002067Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.1814Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Cellular componentMitochondrion0.0006276Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentMitochondrion inner membrane0.0000000001126InformativeDirect
Coding sequence diversitySelenocysteine0.0000000000001133InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationQuinone0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)nitrogen metabolism0.0000000000008717Moderately InformativeDirect
UniPathway (UP)energy metabolism0.0000000007859Moderately InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formate dehydrogenase/DMSO reductase, domains 1-3 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Formate dehydrogenase/DMSO reductase, domains 1-3 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]