SUPERFAMILY 1.75 HMM library and genome assignments server


Dihydrofolate reductase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Dihydrofolate reductase-like [ 53596]
Superfamily:   Dihydrofolate reductase-like [ 53597] (2)
Families:   Dihydrofolate reductases [ 53598] (3)
  RibD C-terminal domain-like [ 142701] (2)


Superfamily statistics
Genomes (3,056) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,762 40,862 32
Proteins 7,752 40,829 32


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process4.499e-062.422e-11Least InformativeDirect
Biological Process (BP)single-organism metabolic process2.824e-057.669e-10Least InformativeDirect
Biological Process (BP)heterocycle metabolic process1.784e-072.141e-13Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process6.946e-072.101e-12Least InformativeDirect
Biological Process (BP)biosynthetic process0.19470.0001406Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.00018690.002681Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process1.494e-091.968e-10Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process6.467e-052.59e-10Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process3.192e-125.37e-14Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.027143.28e-06Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.1540.09423Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.03881.493e-05Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.074461.352e-06Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process1.707e-157.208e-08InformativeDirect
Biological Process (BP)vitamin metabolic process0.00036981.069e-09InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process00Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.0003366.259e-08Highly InformativeDirect
Molecular Function (MF)binding0.0016950.4542Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding0.012670.7823Moderately InformativeInherited
Molecular Function (MF)RNA binding9.111e-101.81e-06InformativeDirect
Molecular Function (MF)cofactor binding0.0018821.637e-06InformativeInherited
Molecular Function (MF)nucleotide binding0.0022690.0004047InformativeInherited
Molecular Function (MF)drug binding2.603e-131.476e-12Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor00Highly InformativeDirect
Molecular Function (MF)NADP binding2.559e-071.056e-10Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 2.422e-11 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0001406 Least Informative Direct
Biological Process (BP) single-organism metabolic process 7.669e-10 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.141e-13 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 2.101e-12 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.002681 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1.968e-10 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 3.28e-06 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.59e-10 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 9.976e-06 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 5.37e-14 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.493e-05 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 1.352e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.09423 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 7.208e-08 Informative Direct
Biological Process (BP) vitamin metabolic process 1.069e-09 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.5715 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.657 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 6.259e-08 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.03601 Highly Informative Inherited
Molecular Function (MF) binding 0.4542 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.7823 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.0004047 Informative Direct
Molecular Function (MF) RNA binding 1.81e-06 Informative Direct
Molecular Function (MF) cofactor binding 1.637e-06 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2009 Informative Inherited
Molecular Function (MF) drug binding 1.476e-12 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.205e-11 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NADP binding 1.056e-10 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.0001523Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor4.166e-15Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases1.304e-06Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines6.147e-09InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds8.039e-05Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.000389Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.7107Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines1.418e-09InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase2.08e-09InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)pteridine biosynthesis0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)tetrahydrofolate biosynthesis0Highly InformativeDirect
UniPathway (UP)riboflavin biosynthesis4.834e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dihydrofolate reductase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Dihydrofolate reductase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]