SUPERFAMILY 1.75 HMM library and genome assignments server

Dihydrofolate reductase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Dihydrofolate reductase-like [ 53596]
Superfamily:   Dihydrofolate reductase-like [ 53597] (2)
Families:   Dihydrofolate reductases [ 53598] (3)
  RibD C-terminal domain-like [ 142701] (2)


Superfamily statistics
Genomes (3,064) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,754 40,862 32
Proteins 7,744 40,829 32


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.00000086370.000000000003482Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00006640.000000001521Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.000000026590.00000000000002422Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00000011430.0000000000002537Least InformativeDirect
Biological Process (BP)biosynthetic process0.11680.00005765Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.000095130.001567Least InformativeInherited
Biological Process (BP)single-organism cellular process0.007190.003417Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00000000018580.0000000000253Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0000086430.00000000009506Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00000000000080230.000000000000009016Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.012460.000001593Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.079780.06089Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.018530.000007532Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.03890.0000004629Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.19220.0001129Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process00.00000002084InformativeDirect
Biological Process (BP)vitamin metabolic process0.00048720.000000001426InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process00Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.000024870.000000003018Highly InformativeDirect
Molecular Function (MF)binding0.00076980.3643Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding0.034130.954Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.02810.0004493Moderately InformativeInherited
Molecular Function (MF)nucleotide binding0.00021760.00004784InformativeDirect
Molecular Function (MF)RNA binding0.000000003040.000007356InformativeDirect
Molecular Function (MF)cofactor binding0.00025180.000000117InformativeDirect
Molecular Function (MF)mRNA binding0.0000000000000052090.00000000002567Highly InformativeDirect
Molecular Function (MF)drug binding0.00000000000043850.000000000002555Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor00Highly InformativeDirect
Molecular Function (MF)NADP binding0.0000000026220.000000000001238Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.000000000003482 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00005765 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000000001521 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000000000002422 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000000000002537 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.003417 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.001567 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0000000000253 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000001593 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000000009506 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0001129 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000000000000009016 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000007532 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000004629 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.06089 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.00000002084 Informative Direct
Biological Process (BP) vitamin metabolic process 0.000000001426 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.5199 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.526 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.000000003018 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.009378 Highly Informative Inherited
Molecular Function (MF) binding 0.3643 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0004493 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.954 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00004784 Informative Direct
Molecular Function (MF) RNA binding 0.000007356 Informative Direct
Molecular Function (MF) cofactor binding 0.000000117 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2311 Informative Inherited
Molecular Function (MF) mRNA binding 0.00000000002567 Highly Informative Direct
Molecular Function (MF) drug binding 0.000000000002555 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.00000000001216 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0.000000000001238 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.0001523Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000000000000004166Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.000001304Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0.000000006147InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.00003012Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.0004268Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.6041Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0.0000000001678InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0.000000002407InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)pteridine biosynthesis0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)tetrahydrofolate biosynthesis0Highly InformativeDirect
UniPathway (UP)riboflavin biosynthesis0.000000000001082Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dihydrofolate reductase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Dihydrofolate reductase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]