SUPERFAMILY 1.75 HMM library and genome assignments server

Nucleoside hydrolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Nucleoside hydrolase [ 53589]
Superfamily:   Nucleoside hydrolase [ 53590]
Families:   Nucleoside hydrolase [ 53591] (4)


Superfamily statistics
Genomes (1,549) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,799 23,640 7
Proteins 3,603 23,516 7


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.0000000025350.00000004644Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.000000039220.0000005763Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0000000023770.00000003594Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0000000076090.0000001352Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0043880.0003353Least InformativeInherited
Biological Process (BP)single-organism cellular process0.13540.1838Least InformativeInherited
Biological Process (BP)biosynthetic process0.14410.146Least InformativeInherited
Biological Process (BP)single-organism catabolic process0.000043350.0008333Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00000011060.0000000000003584Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0000030220.0000001589Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0012630.00429Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00044710.002045Moderately InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.00000000024730.00000000000002753InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.000010940.000005444InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.0000036050.00007153InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process0.00067550.003866InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.001120.003146InformativeInherited
Biological Process (BP)pyrimidine ribonucleoside metabolic process0.000020470.000003756Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound catabolic process0.00000021820.00000006209Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000012980.000000006265Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.00000000019370.00000000000001653InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing N-glycosyl compounds0.0000016010.00000000004921Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00000004644 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000005763 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0003353 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000003594 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000001352 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1838 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.146 Least Informative Inherited
Biological Process (BP) single-organism catabolic process 0.0008333 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000000000003584 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000001589 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00429 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002045 Moderately Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.00000000000002753 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0.000005444 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00007153 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.003866 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.003146 Informative Inherited
Biological Process (BP) pyrimidine ribonucleoside metabolic process 0.000003756 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound catabolic process 0.00000006209 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000000006265 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.00000000000001653 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.00000000004921 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Molecular functionCalcium0.0000000122Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)purine biosynthesis via salvage pathway0InformativeDirect
UniPathway (UP)nucleoside biosynthesis0Highly InformativeDirect
UniPathway (UP)purine nucleoside metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001910 SSF53590 Protein matches
Abstract

Inosine-uridine preferring nucleoside hydrolase (IU-nucleoside hydrolase or IUNH) is an enzyme first identified in protozoan [PubMed8634237] that catalyzes the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates. This enzyme is important for these parasitic organisms, which are deficient in de novo synthesis of purines, to salvage the host purine nucleosides. IUNH from Crithidia fasciculata has been sequenced and characterised, it is an homotetrameric enzyme of subunits of 34 Kd. An histidine has been shown to be important for the catalytic mechanism, it acts as a proton donor to activate the hypoxanthine leaving group.

A highly conserved region located in the N-terminal extremity contains four conserved aspartates that have been shown [PubMed8634238] to be located in the active site cavity.

IUNH is evolutionary related to a number of uncharacterised proteins from various biological sources.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleoside hydrolase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Nucleoside hydrolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]