SUPERFAMILY 1.75 HMM library and genome assignments server

alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,185) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 173,524 577,304 251
Proteins 171,085 573,836 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)positive regulation of biological process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)lipid metabolic process0.000020420Moderately InformativeDirect
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.75780.00003692Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.45810.004561Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.8340.2886Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.7146Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.33640.03358Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)lipid catabolic process0.000000000013550InformativeDirect
Biological Process (BP)regulation of protein localization0.73821InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.25051InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.43921InformativeInherited
Biological Process (BP)negative regulation of cell communication11InformativeInherited
Biological Process (BP)negative regulation of signaling11InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.49071InformativeInherited
Biological Process (BP)positive regulation of transport11InformativeInherited
Biological Process (BP)positive regulation of cellular component organization11InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.84820.993InformativeInherited
Biological Process (BP)leukocyte activation0.33871InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport0.0038680.4305InformativeInherited
Biological Process (BP)regulation of intracellular transport0.27941InformativeInherited
Biological Process (BP)negative regulation of transport0.13391InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.68820.8584InformativeInherited
Biological Process (BP)single-organism membrane organization11InformativeInherited
Biological Process (BP)cell wall organization or biogenesis0.17830.6612InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11InformativeInherited
Biological Process (BP)pigment metabolic process0.570.3624InformativeInherited
Biological Process (BP)regulation of cellular catabolic process11InformativeInherited
Biological Process (BP)single-organism behavior0.40031InformativeInherited
Biological Process (BP)cation homeostasis11InformativeInherited
Biological Process (BP)cellular chemical homeostasis11InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0014740.000001086InformativeInherited
Biological Process (BP)phospholipid metabolic process0.56130.00002313InformativeInherited
Biological Process (BP)protein catabolic process0.00059470.5461InformativeInherited
Biological Process (BP)acyl-CoA metabolic process0.00067590.0004642Highly InformativeDirect
Biological Process (BP)lysosome organization0.0000000014830.0000004682Highly InformativeDirect
Biological Process (BP)protein deacylation00.0000000000008885Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process0.0000000000000032510Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.00058010.0005705Highly InformativeDirect
Biological Process (BP)regulation of synaptic transmission0.0072250.0004673Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.06090.6398Highly InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.009710.000000002874Highly InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.00048370.0586Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.000041310.03509Highly InformativeInherited
Biological Process (BP)negative regulation of protein transport0.001190.2011Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity0.87540.2986Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.0064880.344Highly InformativeInherited
Biological Process (BP)regulation of lipid storage0.00034120.003266Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation homeostasis0.092430.6132Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.15191Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)enzyme binding0.72561InformativeInherited
Molecular Function (MF)receptor binding0.96461InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.54220.0000004518InformativeInherited
Molecular Function (MF)peptidase activity11InformativeInherited
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.11490Highly InformativeInherited
Molecular Function (MF)serine hydrolase activity10.454Highly InformativeInherited
Molecular Function (MF)protein phosphatase binding0.000043320.1236Highly InformativeInherited
Molecular Function (MF)thiolester hydrolase activity0.00000000000044250.003078Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity11Highly InformativeInherited
Molecular Function (MF)O-acyltransferase activity0.066270.0000004936Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cell projection11Moderately InformativeInherited
Cellular Component (CC)vesicle0.98541Moderately InformativeInherited
Cellular Component (CC)lipid particle0.00058510InformativeDirect
Cellular Component (CC)microbody0.00063230.0006158InformativeDirect
Cellular Component (CC)neuron projection0.053641InformativeInherited
Cellular Component (CC)Golgi apparatus0.88241InformativeInherited
Cellular Component (CC)main axon0.0016370.09049Highly InformativeInherited
Cellular Component (CC)Golgi-associated vesicle0.000021270.01097Highly InformativeInherited
Cellular Component (CC)transport vesicle0.000088540.1907Highly InformativeInherited
Cellular Component (CC)coated vesicle0.00035660.6615Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00009358 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00003692 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.004561 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.2886 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7146 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.0238 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.03358 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.8659 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.00002313 Informative Direct
Biological Process (BP) lipid catabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0.0000004739 Informative Direct
Biological Process (BP) amide biosynthetic process 0.0003298 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000001086 Informative Direct
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.993 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.5697 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) peptide metabolic process 0.3094 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.4305 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2193 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.0992 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.3989 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.8584 Informative Inherited
Biological Process (BP) lipid localization 0.1517 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.98 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.2404 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.6612 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3624 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.03133 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.5671 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.1993 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.07943 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.5461 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.000006759 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.0004642 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.000000002874 Highly Informative Direct
Biological Process (BP) lysosome organization 0.0000004682 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00008714 Highly Informative Direct
Biological Process (BP) protein deacylation 0.0000000000008885 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.00003319 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.00002159 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.000001463 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.0005705 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0004673 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.03069 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 0.04984 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.5981 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.9646 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.6398 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.0586 Highly Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.05572 Highly Informative Inherited
Biological Process (BP) cell wall polysaccharide metabolic process 0.04693 Highly Informative Inherited
Biological Process (BP) digestion 0.00303 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.5563 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.03509 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.2011 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.6132 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.04212 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.00471 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2986 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) sterol transport 0.004345 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.344 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.003266 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.0000004518 Informative Direct
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.0000004936 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1 Highly Informative Inherited
Molecular Function (MF) serine hydrolase activity 0.454 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.1236 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.003078 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.6779 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0005601 Informative Direct
Cellular Component (CC) lipid particle 0 Informative Direct
Cellular Component (CC) microbody 0.0006158 Informative Direct
Cellular Component (CC) synapse 1 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) cell projection membrane 0.8522 Highly Informative Inherited
Cellular Component (CC) main axon 0.09049 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.01097 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.1907 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.6615 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000000004291InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000000000449InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000007839InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000219InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000007623InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0.00000000002246Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000004246Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5855Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.06723Moderately InformativeInherited
Disease Ontology (DO)meningioma0.00001671InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1465Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.5064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.07206Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.6374Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.844Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.02094InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.2213InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.2571InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4922InformativeInherited
Phenotypic Abnormality (PA)Steatorrhea0.00001584Highly InformativeDirect
Phenotypic Abnormality (PA)Xanthomatosis0.0001916Highly InformativeDirect
Phenotypic Abnormality (PA)Atherosclerosis0.0002401Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the coronary arteries0.0006811Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.0007621Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.02642Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.7881Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00008432Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001324Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.06641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal phospholipid level0.0006851Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.04493Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.000000000007994Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0000000000001191InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0.004185Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant0.00000007303InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.6017InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.7399InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.8433InformativeInherited
Enzyme Commission (EC)In linear amides0.8861InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.00000000006028Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000003369Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000007051Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00001168Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0002547Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.009235Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.7316Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.2329Least InformativeInherited
Drugbank ATC_code (DB)peripherally acting antiobesity products0.00000002908Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.00003907Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.009281Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processVirulence0.0000004961InformativeDirect
Biological processCytolysis0.00008765InformativeDirect
Biological processWnt signaling pathway0.0007418InformativeDirect
Biological processSteroid metabolism0.6605InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processCholesterol metabolism0.000000000001161Highly InformativeDirect
Biological processDetoxification0.000000000002022Highly InformativeDirect
Biological processHemolysis0.000003612Highly InformativeDirect
Cellular componentMembrane0.01094Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0.00000000002329Moderately InformativeDirect
Cellular componentEndosome0.0000002263Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome3.244e-16InformativeDirect
Cellular componentGPI-anchor0.00000000000001253InformativeDirect
Cellular componentPeroxisome0.00002131InformativeDirect
Cellular componentSynapse0.0004771InformativeDirect
Cellular componentLipid droplet0.0000000000003958Highly InformativeDirect
DiseaseAllergen0.00000002109Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionHeparin-binding4.62e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease0.0000000003348InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.0000000000799Least InformativeDirect
Post-translational modificationZymogen0.000000000002922InformativeDirect
Post-translational modificationNitration0.0000001946InformativeDirect
Post-translational modificationPhosphopantetheine0.0000000009202Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.0000000000001946Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.00000000008754Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.00000000000003848Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.00003596Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.0006443Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.03033Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism0.04627Moderately InformativeInherited
UniPathway (UP)glycan metabolism0.1424Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.8542Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0.000000000004602InformativeDirect
UniPathway (UP)glycan degradation0.000000001369InformativeDirect
UniPathway (UP)siderophore metabolism0.000000002666InformativeDirect
UniPathway (UP)glycerol metabolism0.000001076InformativeDirect
UniPathway (UP)phenylpropanoid degradation0.000002195InformativeDirect
UniPathway (UP)polyketide biosynthesis0.000003308InformativeDirect
UniPathway (UP)toxin biosynthesis0.00001701InformativeDirect
UniPathway (UP)alkaloid metabolism0.00004166InformativeDirect
UniPathway (UP)tryptophan metabolism0.7402InformativeInherited
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)xylan degradation0Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0Highly InformativeDirect
UniPathway (UP)butanoate metabolism0.000000000002247Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation0.00000000001913Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation0.00000000006493Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis0.000006004Highly InformativeDirect
UniPathway (UP)glycerolipid degradation0.00001361Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0006496Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.02119Highly InformativeInherited
UniPathway (UP)bacterial bioluminescence1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]