SUPERFAMILY 1.75 HMM library and genome assignments server


alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,178) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 170,311 0 251
Proteins 167,991 0 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.005958Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.6015Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)homeostatic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.41350.004578Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.050210Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process10.7387Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.310.08126Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.050112.748e-06Moderately InformativeInherited
Biological Process (BP)lipid catabolic process2.023e-110InformativeDirect
Biological Process (BP)negative regulation of cell communication0.94321InformativeInherited
Biological Process (BP)negative regulation of signaling0.91871InformativeInherited
Biological Process (BP)regulation of system process0.19610.3834InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.21651InformativeInherited
Biological Process (BP)positive regulation of transport11InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.99661InformativeInherited
Biological Process (BP)phospholipid metabolic process0.52192.573e-05InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0027523.492e-06InformativeInherited
Biological Process (BP)leukocyte activation0.31951InformativeInherited
Biological Process (BP)regulation of intracellular transport0.18981InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.31791InformativeInherited
Biological Process (BP)cellular membrane organization11InformativeInherited
Biological Process (BP)pigment metabolic process0.53150.5824InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.99361InformativeInherited
Biological Process (BP)single-organism behavior0.66721InformativeInherited
Biological Process (BP)cellular cation homeostasis0.91841InformativeInherited
Biological Process (BP)protein catabolic process0.00036590.5688InformativeInherited
Biological Process (BP)fatty acid metabolic process0.49220.2926InformativeInherited
Biological Process (BP)acyl-CoA metabolic process0.00025840.000241Highly InformativeDirect
Biological Process (BP)lysosome organization1.188e-093.594e-07Highly InformativeDirect
Biological Process (BP)protein deacylation05.296e-13Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process1.707e-150Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.00053630.0004706Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.18791Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.0088170.5185Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.0059230.3254Highly InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.0004270.8373Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.10280.7127Highly InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.016713.086e-08Highly InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.0004280.05011Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0072040.6267Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular transport7.718e-060.01594Highly InformativeInherited
Biological Process (BP)negative regulation of protein transport0.00081790.1611Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity0.87470.2983Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.15290.05038Highly InformativeInherited
Biological Process (BP)regulation of lipid storage0.0003120.002689Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH0.031470.05841Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.14590.9491Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)peptidase activity11InformativeInherited
Molecular Function (MF)enzyme binding0.62921InformativeInherited
Molecular Function (MF)receptor binding0.94011InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.80011.293e-06InformativeInherited
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.095660Highly InformativeInherited
Molecular Function (MF)protein phosphatase binding2.467e-050.08927Highly InformativeInherited
Molecular Function (MF)thiolester hydrolase activity2.542e-130.002755Highly InformativeInherited
Molecular Function (MF)O-acyltransferase activity0.018591.879e-09Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cell projection11Moderately InformativeInherited
Cellular Component (CC)vesicle0.84821Moderately InformativeInherited
Cellular Component (CC)neuron projection0.027631InformativeInherited
Cellular Component (CC)Golgi apparatus0.66941InformativeInherited
Cellular Component (CC)coated vesicle0.00088960.8354InformativeInherited
Cellular Component (CC)main axon0.001510.08365Highly InformativeInherited
Cellular Component (CC)Golgi-associated vesicle1.558e-050.009726Highly InformativeInherited
Cellular Component (CC)transport vesicle7.788e-050.1753Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.00012170.3226Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.005958 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 2.748e-06 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6015 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.004578 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.02296 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.08126 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.1875 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.8612 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.7387 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 2.573e-05 Informative Direct
Biological Process (BP) lipid catabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 7.575e-06 Informative Direct
Biological Process (BP) glycerolipid metabolic process 3.492e-06 Informative Direct
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.09719 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) cellular cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.9475 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2262 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.431 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.3834 Informative Inherited
Biological Process (BP) lipid localization 0.181 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.5824 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.2567 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.6463 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.086 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.1651 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.5688 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.2926 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 3.727e-06 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.000241 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 3.086e-08 Highly Informative Direct
Biological Process (BP) lysosome organization 3.594e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 5.296e-13 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 9.95e-05 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0.0003905 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 1.083e-05 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.0004706 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.08934 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.03696 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.6804 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.1743 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.3254 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.8373 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.7127 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.05011 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.05038 Highly Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.04912 Highly Informative Inherited
Biological Process (BP) digestion 0.002607 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6267 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01594 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.1611 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.008408 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 0.05841 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.003524 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.006061 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2983 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.5185 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.007808 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.002689 Highly Informative Inherited
Biological Process (BP) aging 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.9421 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.9491 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1.293e-06 Informative Direct
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 1.879e-09 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.08927 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.002755 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.4898 Moderately Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.8354 Informative Inherited
Cellular Component (CC) lipid particle 0 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.9971 Highly Informative Inherited
Cellular Component (CC) main axon 0.08365 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.009726 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.1753 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.3226 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases4.291e-10InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat4.49e-10InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s7.839e-10InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase2.19e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase7.623e-06InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.246e-11Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase4.246e-06Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5711Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.05938Moderately InformativeInherited
Disease Ontology (DO)meningioma1.463e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1529Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.5071Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.07698Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3629Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.6359Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.02272InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.2312InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.263InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4991InformativeInherited
Phenotypic Abnormality (PA)Steatorrhea1.592e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Xanthomatosis0.0001937Highly InformativeDirect
Phenotypic Abnormality (PA)Atherosclerosis0.0002414Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the coronary arteries0.0006935Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.0007771Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.02761Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8566Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0001985Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.002211Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.05637Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating phospholipid level0.000928Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0379Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant7.994e-12Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.191e-13InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0.004185Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant4.826e-08Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.6017InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.8344InformativeInherited
Enzyme Commission (EC)In linear amides0.8639InformativeInherited
Enzyme Commission (EC)Acting on a peroxide as acceptor0.8805InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)5.771e-11Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase3.214e-06Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase6.78e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase1.115e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0002543Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.009034Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.8738Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCarbohydrate metabolism3.008e-05Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.009341Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processVirulence1.052e-06InformativeDirect
Biological processCytolysis8.149e-05InformativeDirect
Biological processWnt signaling pathway0.0007069InformativeDirect
Biological processSteroid metabolism0.6304InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processCholesterol metabolism9.998e-13Highly InformativeDirect
Biological processDetoxification1.851e-12Highly InformativeDirect
Biological processHemolysis3.312e-06Highly InformativeDirect
Cellular componentMembrane0.009584Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction2.047e-11Moderately InformativeDirect
Cellular componentEndosome1.796e-07Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome3.235e-16InformativeDirect
Cellular componentGPI-anchor1.187e-14InformativeDirect
Cellular componentPeroxisome1.991e-05InformativeDirect
Cellular componentSynapse0.0004628InformativeDirect
Cellular componentLipid droplet3.81e-13Highly InformativeDirect
DiseaseAllergen2.239e-08Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionHeparin-binding4.636e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease3.6e-10InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond5.686e-11Least InformativeDirect
Post-translational modificationZymogen2.587e-12InformativeDirect
Post-translational modificationNitration1.905e-07InformativeDirect
Post-translational modificationPhosphopantetheine9.489e-09Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

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UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism2.208e-13Least InformativeDirect
UniPathway (UP)amino-acid metabolism8.254e-11Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis2.613e-14Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.0001041Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.0005222Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.0282Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism0.04018Moderately InformativeInherited
UniPathway (UP)glycan metabolism0.1338Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.8418Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis4.487e-12InformativeDirect
UniPathway (UP)glycan degradation1.079e-09InformativeDirect
UniPathway (UP)siderophore metabolism6.584e-07InformativeDirect
UniPathway (UP)glycerol metabolism7.081e-07InformativeDirect
UniPathway (UP)phenylpropanoid degradation2.357e-06InformativeDirect
UniPathway (UP)polyketide biosynthesis7.978e-06InformativeDirect
UniPathway (UP)toxin biosynthesis1.612e-05InformativeDirect
UniPathway (UP)alkaloid metabolism3.692e-05InformativeDirect
UniPathway (UP)tryptophan metabolism0.733InformativeInherited
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)xylan degradation0Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0Highly InformativeDirect
UniPathway (UP)butanoate metabolism1.495e-12Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation1.787e-11Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation5.655e-11Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis5.683e-06Highly InformativeDirect
UniPathway (UP)glycerolipid degradation0.0003041Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0007503Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.02115Highly InformativeInherited
UniPathway (UP)bacterial bioluminescence1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]