SUPERFAMILY 1.75 HMM library and genome assignments server


alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,183) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 172,925 577,304 251
Proteins 170,508 573,836 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.01066Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.684Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.047510Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process10.5622Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.45140.1021Moderately InformativeInherited
Biological Process (BP)lipid catabolic process1.433e-110InformativeDirect
Biological Process (BP)negative regulation of cell communication0.96971InformativeInherited
Biological Process (BP)negative regulation of signaling0.94861InformativeInherited
Biological Process (BP)regulation of system process0.2440.4803InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.25211InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport0.0053490.449InformativeInherited
Biological Process (BP)positive regulation of transport11InformativeInherited
Biological Process (BP)positive regulation of cellular component organization11InformativeInherited
Biological Process (BP)phospholipid metabolic process0.55872.191e-05InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.001531.009e-06InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.74970.9499InformativeInherited
Biological Process (BP)leukocyte activation0.34171InformativeInherited
Biological Process (BP)negative regulation of transport0.1051InformativeInherited
Biological Process (BP)regulation of intracellular transport0.23071InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.35531InformativeInherited
Biological Process (BP)cellular membrane organization11InformativeInherited
Biological Process (BP)pigment metabolic process0.55470.5851InformativeInherited
Biological Process (BP)regulation of cellular catabolic process11InformativeInherited
Biological Process (BP)single-organism behavior0.72791InformativeInherited
Biological Process (BP)cation homeostasis11InformativeInherited
Biological Process (BP)cellular chemical homeostasis11InformativeInherited
Biological Process (BP)protein catabolic process0.00047230.5018InformativeInherited
Biological Process (BP)acyl-CoA metabolic process0.00038230.0003035Highly InformativeDirect
Biological Process (BP)lysosome organization1.519e-094.874e-07Highly InformativeDirect
Biological Process (BP)protein deacylation08.164e-13Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process3.258e-150Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.000590.0005928Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.21221Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.013130.4807Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.0065980.3442Highly InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.0009550.96Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.12350.7637Highly InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.0097513.37e-09Highly InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.00049460.05629Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0086860.6728Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular transport1.081e-050.01973Highly InformativeInherited
Biological Process (BP)negative regulation of protein transport0.0010330.1852Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity0.87360.2986Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.19860.06983Highly InformativeInherited
Biological Process (BP)regulation of lipid storage0.0003480.003317Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation homeostasis0.093120.6029Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.1531Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)peptidase activity11InformativeInherited
Molecular Function (MF)enzyme binding0.70871InformativeInherited
Molecular Function (MF)receptor binding0.95911InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.52823.978e-07InformativeInherited
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.11560Highly InformativeInherited
Molecular Function (MF)serine hydrolase activity10.4324Highly InformativeInherited
Molecular Function (MF)protein phosphatase binding3.516e-050.1207Highly InformativeInherited
Molecular Function (MF)thiolester hydrolase activity6.058e-130.003652Highly InformativeInherited
Molecular Function (MF)O-acyltransferase activity0.021781.448e-08Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cell projection11Moderately InformativeInherited
Cellular Component (CC)vesicle0.98571Moderately InformativeInherited
Cellular Component (CC)microbody0.00061850.0006299InformativeDirect
Cellular Component (CC)neuron projection0.039961InformativeInherited
Cellular Component (CC)Golgi apparatus0.70311InformativeInherited
Cellular Component (CC)coated vesicle0.0012090.8865InformativeInherited
Cellular Component (CC)main axon0.0016560.09189Highly InformativeInherited
Cellular Component (CC)Golgi-associated vesicle1.83e-050.01087Highly InformativeInherited
Cellular Component (CC)transport vesicle9.039e-050.1897Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.00017530.3763Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.01066 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 4.5e-06 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.684 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.02452 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.1021 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.2669 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9465 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.5622 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 2.191e-05 Informative Direct
Biological Process (BP) lipid catabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 5.476e-06 Informative Direct
Biological Process (BP) amide biosynthetic process 0.0003332 Informative Direct
Biological Process (BP) glycerolipid metabolic process 1.009e-06 Informative Direct
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.449 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.9499 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) peptide metabolic process 0.186 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.09593 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2305 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.3985 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.4803 Informative Inherited
Biological Process (BP) lipid localization 0.1418 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.9811 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.5851 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.5579 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.1197 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.143 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.5018 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 5.667e-06 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.0003035 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 3.37e-09 Highly Informative Direct
Biological Process (BP) lysosome organization 4.874e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 8.164e-13 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 3.438e-05 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 1.978e-05 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 4.46e-06 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.0005928 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.1087 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.04532 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.7336 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2215 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.3442 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.96 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.7637 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.05629 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.06983 Highly Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.05681 Highly Informative Inherited
Biological Process (BP) digestion 0.003093 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6728 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01973 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.1852 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.004894 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.6029 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.004362 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.004849 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2986 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.4807 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.009245 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.003317 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.9705 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 3.978e-07 Informative Direct
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 1.448e-08 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1 Highly Informative Inherited
Molecular Function (MF) serine hydrolase activity 0.4324 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.1207 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.003652 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.7548 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0005259 Informative Direct
Cellular Component (CC) microbody 0.0006299 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.8865 Informative Inherited
Cellular Component (CC) cell projection membrane 0.8448 Highly Informative Inherited
Cellular Component (CC) main axon 0.09189 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.01087 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.1897 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.3763 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases4.291e-10InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat4.49e-10InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s7.839e-10InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase2.19e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase7.623e-06InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.246e-11Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase4.246e-06Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5814Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.06133Moderately InformativeInherited
Disease Ontology (DO)meningioma1.67e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1466Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.5067Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.07219Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.6376Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.844Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.02101InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.2214InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.2572InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4924InformativeInherited
Phenotypic Abnormality (PA)Steatorrhea1.608e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Xanthomatosis0.0001937Highly InformativeDirect
Phenotypic Abnormality (PA)Atherosclerosis0.0002428Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the coronary arteries0.0006877Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.0007693Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.02651Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8564Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.000202Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.002731Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.0564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating phospholipid level0.0009047Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.03741Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant7.994e-12Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.191e-13InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0.004185Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant7.319e-08InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.6017InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.7359InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.8384InformativeInherited
Enzyme Commission (EC)In linear amides0.9549InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)5.898e-11Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase3.384e-06Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase6.912e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase1.173e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0002544Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.008799Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.7277Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCarbohydrate metabolism3.668e-05Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.0087Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processVirulence4.736e-07InformativeDirect
Biological processCytolysis8.628e-05InformativeDirect
Biological processWnt signaling pathway0.000731InformativeDirect
Biological processSteroid metabolism0.6529InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processCholesterol metabolism1.128e-12Highly InformativeDirect
Biological processDetoxification1.965e-12Highly InformativeDirect
Biological processHemolysis3.549e-06Highly InformativeDirect
Cellular componentMembrane0.009398Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction2.203e-11Moderately InformativeDirect
Cellular componentEndosome1.886e-07Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome3.239e-16InformativeDirect
Cellular componentGPI-anchor1.28e-14InformativeDirect
Cellular componentPeroxisome2.051e-05InformativeDirect
Cellular componentSynapse0.0004631InformativeDirect
Cellular componentLipid droplet3.93e-13Highly InformativeDirect
DiseaseAllergen2.239e-08Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionHeparin-binding4.635e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease3.36e-10InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond8.432e-11Least InformativeDirect
Post-translational modificationZymogen3.162e-12InformativeDirect
Post-translational modificationNitration1.987e-07InformativeDirect
Post-translational modificationPhosphopantetheine9.243e-10Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism9.525e-12Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis4.137e-09Moderately InformativeDirect
UniPathway (UP)pigment metabolism0.05083Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism0.9477Moderately InformativeInherited
UniPathway (UP)heterocycle metabolism1Moderately InformativeInherited
UniPathway (UP)xenobiotic metabolism0InformativeDirect
UniPathway (UP)glycan degradation3.273e-15InformativeDirect
UniPathway (UP)beta-lactam biosynthesis0.0002101InformativeDirect
UniPathway (UP)aromatic compound degradation0.0002147InformativeDirect
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)pigment degradation1.363e-12Highly InformativeDirect
UniPathway (UP)heterocycle degradation1.363e-12Highly InformativeDirect
UniPathway (UP)penicillin G biosynthesis4.015e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]