SUPERFAMILY 1.75 HMM library and genome assignments server


alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,143) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 160,797 273,088 251
Proteins 158,921 270,923 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.01847Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.6662Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)homeostatic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.098430Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process10.7979Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.31580.09661Moderately InformativeInherited
Biological Process (BP)macromolecule catabolic process0.13821Moderately InformativeInherited
Biological Process (BP)lipid catabolic process3.032e-110InformativeDirect
Biological Process (BP)negative regulation of cell communication0.94321InformativeInherited
Biological Process (BP)negative regulation of signaling0.91981InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.20171InformativeInherited
Biological Process (BP)positive regulation of transport11InformativeInherited
Biological Process (BP)positive regulation of cellular component organization11InformativeInherited
Biological Process (BP)phospholipid metabolic process0.66768.376e-05InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0039755.615e-06InformativeInherited
Biological Process (BP)cell activation0.42181InformativeInherited
Biological Process (BP)regulation of intracellular transport0.18731InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.24671InformativeInherited
Biological Process (BP)regulation of system process0.37530.5268InformativeInherited
Biological Process (BP)membrane organization11InformativeInherited
Biological Process (BP)pigment metabolic process0.55450.5763InformativeInherited
Biological Process (BP)single-organism behavior0.64281InformativeInherited
Biological Process (BP)cation homeostasis0.99461InformativeInherited
Biological Process (BP)cellular chemical homeostasis11InformativeInherited
Biological Process (BP)protein catabolic process0.00031630.5904InformativeInherited
Biological Process (BP)acyl-CoA metabolic process0.00029320.0002858Highly InformativeDirect
Biological Process (BP)lysosome organization1.504e-095.633e-07Highly InformativeDirect
Biological Process (BP)protein deacylation01.313e-13Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process00Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.00058480.0003774Highly InformativeDirect
Biological Process (BP)regulation of synaptic transmission0.0074030.5629Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.0065560.3589Highly InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport0.0034150.3386Highly InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.01041.985e-08Highly InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.69440.9238Highly InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.00039610.04541Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0054990.6343Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular transport7.637e-060.01792Highly InformativeInherited
Biological Process (BP)negative regulation of protein transport0.00079590.174Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity0.87410.3141Highly InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.18731Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.16330.05436Highly InformativeInherited
Biological Process (BP)positive regulation of cellular catabolic process9.199e-050.4119Highly InformativeInherited
Biological Process (BP)regulation of lipid storage0.00028690.002742Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH0.033910.06442Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.26371Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)peptidase activity11InformativeInherited
Molecular Function (MF)enzyme binding0.6021InformativeInherited
Molecular Function (MF)receptor binding0.92271InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.80643.889e-06InformativeInherited
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.390Highly InformativeInherited
Molecular Function (MF)thiolester hydrolase activity2.289e-130.001838Highly InformativeInherited
Molecular Function (MF)O-acyltransferase activity0.018717.128e-09Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)vesicle0.84211Moderately InformativeInherited
Cellular Component (CC)Golgi apparatus0.72561InformativeInherited
Cellular Component (CC)coated vesicle0.00065620.8264InformativeInherited
Cellular Component (CC)Golgi-associated vesicle1.441e-050.01105Highly InformativeInherited
Cellular Component (CC)transport vesicle5.568e-050.1681Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle7.835e-050.3112Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01847 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 4.47e-06 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6662 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.0536 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.09661 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.3524 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.8989 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.7979 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 8.376e-05 Informative Direct
Biological Process (BP) lipid catabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 1.404e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 5.615e-06 Informative Direct
Biological Process (BP) regulation of ion transport 0.8971 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) cell activation 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.084 Informative Inherited
Biological Process (BP) cell-cell signaling 0.9984 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.407 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.4484 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.5268 Informative Inherited
Biological Process (BP) lipid localization 0.1876 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.9698 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.5763 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.261 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.6754 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.09617 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.1402 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.5904 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 3.259e-06 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.0002858 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 1.985e-08 Highly Informative Direct
Biological Process (BP) lysosome organization 5.633e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 1.313e-13 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.000393 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0.0004928 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 1.604e-05 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.0003774 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.3089 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.05226 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.1467 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.3589 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.3386 Highly Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.9238 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.04541 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.05436 Highly Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.04652 Highly Informative Inherited
Biological Process (BP) digestion 0.003246 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6343 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01792 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.174 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.009815 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 0.06442 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.003355 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.004986 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.3141 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.5629 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) cell junction organization 1 Highly Informative Inherited
Biological Process (BP) chromosome segregation 1 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.008818 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.4119 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.002742 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 3.889e-06 Informative Direct
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 7.128e-09 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1 Highly Informative Inherited
Molecular Function (MF) phospholipase activity 1 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.001838 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.5417 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0002493 Informative Direct
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.8264 Informative Inherited
Cellular Component (CC) lipid particle 0 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.9872 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.01105 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.1681 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.3112 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases4.291e-10InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat4.49e-10InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s7.839e-10InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase2.19e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase7.623e-06InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.246e-11Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase4.246e-06Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5757Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.05976Moderately InformativeInherited
Disease Ontology (DO)meningioma1.46e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1532Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.507Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.07724Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3627Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.6359Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.02288InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.2312InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.2628InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4992InformativeInherited
Phenotypic Abnormality (PA)Steatorrhea1.589e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Xanthomatosis0.000194Highly InformativeDirect
Phenotypic Abnormality (PA)Atherosclerosis0.0002415Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the coronary arteries0.0006978Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.0007812Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.02771Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8953Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0002055Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.002064Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level3.881e-06InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.0009047InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.03762InformativeInherited
Mammalian Phenotype (MP)abnormal circulating phospholipid level0.0007468Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.03583Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.1593Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant7.994e-12Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.191e-13InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0.004185Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant7.213e-08InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.6017InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.7386InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.8351InformativeInherited
Enzyme Commission (EC)In linear amides0.875InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)6.043e-11Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase3.168e-06Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase7.074e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase1.1e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0002597Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.009171Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.7304Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCarbohydrate metabolism3.539e-05Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.009328Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processVirulence8.093e-07InformativeDirect
Biological processWnt signaling pathway0.0007056InformativeDirect
Biological processCytolysis0.001079InformativeInherited
Biological processSteroid metabolism0.5957InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processCholesterol metabolism6.709e-13Highly InformativeDirect
Biological processDetoxification1.85e-12Highly InformativeDirect
Biological processHemolysis9.127e-05Highly InformativeDirect
Cellular componentMembrane0.01012Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction1.17e-11Moderately InformativeDirect
Cellular componentEndosome1.51e-07Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentGPI-anchor8.116e-15InformativeDirect
Cellular componentPeroxisome2.116e-05InformativeDirect
Cellular componentSynapse0.0003693InformativeDirect
Cellular componentLipid droplet2.097e-13Highly InformativeDirect
DiseaseAllergen2.218e-07Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionHeparin-binding4.618e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease4.129e-10InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond9.689e-11Least InformativeDirect
Post-translational modificationZymogen2.144e-12InformativeDirect
Post-translational modificationNitration1.813e-07InformativeDirect
Post-translational modificationPhosphopantetheine3.153e-09Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)antibiotic biosynthesis6.697e-15Moderately InformativeDirect
UniPathway (UP)organic acid metabolism1.824e-05Moderately InformativeDirect
UniPathway (UP)glycan metabolism5.998e-05Moderately InformativeDirect
UniPathway (UP)pigment metabolism0.0319Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.1579Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism0.9092Moderately InformativeInherited
UniPathway (UP)heterocycle metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)xenobiotic metabolism0InformativeDirect
UniPathway (UP)glycan degradation1.269e-15InformativeDirect
UniPathway (UP)siderophore metabolism8.152e-08InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0006908InformativeDirect
UniPathway (UP)aromatic compound degradation0.0007234InformativeDirect
UniPathway (UP)beta-lactam biosynthesis0.001921InformativeInherited
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)butanoate metabolism1.957e-13Highly InformativeDirect
UniPathway (UP)heterocycle degradation2.021e-13Highly InformativeDirect
UniPathway (UP)pigment degradation3.152e-13Highly InformativeDirect
UniPathway (UP)penicillin G biosynthesis5.977e-13Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation3.293e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]