SUPERFAMILY 1.75 HMM library and genome assignments server


alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,184) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 173,025 577,304 251
Proteins 170,608 573,836 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.01065Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.7176Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)homeostatic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.064630Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process10.702Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.36340.1072Moderately InformativeInherited
Biological Process (BP)lipid catabolic process3.415e-110InformativeDirect
Biological Process (BP)negative regulation of cell communication0.96751InformativeInherited
Biological Process (BP)negative regulation of signaling0.9461InformativeInherited
Biological Process (BP)regulation of system process0.22920.4473InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.25171InformativeInherited
Biological Process (BP)positive regulation of transport11InformativeInherited
Biological Process (BP)positive regulation of cellular component organization11InformativeInherited
Biological Process (BP)phospholipid metabolic process0.54891.994e-05InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0029171.585e-06InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.73350.9416InformativeInherited
Biological Process (BP)leukocyte activation0.34091InformativeInherited
Biological Process (BP)negative regulation of transport0.099721InformativeInherited
Biological Process (BP)regulation of intracellular transport0.21811InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.35451InformativeInherited
Biological Process (BP)cellular membrane organization11InformativeInherited
Biological Process (BP)pigment metabolic process0.55410.6062InformativeInherited
Biological Process (BP)regulation of cellular catabolic process11InformativeInherited
Biological Process (BP)single-organism behavior0.71081InformativeInherited
Biological Process (BP)cellular cation homeostasis0.94041InformativeInherited
Biological Process (BP)protein catabolic process0.00048970.4792InformativeInherited
Biological Process (BP)acyl-CoA metabolic process0.00029510.0002899Highly InformativeDirect
Biological Process (BP)lysosome organization1.532e-094.447e-07Highly InformativeDirect
Biological Process (BP)protein deacylation08.804e-13Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process3.321e-150Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.00058950.0006023Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.21181Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.011780.5258Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.00660.3432Highly InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.00054860.8819Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.12330.7477Highly InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.016145.809e-09Highly InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.00049450.05605Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0086750.6665Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular transport1.085e-050.01916Highly InformativeInherited
Biological Process (BP)negative regulation of protein transport0.0010310.1804Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity0.87440.2907Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.16330.05672Highly InformativeInherited
Biological Process (BP)regulation of lipid storage0.00034780.003137Highly InformativeInherited
Biological Process (BP)pH reduction0.016360.00825Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH0.041020.06753Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.15271Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)peptidase activity11InformativeInherited
Molecular Function (MF)enzyme binding0.70411InformativeInherited
Molecular Function (MF)receptor binding0.95731InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.83112.579e-06InformativeInherited
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.10250Highly InformativeInherited
Molecular Function (MF)serine hydrolase activity10.4228Highly InformativeInherited
Molecular Function (MF)protein phosphatase binding3.516e-050.1204Highly InformativeInherited
Molecular Function (MF)thiolester hydrolase activity4.518e-130.003798Highly InformativeInherited
Molecular Function (MF)O-acyltransferase activity0.021813.944e-09Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cell projection11Moderately InformativeInherited
Cellular Component (CC)vesicle0.98531Moderately InformativeInherited
Cellular Component (CC)microbody0.0006170.0006406InformativeDirect
Cellular Component (CC)neuron projection0.03441InformativeInherited
Cellular Component (CC)Golgi apparatus0.70361InformativeInherited
Cellular Component (CC)coated vesicle0.0010750.8685InformativeInherited
Cellular Component (CC)main axon0.0016540.09188Highly InformativeInherited
Cellular Component (CC)Golgi-associated vesicle1.83e-050.01083Highly InformativeInherited
Cellular Component (CC)transport vesicle9.061e-050.1894Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.00014880.3528Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.01065 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 6.025e-06 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7176 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.02381 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.1072 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.2425 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.905 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.702 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 1.994e-05 Informative Direct
Biological Process (BP) lipid catabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 1.012e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 1.585e-06 Informative Direct
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.9416 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.09234 Informative Inherited
Biological Process (BP) cellular cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.9936 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2098 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.4072 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.4473 Informative Inherited
Biological Process (BP) lipid localization 0.1347 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.6062 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.3053 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.5289 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.09954 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.1714 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.4792 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 5.406e-06 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.0002899 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 5.809e-09 Highly Informative Direct
Biological Process (BP) lysosome organization 4.447e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 8.804e-13 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 3.57e-05 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 5.433e-05 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 9.934e-06 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.0006023 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.1066 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.04507 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.7297 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2051 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.3432 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.8819 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.7477 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.05605 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.05672 Highly Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.05479 Highly Informative Inherited
Biological Process (BP) digestion 0.003074 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6665 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01916 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.1804 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.01038 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 0.06753 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.004408 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.002754 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2907 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.5258 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.008972 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.003137 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.977 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) pH reduction 0.00825 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 2.579e-06 Informative Direct
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 3.944e-09 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1 Highly Informative Inherited
Molecular Function (MF) serine hydrolase activity 0.4228 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.1204 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.003798 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.7363 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0005064 Informative Direct
Cellular Component (CC) microbody 0.0006406 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.8685 Informative Inherited
Cellular Component (CC) cell projection membrane 0.7933 Highly Informative Inherited
Cellular Component (CC) main axon 0.09188 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.01083 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.1894 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.3528 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases4.291e-10InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat4.49e-10InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s7.839e-10InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase2.19e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase7.623e-06InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.246e-11Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase4.246e-06Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5777Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.06042Moderately InformativeInherited
Disease Ontology (DO)meningioma1.684e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1504Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.5061Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.07466Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.6389Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.0228InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.2324InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.26InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4951InformativeInherited
Phenotypic Abnormality (PA)Steatorrhea1.521e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Xanthomatosis0.0001867Highly InformativeDirect
Phenotypic Abnormality (PA)Atherosclerosis0.0002353Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the coronary arteries0.0006772Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.0007582Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.02686Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8568Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0001993Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.002739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.05565Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating phospholipid level0.0009152Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.03772Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant7.994e-12Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.191e-13InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0.004185Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant5.227e-08InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.6017InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.7326InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.8367InformativeInherited
Enzyme Commission (EC)In linear amides0.8686InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)5.863e-11Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase3.217e-06Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase6.873e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase1.117e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0002544Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.009179Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.7242Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCarbohydrate metabolism3.668e-05Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.0087Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processVirulence4.736e-07InformativeDirect
Biological processCytolysis8.628e-05InformativeDirect
Biological processWnt signaling pathway0.000731InformativeDirect
Biological processSteroid metabolism0.6529InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processCholesterol metabolism1.128e-12Highly InformativeDirect
Biological processDetoxification1.965e-12Highly InformativeDirect
Biological processHemolysis3.549e-06Highly InformativeDirect
Cellular componentMembrane0.009398Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction2.203e-11Moderately InformativeDirect
Cellular componentEndosome1.886e-07Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome3.239e-16InformativeDirect
Cellular componentGPI-anchor1.28e-14InformativeDirect
Cellular componentPeroxisome2.051e-05InformativeDirect
Cellular componentSynapse0.0004631InformativeDirect
Cellular componentLipid droplet3.93e-13Highly InformativeDirect
DiseaseAllergen2.239e-08Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionHeparin-binding4.635e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease3.36e-10InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond8.432e-11Least InformativeDirect
Post-translational modificationZymogen3.162e-12InformativeDirect
Post-translational modificationNitration1.987e-07InformativeDirect
Post-translational modificationPhosphopantetheine9.243e-10Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism3.577e-13Least InformativeDirect
UniPathway (UP)amino-acid metabolism6.792e-11Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis2.655e-14Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.0001128Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.0006289Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.02978Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism0.04481Moderately InformativeInherited
UniPathway (UP)glycan metabolism0.1395Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.8486Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis4.663e-12InformativeDirect
UniPathway (UP)glycan degradation1.224e-09InformativeDirect
UniPathway (UP)siderophore metabolism2.575e-09InformativeDirect
UniPathway (UP)glycerol metabolism1.029e-06InformativeDirect
UniPathway (UP)phenylpropanoid degradation2.357e-06InformativeDirect
UniPathway (UP)polyketide biosynthesis7.983e-06InformativeDirect
UniPathway (UP)toxin biosynthesis1.669e-05InformativeDirect
UniPathway (UP)alkaloid metabolism3.82e-05InformativeDirect
UniPathway (UP)tryptophan metabolism0.7415InformativeInherited
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)xylan degradation0Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0Highly InformativeDirect
UniPathway (UP)butanoate metabolism2.177e-12Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation1.866e-11Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation6.191e-11Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis5.89e-06Highly InformativeDirect
UniPathway (UP)glycerolipid degradation1.359e-05Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0007504Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.02117Highly InformativeInherited
UniPathway (UP)bacterial bioluminescence1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]