SUPERFAMILY 1.75 HMM library and genome assignments server


alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,184) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 172,981 577,304 251
Proteins 170,564 573,836 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.009285Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)lipid metabolic process1.975e-050Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.6872Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.44220.003742Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.44750.1014Moderately InformativeInherited
Biological Process (BP)lipid catabolic process1.366e-110InformativeDirect
Biological Process (BP)negative regulation of cell communication0.99291InformativeInherited
Biological Process (BP)negative regulation of signaling0.97491InformativeInherited
Biological Process (BP)regulation of system process0.18540.4459InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.25081InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport0.0026170.3717InformativeInherited
Biological Process (BP)positive regulation of transport11InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.96771InformativeInherited
Biological Process (BP)phospholipid metabolic process0.55632.134e-05InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0015161.032e-06InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.75360.9498InformativeInherited
Biological Process (BP)leukocyte activation0.33951InformativeInherited
Biological Process (BP)negative regulation of transport0.10931InformativeInherited
Biological Process (BP)regulation of intracellular transport0.25821InformativeInherited
Biological Process (BP)regulation of protein localization0.71731InformativeInherited
Biological Process (BP)cellular membrane organization11InformativeInherited
Biological Process (BP)cell wall organization or biogenesis0.17840.6568InformativeInherited
Biological Process (BP)pigment metabolic process0.56930.593InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.99781InformativeInherited
Biological Process (BP)single-organism behavior0.74611InformativeInherited
Biological Process (BP)cation homeostasis11InformativeInherited
Biological Process (BP)cellular chemical homeostasis11InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11InformativeInherited
Biological Process (BP)protein catabolic process0.00051710.5044InformativeInherited
Biological Process (BP)acyl-CoA metabolic process0.0003780.0003059Highly InformativeDirect
Biological Process (BP)lysosome organization1.489e-094.715e-07Highly InformativeDirect
Biological Process (BP)protein deacylation09.951e-13Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process3.261e-150Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.00058550.0005838Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.22361Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.0077030.4776Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.006540.3413Highly InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.00094570.9641Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.058330.6298Highly InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.0097613.175e-09Highly InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.00048840.05769Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.010590.6716Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular transport1.259e-050.02085Highly InformativeInherited
Biological Process (BP)negative regulation of protein transport0.0011080.1891Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity0.87420.2986Highly InformativeInherited
Biological Process (BP)regulation of lipid storage0.00034480.003268Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation homeostasis0.092710.6136Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.15211Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)peptidase activity11InformativeInherited
Molecular Function (MF)enzyme binding0.70941InformativeInherited
Molecular Function (MF)receptor binding0.96441InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.52874.036e-07InformativeInherited
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.11470Highly InformativeInherited
Molecular Function (MF)serine hydrolase activity10.448Highly InformativeInherited
Molecular Function (MF)protein phosphatase binding3.465e-050.1193Highly InformativeInherited
Molecular Function (MF)thiolester hydrolase activity6.047e-130.003894Highly InformativeInherited
Molecular Function (MF)O-acyltransferase activity0.023261.757e-08Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cell projection11Moderately InformativeInherited
Cellular Component (CC)vesicle0.9861Moderately InformativeInherited
Cellular Component (CC)microbody0.00063810.0006209InformativeDirect
Cellular Component (CC)neuron projection0.052931InformativeInherited
Cellular Component (CC)Golgi apparatus0.71081InformativeInherited
Cellular Component (CC)coated vesicle0.0012610.8942InformativeInherited
Cellular Component (CC)main axon0.0016420.09097Highly InformativeInherited
Cellular Component (CC)Golgi-associated vesicle2.149e-050.01102Highly InformativeInherited
Cellular Component (CC)transport vesicle8.926e-050.19Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.00018660.3834Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.009285 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 3.01e-06 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6872 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.003742 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.02029 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.1014 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.2623 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9475 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 2.134e-05 Informative Direct
Biological Process (BP) lipid catabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 6.06e-06 Informative Direct
Biological Process (BP) amide biosynthetic process 0.0003319 Informative Direct
Biological Process (BP) glycerolipid metabolic process 1.032e-06 Informative Direct
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.3717 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.9498 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.6568 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) peptide metabolic process 0.1901 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.09884 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2309 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.3987 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.4459 Informative Inherited
Biological Process (BP) lipid localization 0.1394 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.9817 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.593 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.5677 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.1222 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.1536 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.5044 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 6.826e-06 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.0003059 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 3.175e-09 Highly Informative Direct
Biological Process (BP) lysosome organization 4.715e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 9.951e-13 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 3.334e-05 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 2.169e-05 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 5.09e-06 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.0005838 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.1073 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.04932 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.7489 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.229 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.3413 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.9641 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.6298 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.05769 Highly Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.05592 Highly Informative Inherited
Biological Process (BP) cell wall polysaccharide metabolic process 0.04707 Highly Informative Inherited
Biological Process (BP) digestion 0.003035 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6716 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.02085 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.1891 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.005331 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.6136 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.009903 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.004842 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2986 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.4776 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.009057 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.003268 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.9687 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 4.036e-07 Informative Direct
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 1.757e-08 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1 Highly Informative Inherited
Molecular Function (MF) serine hydrolase activity 0.448 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.1193 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.003894 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.754 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0005428 Informative Direct
Cellular Component (CC) microbody 0.0006209 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.8942 Informative Inherited
Cellular Component (CC) cell projection membrane 0.8459 Highly Informative Inherited
Cellular Component (CC) main axon 0.09097 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.01102 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.19 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.3834 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases4.291e-10InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat4.49e-10InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s7.839e-10InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase2.19e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase7.623e-06InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.246e-11Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase4.246e-06Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5855Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.06723Moderately InformativeInherited
Disease Ontology (DO)meningioma1.671e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1465Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.5064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.07206Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.6374Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.844Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.02094InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.2213InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.2571InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4922InformativeInherited
Phenotypic Abnormality (PA)Steatorrhea1.584e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Xanthomatosis0.0001916Highly InformativeDirect
Phenotypic Abnormality (PA)Atherosclerosis0.0002401Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the coronary arteries0.0006811Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.0007621Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.02642Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.7881Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis8.432e-05Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001324Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.06641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal phospholipid level0.0006851Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.04493Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant7.994e-12Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.191e-13InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0.004185Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant7.303e-08InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.6017InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.7399InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.8433InformativeInherited
Enzyme Commission (EC)In linear amides0.8861InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)6.028e-11Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase3.369e-06Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase7.051e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase1.168e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0002547Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.009235Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.7316Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCarbohydrate metabolism3.907e-05Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.009281Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processVirulence4.961e-07InformativeDirect
Biological processCytolysis8.765e-05InformativeDirect
Biological processWnt signaling pathway0.0007418InformativeDirect
Biological processSteroid metabolism0.6605InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processCholesterol metabolism1.161e-12Highly InformativeDirect
Biological processDetoxification2.022e-12Highly InformativeDirect
Biological processHemolysis3.612e-06Highly InformativeDirect
Cellular componentMembrane0.01094Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction2.329e-11Moderately InformativeDirect
Cellular componentEndosome2.263e-07Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome3.244e-16InformativeDirect
Cellular componentGPI-anchor1.253e-14InformativeDirect
Cellular componentPeroxisome2.131e-05InformativeDirect
Cellular componentSynapse0.0004771InformativeDirect
Cellular componentLipid droplet3.958e-13Highly InformativeDirect
DiseaseAllergen2.109e-08Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionHeparin-binding4.62e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease3.348e-10InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond7.99e-11Least InformativeDirect
Post-translational modificationZymogen2.922e-12InformativeDirect
Post-translational modificationNitration1.946e-07InformativeDirect
Post-translational modificationPhosphopantetheine9.202e-10Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism1.946e-13Least InformativeDirect
UniPathway (UP)amino-acid metabolism8.754e-11Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis3.848e-14Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism3.596e-05Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.0006443Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.03033Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism0.04627Moderately InformativeInherited
UniPathway (UP)glycan metabolism0.1424Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.8542Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis4.602e-12InformativeDirect
UniPathway (UP)glycan degradation1.369e-09InformativeDirect
UniPathway (UP)siderophore metabolism2.666e-09InformativeDirect
UniPathway (UP)glycerol metabolism1.076e-06InformativeDirect
UniPathway (UP)phenylpropanoid degradation2.195e-06InformativeDirect
UniPathway (UP)polyketide biosynthesis3.308e-06InformativeDirect
UniPathway (UP)toxin biosynthesis1.701e-05InformativeDirect
UniPathway (UP)alkaloid metabolism4.166e-05InformativeDirect
UniPathway (UP)tryptophan metabolism0.7402InformativeInherited
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)xylan degradation0Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0Highly InformativeDirect
UniPathway (UP)butanoate metabolism2.247e-12Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation1.913e-11Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation6.493e-11Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis6.004e-06Highly InformativeDirect
UniPathway (UP)glycerolipid degradation1.361e-05Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0006496Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.02119Highly InformativeInherited
UniPathway (UP)bacterial bioluminescence1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]