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Molybdenum cofactor biosynthesis proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Molybdenum cofactor biosynthesis proteins [ 53217]
Superfamily:   Molybdenum cofactor biosynthesis proteins [ 53218] (2)
Families:   MogA-like [ 53219] (5)
  MoeA central domain-like [ 64103] (2)


Superfamily statistics
Genomes (2,658) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,732 47,786 31
Proteins 8,303 47,311 31


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.0004921 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00002641 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0001487 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00004788 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001494 Least Informative Direct
Biological Process (BP) localization 0.3609 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9218 Least Informative Inherited
Biological Process (BP) developmental process 0.7876 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.007609 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6737 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.000001981 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000002231 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000000005323 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000009397 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000000114 Moderately Informative Direct
Biological Process (BP) nervous system development 0.04178 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.005687 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001079 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.01792 Moderately Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.0002533 Informative Direct
Biological Process (BP) cellular membrane organization 0.00005966 Informative Direct
Biological Process (BP) molybdopterin cofactor metabolic process 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Molybdopterin adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Transferring molybdenum- or tungsten-containing gr0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0.000000000004473Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.02259Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.00007462Moderately InformativeDirect
Molecular functionMagnesium0.00000000001199Moderately InformativeDirect
Molecular functionFlavoprotein0.00001265Moderately InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionFMN0.000000002934InformativeDirect
Molecular functionFAD0.0000005162InformativeDirect
Post-translational modificationTransferase0.00000000000004258Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001453 SSF53218 Protein matches
Abstract Eukaryotic and prokaryotic molybdoenzymes require a molybdopterin cofactor (MoCF) for their activity. The biosynthesis of this cofactor involves a complex multistep enzymatic pathway. One of the eukaryotic proteins involved in this pathway is the Drosophila protein cinnamon [PubMed8088525] which is highly similar to gephyrin, a rat microtubule-associated protein which was thought to anchor the glycine receptor to subsynaptic microtubules.

Cinnamon and gephyrin are evolutionary related, in their N-terminal half, to the Escherichia coli MoCF biosynthesis proteins mog/chlG and moaB/chlA2 and, in their C-terminal half, to E. coli moeA/chlE.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Molybdenum cofactor biosynthesis proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Molybdenum cofactor biosynthesis proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]