SUPERFAMILY 1.75 HMM library and genome assignments server


Zn-dependent exopeptidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphorylase/hydrolase-like [ 53162] (8)
Superfamily:   Zn-dependent exopeptidases [ 53187] (9)
Families:   Pancreatic carboxypeptidases [ 53188] (4)
  Carboxypeptidase T [ 53198]
  Leucine aminopeptidase, C-terminal domain [ 53201]
  Bacterial dinuclear zinc exopeptidases [ 53204] (17)
  FolH catalytic domain-like [ 53210] (2)
  N-acetylmuramoyl-L-alanine amidase-like [ 102517] (2)
  AstE/AspA-like [ 142526] (2)
  Glutaminyl-peptide cyclotransferase-like [ 142532]
  FGase-like [ 159652] (2)


Superfamily statistics
Genomes (3,232) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,238 0 71
Proteins 46,648 0 71


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.057850Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.8781Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.47431Least InformativeInherited
Biological Process (BP)cellular protein modification process0.038630.6478Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.0089111Moderately InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.0051478.708e-14InformativeInherited
Molecular Function (MF)hydrolase activity3.031e-060Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds1.087e-107.11e-13InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.0011781.087e-06InformativeInherited
Molecular Function (MF)peptidase activity0.094450InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups1.842e-080Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.0002210Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.003984 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5742 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.02114 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) system process 0.9417 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6478 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.7057 Moderately Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 8.708e-14 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular amide metabolic process 3.722e-15 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001301 Informative Direct
Biological Process (BP) metal ion homeostasis 0.1382 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.008785 Informative Inherited
Biological Process (BP) response to wounding 0.5146 Informative Inherited
Biological Process (BP) growth 0.924 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.6911 Informative Inherited
Biological Process (BP) cell-cell signaling 0.6964 Informative Inherited
Biological Process (BP) leukocyte activation 0.4102 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 0.8399 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.4134 Informative Inherited
Biological Process (BP) protein catabolic process 0.951 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.1528 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) sensory organ development 0.6457 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) protein processing 4.165e-12 Highly Informative Direct
Biological Process (BP) post-translational protein modification 4.844e-10 Highly Informative Direct
Biological Process (BP) iron ion homeostasis 7.118e-05 Highly Informative Direct
Biological Process (BP) cellular transition metal ion homeostasis 0.0002086 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.0006495 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.0008794 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.005677 Highly Informative Inherited
Biological Process (BP) wound healing 0.2531 Highly Informative Inherited
Biological Process (BP) developmental growth 0.5147 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.003451 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.008085 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.02843 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) cation binding 0.0007286 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7.11e-13 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1.087e-06 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 5.825e-08 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0007336 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 3.302e-12 Highly Informative Direct
Molecular Function (MF) tubulin binding 3.475e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.4163 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 4.421e-09 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1.708e-06 Moderately Informative Direct
Cellular Component (CC) vesicle 0.02958 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 2.823e-05 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0001564 Informative Direct
Cellular Component (CC) endosome 0.5208 Informative Inherited
Cellular Component (CC) lytic vacuole 0.07951 Informative Inherited
Cellular Component (CC) recycling endosome 0.0002907 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0006016InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Aminopeptidases0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0004314Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processVirulence4.701e-16InformativeDirect
Biological processCell wall biogenesis/degradation2.987e-05InformativeDirect
Biological processEndocytosis0.0003555InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processNotch signaling pathway3.838e-06Highly InformativeDirect
Biological processPurine metabolism0.0001093Highly InformativeDirect
Cellular componentCytoplasm3.863e-08Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor5.541e-06InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionCobalt0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.0002661Least InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation9.979e-05Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine degradation0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)ureide metabolism0.004653InformativeInherited
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0.0008453Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 48 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Zn-dependent exopeptidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 48 hidden Markov models representing the Zn-dependent exopeptidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]